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Sexual Dysfunction History

Sexual Dysfunction History

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Older ideas about the harmful effects of sin, guilt, bad habits, or evil spells on sexual function in both men and women have been replaced by the medicalization of sexuality, but these viewpoints are still prevalent today. In reality, many different theories are used to explain sexual dysfunction and dissatisfaction, and biological reasoning is just one of them.

Sexual dysfunction in men
Maintaining a level of male sexual function that is acceptable is crucial in today’s societies. Even though ejaculation disorders and low libido are included in the category of sexual dysfunction in men, erectile dysfunction which is the inability to maintain an erection was the most common issue from antiquity until the present.

Penetration was a sign of manhood and a requirement for a positive reputation in the Greek and Roman conceptions of sexuality. As a result, medical professionals who were impacted offered recipes for healing substances, and pornographic writers created humorous tales about men who didn’t pass the important test. To combat, treat, and explain male sexual dysfunction, philosophers of the 18th century accepted the idea that men and women have different sexual spheres. However, even though this significant issue could not be disregarded, the nineteenth-century culture that insisted on privacy found discussion of such topics repugnant.

During that time, the writers of middle-class marriage guides popularized the idea of the “spermatic economy,” which holds that excesses cause a loss of masculine strength and endurance, which can eventually lead to impotence. Additionally emphasized were the risks of spermatorrhea, prostitution, masturbation, and STDs. Early in the 20th century, theories of male sexual dysfunction shifted from moral to psychological. Impotence was recognized as a problem for both men and women following World War II, and the development of the field of endocrinology in the 1920s validated the scientific study of the male reproductive system.

Numerous historians assert that sex therapy, psychoanalysis, and even surgery have been totally overtaken by Viagra (sildenafil). The Food and Drug Administration authorized the first oral treatment for erectile dysfunction in 1998. It was created at Pfizer Laboratories essentially by accident. Whether the ensuing impotence medications actually transformed sexuality is still up for debate.

Sexual dysfunction in women
The recognition of this kind of issue dates back further, even though the term “female sexual dysfunction” was only recently introduced to the medical literature. The diagnosis of nymphomania was not unusual even in the 16th century, and the Victorian era saw a notable rise in the proportion of women suffering from this illness. New theories of sexual dysfunction emerged as a result of the psychiatric and sexological fields overlapping development at the end of the 19th century. Certain sexual dysfunctions, like the inability to achieve vaginal orgasm, were considered the basis of “frigidity” based on Freud’s statements (most notably in the works of Hitschmann and Bergler).

Early in the 20th century, there was a surge in marriage counseling literature in the US and the UK that highlighted the importance of sexual pleasure in marriage. Given the significant emotional, physical, and spiritual differences between men and women, sexual dysfunction in women was viewed as a technical problem that was a component of a larger social phenomenon that needed to be addressed through education. In 1952, issues like coldness were categorized under “Psychophysiological autonomic and visceral disorders” in the first edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM). Although dyspareunia was added to the list, the second edition, which was released in 1968, was comparable.

Only the third edition of the DSM, published in 1980, saw significant changes, moving from psychoanalytic to biological psychiatry. An umbrella chapter on psychosexual disorders has been added in place of distinct categories for sexual deviations and psychophysiological genitourinary disorders. Historically, female sexual dysfunction has generally been regarded as a descriptive or general term rather than a diagnostic one. Even though it was made up of several diagnostic categories, treatment was still sought as though it were a true monocausal condition. Medical literature from the 20th and 21st centuries has addressed sexuality’s social dimensions and its potential to treat sexual dysfunction in great detail.

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A study reveals that bacterial vaginosis is transmitted sexually.

A study reveals that bacterial vaginosis is transmitted sexually.

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After a groundbreaking study in The New England Journal of Medicine revealed that bacterial vaginosis (BV), which affects almost one-third of women globally, can be spread through sexual contact, important questions still need to be answered. In addition to calling for more research on the condition that can lead to infertility, premature births, and newborn deaths, the study findings may change the focus of treatment from women-only information about bacterial vaginosis (BV) to both men and women. results of the investigation. The study.

Vodstrcil’s team discovered that treating bacterial vaginosis (BV) as an STI and treating both sexual partners at the same time resulted in noticeably higher cure rates than the current practice of treating only women in a trial of 164 couples in which each woman had BV and was in a monogamous relationship with a male partner.

According to a press release from coauthor Catriona S. Bradshaw, PhD, who is also affiliated with the Melbourne Sexual Health Centre at Monash University, this effective intervention is brief, reasonably priced, and has the potential to improve bacterial vaginosis (BV) treatment for women for the first time. It also creates exciting new opportunities for BV prevention.

The male partners in the partner-treatment group received oral and topical antimicrobial treatment (400 mg metronidazole tablets and 2 percent clindamycin cream applied to penile skin, twice daily for 7 days) while the women in the randomized, open-label, controlled trial received first-line recommended antimicrobial agents. In the control group, male partners were not treated while women received first-line care. Recurrence of bacterial vaginosis (BV) within 12 weeks was the main result. The researchers pointed out that historically, after taking oral antibiotics for a week, over half of women with bacterial vaginosis (BV) have a recurrence within three months.

35 percent of women in the partner-treatment group and 63 percent of women in the control group experienced a recurrence of bacterial vaginosis (BV) in the modified intention-to-treat population. This represents an absolute risk difference of −2.6 recurrences per person-year (95 percent CI, −4.0 to −1.2; P < .001). According to the authors, the trial was terminated early because the woman’s treatment alone was subpar compared to that of both her and her male partner. Other Factors May Affect the Development of Bacterial Vaginosis (BV) Nevertheless, some experts highlight unresolved issues that demand more investigation.

While he believes that bacterial vaginosis (BV) can definitely be spread through sexual contact, Mykhaylo Usyk, PhD, MPH, MSci, a research assistant professor in the Departments of Microbiology and Immunology, Department of Pediatrics at the Albert Einstein College of Medicine in the Bronx, New York, stated that further research is necessary to determine which specific types of BV are transmissible, particularly since the trial was not finished for ethical reasons. Recurrence was not prevented for every individual who received the intervention, and the sample size was small.

According to Usyk, who published a study on the impact of bacterial vaginosis (BV) on chlamydia infection recurrence, I’m not sure if I would classify BV as an STI in and of itself. Similar to a fever, bacterial vaginosis (BV) is also an indicator. It is a sign of another illness. He stated that it is evident that men are serving as a reservoir. The men have some underlying infections that will cause bacterial vaginosis (BV) to recur unless they are treated. Usyk stated that he would like to see more research on which subtype of bacterial vaginosis (BV) is transmissible before routinely prescribing antibiotics to men and women to treat and prevent BV. Douching and smoking may be factors.

