April, 2023 Pharmacy and Health Blog from myGenericPharmacy.com

Secrets your heart rate tells about your health.

April 4, 2023 blogadmin Comments 0 Comment

Your heart attack risk and aerobic capacity can be determined by your pulse, both at rest and during exercise.

Your grandma might have called your heart “your ticker,” but that moniker has turned out to be inaccurate. A healthy heart doesn’t beat like a clock every time. As your activities change throughout the day, it speeds up and slows down to match your fluctuating requirement for oxygen. Everybody’s idea of what constitutes a “normal” heart rate is different. Yet, an elevated risk of heart attack and death may be indicated by an unusually high resting heart rate or low maximum heart rate.

Checking one’s resting heart rate is a straightforward action that every one may take. It’s quite simple to execute, and knowing the details now can be useful later. It’s wise to check your pulse from time to time to obtain a sense of what is typical for you. Also, to spot any unusual changes in rate or regularity that may require medical care.

Resting heart rate

Your heart pumps the least quantity of blood when you’re at rest to provide your body the oxygen it needs. Resting heart rates for the majority of healthy adult men and women range from 60 to 100 beats per minute. The Women’s Health Initiative (WHI) published research in 2010 that suggested a resting heart rate at the low end of that range would provide some protection against heart attacks.

Researchers were conducted from the World Heart Institute (WHI) studied data on 129,135 postmenopausal women. They discovered that those with the greatest resting heart rates—more than 76 beats per minute—were 26% more likely to suffer a heart attack or pass away as a result of one than those with the lowest resting heart rates—62 beats per minute or less.

The resting heart rate is regarded as a critical indication by medical professionals because it offers a brief glimpse of how well the heart muscle is working. The resting heart rate can be used to identify potential cardiac issues, according to experts in preventative cardiology. Also, it may show improvements in heart health over time.

You may want to discuss how your heart rate and other personal characteristics affect your risk for cardiovascular disease with your doctor if your resting heart rate is consistently over 80 beats per minute.

Maximum heart rate

Your maximal heart rate is the rate at which your heart beats when it is working the hardest to supply your body with the oxygen it requires. Your aerobic capacity—the amount of oxygen you can take in—is greatly influenced by your maximum heart rate.

According to several sizable observational studies, having a high aerobic capacity reduces your chance of dying from a heart attack and other causes of mortality. Also, small controlled research found that increasing aerobic capacity helped men and women with mild cognitive impairment perform better on memory and reasoning tests.

TACHYCARDIA

Tachycardia is the term for a heart rate of more than 100 beats per minute. It’s important to remember that a rapid heart rate isn’t always unnatural. Your heart rate can be raised by a variety of factors. This includes physical activity, stress, smoking, coffee use, excessive alcohol consumption, and some drugs. A healthcare provider should, however, examine a heart rate that is frequently elevated without any apparent cause. Hyperthyroidism (overactive thyroid), electrolyte imbalances, and high or low blood pressure are all conditions that can cause fast heart rates.

BRADYCARDIA

Bradycardia is a condition in which the heart beats less than 60 times per minute. It can be brought on by drugs, or certain medical diseases, such as hypothyroidism (underactive thyroid), obstructive sleep apnea, and damage or inflammation of the heart muscle. It can also be brought on by chemical imbalances in the blood.

Higher or Lower resting heart rate

According to studies, men in their 50s who have a resting heart rate of 75 beats per minute have a higher risk of developing cardiovascular disease and dying young.

According to the Women’s Health Initiative Research, women are more protected against heart attacks when their resting heart rates are at the lower end of the normal range. Researchers discovered that women with RHRs over 76 heartbeats per minute had a 26% higher risk of having a heart attack than those with RHRs under 62 beats per minute.

