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Can prediabetes be reversed with diet and exercise

Can prediabetes be reversed with diet and exercise

Diabetes, more especially type 2 diabetes, is emerging as one of the 21st century’s most difficult medical issues. It is also anticipated that 380 million individuals globally will receive a diabetes diagnosis by 2025. Diabetes management and treatment are increasingly important because it is a risk factor for many other diseases and chronic health conditions, including stroke, kidney disease, cardiovascular disease, and blindness, to name a few. However, many people are thought to be in a precursor stage known as prediabetes before they go on to develop type 2 diabetes. People with this illness have blood sugar levels that are higher than normal but not high enough to be classified as type 2 diabetes. However, a significant risk factor for type 2 diabetes is prediabetes. The statistics of those who have prediabetes provide a clear picture when it comes to scaling this issue: more than one in three persons in the U.S. S. along with the U. K. have been identified as prediabetic. Therefore, if prediabetes is considered an early warning sign of type 2 diabetes, people can take  steps to reverse the course of this condition and it is possible to reverse this condition with significant lifestyle changes.

On our May podcast, “In Conversation: Can diet and exercise help reverse prediabetes?” Dr. Thomas Barber, an associate clinical professor at Warwick Medical School and consultant endocrinologist at University Hospitals Coventry and Warwickshire, joined Dr. Hilary Guite and me. Additionally, Healthline Media and Medical News Today Managing Editor Angela Chao shared her personal story of reversing her diagnosis of prediabetes and the lifestyle changes she made to maintain it. In Angela’s instance, few medical professionals would have thought that her blood sugar levels were concerning. She is not thin, young, and energetic like most people with prediabetes or those at risk of getting diabetes. She did, however, admit that at the time she led a fairly sedentary lifestyle. She said that because my readings were so low on the spectrum, I don’t even think my primary care physician at the time talked to me about it beyond providing the range and the diagnosis. She did, however, add that some doctors and her medical friends seemed concerned about the changes to the cutoff point for readings that qualified as prediabetes.

According to Dr. Barber, the diagnosis of diabetes and prediabetes was previously made using fasting glucose readings or a conventional glucose tolerance test. In this test, participants were given 75 grams of a sugar-filled beverage, and their blood sugar levels were monitored for the following two hours. Additionally, the definition of prediabetes is constantly changing and may vary from nation to nation. Definitions vary amongst societies and prestigious organizations. According to Dr. Barber, the first thing to really keep in mind is that there is a continuum involved when discussing diabetes or prediabetes. Should we choose the U. S. along with the U. K. For instance, there are variations in the thresholds and units of measurement applied when diagnosing prediabetes. As you point out, there are various units, which makes it a little confusing. However, in essence, in the U. K. for glucose, we use millimoles per liter, and in the U.S. S. milligrams per deciliter, to be exact. We typically use millimoles per mole in clinical settings now, and we have for a while, according to Dr. Barber. He went on, “I think that further complicating matters is the hemoglobin A1C, which has two different percentage units, one that we have historically used and the other that is now replaced by millimoles per mole.

According to Dr. Barber, glucose is a continuous variable rather than a discrete measure. He clarified that while everyone can agree on what is elevated and what is normal, there are kind of disagreements about everything in between. The World Health Organization approved hemoglobin A1C as a test for diabetes a few years ago. While additional glucose readings can be useful, Dr. Barber stated that medical professionals do primarily rely on A1C in current clinical practice. With regard to prediabetes in the U.S. K. this is predicated on an A1C of 39 to 47 mmol per mol; according to him, 39 is equal to an A1C of 5 points 7 percent. Anything that raises the hemoglobin A1C level above 48 millimoles per mole, or 6.5% of the baseline, is considered diabetes by definition. According to him, in order to diagnose type 2 diabetes, we should ideally have at least two of those readings that are elevated. When Angela was diagnosed, her A1C was 5 points8 percent, and anything above 5 points7 was considered prediabetes. Dr. Barber reminded us that, in the United States, Angela’s readings would not have been regarded as prediabetes and that, in recent years, the diagnostic criteria for diabetes have gradually decreased. K. at the time, since the values were extremely near to normal and not quite below the cut-off.

Usually, prediabetes shows no symptoms at all. On the other hand, some people may occasionally have frequent thirst, wake up in the middle of the night to urinate, experience blood sugar spikes, or have energy crashes. Prediabetes is frequently asymptomatic, so many people who are diagnosed with it may have had it for months or even years. Furthermore, it can easily go unreported unless people are tested for it, according to Dr. Barber. In describing her personal experience, Angela said, “I definitely didn’t have a wide range of symptoms.”. On the other hand, I was definitely already drinking water on a regular basis. I therefore found it difficult to determine whether anything was changing. Low blood sugar, particularly if she went for prolonged periods without eating, was something she did notice prior to the diagnosis. Over the years, she said, there has been a consistent pattern of significant fluctuations in her blood sugar levels, which she could feel physically. She can, however, fast trouble-free for more than 16 hours now because of certain lifestyle adjustments. Sugar surges and falls may be considered preemptive indicators of diabetes.

According to Dr. Dot Barber, prediabetes is a general term that can refer to either elevated fasting glucose or elevated postprandial glucose. Dr. Dot Barber stated that fluctuations in blood sugar levels, or glycemia, were often observed in the context of insulin resistance. Glucose levels tend to rise a little higher than they should, he explained, because the beta cells can’t produce enough insulin, for example, or the insulin isn’t as effective after a meal. He explained that without careful monitoring of blood sugar levels throughout the day, people might not physically notice these changes. “I guess the difference really is that most of the time, in the context of prediabetes, we’re not aware of this,” he said. It makes perfect sense that as you lead a healthier lifestyle, lose weight, and reverse prediabetes, your blood sugar levels will stabilize. He mentioned Angela’s description of the changes she saw and said that the insulin becomes more effective and can handle the fluctuations in glycemia better.

Obesity, having a high body mass index, and being overweight are some of the most well-known risk factors for type 2 diabetes. Additionally, as we age, our vulnerability increases. And the reason for that is that as we age, the beta cells and insulin’s receptors can no longer function as well, and insulin itself becomes slightly less effective. Accordingly, as we age, our chance of having prediabetes and diabetes rises, according to Dr. Barber. Dr. Barber added that eating a diet heavy in high-glycemic foods and sugary drinks, as well as stress, can all raise risk. Conversely, he asserted that a diet low in simple carbohydrates and high in fiber can delay the onset of dysglycemia. Genetics and ethnic origin are other factors to consider. Dr. Dot Barber presented the results of a recent study she and her colleagues carried out in the U. K. which revealed that, at a BMI of 23.9%, individuals of South Asian ethnicity had the same risk of developing diabetes as did white people at 30.

