Lack of fiber may be a trigger for inflammatory bowel disease

Lack of fiber may be a trigger for inflammatory bowel disease

Irritable bowel disease (IBD) is characterized by inflammation in the gut or digestive tract, which can cause a variety of occasionally painful digestive problems. It can also present as ulcerative colitis or Crohn’s disease. Although the underlying cause of this illness has not yet been found, a recent study points to a potential link between diet, genetics, and gut microbiota and the development of IBD. Fiber reduces inflammation and encourages the formation of a healthy mucus layer. When interleukin-10, a cytokine linked to inflammatory bowel disease, is absent at birth, IBD usually manifests in the early stages of the infant or childhood. The current study demonstrates that fiber deprivation contributes to the deterioration of the colonic mucus lining in mice deficient in interleukin-10, which results in fatal colitis. This implies that diets high in fiber could be beneficial for people with IBD.

The Centers for Disease Control and Prevention (CDC) estimates that 3 million people in the United States and 6 million people worldwide suffer from IBD. S. who possesses it. The majority of cases of IBD are found in industrialized countries, and the new study suggests that those who migrate to more industrialized societies and start consuming highly processed foods may be at risk for the condition. According to a study published in Gastroenterology, the official journal of the American Gastroenterological Association, last year, some dietary fibers may actually exacerbate the symptoms of inflammatory bowel disease. In that investigation, scientists discovered that soluble fibers from fruits and vegetables, known as unfermented dietary β-fructan fibers, triggered an inflammatory reaction in individuals with inflammatory bowel disease (IBD) whose bodies could not process them.

Exclusive enteral nutrition (EEN), a formula-based, low-fiber diet, is recommended for some individuals with IBD, especially children. This method is effective in lowering gut inflammation. In the current study, which employed mice devoid of interleukin-10, the researchers found that diets devoid of fiber significantly increased inflammation. It has been demonstrated that a diet devoid of fiber promotes the development of bacteria that break down mucus, consuming the mucus layer in the digestive system and lessening the barrier that mucus provides for the gut lining. A high-fiber diet markedly reduced inflammation in the mice. Nonetheless, mice given the EEN diet formula by researchers showed reduced inflammation compared to mice fed a diet devoid of fiber.

Researchers came to the conclusion that the mice exhibited elevated levels of isobutyrate, a fatty acid generated by “good” bacteria through fermentation in the gut. Medical News Today was informed by Dr. Rudolph Bedford, MD, a board-certified gastroenterologist at Providence Saint John’s Health Center in Santa Monica, California, who was not involved in the study, that there is not enough data to support a general approach to lower-fiber diets for patients with IBD among medical professionals. The lack of research data to inform clinical practice has led to a great deal of variability in dietary recommendations for patients with inflammatory bowel disease. However, to reduce gastrointestinal distress during an active flare-up, especially if intestinal strictures are suspected, patients with IBD are frequently advised to restrict their intake of fiber or residue.

Not involved in the study, the director of communications for the nutrition company Prolon and a dietitian nutritionist told MNT that while a high-fiber diet can be advised in the worst phases of IBD, it’s important to consider the long-term effects. When an IBD patient’s gut inflammation gets worse during an acute (active) flare-up, a low-fiber diet may be advised. Since fiber can be difficult to digest, it may worsen pre-existing gut or gut lining irritation, which may lead to symptoms like bloating, diarrhea, stomach pain, rectal bleeding, or even fever. It is advisable to stay away from anything that could exacerbate the gut inflammation that already exists during flare-ups. However, over time, high-fiber diets have demonstrated encouraging outcomes in the management (and even reversal) of IBD in patients. This means that high-fiber foods are advised to help diversify the composition of the gut, which can positively benefit a person’s gut pH, permeability, and ability to produce short-chain fatty acids, even in the absence of acute symptoms or flare-ups.

In addition to supporting both our digestive and immune systems, good gut flora are essential. The integrity of our intestinal barrier is strengthened by certain good bacteria that live in our stomach. The lining of our stomach plays a crucial role in preventing harmful substances from entering our body. A leaky gut, also known as intestinal permeability, is the result of the weakening of the gut lining’s junctures brought on by inflammation or other pathogenic bacteria that can break down the lining. Patients with IBD and IBS frequently have leaky guts, which may be the underlying cause of inflammation or a sign of other digestive disorders. Richter noted that there may be a direct correlation between gut and mental health.

Neurotransmitters like dopamine and serotonin are produced in part by certain gut bacteria and are essential for healthy brain function, regular sleep cycles, and the reduction of anxiety and depression. Mental and emotional disorders may result from the disruption of gut-brain signaling caused by the absence of these beneficial bacteria. The gut lining’s lack of diversity can significantly weaken immune systems. When your gut is dysbiotic, it is more susceptible to illness. The various organisms in your gut may not be present in the proper amounts, which could lead to changes in your gut microbiome. Your chance of developing a chronic illness may rise if the diversity of bacteria in your gut microbiome declines.

The intestinal tract is affected by immune-mediated, chronic, progressive diseases known as inflammatory bowel diseases (IBDs). IBDs primarily include ulcerative colitis (UC) and Chron’s disease (CD) subtypes. Although the exact cause of these illnesses is unknown, host-related, environmental, and genetic factors all play a role in their development. According to recent research, nutritional therapy is the mainstay of IBD treatment for managing symptoms, preventing relapses, and treating the underlying pathology. Patients with IBD demonstrate how diet, particularly dietary fiber, and microbiota dysbiosis can alter its composition. Compared to the general population, these patients are more vulnerable to energy protein malnutrition and micronutrient deficiencies. There is currently no known dietary factor that causes IBD, and there is no special therapeutic diet for the condition. This review aims to assist medical professionals in managing the nutritional aspects of CD and UC by assessing the role that dietary fibers play in these conditions. The right kind and quantity of fiber to recommend in the event of IBD patients improving their psychosocial circumstances and overall quality of life will require more research.


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