Lower heart rates (HR around 60 beats per minute) can signify physical fitness. In other words, if your RHR is under 60, you are probably physically fitter and have better heart health than those whose RHRs are greater. If you don’t engage in regular exercise and have a resting heart rate below 50 beats per minute, it may be a sign of a health issue, such as an issue with the electrical pathways in your heart, such as heart block. You ought to have a qualified medical examination if this is the case.

A high RHR exceeding 100 beats per minute may be caused by stress, excessive coffee use, an infection, a disease, a problem such as heart arrhythmia, or any of several other factors. You should see a doctor if your resting heart rate is continuously above 80 beats per minute and cannot be accounted for by obvious causes, particularly if you are having symptoms like palpitations.

How to lower resting heart rate?

Your gender and genetics, among other uncontrollable variables, can have an impact on your resting heart rate. Your RHR is impacted by several manageable things, though. To reduce your RHR, consider the following health advice:

Make sure you work out frequently. Your resting heart rate may decrease by 10–12 beats as a result of this. Your RHR can drop by up to one beat/minute for each week that you engage in physical exercise. Typical RHRs for elite endurance athletes are in the upper 30s or lower 40s.
Natural relaxation methods like yoga and meditation might help you feel less stressed and anxious.
Reduce your consumption of caffeinated drinks including soda, tea, and coffee.
Give up smoking. Nicotine raises your heart rate and is associated with a higher risk of heart disease.
Don’t drink excessively. Drinking more than four times daily can strain your heart and make it beat more quickly.
With a medical expert, go over your prescriptions. Ask your doctor about any potential effects on your heart rate before beginning a new medicine.

You may experience an increase in RHR if you use certain prescription and over-the-counter medications, including some cold remedies, weight loss medications, and stimulants. Moreover, certain drugs, such as beta-blockers, can cause RHR as a side effect.

Final Comments

The amount of times your heart beats while you’re at rest is known as your resting heart rate (RHR). A lower RHR is typically a sign of greater heart health. A higher chance of getting heart disease and/or having a heart attack is linked to having a high resting heart rate.

The greatest way to lower your resting heart rate is through frequent, strenuous activity. Individuals who regularly engage in physical activity typically have lower resting heart rates than those who lead sedentary lifestyles. If your resting heart rate is unusually low or high, speak with a medical professional.

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Relation between native language and way of thinking.

April 3, 2023 blogadmin Comments 0 Comment

Although though some key brain areas are involved in the processing of all languages, these regions exhibit varied activity patterns when processing other languages.

According to the various brain activation patterns seen when processing particular languages, people who speak different native languages would likely have diverse brain structures. According to a recent study, the wiring of the brain regions responsible for language processing differed between native Arabic and German speakers.

These findings imply that learning one’s native language during childhood changes the connections in the brain and may help to explain why people’s ability to think differently depending on their original language.

The native tongue of a person can influence how they think. For instance, Russian has two different terms that distinguish between bright and dark blue, whereas English only has one word for hues in the blue spectrum.

Intriguingly, native Russian speakers typically perform substantially better than native English speakers in examinations requiring the differentiation of light and dark blue. Similar findings have been made about how different native languages express directions and how well-rounded a person’s sense of orientation is.

There are changes in the wiring of language processing regions in the brains of native Arabic and German speakers, according to a recent study published in the journal NeuroImage.

This raises the possibility that acquiring one’s native language as a youngster could alter the brain’s structural makeup, potentially explaining the disparities in cognitive function between people who speak various first languages.

Language processing in the brain

Throughout the years, research has established that a complex network of interconnected brain regions, primarily in the left side or hemisphere of the brain, processes and produces language. Moreover, research has shown that specific brain regions are linked to processing certain components of language, such as semantics (word meaning), syntax (grammatical structure), and phonology (sounds associated with language).

Brain areas in the left hemisphere are principally where syntactic and semantic processing takes place. However, other language-related information, particularly that pertaining to sounds and intonation, is either processed in the right hemisphere or both of them.

In the world, there are close to 7,000 different languages spoken. Individuals with different native languages display varied patterns of brain activation during language processing, despite the fact that the same basic brain regions are engaged in the comprehension and production of all languages.

