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Most People Aren’t Getting Enough Omega-3: What Are the Health Impacts?

Most People Aren’t Getting Enough Omega-3: What Are the Health Impacts?

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A new research review reports that most people do not consume the recommended amounts of omega-3 fatty acids. These acids are considered beneficial for brain, skin, and heart health.
Experts say a person should obtain omega-3s through foods, but supplements can be considered if a person’s diet doesn’t contain enough fatty acids.
The majority of people worldwide are not consuming a sufficient amount of omega-3 fatty acids, according to new research.

Researchers report that 76% of the global population is not consuming the daily recommended levels of omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). They said the health benefits from these fatty acids are “too important to ignore. They recommend that health officials develop official policies on omega-3 consumption and advise the public on how to best obtain these fatty acids through diet, as well as through supplements such as fish oil.

We hope this work will help inform nutritional scientists, clinicians, food and supplement industries, policy makers, and consumer communities, said Anne-Marie Minihane. The researchers emphasized that the health benefits of omega-3 fatty acids are important at every stage of life, particularly for pregnant individuals, infants, and young children.

The researchers reached their conclusions after reviewing the recommended daily levels of omega-3 fatty acids in over 100 countries. They noted that the recommendations vary significantly from country to country, creating confusion among the public and highlighting the importance of consistent, evidence-based guidance. They reported that the most frequently recommended intake for adults is 250 mg per day of combined EPA and DHA, with an additional 100 to 200 mg of DHA advised for pregnant people.

They said these levels can be achieved by eating more oily fish, such as salmon or mackerel, or through supplementation where needed. The researchers recently shared their findings in Nutrition Research Reviews, a publication of Cambridge University Press. The authors also acknowledged they have ties to companies such as Holland & Barrett that are involved in the supplement industry. Experts not involved in the research said the review sheds light on an important issue.

It highlights the inconsistencies in how much fatty acid intake is necessary,” said Cheng-Han Chen, MD, an interventional cardiologist and medical director of the Structural Heart Program at MemorialCare Saddleback Medical Center in Laguna Hills, CA.

The overall message is clear that people should incorporate fatty acids in their diet, It’s a good overview of some of the challenges with getting enough omega 3s through diet alone as well as a look into how various age groups are doing with getting enough omega 3s, recommendations for amount, and unique deficiency risk factors based on age, added Kristin Kirkpatrick, RD, the president of KAK Consulting as well as a dietitian at the Cleveland Clinic Department of Wellness & Preventive Medicine in Ohio.

Health benefits from omega-3 fatty acids
Omega-3s are a family of essential fatty acids. In addition to EPA and DHA types, there is also alpha-linolenic acid (ALA). These acids are not produced by the human body, so they must be absorbed through diet or supplementation.

David Cutler, MD, Santa Monica, California, explains that fats, such as omega-3s, are important because they help our bodies absorb other fat-soluble nutrients, including vitamins A, E, D, and K. Cutler wasn’t involved in the new review. Omega-3s, in particular the DHA type, are considered essential for brain, skin, and eye health. Research has been mixed on what other health benefits are provided by adequate levels of omega-3 fatty acids.

However, past research has reported that these fatty acids can improve heart health by lowering triglyceride levels and increasing HDL, or “good cholesterol,” levels. The benefits of these omega-3 fatty acids are mostly attributed to lowering triglyceride levels in the bloodstream,” Cut. “This is important if you have abnormally high triglycerides and probably not so important if your triglyceride levels are normal.

There has been other research that reported that omega-3 fatty acids may help improve blood sugar levels and lower inflammation. Experts say omega-3s are particularly important for pregnant and nursing women as these fatty acids are vital for the brain health of fetuses as well as infants. Fatty acids are important, Chen said. In particular, they’re important for infant health. In pregnancy, omega-3 deficiency may have an impact on the overall cognitive and neurological health of the baby,” added Kilpatrick.

Omega-3s may be more important for older adults simply because they are at higher risk of some of the health problems that fatty acids can help prevent. They’re susceptible to the same issues as people with omega-3 deficiencies, he said. Some symptoms indicate a low level of omega-3 fatty acids in the body. They include:

skin irritation and dryness
dry eyes
joint pain
changes in hair texture

The American Heart Association (AHA) recommends two servings of fatty fish per week. Those who are unable to consume sufficient omega-3 acids through their diet may wish to consider omega-3 supplements that include fish oil and algal oil.