In contrast, Angela’s risk was increased by her family history. My mother, a retired medical doctor, had warned me since I was a teenager about the slight family history of type 2 diabetes on my father’s side. She also mentioned that everyone on that side of the family was thin and had no weight problems. Dr. According to Barber, diabetes is frequently attributed to lifestyle decisions, but many people are unaware that it is a hereditary disorder. According to him, patients with a strong family history may not always exhibit the characteristics of type 2 diabetes, such as being middle-aged, male, obese, and having a large abdomen. That’s the idea that most people with type 2 diabetes have of the typical person. And, he added, as you say, Angela doesn’t conform to any of those stereotypes of what that entails. Dr. Barber also emphasized that having a genetic predisposition to diabetes at birth can result in dysglycemia even in the absence of those other factors. More than 40 genes and gene mutations have been found to increase your risk of developing type 2 diabetes. Additionally, he stated that even though each effect is relatively weak on its own, adding them all together can have a cumulative effect. Through a combination of intermittent fasting, a balanced diet with an increased amount of lower-glycemic index foods and complex carbohydrates, and a sig, Angela was able to reverse her diabetes.

She advised against strict dieting, keto, and quick, drastic changes that aren’t long-term. Dr. Barber acknowledged that while this approach obviously worked for Angela, not many people would be able to make such drastic life changes and may find it challenging. According to Dr. Barber, there is evidence to suggest that intensive lifestyle treatments that prioritize diet, physical activity, weight loss, and other related factors can effectively prevent or postpone the onset of type 2 diabetes. In my opinion, it serves as a kind of early warning system that indicates when a person needs to make a lifestyle change. He added that it must be beneficial if it inspires or motivates people to alter their way of life.

REFERENCES:

https://www.medicalnewstoday.com/articles/in-conversation-can-diet-and-exercise-reverse-prediabetes?utm_source=ReadNext
https://www.hopkinsmedicine.org/health/wellness-and-prevention/prediabetes-diet
https://www.healthline.com/health/diabetes/how-to-reverse-prediabetes-naturally
https://www.healthcentral.com/condition/type-2-diabetes/how-can-you-reverse-prediabetes
https://www.breathewellbeing.in/blog/reverse-your-prediabetes-with-the-best-diet-and-exercise/

For diabetes disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_95

People with diabetes and other conditions can benefit from high-intensity water exercise.

People with diabetes and other conditions can benefit from high-intensity water exercise.

According to research, adults with chronic conditions can exercise more effectively when they participate in aquatic high-intensity interval training (AHIIT). They observed that AHIIT had an effect comparable to that of land-based training (LBHIIT) and that it might be a useful and safe substitute for those with long-term medical conditions who are unable to engage in land-based exercise. Although there is conflicting data regarding the physiological benefits of exercising in the water, experts agree that it can help reduce joint strain and enable individuals to perform movements that they may not be able to on dry land. For those with long-term medical conditions who find land-based training too challenging, researchers have a message. Come on in. The water is clear. Currently available in the BMJ Open Sport and Exercise Medicine journal. According to the study, adults with chronic conditions like diabetes and arthritis can exercise more effectively when they participate in high-intensity interval training (AHIIT), which is conducted in water. Additionally, the researchers claim that AHIIT has an effect comparable to that of land-based training (LBHIIT) and that it could be a beneficial and safe substitute for LBHIIT for those with long-term medical conditions. Dr. Sports medicine expert Mark Slabaugh of Mercy Medical Center in Baltimore told Medical News Today that exercising in the water has obvious advantages for those with chronic pain, arthritis, and tendinitis.

Salbaugh, who was not involved in the study, said, “This study gives us as clinicians even more options for patients who are interested in cross training and doing HIIT workouts but can not due to joint pain.”. “I advise my patients to begin with these brief AHIIT sessions and work their way up to longer swimming sessions, as swimming is a sport that can be continued well into old age. The study team examined 18 trials to compare the effects of AHIIT and LBHIIT on participants’ ability to exercise (as determined by oxygen consumption, walking tests, and other physical fitness assessments). Additionally, they contrasted AHIIT with a control group that did not exercise and moderate-intensity exercise in water (AMICT). Using the widely accepted GRADE system, the researchers evaluated the degree of certainty in the evidence. They examined 868 participants with a variety of illnesses, including multiple sclerosis, back pain, arthritis, type 2 diabetes, and chronic lung disease (COPD), with 74% of the participants being female. A few individuals were dealing with multiple chronic illnesses. Standardized mean differences (SMD) were used in the study to represent group differences. A small effect was indicated by an SMD of 0.2-0.49, a moderate effect by 0.5-0.79, and a large effect by 0.8 or more.

According to the study, AHIIT had a minor positive impact when compared to AMICT (SMD 0.45) and a moderately positive impact when compared to no exercise (SMD 0.78). Furthermore, there was no discernible difference in the exercise capacity between LBHIIT and AHIIT. Compared to LBHIIT, fewer adverse events were reported with AHIIT. The range of 84 percent to 100 percent was the adherence rate for AHIIT. Physical therapist Sydnee Corbin is also the clinic director of SporTherapy in Texas, where therapy is conducted in a swimming pool. Water-based therapy, according to Corbin, who was not involved in the study, helps people with conditions like osteoarthritis, balance issues, sensory processing disorders, generalized weakness/deconditioning, and post-operative patients by offloading joints while increasing resistance. According to Corbin, “the pool is a great opportunity to provide resistance and sensory feedback—a unique property that is difficult to replicate on land.”. Reaching a patient population that would otherwise be sedentary or inactive can be greatly facilitated by an aquatic setting. “.

According to Corbin, individuals who suffer from osteoarthritis, persistent low back pain, or other long-term medical conditions might not be able to fully engage in LBHIIT and reap the full benefits of HIIT. “By introducing AHIIT, we can decrease further health risks to those populations and be more inclusive to them,” the speaker stated. In addition to offloading joints, the aquatic environment gives users’ systems sensory input that might otherwise be sensitized due to chronic pain, constant resistance from the water, and, if done in a heated pool, the ability to relax otherwise painful muscles and joints. “Mr. Medical News Today was informed by William Ashford, an orthopedic surgeon at AICA Orthopedics in Atlanta who was not involved in the study, that AHIIT presents a highly effective treatment modality, especially for individuals with musculoskeletal conditions like chronic back pain and arthritis. According to Ashford, the buoyancy of the water minimizes joint stress and offers a natural resistance, enabling people to engage in exercises that would be too painful or impractical on land. Additionally, Ashford noted that the cardiovascular benefits of HIIT are well-established, and applying this knowledge to an aquatic setting appears to enhance these benefits for some populations. According to Ashford, maintaining an exercise routine is essential to managing chronic illnesses.

Water exercise has its limitations as well. “Although beneficial for numerous individuals, it may not be appropriate for all patients, particularly those with specific chronic lung conditions, as the water pressure may cause difficulties in breathing,” stated Ashford. Also, some patients may find it difficult to get to the right facilities. Having said that, Ashford recommended further study to find strategies for expanding the reach of water-based therapy. “AHIIT is a highly effective, flexible, and patient-centered method for treating a range of chronic illnesses,” the speaker stated. The benefits of HIIT are combined with the special qualities of water to create a synergistic effect that can be especially helpful for patients who have trouble with land-based exercises. “.