The brains of people who speak different native languages are structurally different, according to studies. This shows that learning one’s native language throughout childhood causes differences in the brain’s structure from individuals who speak a different first language.

There are two types of brain tissue: grey matter and white matter. The processing of information takes place in the grey matter, which is made up of the cell bodies of neurons or nerve cells. Axons and dendrites, which transmit information from one neuron to the next, make up white matter, on the other hand.

Gray and white matter density in the regions involved in language processing differs between English and Chinese speakers, according to a prior study. In a similar vein, research has revealed variations in the white matter tract patterns connecting several brain regions in native English, German, and Chinese speakers.

Differences in brain connectivity

Researchers compared the differences in the wiring of the brain areas responsible for language processing in speakers of Arabic and German in the current study. These languages were chosen by the researchers because of how differently semantics and syntax are used in each.

First of all, these languages are not related to one another; German is an Indo-German language, while Arabic is a Semitic language. Arabic is more pronounced semantically than German, which has a more complicated grammatical or syntactic framework.

Arabic words frequently lack short vowels, unlike German, and their pronunciation and meaning depend on their context. In addition, German script is written from left to right, whereas Arabic script is written and read from right to left.

Studies have revealed increased syntactic processing activity during German comprehension, which is consistent with this. Others, however, have demonstrated a larger engagement of semantic processing regions during Arabic comprehension. In these investigations, individuals analyse a specific language while magnetic resonance imaging (MRI) is used to look at brain patterns.

Left and right hemispheres connection

The purpose of the current investigation was to determine whether native Arabic and German speakers have structural differences in their brains at baseline as a result of the distinct demands that each language places on the brain.

The researchers specifically looked at whether baseline brain connectivity patterns differed between native German and Arabic speakers. Diffusion-weighted MRI was utilised to find the white matter tracts that link the various parts of the brain.

Both groups’ participants had increased connection in the left hemisphere, which is where language processing is predominately processed. Yet, compared to Arabic speakers, participants whose native language was German had better connections between brain areas involved in language processing in either hemisphere.

Native German speakers, on the other hand, displayed weaker connections between regions in the left and right hemispheres than native Arabic speakers. The right-to-left writing system and the semantic intricacy of Arabic may be to blame for the increased activation of both hemispheres.

Brain scans of German speakers also showed greater connectivity between left hemispheric brain areas involved in syntactic processing. In contrast, native Arabic speakers had stronger connections between the brain regions involved in semantic processing.

Can language change personality?

In conclusion, the current study demonstrates that lifetime exposure to one’s native language causes structural changes in the brain. Dr. Alfred Anwander, a neuropsychologist at the Max Planck Institute and the study’s author, stated:

“The study provides significant evidence for the impact of the environment and first language on brain development, particularly the shaping of the connections that directly affect how our brains process information during thought. This may indicate that unique personality is a product of life experiences rather than being “hard-wired” in our brains.

Dr. Anwander added that the study’s findings might be applied to develop strategies specifically for people with neurological disorders.

Childhood in especially, when the brain still exhibits a larger capacity for adaptation, may leave lasting imprints on our brains and lay the groundwork for the specialised nature of each unique brain. Dr. Alfred Anwander, study author, noted that this may have some implications for clinical situations where individualised treatment may be necessary, such as in neurological rehabilitation strategies, in addition to improving our understanding of how the brain processes various languages differently.

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Walking steps 1-2 days a week linked to health benefits.

April 3, 2023 blogadmin Comments 0 Comment

According to recent studies, the optimum daily step count for reaping the health advantages of walking is 8,000 brisk steps.

A recent study shows that walking merely one to two days per week is still significantly connected with a decrease in all-cause and cardiovascular mortality, which will inspire people who find it difficult to walk every day of the week.

The authors of the study discovered that the advantages of walking increase with each consecutive day.