Cutler offered a word of caution about fish oil capsules. He noted that supplements are not regulated by government agencies like medications and other products. He also said there can be side effects such as nausea and diarrhea.

Additionally, fish oil supplements may increase the risk of bleeding. He noted that it’s particularly important for anyone taking blood-thinning medications. Any benefits to omega-3 supplements should be weighed against potential side effects and risks.

Chen doesn’t generally recommend supplements to boost omega-3 counts. He says the research doesn’t support the notion that supplements effectively boost fatty acid levels. In general, the recommendation is to get fatty acids through diet,” Chen said. “All supplements affect is your wallet.

Reference:
https://www.healthline.com/health-news/omega-3-deficiency-health-impacts#How-to-know-if-you-re-getting-enough-omega-3

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Diet, exercise, or both? Study finds best strategy for reducing belly fat…

Diet, exercise, or both? Study finds best strategy for reducing belly fat…

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This gets to the heart of a very common fitness goal. The short answer is that for a significant, lasting reduction of belly fat, combining diet and exercise is the undisputed champion.

However, let’s break down the science of why this is the case, and the specific roles that diet and exercise play.

The Verdict: Diet + Exercise is the Winner

Multiple studies, including a seminal one from Duke University, have clearly demonstrated that a combination of aerobic exercise and a controlled diet is the most effective strategy for reducing visceral fat (the dangerous belly fat deep inside your abdomen).

Here’s a simplified breakdown of the findings:

StrategyEffect on Belly Fat (Visceral Fat)
Diet OnlyGood reduction. Creates a calorie deficit, leading to overall fat loss, including from the belly.
Exercise OnlyModerate reduction. Effective, but often slower than diet for fat loss alone.
Diet + ExerciseBest and most significant reduction. The effects are synergistic, meaning they add up to more than the sum of their parts.

The “Why”: Understanding the Roles of Diet and Exercise

1. The Role of Diet: The Key to Unlocking Fat Stores

You cannot out-exercise a bad diet when it comes to fat loss. This is because of the simple math of a calorie Deficit.

  • Calorie Deficit: To lose fat, you must consume fewer calories than your body burns. Diet is the most efficient way to create this deficit.
  • Targeting Visceral Fat: When you create a sustained calorie deficit through diet, your body is forced to use stored energy. Visceral fat is often more “metabolically active” and can be mobilized for energy more readily than some subcutaneous fat (the fat under your skin), especially with the right hormonal environment.
  • Food Quality Matters: A diet high in protein (increases satiety, preserves muscle), fiber (from vegetables, fruits, whole grains), and healthy fats helps control hunger and stabilizes blood sugar, reducing the hormones that promote belly fat storage (like cortisol and insulin).

In short, Diet is the primary driver for creating the energy deficit needed to burn fat.

2. The Role of Exercise: The Turbocharger and Body Shaper

Exercise doesn’t just burn calories; it fundamentally changes your body’s composition and metabolism.

  • Aerobic Exercise (Cardio): Great for burning a high number of calories during the activity itself. It’s very effective at directly reducing visceral fat.
  • Resistance Training (Weight Lifting): This is the secret weapon. Muscle is a metabolically active tissue, meaning it burns calories even at rest. The more muscle you have, the higher your resting metabolic rate.
    • Prevents Muscle Loss: When you’re in a calorie deficit from dieting, your body may break down muscle for energy. Lifting weights signals your body to preserve muscle mass, ensuring that the weight you lose comes primarily from fat.
    • The “Afterburn” Effect: Intense exercise, especially strength training and HIIT, can keep your metabolism elevated for hours after your workout.

In short: Exercise ensures the weight you lose is fat, not muscle, and improves your metabolism for long-term leanness.

The Special Case of Belly Fat: Stress and Sleep

It’s crucial to understand that belly fat is particularly influenced by hormones, especially cortisol (the stress hormone). High stress and poor sleep can elevate cortisol levels, which directly encourage the storage of fat in the abdominal area.

Therefore, the most effective “belly fat reduction plan” also includes:

  • Stress Management: Practices like meditation, yoga, walking in nature, and adequate leisure time.
  • Quality Sleep: Aim for 7-9 hours of quality sleep per night.