Other contributing factors, like smoking or intravaginal practices like douching and using lubricants, may also disrupt the vaginal microbiome and contribute to the development of bacterial vaginosis (BV), according to Rebecca Brotman, PhD, MPH, who studies the human vaginal microbiome and bacterial vaginosis (BV) at the Center for Advanced Microbiome Research and Innovation at the University of Maryland School of Medicine, Baltimore. She agreed that the trial’s findings will change how doctors treat and care for bacterial vaginosis (BV) and said it offers strong evidence in favor of the long-held theory that BV-associated bacteria can be sexually transmitted. She pointed out that there was little proof that men could spread bacterial vaginosis (BV) before the trial was published.

She did, however, note that although the trial is a major step forward in the treatment of bacterial vaginosis (BV), more research is required to confirm the results in other populations. For instance, a third of the women in the trial were using intrauterine devices, and 80% of the men were not circumcised. These factors can both have an impact on the presence of bacteria linked to bacterial vaginosis (BV). She cites numerous studies that support the idea that bacterial vaginosis (BV) can be sexually transmitted, including the high concordance in lesbian couples, the frequent co-occurrence of BV with STIs, the higher prevalence among women who have multiple or new sexual partners, and the higher incidence among women whose male partners have multiple recent partners.

According to her, studies show that women who regularly use condoms or refrain from having sex have a lower risk of contracting bacterial vaginosis (BV), while unprotected sex is associated with a higher rate of treatment failure. As the director of the Vulvovaginal Disorders Program at Massachusetts General Hospital in Boston, Caroline M. Mitchell, MD, MPH, told Medscape Medical News, “A Huge Win for Women,” it’s crucial to keep in mind that bacterial vaginosis (BV) is a syndrome, meaning that different bacteria may be present in different people or episodes.

Clinically, I do see patients who appear to have highly sexually facilitated bacterial vaginosis (BV), which only occurs with one partner and goes away when they are not with that person. Others, however, do not feel this way at all. This isn’t universal, in my opinion. I do encounter patients who have attempted abstinence but continue to experience recurrence. In contrast to chlamydia, I do not believe that a person’s partner is being unfaithful if they have BV. However, the results of this study indicate that bacteria on the penis probably contribute to at least some cases of bacterial vaginosis (BV), which does appear to be sexually facilitated.

I do believe that there may be some passing back and forth of BV-associated bacteria between sexual partners for people with highly recurrent bacterial vaginosis (BV), and that treating both people as [recommended] in this paper will be necessary to clear those organisms,” she continued. She claimed that the study represents a significant advancement in the prevention of bacterial vaginosis (BV) recurrence in certain patients. This is a major victory for women, she said, because the field’s treatment options haven’t changed significantly since 1982. The results should alter counseling.

In an editorial that goes with it, Christina A. According to Jack D. Dot Sobel, MD, of the Division of Infectious Diseases at Wayne State University in Detroit, and Muzny, MD, MSPH, of the Division of Infectious Diseases at The University of Alabama at Birmingham, the results should alter counseling for women. According to the editorialists, the results also highlight the need for a significant shift in the way that women with bacterial vaginosis are treated, specifically in terms of counseling them about the cause of their infection and involving their male partners in sharing responsibility for treatment and transmission. Other than using condoms consistently, there are currently no effective methods to stop the sexual spread of bacteria linked to bacterial vaginosis.

The StepUp Australian New Zealand Clinical Trials Registry and the National Health and Medical Research Council of Australia provided funding for this study. The complete text of the papers is available along with the disclosures made by the authors and editorialists. Usyk disclosed no pertinent financial ties. Brotman disclosed no pertinent financial ties. Mitchell was granted stock options and serves on the scientific advisory boards of Concerto Bio and Ancilia Bio. Up to Date paid royalties to her.

Could eating on a time schedule affect my fertility?

Could eating on a time schedule affect my fertility?

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An increasingly well-liked weight-control strategy is time-restricted eating. This entails eating all of your meals and snacks during that time and fasting outside of it.

Evidence suggests that it may also reduce the risk of metabolic illnesses like diabetes. Some people find that it aids them in losing weight or maintaining a healthy weight.

An unfavorable effect of time-restricted eating on zebrafish fertility was discovered in a recent study. More study is required to find out similar occurrences in humans.

A type of intermittent fasting called time-restricted eating (TRE) emphasizes meal timing rather than calorie intake. It entails sticking to a rigid schedule of eating all of your meals and snacks — often between six and twelve hours each day. And only consuming water and calorie-free beverages outside of that window.

When following a TRE plan, a participant will select the eating window that best fits their lifestyle. By limiting their eating window, many people discover that they tend to eat less. This may make it an easy way to manage their weight. In recent years, the practice has grown in acceptance.

According to studies, TRE has various advantages. People with obesity who followed a 10-hour eating 14-hour fasting schedule for 8 weeks experienced clinically significant weight loss. Also, improvements in fasting blood glucose levels were observed. When obese women followed an 8:16 fasting schedule for three months, similar weight loss was observed.

Results haven’t always been favorable, either. According to a meta-analysis of 43 trials, calorie restriction was the best weight loss strategy, while intermittent fasting had a smaller impact.

TRE was found to have deleterious impacts on the quality of sperm and eggs in zebrafish. These effects persisted even when normal feeding was resumed.

Little impact on physical growth

For the study, the researchers employed zebrafish (Danio rerio), a little tropical fish that shares more than 70% of its genome with people. Zebrafish are tiny, thrive in big shoals in tanks, and reproduce quickly, making them a popular choice for research.

All of the fish had been fed an unrestricted diet before the experiment and were sexually mature. They were then randomly split into two groups by the researchers. One kept up the unrestricted diet, while the other went on a fast. The entire fish was added back to the diet after 15 days, according to the researchers.

The researchers measured the tail fin to determine somatic (body) growth during the 15-day experimental phase and after the animals were allowed to resume unrestricted feeding. They also evaluated reproductive performance, including the quality of the eggs and sperm produced.

The study’s authors discovered no distinction in somatic growth between the fish that had been fed normally and those that had been starved. Female fish, however, exhibited quicker fin growth than male fish after the fasting fish were put back on their regular diet.

Decline in egg and sperm quality

Females that were fasting had fewer offspring overall than those who were eating normally during the fast. However, the distinctions between fed and fasting fish vanished once they started re-feeding.

The quality of the offspring did differ before and after fasting, according to the researchers. Females produced fewer, but higher-quality children when fasting. The number of progeny increased once the fasting females resumed feeding, but their survival rate decreased.

Similarly, there was a decline in the quality of male sperm both during the fast and when feeding resumed.