REFERENCES:

https://www.diabetes.org.uk/guide-to-diabetes/managing-your-diabetes/exercise/swimming-diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347725/
https://www.swimming.org/justswim/diabetes-and-swimming/
https://www.medicalnewstoday.com/articles/how-high-intensity-water-exercise-can-help-people-with-diabetes-and-other-conditions

For diabetics medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_95

Depression increases the risk of mortality among people living with diabetes

Depression increases the risk of mortality among people living with diabetes

More than 462 million people worldwide suffer with type 2 diabetes, making it the ninth most common cause of death. People with type 2 diabetes frequently experience mental health problems; research indicates that the likelihood of depression is twice as high in those with the disease as in those without it. According to a recent study, the risk of dying young is four times higher for those who have type 2 diabetes and depression combined than for those who don’t. The authors advocate for the inclusion of mental health services in type 2 diabetes patients’ medical regimens.

Using data from the Global Burden of Disease dataset, a study conducted in 2017 projected that 462 million individuals worldwide, or 6.28% of the total population, had type 2 diabetes. Since then, the number has grown, and by 2050, it is anticipated that there will be more than 1.3 billion type 2 diabetics globally. Individuals who have diabetes are more likely than those who do not to experience depression. The World Health Organization (WHO) estimates that 5% of persons worldwide suffer from depression, also known as depressive disorder. Research has also shown that people with type 2 diabetes have twice the risk of developing depression compared to the general population.

Type 2 diabetes and depression together can raise the chance of death by up to four times, according to a recent study. Both illnesses increase the risk of mortality. Professor of public health at current Mexico State University and lead and corresponding author of the current study Dr. Jagdish Khubchandani told MNT that “it is estimated that almost a fifth of people with diabetes may also have depression symptoms of varying severity” globally. Data from 14,920 participants in the National Health and Nutrition Examination Survey, conducted between 2005 and 2010, were analyzed by the researchers. The Centers for Disease Control and Prevention (CDC) death records up to December 31, 2019, were then linked to these data.

When it came to the participants’ diabetes status, the researchers recorded it as diabetes if they replied “yes” or “borderline” to the question, “Other than during pregnancy, have you ever been told by a doctor or other health professional that you have diabetes or sugar diabetes?”. They measured depression using the PHQ-9, a tool for gauging depression severity. Anyone who received a score of 10 or higher on the questionnaire—which has a maximum score of 27—was deemed to have depression. 10% of the cohort had type 2 diabetes, and 9 points08 percent had depression. Sixteen percent of people with type 2 diabetes also experienced depression. The researchers discovered that, overall, individuals with type 2 diabetes had a 1:7 chance of dying before their time after adjusting for sociodemographic variables. The risk of dying young was more than four times higher for those with type 2 diabetes and depression than for those without either illness.

“Considering the range of additional conditions, including depression, that often coexist with diabetes, specialists in diabetes care may not be able to provide assistance on their own,” he continued. Dr. This viewpoint was echoed by Gabbay, who stated that “[t]he American Diabetes Association Standards of Care recommends routine screening for depression because it is a common condition in people with diabetes, predicts poor outcomes, and, shockingly, now increases the risk of death.”. “It is crucial to screen for depression, which can be as easy as asking a PHQ-2 question [about the frequency of depressed mood], and then concentrate on appropriate treatments, given that there are effective treatments for depression,” he said. According to Dr. Gabbay, there are a number of factors that may contribute to diabetes and depression, including inflammation, sleep disturbance, an inactive lifestyle, poor dietary habits, and environmental and cultural risk factors.

There are several possible explanations for the link between type 2 diabetes and depression. He pointed out that people who are depressed are frequently less likely to lead healthy lifestyles, which can result in poorer glucose regulation and an increased risk of diabetes complications. We may not fully understand the biological connection, but it appears to play a significant role in the relationship between depression and type 2 diabetes, Dr. Gabbay continued. Dr. Khubchandani stressed how critical it is to treat both illnesses. He informed us that a combination of antidepressants and hypoglycemic drugs are recommended for optimum management of both the disorders and to prevent worsening of any of these, although receiving treatment for any one of the two disorders is still preferable to receiving none at all. He continued, Frequent monitoring and screening is essential for this to occur, and diabetes care practitioners must remain vigilant about mental health issues among patients.. Dr. Khubchandani further emphasized the need for prompt action to stop needless diabetes-related deaths. He emphasized that by 2050, the number of people with diabetes worldwide will have rapidly doubled from 400 million today, adding that diabetes imposes a lot of social, economic, and emotional burdens.. In the absence of a more thorough and serious approach to mental health issues, the number of diabetics who pass away too soon will increase. .

High blood sugar levels brought on by diabetes can cause a number of health problems that can impact the body’s organs. Controlling these levels can lower the chance of harm occurring to the entire body. Diabetes can be treated to a lesser extent by receiving an early diagnosis and adhering to a treatment plan that includes medication, lifestyle modifications, and routine medical care. The primary cause of early death for diabetics is cardiovascular disease, according to the Centers for Disease Control and Prevention (CDC). According to the CDC, the risk of having a stroke or passing away from heart disease is two to three times higher for those who have diabetes than for those who do not. Moreover, diabetes patients typically experience more severe cardiac issues earlier in life than non-diabetic individuals. Furthermore, diabetes frequently coexists with other heart-stressing conditions like obesity, hypertension, and high cholesterol. Diabetes and cardiovascular disease are both at risk due to poor diet and inactivity. When there is an infection or wound, the body’s capacity to heal is compromised by poor circulation. The lack of blood, oxygen, and nutrients is the cause of this. Diabetes patients should frequently examine their skin for wounds and should consult a physician if they experience any infection-related symptoms, such as redness, swelling, or fever.

One of the most frequent side effects of diabetes is neuropathy, or nerve damage. Nerve damage affects roughly 10–20% of individuals with diabetes at diagnosis. A person’s risk of developing neuropathy increases with the length of time they have diabetes. Over 50% of individuals with diabetes will develop the illness at some point. Any area of the nervous system, including the nerves governing autonomic or involuntary processes like digestion, can be affected by neuropathy. On the other hand, peripheral neuropathy is the most prevalent type. The legs, feet, and toes, as well as the arms, hands, and fingers, are affected, resulting in pain and numbness. The upper legs and hips can also be affected by neuropathy. According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), peripheral neuropathy accounts for up to 50% of cases of diabetes, while autonomic neuropathy accounts for over 30% of cases. High blood sugar levels have the potential to harm kidney blood vessels over time. The kidneys’ ability to filter waste from the blood is compromised by this damage. Kidney failure may develop eventually. One of the primary causes of kidney disease, according to the NIDDK, is diabetes. It impacts one in three diabetics.

