Yes, research suggests that low-calorie diets (especially very restrictive ones) may have negative effects on mental health, including increased stress, anxiety, irritability, and even depression. Here’s why:

How Low-Calorie Diets May Harm Mental Health

1. Nutrient Deficiencies – Severely cutting calories can lead to low levels of:
   • B vitamins (important for mood regulation)
   • Omega-3s (linked to reduced depression risk)
   • Magnesium & Zinc (affect stress and neurotransmitter function)
2. Hormonal Changes – Extreme calorie restriction can:
   • Lower serotonin (the “feel-good” hormone)
   • Increase cortisol (stress hormone), worsening anxiety
3. Brain Fuel Shortage – The brain relies on glucose, and very low-calorie diets (especially low-carb) may lead to:
   • Brain fog
   • Fatigue
   • Mood swings
4. Psychological Effects – Strict dieting can lead to:
   • Food obsession (increased cravings)
   • Guilt & shame around eating
   • Higher risk of disordered eating

Who’s Most at Risk?

• People with a history of anxiety, depression, or eating disorders
• Those on very low-calorie diets (<1,200 kcal/day for women, <1,500 kcal/day for men)
• Long-term dieters with yo-yo weight fluctuations

Healthier Alternatives

Moderate calorie deficit (e.g., 300–500 kcal below maintenance)
Balanced macros (enough protein, healthy fats, and fiber)
Mindful eating (not overly restrictive)
Regular meals (avoiding extreme hunger.

While weight loss can benefit physical health, extreme calorie restriction often backfires mentally. A sustainable, nutrient-rich diet is better for both body and mind.

Reference:

https://www.medicalnewstoday.com/articles/low-calorie-diets-may-negatively-impact-mental-health

https://edition.cnn.com/2025/06/03/health/diet-calories-depression-wellness

https://pmc.ncbi.nlm.nih.gov/articles/PMC4790398

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/disease/mental-health