Thus, fasting appeared to have a deleterious impact on gamete quality in both sexes, and the effects persisted even when normal food was resumed. According to the researchers, when food was scarce, fish focused more of their energy on maintaining their bodies and surviving rather than reproducing.

Similar effect on people?

UEA’s School of Biological Sciences professor and study’s corresponding author, Alexei Maklakov, stated: “Time-restricted fasting is a well-liked fitness and health trend that people follow to get in shape and lose weight,”

Prof. Alexei Maklakov stated, “But the way organisms adapt to food scarcity can affect the quality of eggs and sperm, and such effects could possibly persist after the end of the fasting period.”

Few research on the effects of TRE on fertility and reproduction have been conducted thus far, and the majority of these have involved rodents. The few human investigations, the majority of which had modest sample sizes, created more questions than they did answers.

Studies on humans

An extremely limited window (4-6 hours) for eating was discovered in a recent study to result in lower DHEA levels in obese women. DHEA is a steroid hormone that is crucial for the production of both estrogen and testosterone. Although this study was modest, experts emphasized the necessity for comparative studies in adults who are of a healthy weight.

Although the authors highlighted that there was little data in this area, another evaluation of papers revealed that intermittent fasting may lower androgen indicators in both men and women. This effect might help women with the polycystic ovarian syndrome (PCOS), but it could also have negative effects on men, like a loss of muscular mass.

The University of Illinois at Chicago’s Dr. Krista Varady, a professor of nutrition who was not involved in the study, has written extensively about TRE, She uttered:

Overall, I don’t believe that humans can benefit from these zebrafish research findings. According to findings from TRE studies conducted on humans, fasting has almost no negative effects on either a woman’s or a man’s reproductive hormones.

More study is required

Even though this study was done on fish, the authors claim that the results demonstrate how crucial it is to take into account how fasting may affect human fertility.

The study’s corresponding author, Dr. Edward Ivimey-Cook of the School of Biological Sciences at the University of East Anglia, said:

These findings emphasise how crucial it is to take into account not just how fasting affects body maintenance but also how it affects egg and sperm production.

He continued, “More research is needed to determine how long it takes for sperm and egg quality to get back to normal following the fasting period“.

Every year, hundreds of TRE articles in humans are published. I believe that rather than worrying about what is occurring in other non-mammalian species, we should concentrate on human discoveries. Humans and fish have radically different reproductive processes, making them quite different creatures. If this study had been conducted on people, it would have had a considerably greater impact.

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New combination could reduce the risk of Prostate cancer.

New combination could reduce the risk of Prostate cancer.

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The effectiveness of talazoparib plus enzalutamide in treating metastatic castration-resistant prostate cancer in adult males was investigated in the TALAPRO-2 international phase 3 clinical trial.

Comparing talazoparib and enzalutamide therapy to placebo and enzalutamide therapy, a 37% lower risk of cancer progression or death was observed.

In 2023, the Food and Drug Administration (FDA) is anticipated to make a decision on the use of this combination therapy to treat men with metastatic castration-resistant prostate cancer.

Prostate cancer affects one in eight men in the United States and is the second most frequent cancer in males after skin cancer, according to the American Cancer Society.

Male hormones called androgens, such testosterone, promote the growth of prostate cancer cells. Even when blood testosterone levels are controlled, prostate cancer occasionally still progresses. Castration-resistant prostate cancer is the term for this.

Metastatic castration-resistant prostate cancer is the term used to describe a type of cancer that has migrated from the prostate gland to other bodily tissues like the lymph nodes and bones.

Treatment for metastatic castration-resistant prostate cancer has greatly advanced in recent years. Despite these advancements, cancer might recur after therapy because existing medicines only have a temporary impact.

Pfizer researchers have combined the drugs talazoparib (Talzenna) and enzalutamide to create a breakthrough treatment for metastatic castration-resistant prostate cancer (Xtandi). In the phase 3 trial of TALAPRO-2, they evaluated the effectiveness and safety of this combination medication.

Dr. Neeraj Agarwal, professor of oncology and Presidential Endowed Chair of Cancer Research at Huntsman Cancer Institute, University of Utah, and principal investigator for TALAPRO-2, delivered the trial’s findings at the 2023 ASCO Genitourinary Cancers Conference.

Why this combination therapy?

Enzalutamide is a type of hormone therapy that has been approved for the treatment of prostate cancer in males. It functions by preventing testosterone from growing prostate cancer cells. Even after they have migrated to other parts of the body, without which they cannot proliferate.

The group of cancer medications known as poly-ADP ribose polymerase (PARP) inhibitors includes talazoparib. An enzyme (protein) called PARP is present in all cells and aids in the self-healing of injured cells. The repair activity of PARP in cancer cells is blocked by PARP inhibitors, which leads to the death of the cancer cells.

The FDA has authorised the PARP inhibitor talazoparib to treat germline (inherited) HER2-negative advanced breast cancer. However, has not yet licenced it to treat prostate cancer.

When combined with medications that restrict testosterone, PARP inhibitors may be beneficial for the treatment of advanced prostate cancer, according to earlier research.

This inspired Pfizer researchers to create a combination therapy that combines the testosterone-blocking drug enzalutamide with the PARP inhibitor talazoparib.

Study

Adult men from 26 different countries who had metastatic castration-resistant prostate cancer were included in the trial in December 2017.

At random, the participants were given one of the following:

  • Enzalutamide 160 mg once daily and talazoparib 0.5 mg were given to 402 individuals.
  • Or, for 403 individuals, a placebo and enzalutamide 160 mg once daily.

The TALAPRO-2 trial’s main goal was to determine whether adding talazoparib to enzalutamide extends radiographic progression-free survival (rPFS)—the period of time patients remain cancer-free—in comparison to placebo plus enzalutamide.

To see if any study participants had defective DNA repair genes, the researchers also analysed the DNA from the cancer cells of all study participants.

Drug combo lowers cancer progression risk

The median follow-up period for the combination therapy group was 24.9 months. However, the group receiving placebo + enzalutamide experienced a median follow-up period of 24.6 months.

According to the findings, talazoparib plus enzalutamide significantly decreased the risk of disease progression or mortality compared to placebo and enzalutamide by 37%. This was true whether “homologous recombination repair,” or DNA repair gene mutations, were present or not (HRR).

Dr. Andrew J. noted that TALAPRO-2, which joins the PROPEL research, is the second randomised phase 3 trial to show a benefit with combination [androgen receptor] plus PARP inhibition in delaying rPFS in the first line [metastatic castration-resistant prostate cancer] context.

According to Dr. Armstronf, “the delays in rPFS range from > 50% relative improvements in HRR+ patients to 30-40% improvements in HRR-undetected individuals.