Your Action Plan: The Best Strategy

  1. Start with Your Plate: Focus on creating a moderate calorie deficit. Eat whole, minimally processed foods: lean proteins, vegetables, fruits, and whole grains. Reduce sugar, refined carbs, and ultra-processed foods.
  2. Incorporate Cardio: Aim for at least 150 minutes of moderate-intensity cardio (like brisk walking, cycling) or 75 minutes of vigorous-intensity cardio per week.
  3. Lift Weights: Include resistance training at least 2-3 times per week, targeting all major muscle groups.
  4. Manage Stress and Sleep: Make this a non-negotiable part of your routine. It is as important as your diet and workout.

Conclusion: Don’t choose between diet and exercise. Use them together. Think of diet as the key that unlocks the fat store, and exercise as the tool that ensures you’re burning the right type of fuel (fat) and building a body that keeps it off for good.

Reference:
https://www.hopkinsmedicine.org/health/wellness-and-prevention/8-ways-to-lose-belly-fat-and-live-a-healthier-life
https://www.health.harvard.edu/newsletter_article/taking-aim-at-belly-fat
https://www.healthline.com/nutrition/20-tips-to-lose-belly-fat

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Which is better for losing weight – diet or exercise?

Which is better for losing weight – diet or exercise?

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Yes, for weight loss, diet generally matters more than exercise. While both play important roles, research and practical evidence show that controlling calorie intake is more effective for shedding pounds than increasing physical activity alone. Here’s why:

1. Caloric Deficit is Key

  • Weight loss occurs when you burn more calories than you consume (a caloric deficit).
  • It’s easier to reduce calorie intake by 500 calories/day (e.g., skipping a sugary drink and dessert) than to burn 500 calories through exercise (which might require 45–60 minutes of intense cardio).

2. Exercise Burns Fewer Calories Than People Think

  • A 30-minute run may burn ~250–400 calories, but that can be undone quickly by eating a small snack (e.g., a muffin or a handful of nuts).
  • Many people overestimate exercise’s calorie burn and compensate by eating more, negating the deficit.

3. Diet Directly Controls Fat Storage & Hormones

  • Foods high in refined carbs and sugars spike insulin, promoting fat storage.
  • Protein and fiber-rich diets improve satiety, reducing overall calorie intake.
  • Exercise alone doesn’t compensate for a poor diet’s metabolic effects (e.g., insulin resistance).

4. Exercise is Great, But Not Primarily for Weight Loss

  • Exercise supports weight maintenance, muscle retention, and overall health (heart, mood, metabolism).
  • However, without dietary changes, exercise alone often leads to minimal weight loss.

Practical Takeaways

  • Focus on whole, unprocessed foods (vegetables, lean proteins, healthy fats) and portion control.
  • Combine diet with strength training & cardio to preserve muscle and boost metabolism.
  • Avoid liquid calories (soda, alcohol, sugary coffee) and mindless snacking.

While exercise is crucial for long-term health and fitness, you can’t out-exercise a bad diet. For significant weight loss, prioritize nutrition first, then use exercise to enhance results and maintain your progress.

Reference:

https://www.medicalnewstoday.com/articles/for-weight-loss-diet-may-matter-more-than-exercise

https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-which-is-better-for-losing-weight-diet-or-exercise-video

https://www.healthhub.sg/live-healthy/exercise-vs-diet

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2 low-calorie days a week could aid weight loss, blood sugar control in diabetes

2 low-calorie days a week could aid weight loss, blood sugar control in diabetes

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Incorporating two low-calorie days per week (often referred to as intermittent fasting or the 5:2 diet) may help with weight loss and blood sugar control in people with diabetes or prediabetes, according to research. Here’s how it works and its potential benefits:

How It Works:

  • 5 Normal Days: Eat a balanced, healthy diet without strict calorie restrictions.
  • 2 Low-Calorie Days: Consume ~500-800 calories (varies by individual), focusing on high-protein, fiber-rich, and low-glycemic foods to stay full and maintain blood sugar stability.

Potential Benefits for Diabetes & Weight Loss:

  1. Improved Insulin Sensitivity – Fasting periods may help lower insulin resistance, aiding blood sugar control.
  2. Weight Loss – Calorie restriction promotes fat loss, which is crucial for managing type 2 diabetes.
  3. Lower Blood Glucose Levels – Some studies show reduced fasting glucose and HbA1c levels with intermittent fasting.
  4. Reduced Inflammation – May help decrease markers of inflammation linked to metabolic diseases.

Considerations & Precautions:

  • Not for Everyone: People with type 1 diabetes, a history of eating disorders, or those on insulin/medications should consult a doctor before trying this, as fasting can cause hypoglycemia (low blood sugar).
  • Hydration & Nutrient Balance: Stay hydrated and prioritize lean proteins, non-starchy veggies, and healthy fats on low-calorie days.
  • Monitor Blood Sugar: Frequent glucose checks are important to avoid dangerous drops or spikes.