Diabetes raises the possibility of several ocular issues, some of which can result in blindness. One of the short-term issues is hazy vision from elevated blood sugar. Diabetic retinopathy, macular edema, cataracts, and glaucoma are long-term complications. Controlling blood sugar, avoiding or quitting smoking, and scheduling routine eye exams can all help preserve eye health in diabetics. Nervous system damage can impact autonomic bodily processes, such as digestion. When nerve damage prevents the digestive system from properly moving food from the stomach into the small intestine, the condition known as gastroparesis may result. Diabetes may cause a person to experience nausea, vomiting, acid reflux, bloating, abdominal pain, and, in extreme situations, weight loss. Stress can be reduced by learning as much as possible about diabetes. It may also cause concerns about treatment, health, and potential complications that can lead to stress, anxiety, and depression. Concerns about the cost of treatment and whether or not they are getting it right, especially if symptoms change mood disorders that make it difficult for a person to maintain a healthy lifestyle. A person will feel more in control of their diabetes and its management the more informed they are about their illness. Being aware of what to do in every circumstance can help someone feel more confident and better about themselves in general. Reducing these issues can be achieved by collaborating with a healthcare provider. A physician or therapist may do so.

REFERENCES:

https://www.sciencedirect.com/science/article/pii/S016383431300011X
https://www.cdc.gov/diabetes/managing/mental-health.html
https://pubmed.ncbi.nlm.nih.gov/37898065/
https://www.medicalnewstoday.com/articles/317483

For  Anti Depression and Diabetes  medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=30

According to a study, insulin may be kept at room temperature for months without losing its effectiveness.

According to a study, insulin may be kept at room temperature for months without losing its effectiveness.

According to recent studies, insulin does not lose its efficacy even when kept out of the refrigerator for several months. Insulin can be maintained at room temperature, according to guidelines already in place, but the new information provides further detail on acceptable temperature ranges. Insulin must be kept out of direct sunlight and kept at or above 25°C (77°F) or below freezing for optimal effects. For those with type 1 diabetes who are unable to consistently refrigerate their insulin, new research reveals that insulin can be kept at room temperature for months and still maintain its efficacy.

In a recent review, the Cochrane Collaboration examined the effects of various temperatures on insulin and discovered that unopened containers of some human insulin types could be kept at 77°F, or 25°C, for up to six months without significantly losing potency. The information affects both individuals without refrigerators and those whose refrigerators may not be dependable. Richter points out that some refrigerator pockets truly get too cold below freezingwhich reduces the effectiveness of any insulin that may be kept there.

It is possible to maintain the efficacy of insulin if it is not refrigerated and is stored outside. Richter advises avoiding direct sunlight and letting it grow too hot or too chilly. Insulin that hasn’t been opened should normally be stored in refrigerators at 4°C (39°F), whereas insulin that is being used should be left at room temperature. Richter noted that the new data from our research indicated that insulin could be administered for longer periods of time and at greater temperatures without significantly reducing activity in those living in challenging settings.

According to him, the results have raised new issues that might be the subject of further investigation, such as examining the impacts of both motion and temperature. According to him, “people who use insulin pumps, for instance, wear them close to their bodies, which causes a higher temperature, and they’re more or less continuously moving.” We also seek information on how people who live in cold climates keep their insulin from freezing. Individuals with type 1 diabetes are well aware of the urgent necessity of insulin. Insulin is a dependable and efficient treatment for type 1 diabetes since it lowers blood glucose in those whose systems are unable to manage glucose on their own.

It is imperative for physicians to inform their patients about the warning signs and symptoms of hypoglycemia reactions. For this reason, he said, it’s imperative that you constantly remind your patients that they must eat in order for their bodies to absorb glucose and that they should always carry a glucose tablet. Dr. Romain mentioned that he treats patients from a low-income community, which can make it difficult for them to get insulin.

For the patient, it might be quite difficult, especially if they don’t have insurance. I make an effort to learn about my patients’ daily lives because many people are unaware of the seriousness of type 1 diabetes. He stated that it is important to consider the potential for serious problems. Knowing what foods to eat and how much exercise is necessary since diabetes, whether type 1 or not, can induce myocardial infarction, which is the main cause of death for diabetics. Dr. Romain continued, “It all comes down to teaching the patient how critical it is to get the illness under control so we can avoid those consequences from developing.

REFERENCES:

https://www.cochrane.org/news/human-insulin-less-temperature-sensitive-previously-thought
https://www.healthline.com/health-news/safe-insulin-storage-room-temperature
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015385.pub2/full

For diabetes medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_95

Daily exercise of just 20 to 25 minutes may reduce the risk of death from extended sitting.

Daily exercise of just 20 to 25 minutes may reduce the risk of death from extended sitting.

The higher risk of death linked to a sedentary lifestyle can be eliminated with about 22 minutes of moderate to intense physical activity every day, according to a recent study. People’s risk of dying reduces more the more they exercise. The results of the study demonstrate that regular exercise can be done in one sitting or in smaller bursts during the day. Contrary to popular belief, a recent study indicates that much less exercise can lower a person’s risk of death. The study discovers that a sedentary lifestyle can lower one’s chance of dying young by as much as 22 minutes per day of moderate to vigorous physical activity (MVPA).

Naturally, the benefits of exercise are dose-dependent, meaning that, up to a certain degree, the more activity, the lower the risk of mortality. 11,989 participants in multiple fitness-tracker studies—the Swedish Healthy Aging Initiative, the Norwegian National Physical Activity Survey, the Norwegian Tromso Study, and the U.S. National Health and Nutrition Examination Survey—were monitored by the study’s authors. Every participant in the studies, who was at least fifty years old, gave the researchers information about their height, weight, sex, education, alcohol and smoking habits, and history of diabetes, heart disease, or cancer. 6,042 people sat for 10.5 hours or more every day, compared to 5,943 participants who sat for less than that amount. The purpose of the study was to evaluate the impact of physical activity and inactive time on mortality risk as determined by death registries. If an individual does not exercise for more than 22 minutes per day, sitting for more than 12 hours per day is linked to a 38% higher risk of death than sitting for 8 hours.

A minimum of 75 minutes of intense activity, 150–300 minutes of moderate–to–vigorous exercise per week, or a combination of both is advised by the World Health Organization (WHO).

The first author of the study, Dr. Edvard H. Sagelv of UiT The Arctic University of Norway in Tromso, stated: “There is some disagreement in the research community regarding the dangers of prolonged periods of inactivity. Sedentary time is not that harmful when compared to not exercising, in my opinion. He continued, “Yet prior research suggests that prolonged periods of inactivity are elevating the likelihood of illness and untimely demise.”

“Our legs and core muscles will weaken if we’re not using them, which will make it harder for us to walk a little distance, which will decrease our desire to be active,” she continued. Additionally, this raises the possibility of falling, which increases our risk of injuries that further discourage us from engaging in physical activity. “Keep in mind that the heart is a muscle,” Dr. Zaslow advised. She pointed out that the cardiac muscle weakens with less activity, making physical activity much more difficult as the heart must be reconditioned. According to Dr. Zaslow, cardiometabolic illness has been linked to sedentary lifestyles.

Dr. Melody Ding, who was not involved in the study, stated that although the study is focused on older adults, physical activity is known to give a range of advantages, including mental health, cardiometabolic profiles, and cognitive functioning. Dr. Ding stated, “There are good reasons to be active throughout your lifespan.” Dr. Zaslow made the point that exercise is necessary for even young children to develop and strengthen their muscles since it prepares them for a lifetime of physical activity. Furthermore, physical activity is linked to improved mental health, including a decrease in anxiety and depression. This is still another significant advantage, according to Dr. Zaslow, considering the highly publicized mental health issue among youth.