The results of TALAPRO-2 “differ from what was seen in the MAGNITUDE study with niraparib and abiraterone. Those without HRR deficiency (biomarker negative) group were stopped early due to lack of efficacy,” added Dr. Cora N. Sternberg, a genitourinary cancer specialist at Weill Cornell Medicine who was not involved in the study.

Data on overall survival were “immature” when the trial findings were announced. This indicates that more research is required to evaluate whether combination therapy with talazoparib and enzalutamide extends patient survival when compared to placebo and enzalutamide.

Is the combination therapy safe?

The study assessed any negative effects that men may have had from combination therapy.

The most frequent negative consequences were:

  • (65.8%) Anemia
  • reduction in neutrophil count (35.7%)
  • exhaustion (33.7%)
  • reduction in platelet count (24.6%)
  • Leukocyte count dropped (22.1%).
  • a backache (22.1%)
  • loss of appetite (21.6%
  • sickness (20.6%).

According to Dr. Zorko, the severe anaemia and neutropenia in the combination therapy group are not surprising given what is known about the side effects of PARP inhibitors.

Also, he advised that “before beginning combination therapy, consideration should be given to the necessity for transfusions and dose cessation. Particularly since 49% of patients had anaemia previous to therapy.”

The time toxicity required to obtain transfusions and supportive care in the clinic may further lessen patients’ enthusiasm for this oral combo therapy, the doctor added.

According to Dr. Armstrong, “there is higher toxicity and cost to patients getting combination [treatment], but these are tolerable for most patients and do not seem to impede quality of life in the long run in most patients with [dose] changes and side effect control.”

Study limitations and next steps

The primary limitations of this trial, according to Dr. Scott T. Tagawa, professor of medicine and urology at Weill Cornell Medicine who was not involved in it, include “early data for overall survival as well as [unknown] long-term adverse events.”

Dr. Zorko added: “In the trial, only 5.2% of patients had received abiraterone treatment in the past. We will see more patients in this area as they become castration-resistant as [triple therapy with] androgen-deprivation therapy, docetaxel, abiraterone/prednisone is used more frequently in the metastatic hormone-sensitive prostate cancer setting, but whether this specific subgroup benefits will be interesting to see.

The final stage of medication development was the phase 3 clinical trial. The FDA must now analyse the results of the clinical trials and make a determination regarding the applicability of this therapy to patients with metastatic castration-resistant prostate cancer. In 2023, the FDA is anticipated to make a decision regarding the clinical application.

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Genetic Overlap of Endometriosis & Chronic pain conditions

Genetic Overlap of Endometriosis & Chronic pain conditions

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There is presently no cure for the disease endometriosis, which can lead to discomfort and infertility. In order to determine whether endometriosis has a hereditary component, researchers at the University of Oxford in the United Kingdom examined DNA samples from hundreds of female participants.

25 teams from around the world worked together with the researchers to collect and analyse a sizable amount of data from female participants with and without endometriosis.

Their results demonstrated a link between endometriosis and other inflammatory disorders in addition to demonstrating the genetic component of this condition. For those who have it, endometriosis can be a crippling ailment, and identifying it can be expensive and challenging.

Scientists from the University of Oxford collaborated with experts from other countries to study the DNA from tens of thousands of female volunteers. In order to understand more about the genetic variables influencing the illness. They found that endometriosis might be related to other inflammatory diseases.

Endometriosis overview

The endometrial lining, the tissue that lines the inside of the uterus, thickens during the menstrual cycle as part of the process. This lining usually sheds throughout the menstrual cycle if a person does not become pregnant.

A tissue that resembles this lining can occasionally proliferate where it shouldn’t, which is what happens with endometriosis. This lining may develop in the pelvic region, around the ovaries, or around the fallopian tubes. It can occasionally even grow around other organs like the intestines or the bladder.

Endometriosis symptoms and indicators might include:

The World Health Organization (WHO) estimates that 10% of menstrual women worldwide who are in their reproductive stage are affected by endometriosis.

The study methods

In order to ascertain whether there is probably a genetic component to endometriosis, the research team from the University of Oxford planned to undertake a genome-wide association study (GWAS). They did a meta-analysis of the data gathered.

The researchers gathered data from more than 60,000 people. People had been diagnosed with endometriosis in collaboration with 25 other teams. They compared it to DNA samples from slightly more than 700,000 people who had been diagnosed with endometriosis.However they not have the disease.

Participants with either European or East Asian heritage provided the samples.

The genetic differences between those who have endometriosis and those who do not were taken into consideration by the researchers when they examined the data. The implications of these variations on “endometrium, blood, and other important tissues” were also taken into account.

In order to determine whether there was a connection between endometriosis and nine other immunological or inflammatory illnesses, researchers also looked at those conditions.

Genetic map of endometriosis

The scientists discovered 42 genetic loci sites of genes or genetic sequences in the genome. They regarded important for developing endometriosis after reviewing the data provided.

This research supports the hypothesis that endometriosis may have a hereditary component, which may be important for the advancement of diagnostic procedures and therapeutic approaches.

The researchers were able to pinpoint a number of genes and hormone regulators that were linked to both endometriosis and other pain problems after further investigating these locations.

The scientists discovered links between a number of medical illnesses and symptoms, including asthma, osteoarthritis, chronic back pain, and migraines.

Senior research scientist at the Wellcome Centre for Human Genetics at the University of Oxford and the study’s first author, Dr. Nilufer Rahmioglu, spoke about the study.

“We were able to generate a treasure trove of new information about genetically driven endometriosis subtypes. Also, pain experience using different datasets of women with and without endometriosis. Some of which had unprecedented detailed data on surgical findings and pain experience collected using standardised criteria,” said Dr. Rahmioglu.

Links to IBS, migraine, asthma

MNT spoke with Dr. G. Thomas Ruiz, the head of OB/GYN at Memorial Care Orange Coast Medical Center in Fountain Valley, California, who was not associated with this study.

This study confirms the significance of a family history of endometriosis. Gynecologists have long known this, and this study confirms their theory, according to Dr. Ruiz.

Dr. Ruiz stated that the study’s huge sample size is a strength and that a lot of useful information can be extrapolated from it. He advises concentrating on the overall concept that “endometriosis and advanced stage endometriosis” have a genetic basis.

Dr. Ruiz continued, “There seems to be a connection between the body’s response to endometriosis and other inflammatory diseases like osteoarthritis and asthma.

The results of the study were also discussed by Dr. Steve Vasilev, an integrative gynecologic oncologist who is board-certified, the medical director of integrative gynecologic oncology at Providence Saint John’s Health Center, and a professor at Saint John’s Cancer Institute in Santa Monica, California. Dr. Vasilev was not involved in the study.

Diagnosis and management

Endometriosis may be the cause of persistent pelvic discomfort, painfully heavy periods, and other menstrual symptoms. Women who are concerned about these symptoms should speak with their gynaecologists.