Research Support:

  • A 2023 study in Diabetes Care found that intermittent fasting (including 5:2 diets) led to greater weight loss and HbA1c reductions compared to daily calorie restriction in type 2 diabetes patients.
  • Another 2021 meta-analysis in Clinical Diabetes and Endocrinology suggested that intermittent fasting improved metabolic health in prediabetes and early diabetes.

The 5:2 approach may be a useful tool for weight loss and blood sugar management in some people with type 2 diabetes or prediabetes, but it should be personalized and medically supervised. Always consult a doctor or dietitian before making significant dietary changes, especially if taking diabetes medications.

Reference:

https://www.medicalnewstoday.com/articles/2-low-calorie-days-a-week-could-aid-weight-loss-blood-sugar-control-in-diabetes

https://pmc.ncbi.nlm.nih.gov/articles/PMC8756303

https://www.sciencedaily.com/releases/2025/07/250715043351.htm

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According to a study, Mediterranean and ketogenic diets may help people lose weight and reduce blood pressure.

According to a study, Mediterranean and ketogenic diets may help people lose weight and reduce blood pressure.

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A new study suggests that both the Mediterranean diet and keto (ketogenic) diet may support weight loss and lower blood pressure, though they work in different ways. Here’s what the research reveals:

Key Findings

  1. Weight Loss Benefits
    • Mediterranean Diet: Emphasizes whole foods (olive oil, fish, nuts, veggies, whole grains) and led to moderate, sustainable weight loss (~5-10% body weight over 6-12 months).
    • Keto Diet: Very low-carb, high-fat approach caused rapid initial weight loss (mostly water and fat), but long-term adherence was tougher.
  2. Blood Pressure Reduction
    • Mediterranean Diet: Linked to lower systolic/diastolic BP (by ~5-7 mmHg) due to high potassium, fiber, and healthy fats.
    • Keto Diet: Also showed BP improvements, likely from reduced insulin resistance and inflammation.
  3. Other Health Impacts
    • Mediterranean Diet: Improved cholesterol, heart health, and longevity.
    • Keto Diet: Beneficial for blood sugar control (Type 2 diabetes) but may raise LDL cholesterol in some.

Which Diet Is Better?

  • For long-term heart health & sustainability → Mediterranean diet (more flexible, nutrient-rich).
  • For quick metabolic benefits (e.g., prediabetes) → Short-term keto, then transition.

Practical Tips

  • Mediterranean: Swap butter for olive oil, eat fatty fish twice weekly, load up on veggies.
  • Keto: Focus on avocados, eggs, low-carb greens; monitor saturated fat intake.

Both diets can work, but the best choice depends on health goals, preferences, and adherence.

Reference:

https://www.news-medical.net/news/20250526/Which-diet-lowers-blood-pressure-more-keto-or-Mediterranean.aspx

https://pmc.ncbi.nlm.nih.gov/articles/PMC12114320

https://www.sciencedirect.com/science/article/pii/S0531556523000426

https://www.medicalnewstoday.com/articles/mediterranean-keto-diets-may-help-weight-loss-lower-blood-pressure-study

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Lupus Signs, Symptoms, and Co-occuring Conditions

Lupus Signs, Symptoms, and Co-occuring Conditions

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Lupus affects everyone differently, but certain signs and symptoms are common to most individuals. According to the Centers for Disease Control and Prevention (CDC, a sign is a medical finding your doctor observes during a physical exam, while a symptom is a subjective experience, such as joint stiffness or headache. In addition, several autoimmune diseases share overlapping features. Other conditions, such as fibromyalgia in people with lupus, occur commonly but are not directly due to disease activity. These co-occurring conditions are known as “comorbidities.”

Fever

The average human body temperature is approximately 98.5°F, but many people run slightly above or below this mark. A temperature of 101°F is generally accepted as a fever. According to Mayo Clinic, many people with lupus experience recurring low-grade fevers that may signal inflammation, infection, or an approaching lupus flare. Persistent or high fever should always be reported to a physician.

Joint Stiffness

Many lupus patients experience joint stiffness, especially in the morning. Warm showers may provide temporary relief. If stiffness interferes with daily activities, a medical evaluation is important. Similar symptoms are also seen in rheumatoid arthritis and other inflammatory joint conditions. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) notes that joint pain may occur with or without true arthritis.