She said that exercise helps people sleep better as well, making it easier to fall asleep and stay asleep longer. “We are aware that injury rates are lower when we get better sleep. Thus, research indicates that children who get more than eight hours of sleep have 50% fewer injuries. “I consider exercise and exercising consistently to be like an upward spiral,” Dr. Zaslow remarked. Dr. Sagelv emphasized that the study’s 22 minutes of daily physical exercise equates to the 150 minutes that the WHO recommends. According to our research, people who engage in moderate-to-intense physical exercise for longer than 22 minutes a day do not have a higher risk of dying from being inactive for longer. This runs counter to the WHO’s guideline, according to him, to deal with high sedentary time that cannot be avoided by consuming more than 150–300 minutes of MVPA each week.

It doesn’t seem to have an upper limit at which it stops being beneficial to health. The risk decrease does however, seem to level off at the higher ends, roughly 60–120 minutes per day, especially for people who are extremely sedentary.” It’s also not necessary for people to engage in 22 minutes of action all at once every day, as per Dr. Zaslow and earlier studies. Taking ten or fifteen minutes here and there to engage in “exercise snacking” may be a more manageable task for individuals with hectic schedules. It’s crucial to keep in mind that, from the standpoint of public health, performing any MVPA is preferable to performing none at all. Dr. Ding stated that it is better to exert a little bit more effort even if one is unable to meet the goal.

REFERENCES:

https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/exercising-just-for-20-25-minutes-can-prevent-death-risk-due-to-prolonged-sitting/articleshow/104784810.cms?from=mdr
https://www.medicalnewstoday.com/articles/daily-20-25-mins-of-physical-activity-may-offset-death-risk-from-prolonged-sitting
https://www.bmj.com/company/newsroom/daily-20-25-mins-of-physical-activity-may-offset-death-risk-from-prolonged-sitting/

For any medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com

Getting rid of belly fat could aid in reversing prediabetes.

Getting rid of belly fat could aid in reversing prediabetes.

Prior to developing into type 2 diabetes, prediabetes raises the risk of heart attack, kidney, eye, and other cancers. There isn’t a recognized pharmacological therapy for prediabetes at the moment. Researchers at the German Center for Diabetes Research (DZD) have now demonstrated the mechanisms by which prediabetes can be put into remission, or a condition in which blood glucose levels return to normal. The DZD multicenter trial further demonstrates that long-term improvement in renal and vascular function is linked to long-term protection against type 2 diabetes and prediabetes remission. The researchers write in The Lancet diabetic & Endocrinology that it’s interesting because the underlying mechanisms are distinct from those in type 2 diabetic remission.

People with type 2 diabetes are more likely to experience heart attacks, renal problems, strokes, and death. Up until a few years ago, type 2 diabetes was believed to be untreatable. We now understand that significant weight loss can significantly reduce the risk of type 2 diabetes in a large number of people. The majority of people often develop type 2 diabetes once more within a few years, therefore this remission rarely lasts. Due to their higher risk of developing type 2 diabetes as well as issues with the heart, kidneys, and eyes, among other things, people with prediabetes may need to know this.

But what triggers the remission of prediabetes? In order to answer this query, researchers from the Department of Diabetology, Endocrinology, and Nephrology at the University Hospital of Tübingen and the Institute of Diabetes Research and Metabolic Diseases (IDM) at Helmholtz Munich performed a post-hoc analysis on participants with prediabetes from the Prediabetes Lifestyle Intervention Study (PLIS).

In a one-year lifestyle intervention involving a balanced diet and more exercise, 1,105 people with prediabetes participated in this randomized-controlled multicenter trial run by the DZD. The 298 participants who had lost at least 5% of their body weight as a result of the intervention were next evaluated by the researchers. Participants who had responded were those whose fasting, 2-hour, and HbA1c levels had returned to normal after a year, indicating that they had entered remission. Non-responders were people who lost weight but still had prediabetes and did not go into remission.

Contrary to what the researchers had hypothesized, there was no difference in relative weight loss between responders and non-responders, indicating that it was not weight loss that separated those who entered remission from those who did not. Individuals who were able to attain remission, as opposed to non-responders, showed a noticeable improvement in insulin sensitivity. In essence, they were better able to increase their sensitivity to the hormone insulin, which decreases blood glucose levels, than those who did not respond. The amount of insulin secreted did not change in either group, though. This distinction is important since type 2 diabetes remission mostly rely on increased insulin secretion.

The researchers compared the two groups in order to pinpoint the reason behind responders’ elevated insulin sensitivity. Despite reducing the same amount of body weight, the responders had reduced their abdomen fat more than the non-responders. The intestines are encircled by visceral abdominal fat, which is situated inside the abdominal cavity. An inflammatory response in adipose tissue is partly responsible for its effect on insulin sensitivity.

In fact, those subjects who achieved remission also had lower blood levels of inflammatory proteins. “Since the responders showed a reduction in abdominal fat in particular, it will be important in the future to identify the factors that promote the loss of this fat depot,” says Arvid Sandforth, one of the two primary authors. Surprisingly, the reduction of liver fat, which is a significant risk factor for the onset of diabetes, did not differ between the two groups. Even two years after the conclusion of the lifestyle intervention, the chance of acquiring type 2 diabetes was reduced by 73% in those who achieved remission. Additionally, they displayed fewer indicators of renal injury and improved blood vessel health.

To delay the emergence of type 2 diabetes, prediabetes is currently treated with weight loss and lifestyle changes, but without glucose-based objectives to direct the treatment process. The new analysis from the DZD closes this gap: Remission should be the new therapeutic goal for persons with prediabetes, according to the newly available evidence. According to co-first author Prof. Dr. Reiner Jumpertz-von Schwartzenberg, this could alter treatment strategies and reduce the risk of complications for our patients.The study found that remission in prediabetes is defined as a fasting blood glucose level of less than 100 mg/dl (5.6 mmol/l), a 2-hour glucose level of less than 140 mg/dl (7.8 mmol/l), and a HbA1c level of less than 5.7 percent. When body weight is decreased and waist circumference shrinks by at least 4 cm in women and 7 cm in men, the likelihood of remission rises. According to researchers, these characteristics can now be applied as biomarkers.

REFERENCES:

https://www.medicalnewstoday.com/articles/reducing-abdominal-fat-may-help-reverse-prediabetes
https://www.news-medical.net/news/20230927/Loss-of-abdominal-fat-may-be-key-to-reversing-prediabetes.aspx
https://www.verywellhealth.com/weight-loss-reverse-type-2-diabetes-6670449

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Daily tea consumption lower the incidence of type 2 diabetes

Daily tea consumption lower the incidence of type 2 diabetes

Type 2 diabetes develops when the body is unable to control blood sugar levels, typically because insulin, the hormone that regulates blood glucose, is no longer being properly reacted to by the body. Type 2 diabetes can cause high blood pressure, cardiovascular illness, nerve damage, eyesight loss, and kidney damage if it is not well managed.