There is currently no blood test that can validate a doctor’s diagnosis of endometriosis, according to recommendations published in the Canadian Medical Association Journal earlier this month.

Endometriosis is generally diagnosed by laparoscopic surgery. But like all operations, this one is a little intrusive and comes with certain dangers.

As a result, these new diagnostic guidelines advise doctors to detect endometriosis by combining patient history with imaging. Diagnostic techniques covered by the recommendations include magnetic resonance imaging (MRI) and transvaginal ultrasound.

Hormone therapy, such as birth control tablets can have efficacy rates of 60-80%, people with endometriosis can manage their symptoms. Nonetheless, surgery may be required to eliminate lesions in those who are attempting to get pregnant.

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Dysuria: When It Hurts to Go With the ‘Flow

Dysuria: When It Hurts to Go With the ‘Flow

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Dysuria, or painful urination, can occur for a number of causes. When someone urinates, it could ache because of an infection, kidney stones, a cyst, or another illness affecting the bladder or adjacent organs.

This symptom has a wide range of possible explanations, many of which are curable.

Individuals who experience dysuria should inform their doctor of any other symptoms. If these are associated with painful urination, it may be possible for doctors to diagnose the condition and suggest the best course of action.

Causes of painful urination

Urinary tract infections

A urinary tract infection frequently manifests as painful urination (UTI). A bacterial infection may lead to a UTI. Urinary tract irritation may also be to blame.

The urinary tract is made up of the urethra, bladder, ureters, and kidneys. Urine travels from the kidneys to the bladder through tubes called ureters. Any of these organs that are inflamed can induce urinating pain.

UTIs are more common in those who have vagina than in those who have a penis. This is so because people with a vagina have shorter urethras. Bacteria need to travel less distance to reach the bladder if the urethra is shorter.

Urinary tract infections are also more likely to occur in menopausal or pregnant women.

Sexually transmissible diseases (STIs)

Also, if you have a sexually transmitted infection, you might feel pain when peeing (STI). Chlamydia, gonorrhoea, and genital herpes are a few STIs that can make urinating unpleasant.

Due to the fact that STIs are sometimes asymptomatic, it is crucial to get checked for them. STI testing should be done on a large number of sexually active individuals.

Prostatitis

Painful urination might be brought on by other medical disorders. Prostatitis, which affects the prostate, can cause painful urinating in men. The prostate gland is inflamed in this syndrome. It is the main source of burning, stinging, and pain in the urinary system.

Cystitis

Urination pain can also be brought on by cystitis, an inflammation of the bladder lining. The term “painful bladder syndrome” (PBS) is another name for interstitial cystitis (IC). The most typical kind of cystitis is this one. Pain and tenderness in the bladder and pelvic area are IC symptoms.

Radiation therapy occasionally results in pain in the bladder and urethra. Radiation cystitis is the name of this condition.

Urethritis

The condition known as urethritis denotes inflammation of the urethra, typically brought on by bacterial infection. In addition to frequently causing pain while urinating, urethritis can also increase the urge to urinate.

Epididymitis

Epididymitis, or inflammation of the epididymis in people with a penis, can also result in painful urination. Sperm from the testes are stored and transported by the epididymis, which is situated behind the testicles.

Pelvic inflammatory disease (PID)

PID can have an impact on the uterus, cervix, ovaries, and fallopian tubes. Among other symptoms, it can lead to painful urination, painful intercourse, and abdominal pain.

PID is a severe infection that typically results from a bacterial infection that starts in the vagina and spreads to the reproductive organs.

Uropathy with obstruction

Urine flowing back into the kidneys is known as obstructive uropathy, which is caused by an obstruction in the ureter, bladder, or urethra. Regardless of the cause, it’s critical to get medical attention as soon as symptoms appear.

Similar problems with urination and pain can be brought on by another disorder called urethral stricture, which causes the urethra to narrow.

Renal stones

If you have kidney stones, it could be uncomfortable for you to urinate. The urinary tract contains masses of hardened material called kidney stones.

Medications

Painful urination is a side effect of various drugs, including some antibiotics and cancer treatments. Discuss any possible pharmaceutical side effects with your healthcare professional.

Hygiene items

It’s not always an infection that causes painful urinating. Moreover, it could be brought on by genital product use. Vaginal tissues can become particularly irritated by soaps, lotions, and bubble baths.

Dyes in laundry detergents and other personal care items can irritate and contribute to health problems such as dysuria.

Differences in males and females

Both sexes can experience pain during urinating, and the causes may depend on the anatomy.

For instance, female urethras are shorter than male urethras. This makes it easier for germs to enter the bladder, which can result in UTIs.

A person might discuss with their doctor the likelihood that they will experience painful urinating based on their sex and medical history.

Treatment options for painful urination

The initial step before receiving therapy will be to identify the source of the pain.

To address painful urinating, your doctor could prescribe medication. UTIs, some bacterial infections, and some STIs can all be treated with antibiotics. Also, your doctor might prescribe you medicine to soothe your agitated bladder.

If you start taking medicine, painful urination brought on by a bacterial infection typically gets better quite soon. Take the medication exactly as directed by your doctor every time.

Certain infections, like interstitial cystitis, can cause pain that is more difficult to treat than others. The effects of pharmacological therapy could take longer. Before you start to feel better, you might need to take medicine for up to 4 months.

Prevent painful urination

There are lifestyle adjustments you can undertake to help with symptom relief.

  • Avoid using scented toiletries and laundry detergents to lower your chance of irritation.
  • When engaging in sexual activity, use condoms or other barrier techniques.
  • Eliminate foods and beverages from your diet that can irritate the bladder (such as highly acidic foods, caffeine, and alcohol).
  • Drink plenty of water.

When to see a doctor

Get in touch with your doctor:

  • if the discomfort is ongoing or severe
  • if you are expecting
  • There is fever and ache together.
  • if you develop vaginal or penile discharge
  • your urine smells strange, contains blood, or is cloudy
  • if abdominal discomfort is present along with the pain
  • if you expel a kidney or bladder stone

To help identify the source of the pain, your doctor may request lab tests and inquire about any further symptoms.

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Typical lifestyle habits that can kill your sex lfe.

Typical lifestyle habits that can kill your sex lfe.

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Do you believe your lover no longer wants to have sex? Do you believe that there aren’t many sexual embers in the bedroom? Let us warn you that the issue is not with your partner before you lash out and place the blame there. There are other factors at play than your relationship. Your sex drive might be killed by a number of habits.

Working long hours, drinking alcohol, and having stringent deadlines frequently cause couples to place less significance on their sexual life. Because of our way of life, we frequently prefer to disregard our personal lives. Perhaps you are also leading a lifestyle that is killing your sex drive without you realising it. We have provided a list of unhealthy behaviours that are impacting your sex desire to better help you understand. Long sex sessions, dirty moments, and flirting with one another all become faraway dreams.