If fevers last several days or recur frequently, record your temperature twice daily. A fever of 101°F or higher requires medical attention. Patients taking steroids or immunosuppressive drugs should be especially alert for infection, as outlined by the U.S. National Library of Medicine.

Weight Changes

Increased lupus activity or medication side effects may cause weight loss or appetite changes. The Lupus Foundation of America recommends reporting unexplained weight changes to your doctor to rule out complications.

Conversely, corticosteroids can lead to weight gain. Maintaining a balanced diet and physical activity is important. Chronic inflammation may also raise the risk of heart disease, making weight management especially important for people with lupus.

Fatigue and Malaise

Nearly 90% of people with lupus experience fatigue at some point. According to Mayo Clinic, fatigue may also be related to treatable conditions such as anemia, thyroid disease, or fibromyalgia. Persistent fatigue should be discussed with a healthcare provider.

Sjogren’s Syndrome

Up to 10% of people with lupus may develop Sjögren’s syndrome , an autoimmune disorder affecting tear and saliva production. Regular treatment helps prevent discomfort and long-term complications.

Depression

Depression and anxiety affect nearly one-third of people with lupus. The National Institute of Mental Health (NIMH) notes that chronic illness and steroid medications can both contribute to clinical depression, which is treatable with appropriate care.

Gastrointestinal Problems

Heartburn and GERD are common in lupus, often related to medications. The American College of Gastroenterology recommends a medical evaluation if reflux symptoms persist beyond two weeks.

Thyroid Problems

Autoimmune thyroid disease frequently co-occurs with lupus. According to the American Thyroid Association, both hypo- and hyperthyroidism can significantly affect metabolism and organ function.

Osteoporosis

People with lupus are at increased risk of bone loss due to inflammation and steroid use. Learn more about osteoporosis causes, symptoms, and prevention to better understand how to protect long-term bone health. The National Osteoporosis Foundation states that appropriate treatment can significantly reduce fracture risk.

Weight loss is encouraged by a naturally occurring molecule that suppresses appetite.

Weight loss is encouraged by a naturally occurring molecule that suppresses appetite.

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Researchers from Stanford Medicine have discovered a naturally occurring molecule that functions similarly to semaglutide, commonly marketed as Ozempic, in terms of appetite suppression and weight loss. Interestingly, studies conducted on animals also revealed that it was effective without some of the negative effects of the medication, including nausea, constipation, and a marked loss of muscle mass.

The recently identified molecule, BRP, appears to provide a more focused method of body weight loss by activating distinct neurons in the brain and acting through a different but comparable metabolic pathway. In addition to the brain, semaglutide also targets receptors in the pancreas, gut, and other tissues. Because of this, Ozempic has a variety of effects, such as lowering blood sugar levels and slowing the passage of food through the digestive system. BRP, on the other hand, seems to have a specific effect on the hypothalamus, which regulates metabolism and appetite.

Without using artificial intelligence to sort through dozens of proteins in a class known as prohormones, the study would not have been feasible. Prohormones are physiologically inert molecules that become active when other proteins break them down into smaller molecules known as peptides. Some of these peptides then act as hormones to control intricate biological processes in the brain and other organs, such as energy metabolism.

Numerous functional peptide progeny can be produced by splitting each prohormone in different ways. However, it is challenging to separate peptide hormones which are comparatively uncommon from the biological soup of the far more common natural byproducts of protein processing and degradation using conventional protein isolation techniques. The prohormone convertase 1/3, which is known to play a role in human obesity, was the focus of the study. It separates prohormones at particular amino acid sequences. Glucagon-like peptide 1, or GLP-1, is one of the peptide products that control blood sugar and appetite; semaglutide functions by simulating GLP-1’s physiological effects. To find additional peptides involved in energy metabolism, the team looked to artificial intelligence.

Peptide predictor
The researchers created a computer algorithm they called Peptide Predictor to find common prohormone convertase cleavage sites in all 20,000 human protein-coding genes, eliminating the need to manually separate proteins and peptides from tissues and use methods like mass spectrometry to identify hundreds of thousands of peptides. They then concentrate on genes that encode proteins with four or more potential cleavage sites and that are secreted outside of the cell, which is a crucial feature of hormones. By doing this, the search was reduced to 373 prohormones, which is a manageable quantity to check for biological effects.