The greatest strategy to prevent type 2 diabetes and, in conjunction with medicine, to manage its symptoms is through lifestyle changes. Doctors advise regular exercise, maintaining a healthy body mass index, and following a heart-healthy diet that includes lots of fresh vegetables, whole grains, protein, and heart-healthy fats.

Type 2 diabetes, whose incidence is rising globally, is a serious health concern.

Type 2 diabetes is closely linked to aging, being overweight, and obesity. It is largely brought on by bad diets and lifestyles.

Changes in lifestyle, such as more exercise and a healthy diet, can lower the risk of type 2 diabetes.

A recent study also suggests that frequent tea consumption may help to control blood sugar levels and lower the risk of diabetes.

An observational study from China now reveals that those who frequently consume tea, especially dark tea, may lower their insulin resistance and improve their blood glucose levels, which lowers the risk of type 2 diabetes.

Regular tea drinkers have better blood glucose control

The study included 562 men and 1,361 women, aged 20 to 80, from eight Chinese provinces. A total of 1,135 of them had normal blood sugar levels, 436 of them had diabetes, 352 had prediabetes.

1,000 of the 1,923 participants regularly drank tea. They drank a variety of teas: 300 said they drank green tea, 125 said they drank black tea, 521 said they drank dark tea, and 54 said they drank other kinds. Everyone drank their tea devoid of milk and sugar.

The morning spot urine glucose-to-creatine ratio (UGCR), a measure of the excretion of glucose in the urine, was used by the researchers to investigate for any correlation between the frequency and type of tea drinking and excretion of glucose in the urine. In addition, they assessed insulin resistance and noted any glycemic abnormalities (such as past or present type 2 diabetes, usage of anti-diabetic drugs, or an abnormal 75g oral glucose tolerance test).

They discovered that daily tea drinkers had less insulin resistance and excreted more glucose in their urine. In comparison to people who never drank tea, they also had a 28% lower risk of type 2 diabetes and a 28% lower risk of prediabetes.

Greater advantages of dark tea

People who consumed dark tea, a particular variety of tea that contains a fermentation process involving microbes, were more susceptible to the effects.

Dark teas include Ripen Pu-erh tea, Qingzhuan brick tea, Kangzhuan brick tea, and Liubao tea.

Black tea versus fermented tea for diabetes

The authors concur that because this research was observational, it cannot conclusively show that tea consumption enhances blood sugar regulation. But Dr. Wu did offer an explanation for why it might have this effect:

“These findings suggest that the actions of bioactive compounds in dark tea may directly or indirectly modulate glucose excretion in the kidneys, an effect, to some extent, mimicking that of sodium-glucose co-transporter-2 (SGLT2), a new anti-diabetic drug class that is not only effective at preventing and treating type 2 diabetes but also has a substantial protective effects on the heart and kidneys.”

Dr. Wu informed MNT that the research team is preparing additional investigations:

Our team is conducting a double-blind, randomized experiment to examine the therapeutic benefits of routine drinking of microbial fermented tea vs. black tea on glycemic management in individuals with type 2 diabetes, with results expected in 2024.

As Dr. Inogong stated to MNT, “It would be interesting to see if these results could be reproduced in larger populations around the world, and if the association still holds, to then study any potential mechanisms by which dark tea impacts glucose regulation.” This could be a helpful step to try and confirm their findings. “[Dark tea] would be a wonderful natural supplement to consider in a treatment plan for those at risk for or who have established type 2 diabetes, if a mechanism is discovered.” Dr. Sue Inonog.

More proof of the health advantages of tea

Tea has long been believed to be healthy, and now scientific study is beginning to support those beliefs. Black and green tea contain polyphenols, which have been demonstrated to have anti-aging effects, cardiovascular advantages, and may even help prevent some cancers. According to the most recent study, reducing the risk of diabetes could be added to that list. Unless you consume excessive amounts, there is little evidence that drinking tea is harmful to your health. According to the current study, consuming a cup of tea each day may help keep blood glucose levels within a healthy range.

REFERENCES:

https://www.medicalnewstoday.com/articles/could-drinking-tea-every-day-reduce-type-2-diabetes-risk
https://www.everydayhealth.com/type-2-diabetes/drinking-tea-tied-to-lower-risk-of-type-2-diabetes/
https://www.thenationalnews.com/health/2023/10/02/drinking-dark-tea-every-day-may-reduce-risk-of-type-2-diabetes/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669862/

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Time limited eating helps in weight loss & type-2 diabetes.

Time limited eating helps in weight loss & type-2 diabetes.

According to recent studies, type 2 diabetics who practise time-restricted eating may experience weight loss and better blood sugar control.

According to a new randomized controlled research, those who restrict their eating to the eight hours from midday to eight o’clock lose more weight than people who lower their overall calorie intake by calorie counting.

However, experts advise patients to work closely with their doctor because certain medications and dietary needs may affect how beneficial a patient’s diet plan is.

In a recent study, people who restricted their eating to the hours between noon and eight o’clock lost more weight than those who merely cut their caloric intake overall by counting calories.

Despite the growing popularity of time-restricted eating, no studies had previously specifically examined an eight-hour meal window in people with type 2 diabetes.

In the study, 57 people with type 2 diabetes and obesity were divided into three groups: one group adhered to time-restricted eating, another group engaged in calorie restriction, and the third group acted as the control group.

The people in the time-restricted eating group could only eat between midday and 8 p.m., whereas the people in the calorie-restriction group could eat whenever they wanted as long as they kept track of their calories.

While the control group maintained eating normally without any special modifications, their objective was to cut their caloric consumption by 25% of what was needed to maintain their current weight.

Eating within a time limit reduces body weight.

The time-restricted eating diet resulted in a 3.55% weight loss in comparison to the control group during the course of the six-month study, according to the researchers.

To put this into perspective, it would mean that a person who weighs 275 pounds would have lost about 10 pounds.

Contrary to expectations, the calorie-restricted group did not significantly lose weight when compared to the control group.

In comparison to the control group, the time-restricted eating and calorie restriction groups both showed lower blood sugar levels (HbA1C), with decreases of about 0.91% and 0.95%, respectively.

The researchers also looked into whether these dietary approaches may lower blood pressure, lower LDL cholesterol, and lower fasting glucose levels, which are all cardiometabolic risk factors.

The weight loss brought on by time-restricted eating, however, did not reach the 5% mark usually linked with improvements in these parameters.

An interview with experts, Vicky Pavlou, registered dietitian nutritionist, University of Illinois at Chicago doctoral student, and author of the study, said, “We found that eating all calories within an 8-hour window is a good alternative to calorie counting for people with type 2 diabetes who want to lose weight and improve their A1C.”

“In comparison to the calorie counting group, the time-restricted eating (TRE) group dropped 4.28% of their body weight in six months. In both groups, the HbA1C was lowered by 1%, the expert said.