Huddling in bed with your iPad

Indeed, it can be challenging to stop using Pinterest or to resist binge-watching the newest Orange Is the New Black season. But time, passion, and emotional energy can be lost to technology. Many women claim they have no time for sex, but Andrea Syrtash, a relationship specialist and the author of Cheat on Your Husband, notes that many admit to checking Facebook an hour before bed (With Your Husband). Also, sending that final email before turning out the lights ensures that you are concentrating on your work and not on getting into bed with your spouse.

Dr. Jane Greer, a marriage and sex therapist in New York, argues that this means that emotionally, you are elsewhere. (Having a TV in the bedroom also doesn’t help: A new study reveals that couples only engage in sexual activity half as frequently!) To reduce distractions, both experts advise turning off your electronics an hour before bed.

Eating much or too late

According to Dr. Rachel A. Sussman, LCSW, stress and busy schedules both contribute to late dinners, midnight snacking, and overeating. “Such habits can make us drained, stuffed, and self-conscious.” What occurs when we don’t feel good about ourselves, do you know? a great deal of nothing. she gave? Consider sex as your dessert, Sussman exhorts. “There’s a fairly good possibility that if you eat less, you’re going to have more energy and want to have sex later that evening.” (And, afterward, you can always have something sweet.)

Adding an extra wine glass

Another cunning culprit that can be putting a stop to your desire is alcohol usage. Sussman says, “People frequently drink to deal with stress, but it might backfire, making them fatigued or grumpy. Why? since alcohol has a depressive effect. But, not all alcoholic beverages are unhealthy; just be mindful of your intake. Sussman continues, “A little bit can excite you on, but too much can definitely destroy a sex drive and make it hard to orgasm.

Allowing your pet to sleep in your bed

We comprehend. The puppy-dog eyes are difficult to avoid. However, Virginia Sadock, M.D., Head of the Department in Human Sexuality at NYU Langone Medical Center, advises against bringing pets into the bedroom. In fact, your dog might gain from giving you some breathing room. Pets, like kids, don’t appreciate being left out, but Sadock observes that they dislike parental conflict even less. And since having sex helps relieve stress, shut the door for the evening.

Being a one-trick pony 

Monogamy can get boring after a while. Routines are simple to get into, especially once you find one that “works,” but restraining yourself from repeating the same moves will help keep you interested in playing again. Sussman advises doing some reading, experimenting with different body postures, or coming up with original techniques to entice your partner: “It doesn’t need to be difficult. As simple as flirting can do it.”

Always taking the kids on vacation

In a family situation, Disney World typically prevails over Aruba. Yet, a February 2013 study commissioned by the U.S. Travel Association found that couples who travel together at least once a year have more contented sexual lives. A weekend getaway might foster greater connection than meagre presents. Thus, avoid giving gifts of affection and spend more on vacations by saving your money.

Putting on your jammies

That baggy tee or prairie-chic plaid dress are probably not helping either of you feel particularly motivated. Syrtash notes that wearing gorgeous underwear can make sexual activity feel more seductive. “If you often wear granny pants to bed, try switching it up with sensuous materials that feel wonderful on your skin. You’ll feel sensual, and he’ll think it’s sexy.” Hence, everyone benefits.

Skipping the gym

Confidence doesn’t mean you should let everything go: “A moderate amount of exercise helps you build up stamina, it energises you, and it is also a fantastic method to release anxiety,” advises Sadock. The more energy you have left over to feel aroused for sex, the less energy you are expending on feeling anxious. A University of Florida research found that post-workout sex can be fantastic. Why? Even if you haven’t dropped any weight, you end up feeling more confident and liberated.

Not setting aside any “special time”

Although it may not sound romantic, organising romps in the bedroom improves them by frequently removing guilt. “It’s easy to feel like you always have something more important to be doing than having sex if you’re a really busy person, especially a stay-at-home mom or a working mom,” Sussman claims, adding that she advises arranging couples’ time at least once a week.

Passing up those small opportunities to connect

Additionally, you can revive your libido outside of the bedroom. According to Sadock, lunch dates are particularly helpful for helping couples reconnect on a deeper level. “Twenty minutes of talking — when you’re not washing the dishes, folding clothes, or watching TV — helps you reconnect with your partner on a deeper level,” she says. It’s uniquely nice because it’s a rest during the day and you’re not as worn out as you are at night.

Waiting for the appropriate time

Do it now. Seriously. The decline in oestrogen levels that occurs in women as they age, as well as after giving birth, can cause dryness in the vagina and decreased desire. Yet, starting to kiss and fondle while being out of the mood can actually turn you on. You can thank us later if you try it.

News viewing while in bed

The mood could be seriously destroyed by watching the news while in bed. The news can be downright gloomy at times, which may be negatively affecting your sex life by lowering your desire or putting you in a depressed frame of mind.

Having insufficient sleep

A weak sex desire could be caused by insufficient z’s. Changes in hormone levels result in a decrease in libido when sleep is lacking. Also, being sleep deprived can make you feel bad, which means you probably won’t be in the mood for an intimate relationship with your spouse.

Avoid letting these negative behaviours spoil your sexual life. Make an effort to keep things exciting in the bedroom and cherish that connection with your lover!

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Critical reasons you need to know about Gonorrhea.

Critical reasons you need to know about Gonorrhea.

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What is gonorrhea?

A bacterium called Neisseria gonorrhoeae is the prevalent sexually transmitted infection (STI) known as gonorrhoea (N. gonorrhoeae). Additionally, it goes by the names “the clap” and “drip.” Semen and vaginal fluid are two sexual fluids that can spread gonorrhoea. Intercourse, anal sex, oral sex, and sharing sex toys with an infected person are all ways to contract gonorrhoea.

Gonorrhea frequently has no symptoms. This makes it simple to unintentionally infect your companions. You can lower your risk of infection by getting tested periodically, as advised by your healthcare professional, and using safer sex techniques.

How is gonorrhea transmitted?

Having vaginal, anal, or oral intercourse can result in gonorrhoea transmission or infection. When having intercourse, using a condom or another barrier device can significantly reduce your risk of developing or spreading STIs like gonorrhoea.

Just bear in mind that, especially if you misuse these barrier measures, they may not always entirely reduce your risk. Here’s how to properly use barrier devices and condoms.

According to some data, French kissing, or kissing with the tongue, may also be a means of transmission for oral gonorrhoea. To fully grasp the potential risk of transmission, more research is necessary.

You are more likely to get gonorrhoea again if you have once had it. Gonorrhea left untreated can raise your chance of acquiring more STIs. During delivery, gonorrhoea can potentially be passed from the mother to the child.