Walking briskly for 8,000 steps or more each day of the week is linked to a considerable drop in cardiovascular and all-cause death. Yet, a recent study reveals that those who walk just 8,000 steps on one or two days per week also have a lower mortality rate over a 10-year follow-up.

According to a study published in JAMA Network Open, participants 20 years of age and older who walked 8,000 steps or more on one or two days per week had a 14.9% lower mortality rate than sedentary individuals over the course of ten years of follow-up.

As the number of days engaged rose, the probability of mortality decreased. For instance, exercising three to seven days per week was linked to a 16.5% decrease in cardiovascular and all-cause fatalities.

Those who achieved their step objectives of 6,000 to 10,000 steps per day showed the similar pattern. According to prior studies, the risk of mortality drops by up to 10,000 steps per day for persons under 60 and by 8,000 for those over 60.

Method of exercise

The study’s conclusions apply to both “weekend warriors,” or individuals who limit their exercise to days off from work, and individuals who sneak a few hours of walking throughout the week.

The report cites recent data showing that the average American only takes 4,800 steps per day, which is far too low to have a significant positive impact on health.

The speed limit for “brisk walking” is three miles per hour. You are walking quickly if you can speak song lyrics but not sing them.

The current study analyzed information from the National Health and Nutrition Examination Survey conducted in the United States in 2005 and 2006 with data from the National Death Index until 2019.

It included accelerometer data from 3,101 individuals, who had to be at least 20 years old, and was a sample that was nationally representative. There were almost the same number of males and women in it, and the racial makeup was 50.9% White, 21.5% Black, 23.7% Hispanic, and 3.9% other.

The people who walked 8,000 steps or more per day were more likely to be Hispanic, young, male, insured, and married. Also, they were frequently never smokers and were less likely to be overweight or have concomitant conditions.

A daily challenge of walking

For many people, it takes a significant amount of time to walk 8,000 steps per day. Walking at a speed of three miles per hour, 8,000 steps equals around four miles, or roughly an hour and 20 minutes every day. Steps can be taken in brief bursts of vigorous walking or simultaneously.

Dr. Kosuke Inoue of Kyoto University in Japan served as the study’s principal investigator, working with scientists from UCLA in California. Dr. Inoue provided the following justification for the study:

“We began this study to address a concern raised by one of my patients at an outpatient clinic: ‘It is difficult for me to maintain enough steps each day. Is it acceptable to devote my time to walking exclusively on the weekends?

Dr. Inoue observed a dearth of evidence on the potential advantages of walking merely a few days per week. Steps studies frequently take a week’s worth of various step targets into account.

According to Dr. Inoue, “our findings provide useful information to encourage walking even for a couple of days per week to lower mortality risk,” given that a lack of time is one of the main obstacles to exercise in contemporary society.

According to Dr. Paul Arciero, a professor in the Skidmore College Department of Health and Human Physiological Sciences who was not involved in the study, “This is one of the first studies to employ direct assessments of daily steps using a wearable accelerometer throughout a 10-year follow-up period.”

Walking benefits overall health

Walking is regarded as a straightforward, low-impact way to reduce someone’s inactive lifestyle. Sedentary behaviour has been associated with a higher risk of cardiovascular and all-cause mortality.

Dr. Arciero continued, “Furthermore, a sedentary lifestyle dramatically raises the risk of cardiometabolic disease, including abdominal obesity, hypertension (high blood pressure), type 2 diabetes, stroke, heart disease, and some inflammatory disorders and malignancies.”

Walking can help someone keep a healthy weight, build stronger muscles and bones, and reduce their chance of developing diabetes, heart disease, and high blood pressure. Another thing that has been connected to improving mood is walking.