Calorie restriction versus intermittent fasting

Studies have previously examined the effectiveness of various dietary strategies among obese people. The prospective effects of time-restricted eating in individuals with obesity and type 2 diabetes, however, have not been studied.

75 obese persons with type 2 diabetes participated in the new study, which was directed by Vicky Pavlou, a doctorate student at the University of Illinois at Chicago who is also a registered nurse. Three groups of participants, ranging in age from 18 to 80, were created: control, calorie restriction, and time-restricted eating.

The calorie intake needed to maintain a person’s present weight (maintenance calories) was lowered by 25% for those in the calorie restriction group and remained unchanged for those in the control group. At any time of day, they could eat.

The time-restricted eating group, on the other hand, was only permitted to eat between noon and 8 p.m. every day without having a set calorie goal or keeping track of their consumption.

For the first three months of the trial, participants in both groups met with a dietician once per week; for the next three months, they met every other week.

Pavlou stated that the dietician “helped them with any challenges in following the diet and gave general nutrition advice,” emphasizing “the importance of reading labels and understanding calories.”

What kind of diet is best for those who have diabetes?

The researcher who was not engaged in this study, Dr. Seun Sowemimo, a board-certified surgeon at Prime Surgicare in Freehold, New Jersey, stressed that “using a combination of disease management tools is more effective than a single effort.”

Time-restricted eating (intermittent fasting) is a powerful strategy for weight loss and blood sugar control because it allows the body to switch from burning sugar to burning fat, resulting in weight loss,” he claimed.

Additionally, it helps diabetic control and lessens the frequency of blood glucose spikes, which can result in insulin surges.

Consuming whole meals with a high fibre content rather than processed foods with added sugar can also help people with diabetes maintain better blood sugar control. Unlike processed foods with free sugar, which are quickly absorbed and cause increased sugar levels and insulin spikes, natural fibre foods help regulate sugar absorption by allowing for a steady release into the bloodstream. Since the idea that fruit contains a lot of sugar is untrue, I also advise persons with diabetes to eat fresh fruits, stated Dr. Seun Sowemimo

Time-restricted eating “may help improve blood sugar control in individuals with type 2 diabetes,” according to registered dietitian Crystal Scott of Top Nutrition Coaching, who was also not involved in the study.

The insulin response may become more efficient by avoiding constant grazing and giving the body longer periods without food intake,” Scott said. Studies have revealed that time-restricted meals can increase insulin sensitivity, glucose levels, and HbA1c levels, which are indicators of long-term blood sugar control. But it didn’t in this study.

Potential effects on type 2 diabetic patients

Dr. Sowemimo stated that this “study adds another layer of clinical evidence that the timing of food consumption is a major contributing factor to diabetes management, weight loss, and overall well-being.

Patients with diabetes can safely be prescribed time-restricted eating, but they should do so in partnership with their physician,” Dr. Sowemimo stated.

Scott also emphasized the significance of investigating potential confounders, such as participant water intake, activity level, and stress-reduction techniques, as well as their use of diabetes medications.

Many additional factors must be addressed concurrently in order for a study like this one on dietary regimens to be entirely successful, according to Scott.

Scott further emphasized that this study shows there are “easier approaches to weight management that don’t involve tracking every piece of food,” even though people may recognize the necessity to implement time-restriction tactics to observe weight loss.

REFERENCES:

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Dahlias might be the newest diabetes weapon.

Dahlias might be the newest diabetes weapon.

Three chemicals found in the petals of vibrant dahlias may help people with prediabetes or diabetes maintain their blood sugar levels, according to recent studies. These substances lessen brain inflammation, which enhances insulin performance.

The discovery may help millions of individuals throughout the world who lack access to pricey and frequently unavailable drugs to some degree of blood sugar management.

D. pinnata dahlias are more than just exquisitely symmetrical flowers. Three chemicals that were discovered in the petals of these flowers, according to a recent study, may help persons with prediabetes and type 2 diabetes better control their blood sugar levels.

The researchers discovered that an extract containing the three dahlia compounds greatly enhanced the study participants’ control of blood sugar during a randomised, controlled, cross-over clinical trial.

Researchers from the University of Otago in Aotearoa, which is the aboriginal name for New Zealand, found in 2015 that a dietary flavonoid called lutein may be able to lower brain inflammation. Also, it improves blood sugar levels in people who have trouble controlling their blood sugar levels.

The dahlia flower’s petals are identified in the latest study as a source of butein and two additional compounds that increase its effectiveness.

The U.S. Centres for Disease Control (CDC) estimates that 37.3 million Americans have diabetes and 96 million Americans have prediabetes. The CDC believes that 8.5 million of them have not yet received a diagnosis. According to the World Health Organisation, diabetes affected 422 million people globally in 2014. Also, it directly contributed to 1.5 million deaths in 2019.

Uncontrolled diabetes can result in lower limb amputation, kidney failure, blindness, strokes, and heart attacks. Continuous blood sugar monitoring, lifestyle adjustments, and often taking insulin or medications that can aid with blood sugar control are required to prevent such results.

Treating diabetes with dahlias

The discovery that dahlias might contain the butein that his team had been looking for, according to study author Dr. Alexander Tups, was fairly accidental. He brought it up to a coworker over coffee. They then inquired, “Did you know that dahlias may contain that molecule?

International dahlia experts were cultivating dahlias in the extreme south of New Zealand and were willing to offer the flowers. Thus, this was the beginning of a magnificent trip, according to Dr. Tups.

The group created a button-containing extract, which was successfully tested on mice. The other two compounds that might increase the impact of butein were then discovered in cooperation with a group of plant chemistry specialists.

In a preclinical context, the researchers discovered that all three molecules are necessary to maximise the blood sugar-lowering impact.

Additionally, we were able to demonstrate that the compounds’ ability to suppress brain inflammation in mice. Also, their dependence on doing so for the glucose-lowering impact, said Alexander Tups, M.D.

Human trials revealed the extract was efficient and generated no observable negative effects.

The tablet form of Dahlia

Since then, the group has obtained a patent for their discovery, released their research, and launched Dahlia4, an extract for bettering blood sugar regulation. There is a tablet version of Dahlia4. The American Food and Drug Administration has not yet reviewed it.

Although various plant extracts have been identified and studied, Dr. Thomas Lutz, full professor of veterinary physiology at the University of Zurich, who was not involved in the study, observed that “the question is always about the availability, the efficacy, and potential toxicity.”

The discovery made here has a lot of importance in these regards, according to Dr. Lutz. According to Dr. Tups, the dahlia molecules may be capable of more than just regulating blood sugar.

We are now conducting a clinical trial in people with chronic fatigue syndrome or long COVID syndrome,” he said. “It showed promise in helping to improve brain function.”

Blood sugar regulation and brain inflammation

We know that ‘brain inflammation’ is associated with many metabolic disorders, e.g., access to high energy/high fat food, obesity, type 2 diabetes,” said Dr. Lutz.

The reduction of brain inflammation has been shown to improve/restore the sensitivity to various hormones involved in the physiological control of metabolism. Particularly in insulin and leptin,” the author added.

This idea has been around for a while. The issue was how to approach it in a way that benefits the patients concerned“, according to Dr. Lutz.