Prohormone convertase 1/3 was expected to produce 2,683 distinct peptides from the 373 proteins, according to Peptide Predictor. Coassolo and Svensson concentrated on sequences that the brain is probably biologically active. They tested 100 peptides, including GLP-1, for their capacity to stimulate neuronal cells cultured in a lab. The GLP-1 peptide, as anticipated, had a strong effect on the neurons, causing them to become three times more active than the control cells. However, a tiny peptide consisting of only 12 amino acids increased the cells’ activity ten times more than controls. Based on its parent prohormone, BPM/retinoic acid inducible neural specific 2, also known as BRINP2 (BRINP2-related-peptide), the researchers called this peptide BRP.

An intramuscular injection of BRP before feeding decreased food intake over the following hour by up to 50% in both animal models, according to the researchers’ testing of the drug’s effects on lean mice and minipigs, which more closely resemble human metabolism and eating patterns than mice do. Over 14 days, obese mice given daily injections of BRP lost an average of 3 grams, almost entirely as a result of fat loss, whereas control mice gained roughly 3 grams. Additionally, the mice showed enhanced insulin and glucose tolerance.

Behavioral studies of the pigs and mice revealed no differences in the fecal production, water intake, anxiety-like behavior, or movement of the treated animals. Additionally, additional research on brain and physiological activity revealed that BRP activates metabolic and neuronal pathways independently of those triggered by semaglutide or GLP-1. In addition to further deconstructing the mechanisms of action of BRP, the researchers aim to identify the cell-surface receptors that bind it. If the peptide is successful in controlling human body weight, they are also looking into ways to prolong its effects on the body so that a more convenient dosing schedule can be used.

According to Svensson, the dearth of efficient medications to treat obesity in people has existed for many years. The ability of semaglutide to reduce appetite and body weight is superior to anything we have tested previously. We are very interested in finding out if it works and is safe for people. The study included contributions from researchers at the University of British Columbia, the University of Minnesota, and the University of California, Berkeley.

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Beyond weight loss: Bariatric surgery may reduce cancer risk…

Beyond weight loss: Bariatric surgery may reduce cancer risk…

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You might not associate obesity with cancer when you think about it. Still, scientists have long surmised a connection between weight and some types of cancer. Among them are postmenopausal breast cancer, ovarian, colon, liver, pancreatic, and endometrial cancer, which combined account for 15 to 20 percent of cancer-related deaths in the U.S.

Cancer risk increases with obesity
Over one-third of American adults. S. are deemed obese if their body mass index (BMI) is thirty or greater. The body mass index (BMI) calculates body fat based on height and weight. The number of people with severe obesity, which is a BMI of 40 or higher, has increased significantly. A person’s chance of developing cancer rises by 10% if their BMI rises by even five points, per a study published in the New England Journal of Medicine.

Obesity increases a person’s risk of cancer by two times compared to optimal weight. For instance, a BMI of greater than 40 is associated with a seven-fold increased risk of endometrial cancer. It seems that an elevated risk of cancer is largely attributed to excess weight, primarily in the form of body fat. Obesity triggers an increase in fat cells within the body. With the rise in the number of these fat cells, the body’s hormone release pattern alters. This shift typically boosts the production of pro-inflammatory hormones and estrogen. Over an extended period, this persistent inflammatory condition can induce harm to cells and their DNA, thereby enhancing the likelihood of specific types of cancers.

Researchers are examining the connection between chronic inflammation and body fat. Furthermore, diabetes and other chronic metabolic diseases can be brought on by hormones like estrogen and insulin resistance. According to the Centers for Disease Control, one in three adults will have diabetes and related health issues by 2050.

Bariatric surgery and reduction of cancer risk link
More research is needed, but researchers think a decrease in inflammatory fat cells may lower the risk of cancer. Additionally, the amount that nonsurgical, or purposeful, weight loss reduces the risk of cancer is still unknown.
However, maintaining the weight loss for those who have done so through lifestyle modifications can be difficult. The body’s intricate neurohormonal systems prevent starvation, which makes it challenging to keep off weight loss.

Even when weighed against medications and intensive lifestyle therapy, bariatric or metabolic surgery is currently the most effective obesity treatment. Following surgery, patients usually lose 25 to 35 percent of their total body weight or 50 to 70 percent of their excess weight, and these weight losses are frequently maintained for years.