The Harvard Medical School claims that walking has additional, less evident advantages. Walking counteracts the effects of genes that make you gain weight, lowers your risk of developing breast cancer, and strengthens your immune system. Walking can help alleviate joint pain caused by arthritis, and even a brief stroll of 15 minutes can stop a general or stress-related chocolate appetite.

limited time for walking

According to Dr. Inoue, the study’s findings should be useful information for clinicians and other health professionals. He advised that the key message for readers should be that, for those who find it difficult to exercise regularly, “reaching required daily steps merely a few days per week can have considerable health advantages.”

Dr. Arciero referred to the study’s findings as “encouraging,” and he proposed that they might assist those who don’t have enough time to walk 8,000 steps a day in overcoming the belief that walking less is ineffective.

Dr. Arciero declared, “We now have scientific proof that shows this thinking is false, and even a couple of days is helpful. The study, according to him, emphasizes the importance of boosting one’s daily step count.

It’s a wonderful reminder to walk at least once or twice a week because even a little bit is better than nothing.

Current guidelines

The American Heart Association (AHA) and Department of Health and Human Services (HHS) advise aiming for at least 150 minutes of moderate-intensity aerobic activity per week, along with two days of muscle-strengthening activity.

The AHA urges people to move about more and notes that even modest exercise can counteract some of the negative impacts of sedentary lifestyles. Yet, the AHA also asserts that spending at least 300 minutes a week engaged in physical activity can provide even greater advantages.

Yet, Dr. Heffron notes that even the most fundamental aims are rarely achieved by the majority of people. According to statistics from the Centers for Disease Control and Prevention, just 47% of Americans fulfil the aerobic criteria and 24% do both aerobic and strength training recommendations (CDC).

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New drug combination reduces Lung cancer tumors.

April 1, 2023 blogadmin Comments 0 Comment

The second most frequent type of cancer in the world is lung cancer. Around 2 million people are given a lung cancer diagnosis each year, and 1.8 million people pass away from the condition.

Small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) are the two forms of lung cancer, with NSCLC accounting for the majority of instances. Surgery, radiation, and chemotherapy are all effective treatments for NSCLC, although it is rarely curable.

Today, studies have discovered that a combination of two medications reduces the size and quantity of tumours in mice with NSCLC, a finding that could result in human clinical trials.

Lung cancer is the second most prevalent cancer diagnosed in the United States, according to the American Cancer Society. Moreover, it is the main cause of cancer mortality, accounting for one in five cancer-related deaths, more than colon, breast, and prostate cancers put together.

The typical age of diagnosis for lung cancer is 70 years old, with most cases being found in older patients. The good news is that cases are declining as fewer individuals smoke tobacco, which is responsible for more than 80% of lung cancer cases. A diagnosis of lung cancer is still given to over 2 million people annually worldwide.

Lung tumours other than small cell comprise 85% of cases (NSCLCs). There is an urgent need for novel therapies because immunotherapy and chemotherapy are not very successful against this kind of lung cancer.

Now, researchers from the Salk Institute and Northwestern University have discovered that treating NSCLC-affected mice with a cocktail of two drugs—one of which is already approved by the Food and Drug Administration (FDA) and the other is undergoing clinical trials—reduced the size and frequency of the tumours.

Need for new treatments

According to Dr. Lillian Eichner, a principal author of the study and an assistant professor of biochemistry and molecular genetics at Northwestern University, “This medication might be helpful for patients with KRAS/LKB1 mutant lung adenocarcinoma.”

About 20,000 new cases of this disease’s molecular subtype are reported each year in the United States, she said. “Patients with this terrible disease currently have an average survival duration of 10 months after diagnosis, and improved therapeutic techniques are desperately needed.”

Histone deacetylase (HDAC) inhibitors have been suggested as a possible therapy for this particular form of lung cancer by the researchers. Animal tumour growth has been demonstrated to be slowed by HDAC inhibitors, which are epigenetic regulators.

After proving that HDAC3 was essential for the development of difficult-to-treat LKB1-mutant cancers, the study’s authors investigated if pharmacologically inhibiting HDAC3 may have an impact on tumour growth.