Symptoms of Gonorrhea

Many gonorrhoea sufferers show no signs of the disease. People who do frequently have a burning feeling while urinating.

Additionally, a man with a penis might see:

  • discharge that is white, green, or yellow.
  • swelling or discomfort in the testicles
  • Foreskin irritation or edoema
  • Increased vaginal discharge and bleeding between periods are possible in vaginal patients.

If someone has anal sex, they may also experience rectal problems. These may consist of:

  • discharge
  • scratching at the anus
  • soreness
  • bleeding
  • Having bowel motions hurt

Oral intercourse can induce gonorrhoea, which can be found in the throat but may not show any symptoms. Because gonorrhoea is a bacterial illness, conjunctivitis, a common eye condition, could result from semen or vaginal fluid containing the bacterium.

What causes gonorrhea?

When the gonorrhea-causing bacteria (N. gonorrhoeae) enters your body through sexual fluids like semen or vaginal fluid—often through unprotected sex—you get an illness. Your mouth, vagina, penis, or anus are all possible entry points for the germs. To transfer the bacterium, neither you nor your partner need to ejaculate (cum). Sharing sex accessories that haven’t been cleaned or wrapped with a fresh condom can potentially spread gonorrhoea.

The cervix is the most typical site of infection in those who are born with the gender given to them. Your uterus and vagina are connected by a passageway called the cervix.

Infection commonly begins in the urethra, the tube through which urine leaves the body, in those who were born with the gender ascribed to them as male.

Who gets gonorrhea?

Gonorrhea can be contracted by sexually active individuals of any age or sex and passed on to partners. When you give birth, you could infect your child.

You’re more likely to contract an infection if you:

  • are under 25.
  • have a STI history.
  • Never use dental dams or condoms every time you have intercourse.
  • are engaging in sexual activity with one or more partners who have not had gonorrhoea tested.
  • Are a man or woman with a penis who engages in sexual activity with other men or women with penises (MSM).

Complications of gonorrhea

You are more likely to have long-term gonorrhea-related issues if you have a vagina.

Gonorrhea and chlamydia are two STIs that can spread into the reproductive system and harm the uterus, fallopian tubes, and ovaries if left untreated. This may result in pelvic inflammatory disease, a disorder (PID). PID can harm the reproductive organs and result in excruciating, ongoing agony.

Another potential problem is fallopian tube blockage or scarring, which can:

  • make getting pregnant more challenging
  • cause ectopic pregnancy, which occurs when an egg that has been fertilised implants outside the uterus.

During delivery, gonorrhoea can potentially spread to a newborn child. Gonorrhea, if left untreated, can result in: if you have a penis.

  • Urinary tract scarring
  • a distressing penile abscess that could have an impact on your fertility
  • Inflammation of the semen-carrying tubes close to your testicles is known as epididymitis.
  • Untreated infections can also enter your bloodstream, where they might result in uncommon but severe side effects like arthritis and heart valve damage.

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What are the side effects of prostate massage therapy?

What are the side effects of prostate massage therapy?

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A component of the male reproductive system, the prostate is situated in front of the rectum and just below the bladder. Although there are conventional medical procedures to treat prostate inflammation, or prostatitis, some alternative practitioners do a prostate massage when it becomes irritated.

In traditional medicine, a doctor does a digital rectal examination (DRE) to identify prostatitis, prostate enlargement, or inflammation.

According to some alternative healthcare professionals, “milking the prostate” in this way can improve sexual function and improve some symptoms associated with an inflamed prostate.

What is a prostate massage?

A DRE is comparable to a prostate massage. In addition to using their fingertips to feel for lumps or other anomalies, a professional performing a DRE will also massage the prostate.

There are two parts to this prostate. It encircles the area where the urethra connects to the bladder. Male fertility depends on the prostate since it is responsible for the majority of the fluid that surrounds sperm in semen.A prostate massage is frequently referred to as “drainage,” and it typically takes longer. The prostate is intended to be “wrung out.”

A DRE is typically used by a physician to assess the prostate gland’s overall size and health. A doctor will keep an eye out for any changes that might point to health problems during the treatment. A doctor touches the sides of the prostate close by with a finger while wearing a lubricated glove.

The doctor may rub the prostate to extract fluid for later analysis if symptoms point to the existence of an infection. Practitioners of prostate massage also assert that symptom reduction benefits from discharging this fluid. Expressed prostatic secretion refers to the fluid the prostate releases. It will be examined by doctors to look for inflammation or infection.

For the first month, people with chronic prostatitis frequently return for prostate massages two to three times a week, then taper off as their symptoms become better.

Types of Prostate massage.

Some people regularly massage their prostates to treat the symptoms of prostate issues. This can be done by professionals using their hands or a prostate-massaging tool. It can be slightly unpleasant to massage the prostate. Since the fluids include burning agents, some persons experience increased burning following drainage.

Pressure can be applied to the perineum, a region situated midway between the anus and the scrotum, during an external prostate massage. Prostate massage can also be given by gently massaging the area of the belly between the pubic bone and the belly button. Additionally, there are tools that can help with external prostate massage.

How to Do a Prostate Massage

It frequently assists to achieve an arousal level before doing prostate massage for sexual purposes. As the penis becomes erect, this causes the gland to migrate into a slightly upward and backward position.

That’s when:

  • Around the anus, liberally apply lubricant.
  • Start masturbating by softly inserting your index finger over the first knuckle.
  • Reapply lubricant after pulling the finger out.
  • Replace your finger in the anus once more, this time to the second knuckle, and carry on masturbating.
  • Up until the third knuckle, repeat steps 3 and 4 as necessary.
  • Once the finger is fully inserted, look into the rectum, up toward the root of the penis, for a rounded lump that is about 4 inches long. The prostate appears here.
  • Use the pad of a finger to gently rub the prostate in a circular or back-and-forth motion. You can also use the pad of your finger rather than the tip to gently push down for seven to ten seconds.

Purpose of Prostate Massage

Prostate massages aim to drain extra seminal fluid from the prostate gland’s channels, which mixes with sperm to form semen. Some people believe that this will reduce inflammation, encourage urination, and alleviate symptoms of prostate issues.

Between the bladder and the root of the penis is where the prostate gland is situated. It creates seminal fluid, which during ejaculation nourishes and transports sperm. The centre of the prostate is where the urethra, the tube through which urine and sperm leave the body, passes.

Prostate massage is thought to be beneficial for some prostate conditions, such as prostatitis and benign prostatic hyperplasia (BPH).

Benign Prostatic Hyperplasia (BPH)

Prostate enlargement with ageing is known as BPH. The prostate is typically the size of a walnut, but in those over 60, it can grow to be the size of a plum or even larger. This may result in urinary issues and urethral compression.