Why this finding is significant?

Dr. Lutz claims that “potentially, the discovery described here may be of benefit for a very large number of people.”

He clarified that in addition to the newly developed dahlia extract, there were numerous other therapy options that were either recently approved or that were being studied in pre-clinical or clinical settings.

He stated: “Many of these are pharmacological approaches based on agonists of endogenous hormones.” Adding, “Efficacy and safety is very good, [but] cost is high, and availability has been an issue.”

From a legal standpoint, we are not discussing drugs here; rather, we are discussing food additives. Their broad use may benefit from this,” according to Dr. Lutz.

Dr. Tups stated that there are “literally millions” of people who could gain from promoting normal levels of insulin and blood sugar.

Therefore, the finding is crucial for all patients with metabolic diseases, particularly type 2 diabetes mellitus, but possibly also with other illnesses where brain inflammation is involved, according to Dr. Thomas Lutz.

REFERENCES:

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Depression: High blood sugar and lower grey matter links.

Depression: High blood sugar and lower grey matter links.

Around the world, 5% of adults are thought to be depressed. A known risk factor for depression is fluctuations in a person’s blood sugar levels.

The relationship between blood sugar levels and the likelihood of developing depression, according to Sun Yat-sen University researchers, may be mediated by decreased grey matter volume in the brain.

About 5% of the adult population worldwide suffers from depression, a mental illness that makes a person feel incredibly depressed and hopeless to the point where they are unable to enjoy their daily activities.

Variations in glycemia, or a person’s blood sugar levels, are one of the many risk factors for depression.

According to earlier research, people with diabetes, a disorder in which a person struggles to maintain adequate blood sugar levels, are two to three times more likely to experience depression.

The relationship between blood sugar levels and depression may now have a precise biological cause. This is according to researchers from Sun Yat-sen University in Guangzhou, China.

According to research, the association between blood sugar levels and the risk of depression may be mediated by a decreased grey matter volume in the brain.

Depression, blood sugar, and brain structure

According to Dr. Hualiang Lin, a professor in the Department of Epidemiology at Sun Yat-sen University and the study’s corresponding author, they chose to investigate the effect of blood sugar on the risk of developing depression. Earlier research has established a link between changes in blood sugar levels and the development of depression.

Also, a lot of research has shown a clear connection between depression development and changes in brain structure and function. As a result, the information that is now available strongly supports that brain anatomy may play a moderating role in the co-morbidity of diabetes and depression. As a result, we carried out this research to learn more about this connection, said Dr. Lin.

Changes in the amount of grey matter in the brain have been linked in the past to depression. According to a 2019 study, particular changes in gray-matter volume were linked to lifetime major depressive illness.

Additionally, a study conducted in 2022 discovered that individuals with significant depression, bipolar illness, and schizophrenia spectrum disorders frequently have lower hippocampus grey matter volume.

Examining brain’s grey matter

Dr. Lin and his team gathered information from more than 500,000 UK Biobank individuals between the ages of 40 and 69 for this observational study.

Researchers examined the data and discovered a “significant correlation” between sadness, decreased grey matter volume, and raised levels of HbA1c, or glycosylated hemoglobin.

A quick test called HbA1c determines a person’s blood sugar levels during the previous three months, or glycosylated hemoglobin.

In comparison to study participants with or without diabetes, researchers found that a reduced grey matter volume was associated with depression. This association was particularly pronounced in study participants with prediabetes.

Even if the outcome supports our hypothesis, Dr. Lin stated, “We are still very excited about it.”

Previous studies on the specific brain regions connected to depression have been rather scarce, frequently concentrating on well-established clinical regions such the hippocampus or prefrontal cortex. Contrarily, we were able to more thoroughly analyse and identify probable grey matter regions that may be connected to depression in our study since it made use of MRI data from hundreds of different brain areas,” he said.

Age as a risk factor for increased risk

Furthermore, participants in the study who were 60 years of age or older had the strongest correlation between decreased grey matter volume and depression.

According to Dr. Lin, “This finding has important public health implications, particularly for the neurological health of older individuals.”

In particular, the findings indicate that in older people compared to younger people, the decline in grey matter volume is more pronounced for every one unit increase in HbA1c. The difference can be more than twice as great in some brain regions, according to Dr. Hualiang Lin.

This study shows that we may soon face increased dangers to brain health and mental well-being, he said, “given the global trend of population aging and the rising risk of diabetes.”

What does a normal blood sugar level mean?

Glucose, sometimes referred to as blood sugar, is crucial for numerous bodily processes. It is the body’s main source of energy, to start. And glucose is what “feeds” the brain, keeping it active and maintaining connections amongst its associated nerve cells.

The food you eat, especially carbohydrates like starchy vegetables, whole grains, and fruits, provides the body with blood sugar. Glucose is released into the bloodstream as these nutrients are broken down by the body through the digestive tract.

The pancreas starts to secrete insulin as soon as blood glucose levels increase. To give the body’s cells with the energy they require, insulin aids glucose absorption.

An individual with diabetes or one who is at risk for getting it may have high fasting blood sugar levels:

  • A good fasting blood sugar level is one that is 99 mg/dL or lower.
  • Prediabetes is indicated by a fasting blood sugar level between 100 and 125 mg/dL.
  • One has diabetes if their fasting blood sugar level is 126 mg/dL or greater.

Hyperglycemia, or having too much glucose in the bloodstream, can cause the following symptoms:

Could controlling blood sugar lessen depression?

Dr. Daniel Pompa, a cellular health expert, author of the “Cellular Healing Diet,” and host of a weekly Cellular Healing TV podcast and YouTube show. He stated after reviewing this study that it has long been known that blood sugar levels have a significant impact on brain health. Also, this study only serves to further that understanding.

High glucose levels cause brain inflammation, which lowers cognitive function and emotional control. According to Dr. Daniel Pompa, long-term exposure to elevated glucose levels has been related to altered brain circuits that raise the chance of developing depression.

In those with prediabetes and type 2 diabetes, higher levels of glycosylated hemoglobin (HbA1c) are associated with a reduction in brain capacity. Elevated HbA1c is linked to decreased grey matter sizes in regions including the hippocampus, thalamus, and prefrontal cortex. This is according to several other research that have supported this, Dr. Pompa continued.

As a strategy to treat type 2 diabetes, Dr. Pompa said he would like to see further research on the impact of lifestyle modifications and fasting. It also brain scans to measure these people’s grey matter volume.

In particular, he asked, “Can reducing type 2 diabetes symptoms stop or even reverse the loss of grey matter and lower rates of depression?”

Dr. Matthew J. Freeby, director of the Gonda Diabetes Centre and associate director of diabetes clinical programmes at the David Geffen UCLA School of Medicine, said: “Unfortunately, depression is quite common in people living with diabetes, and there’s not much known as to the connection. For a better understanding of the problem’s causes and potential treatments, more research is urgently needed.

Although this research makes an interesting observation, Dr. Freeby stated that he did not believe we could yet identify physical changes in grey matter volume as the explanation.

REFERENCES:

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