Tissue regeneration is the process by which the body repairs or replaces damaged tissues and organs. Since regenerative medicine is still in its infancy, scientists are investigating how to treat specific diseases with tissue regeneration. It has been discovered by researchers at the Institute for Research in Biomedicine in Spain that vitamin B12 is crucial for tissue regeneration. Researchers also discovered that in a model of ulcerative colitis, vitamin B12 supplementation sped up tissue repair. Regenerative medicine, or tissue regeneration, is the process of rebuilding the body’s damaged tissues and organs in order to replace or heal them. There are several possible causes of damage to these tissues and organs, including aging, trauma, illness, and birth defects. Regenerative medicine is still a relatively new and experimental field. Scholars are investigating the potential applications of tissue regeneration in the management of conditions such as inflammatory bowel disease, pancreatitis, bone fractures, cartilage disorders, and heart injuries. Vitamin B12 may be crucial for tissue regeneration and cellular reprogramming, according to research from the Institute for Research in Biomedicine in Spain.
The journal Nature Metabolism published the findings recently. In a model of ulcerative colitis, a form of inflammatory bowel disease (IBD), scientists tested their theory and found that vitamin B12 supplementation would help intestinal cells that are attempting to heal themselves. Dr. Manuel Serrano, a co-lead author of this study and researcher at the Institute for Research in Biomedicine in Spain during the studys period, recently moved to Altos Labs in the United Kingdom. He says that after discovering something unexpected when examining how the microbial populations of the colon change during reprogramming, they decided to investigate the effect of vitamin B12 on cellular reprogramming and tissue regeneration. According to Dr. Serrano, the microbiota of mammals is in equilibrium with the host, as she told Medical News Today. The microbiota is impacted by changes in the hosts metabolism and vice versa. We discovered that the microbiota of mice underwent alterations during reprogramming that were suggestive of a vitamin B12 deficiency. Both microorganisms and mammals require vitamin B12. According to earlier studies, vitamin B12 helps the body heal by promoting the neurological tissues required for muscle restoration or when nerves are injured, as in the case of a traumatic brain injury. It has also been demonstrated that vitamin B12 contributes to bone health.
Furthermore, a research study released in August 2022 discovered that vitamin B12 can aid in the regeneration and repair of skin damaged by radiodermatitis, a side effect of radiation therapy used to treat cancer. The researchers discovered that vitamin B12 supplementation enhanced the effectiveness of cell reprogramming, which is thought to be an early stage of tissue repair, using both mouse and cultured cell models. Vitamin B12 helps with cellular reprogramming and tissue regeneration, as Dr. Marta Kovatcheva, a researcher at the Institute for Research in Biomedicine in Spain and co-lead author of this study, explained to . According to her, vitamin B12 is only involved in two metabolic reactions in mammals, such as mice and humans, and one of these reactions is essential for creating a chemical tag, or more precisely, a methyl donor. This chemical group is used to tag a number of the DNAs regulatory proteins as well as the DNA itself; in doing so, the DNA is reprogrammed and its activity is altered. This tagging is very dynamic and complex and, though not fully understood yet, is essential for figuring out how cells behave, including how they can regenerate or repair tissue, explained Dr. Dot Kovatcheva.
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