Continuing research
Numerous extensive investigations have been carried out to examine the connection between weight loss achieved through bariatric surgery and the decreased risk of cancer. A 2019 study published in the Annals of Surgery compared 66,000 individuals without bariatric surgery to over 22,000 who underwent the procedure. The study site, BMI, age, and sex of the participants were taken into consideration when matching them. In comparison to individuals who did not undergo bariatric surgery, statistical models were utilized to examine the cancer incidence up to ten years following the procedure.

Individuals who underwent bariatric surgery experienced a reduced risk of developing any form of cancer by 33% over the observation period, contrasting those who did not undergo such surgery. The findings were more substantial when the focus was on cancers linked to obesity.

A study published in the Journal of the American Medical Association in 2022 tracked 30,000 individuals, all of whom had a BMI higher than 35. The subjects were split up into two groups and matched according to age and gender. Approximately 5,000 patients in one group had bariatric surgery, while slightly over 25,000 patients in the other group had no surgery. A follow-up period of roughly six years was the median.

The follow-up data demonstrated a significant reduction in the risk of cancers related to obesity and other malignancies following bariatric surgery. Additionally, it showed that patients who had bariatric surgery had a lower rate of cancer-related mortality when compared to those who had not had the procedure.

More research is required to validate these findings as researchers continue to explore the reasons and mechanisms underlying the reduced risk of diabetes and cancer following bariatric surgery. Bariatric surgery, however, holds promise for patients battling obesity as it may lower the risk of cancer and metabolic diseases like diabetes.

This new data regarding the advantages and efficacy of bariatric surgery may help you decide if you’re thinking about having it done. Talk about it further with your bariatric surgery team or primary care physician. M.D Maria Linnaus. is a bariatric surgeon at the Mayo Clinic in Eau Claire, Wisconsin.

It seems that having excess body weight in the form of fat is what increases the risk of cancer. The body produces more fat cells when an individual is obese. Hormone release by the body varies with the number of these fat cells. Estrogen and pro-inflammatory hormones are generally elevated by these modifications. This persistent inflammatory condition raises the possibility of developing some cancers by damaging cells and their DNA.

More research is required to validate these findings as researchers continue to explore the reasons and mechanisms underlying the reduced risk of diabetes and cancer following bariatric surgery. Bariatric surgery, however, holds promise for patients battling obesity as it may lower the risk of cancer and metabolic diseases like diabetes. This new data regarding the advantages and efficacy of bariatric surgery may help you decide if you’re thinking about having it done. Talk about it further with your bariatric surgery team or primary care physician.

References:
https://cancerblog.mayoclinic.org/2024/04/23/beyond-weight-loss-bariatric-surgery-may-reduce-cancer-risk/
https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/bariatric-surgery-and-cancer-risk

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New weight loss pill Amycretin is more effective than Semaglutide

New weight loss pill Amycretin is more effective than Semaglutide

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The Danish company Novo Nordisk recently revealed the preliminary results of a phase 1 clinical trial, which suggests that amycretin, an experimental medication they developed to treat obesity, may significantly improve weight loss compared to Ozempic and Wegovy (semaglutide). The business has not yet disclosed when to publish the data in a peer-reviewed publication. Given that adults with type 2 diabetes are primarily prescribed Ozempic and Wegovy to help control their blood sugar levels, this may not come as a surprise. Even though all semaglutide medications seem to be linked to weight loss, only Wegovy has received FDA approval for long-term weight management in adults.

These drugs, which are glucagon-like peptide-1 (GLP-1) receptor agonists, function by imitating the actions of a hormone that aids in controlling hunger and blood sugar levels. According to preliminary findings, taking amycretin for three months reduced body weight by 13%. According to earlier studies, semaglutide reduced body weight by about 6% over a comparable period. Experts, however, have stressed the need for more comprehensive research to verify the long-term benefits and safety profile of amycretin. Despite these cautions, Novo Nordisk’s stock value surged by over 8% following the drug’s presentation at an investor meeting on March 7, 2024.

The surging interest in a new class of medications known as GLP-1 agonists has propelled Novo Nordisk to become the most valuable company in Europe, despite facing significant supply shortages due to high demand. Amycretin differentiates itself from semaglutide medications like Ozempic and Wegovy, and from Eli Lilly’s Mounjaro and Zepbound (tirazepide) by being administered orally as a pill rather than through a weekly injection.