Prostatitis

The prostate gland becomes inflamed when someone has prostatitis. A bladder infection or a urinary tract infection (UTI) may be the culprit. However, it could also be brought on by activities like strenuous riding a horse or a bicycle or by using a urinary catheter.

For some people, especially older males, prostatitis can develop suddenly and for no apparent reason. Contrary to BPH, which worsens over time, prostatitis can resolve

Possible Side Effects

The sensitive tissues lining the prostate and rectum are prone to abrasions, rips, and wounds. An overly vigorous massage of the prostate can quickly cause soreness. For instance, 8.3% of participants in the study mentioned above felt uncomfortable following a prostate massage.

In addition to causing rectal bleeding, a too forceful prostate massage can aggravate haemorrhoids or increase the risk of bacterial infection.

Men with acute bacterial prostatitis should also avoid manual prostate massage. The massage exacerbates inflammation and might encourage the spread of bacteria to the bloodstream, other urinary tract regions, and the urethra.

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Can Weed/Marijuana results in Erectile dysfunction?

Can Weed/Marijuana results in Erectile dysfunction?

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Marijuana is presently legal in 37 states, three territories, and the District of Columbia as a result of numerous marijuana initiatives, with 19 states permitting recreational use.

In 2018, more than 11 million Americans consumed marijuana, according to data from the National Institute on Drug Abuse (NIDA). In conclusion, marijuana usage, whether for therapeutic or recreational purposes, is very widespread.

Pain management is a common use of medical marijuana in the US. Although marijuana doesn’t have the potency to significantly lessen really severe pain, it does work quite well to alleviate the chronic pain that afflict millions of Americans each year, according to reputable sources like Harvard Medical School.

Similar to the majority of recreational substances, marijuana can have both advantages and disadvantages. The immediate effects of marijuana include pain alleviation, changed perceptions, emotional changes, and some degree of mental and functioning impairment.

The majority of these are brought on by delta-9-tetrahydrocannabinol (THC), the main psychoactive component of marijuana. Additionally, marijuana has certain negative impacts on the sex life, such as a higher chance of erectile problems (ED). The scientific evidence for this connection is, however, contradictory, with some studies pointing to a reduction in sexual performance caused by marijuana and others pointing to an increase.

Marijuana and ED

Although a few small studies have suggested that using marijuana for recreational purposes may cause ED, the authors of a 2018 meta-analysis came to the conclusion that there is not enough data to prove a connection. However, it is easy to pinpoint which THC side effects might be to blame for the malfunction. A person may have a larger danger if they combine marijuana and tobacco.

Smoking cigarettes increases the chance of having ED because it inhibits blood flow to the veins and arteries. Similar risks may be associated with marijuana use, particularly when combined with tobacco. The smooth muscle of the penis has cannabinoid receptors. Because of this, it is theoretically feasible that THC will affect penile function, which may result in ED. There isn’t enough evidence, though.

Cannabis use can result in feelings of exhilaration, followed by tiredness and a reduced reaction time, according to NIDA. Less sex cravings may result from these results.

According to the Centers for Disease Control and Prevention (CDC), marijuana use may also have an impact on the circulatory system, raising blood pressure and heart rate. Both of these consequences increase a person’s risk for ED and are more likely to be felt by marijuana smokers.

There is some evidence that regular cannabis usage may make it more difficult for males to experience orgasms or to have them when they want them. There was, however, no discernible difference in the risk for ED between a group that used cannabis and a control group according to at least one study.

Effects of Cannabis

THC enters the circulation through the lungs when marijuana is smoked. It travels through the bloodstream to the brain and other bodily organs.

The reward and pleasure centres of the brain are impacted by THC. Dopamine influences mood and experience by signalling the body to release more than usual. This is the reason why using the medication results in a “high.”

Other immediate impacts of marijuana use could be:

  • sensory perception altered
  • followed by euphoria, sleepiness, and relaxation
  • alterations in coordination and balance
  • higher heart rate
  • issues with memory and learning
  • anxiety

Long-term impacts that could occur include:

  • mental illness issues
  • respiratory infections that recur frequently and a persistent cough
  • loss of memory

Does weed cause infertility?

Current scientific research is contradictory and inconclusive. Cannabis doesn’t seem to have an impact on live births or actual pregnancies, despite the fact that we have shown harmful impacts of the drug in lab trials.

THC in particular, according to laboratory research, may have an impact on sperm quantity, activity, and quality. In a similar vein, laboratory and animal research indicate that cannabis may alter testosterone levels. Again, no human subjects have been used to replicate these results, thus more study is required.

Some specialists believe that cannabis’ impact on hormones and sperm may make matters worse for persons who are already dealing with fertility problems. They advise abstaining from cannabis when trying to conceive.

Marijuana and Medication

The use of marijuana and its components for medical purposes has recently drawn a lot of interest. Cannabidiol (CBD) was approved by the FDA in June 2018 for treating epilepsy that is brought on by Lennox-Gastaut syndrome and Dravet syndrome, two severe and uncommon diseases.

Marijuana contains certain substances that have therapeutic potential for a number of other ailments. Before these treatments can be approved, however, there is still a lot more research to be done. Many Americans consume marijuana or its derivatives in the expectation that it would improve their health, even in states where it is still illegal to do so. Most dangers associated with doing so are unclear.

Like other drugs, marijuana may interfere with various prescription medications and complementary therapies, such as:

  • Blood thinners: Warfarin, various herbs, and supplements, as well as marijuana, may all have stronger blood-thinning effects.
  • Alcohol: The psychoactive and depressive effects of marijuana may be enhanced.
  • Theophylline: Marijuana may mitigate this medication’s side effects when used to treat asthma and other respiratory conditions. Marijuana may intensify the central nervous system depressing effects of benzodiazepines and barbiturates.
  • Psychiatric medications: Medical marijuana may alter the effects of psychiatric drugs.
  • Antiretroviral therapy: Marijuana may reduce the effectiveness of several antiretroviral medications.

Further study is required since there might be other medication interactions. Anyone worried about the effects of using cannabis or its derivatives for medical or recreational purposes should consult a healthcare provider. A doctor can provide you more specific information regarding potential side effects and drug interactions.

Conclusion:

To link marijuana consumption with ED, more data is needed. However, certain of the medication’s negative effects, like cardiovascular issues, may raise your risk of developing ED.

One review’s authors found no conclusive evidence of a connection between cannabis consumption and ED. They did find that drinking alcohol and smoking cigarettes raised the risk of ED, but exercise appeared to lower it.

Anyone worried about ED might benefit from increasing their exercise routine and abstaining from alcohol and smoke. Marijuana should only be used in compliance with local regulations and when under a doctor’s supervision.

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