The limited information available suggests this method could be quite promising, but it is important to note that much more data are required. This is because amycretin has yet to be evaluated against other medications in a direct comparison trial. At a recent investor event, a senior development executive from Novo Nordisk highlighted the potential for amycretin to match the effectiveness and safety profile of CagriSema, another GLP-1 agonist drug by the company, targeting amylin. The company anticipates the results of a study on an injectable version of amycretin to be released next year. Based on these findings, Novo Nordisk intends to initiate a comprehensive development program.

In an amycretin trial with sixteen subjects weighing an average of eighty-nine kilograms, the placebo group lost one percent of their body weight over twelve weeks. Research shows that GLP-1 agonist drugs can lower the risk of obesity-related cardiovascular diseases, but they also raise the risk of gastrointestinal problems. Patients must know that studies indicate most people who stop taking these medications end up gaining back most of the weight they have lost.

REFERENCES:

https://www.medicalnewstoday.com/articles/new-weight-loss-pill-amycretin-more-effective-than-semaglutide-in-early-trial
https://qz.com/ozempic-weight-loss-pill-amycretin-novo-nordisk-1851326591
https://www.forbes.com/sites/roberthart/2024/03/07/novo-nordisks-new-obesity-pill-beats-wegovy-in-early-trial/?sh=1bfdece9456e
https://www.sciencealert.com/experimental-weight-loss-pill-twice-as-effective-as-ozempic-trial-shows

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How To Loose Weight Naturally

How To Loose Weight Naturally

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It is advisable to lose weight gradually, according to several specialists. It will probably remain off longer. According to the Academy of Nutrition and Dietetics, if you lose weight too quickly, you’ll lose water, muscle, and bone instead of fat. The adage “calories in, calories out” means that you must expend more calories than you consume through food and drink. However, as many individuals can attest to from personal experience, it’s not that easy.

You might believe that fasting can help you lose weight quickly. However, it is preferable to have a diet that you can follow over time and that fits with your lifestyle. If fasting is long-term safe, more study is required to determine this. The majority of studies on the effects of intermittent fasting were conducted on middle-aged, overweight adults. If it is safe for those who are older or younger or those who are at a healthy weight, more research is required.

When attempting to reduce weight, both proper nutrition and exercise are crucial. If your nutrition is out of balance, no amount of activity can help you lose weight. However, evidence indicates that whether you’re attempting to reduce weight or not, exercise has significant positive effects on your body and mind. Your body’s ability to convert calories into fuel, or metabolism, is important. Additionally, it’s harmful to limit calories too much. Your metabolism slows down, which can cause you to consume less nutrients.

You can accomplish this in a variety of ways without drastically reducing your calorie intake. You might reduce portions, calculate how many calories you consume on a daily basis, and cut down a little. You could also check food labels to determine how many calories are in each serving and drink more water to help you feel less hungry. To reduce weight, you don’t have to cut out any specific food groups, go vegan, or give up gluten. In fact, if it’s something you can maintain over time, you’re more likely to keep the weight off permanently. However, it does make sense to drastically reduce or eliminate empty calories. As an example. sweet foods There are frequently few nutrients but many calories in foods like cookies, cakes, sugar-sweetened beverages, and other things. Aim to consume added sugars at a rate of no more than 10% of your daily calories.

Consuming enough protein will keep your muscles strong. In addition to lean meat, chicken, fish, and dairy, there are vegetarian and vegan alternatives (nuts, beans, and soy are a few). Depending on your age, gender, and level of activity, you may require more or less protein. Also You might feel fuller and less like you’re on a diet by consuming little amounts of fat. Olive oil, salmon, and nuts and seeds are the healthier options. It may prevent hunger if you eat five to six times each day. Each of those mini-meals may have an equal number of calories, or you could make some larger than others. In order to avoid overeating, you must plan your quantities. Eliminating liquid calories like soda, juice, and alcohol is one simple approach to reduce weight quickly. Replace them with calorie-free beverages like black coffee, unsweetened tea, or lemon water.

Whatever approach you choose, you must prioritize healthy foods like fruits, vegetables, whole grains, and lean protein to maintain a balanced diet. However, there isn’t a single, universal healthy eating strategy. A excellent approach is to work with a dietician to create a plan that addresses your unique requirements. Additionally, it’s crucial to follow through with a healthy weight loss plan that you create. The tendency must continue over the long term in order to become healthy and maintain that state.

REFERENCES:

https://www.medicalnewstoday.com/articles/322345
https://www.nhs.uk/live-well/healthy-weight/managing-your-weight/tips-to-help-you-lose-weight/
https://www.webmd.com/diet/ss/slideshow-no-diet-weight-loss

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