In this study, they treated KRAS/LKB1 mutant NSCLC in mice with two different medications: the FDA-approved MEK inhibitor trametinib and the HDAC1/HDAC3 inhibitor entinostat, which is currently in clinical development.

Lung tumor study

The LKB1 genetic mutation is present in NSCLCs, and Salk researchers were interested in investigating a novel targeted therapeutic option.

According to Dr. Andrew McKenzie, vice president of personalised medicine at Tennessee’s Sarah Cannon Research Institute and scientific director at Genospace, targeted therapies are medicines created for certain molecular subtypes of NSCLCs.

Since that these treatments are “tailored,” he explained, “it is preferable to administer a targeted therapy rather than immunotherapy or immunotherapy and chemotherapy if you test a patient and discover a mutation.

Initially, the Salk team demonstrated that the body’s histone deacetylase 3 (HDAC3) protein is essential for the development of NSCLCs with the LKB1 mutation.

This was unexpected, according to co-lead of the study Lillian Eichner, PhD, a professor at Northwestern University in Illinois who was a postdoctoral researcher at Salk during the research.

She said, “We believed the entire HDAC enzyme class was intimately related to the origin of LKB1 mutant lung cancer.

“We didn’t know the exact involvement of HDAC3 in lung tumour formation,” Eichner stated. She then moved to two drugs with the assistance of the team.

The potent drug combination

Entinostat was the first medication. Although the Food and Drug Administration (FDA) has not yet approved this medication, clinical tests have demonstrated that it targets HDACs.

Trametinib was the second medication and it works by preventing the growth of cancer cells. Trametinib is FDA-approved for the treatment of NSCLCs, but it must be used in conjunction with the medication dabrafenib, McKenzie added.

These two medications are only permitted for use in NSCLCs with the BRAF V600E mutation, the author continued.

According to McKenzie, “Trametinib on its own has not been very effective and requires to be paired with dabrafenib to see the clinical outcomes associated with FDA approval.” Because trametinib might cause tumours to become resistant, dabrafenib is often used in conjunction with it.

The goal of the study was to determine whether trametinib and the HDAC3-targeting drug entinostat would reduce resistance in the same way. Mice with LKB1-mutated NSCLC were treated with the medication cocktail for 42 days, and then the tumours were examined again.

Tumors in recipient mice have shrunk by 79% in size compared to mice not receiving the medication treatment. The researchers also noted a 63% decrease in lung cancers in the treated animals.

Human trials needed

Cancers are already being treated with these medications. For the first time, the FDA approved trametinib in 2013 to treat metastatic malignant melanoma. In 2017, it received approval for the treatment of NSCLC.

Entinostat has undergone phase 1 and phase 2 clinical trials but has not yet received FDA approval for clinical usage. Phase 3 trials in people with breast cancer are also still being conducted. People have typically tolerated the medication well during the studies.

The medications have not yet been combined in human subjects. The following stages in evaluating the combined therapy were described by Dr. Eichner.

She said that in order to determine the safety of this combined therapeutic method, a phase 1 clinical research would be conducted first.

“Based on the known safety profiles of both medications, we are hoping that this would also be the case in people,” said Dr. Eichner. “Our preclinical investigations were extremely encouraging with regard to the safety of this pharmacological combination.”

A phase 2 research would then determine whether this combination inhibits tumour growth and lengthens the patients’ lives, she continued.

New hope for cancer patients

On average $1.3 billion is spent to bring a new treatment to market, according to a recent study, making drug development a time-consuming and expensive process.

Also, it often takes 6 to 12 years for new cancer medications to be approved. So, it is quicker and more cost-effective to identify new ways to use existing medications.

According to our research, cancer treatments that were previously unsuccessful might be successful if they are modified. In some cases, understanding basic tumour biology can result in novel cancer therapy strategies without the need to first create new medications, which can be a lengthy process, according to Dr. Lillian Eichner.

Although it is still early, their discoveries might result in new lung cancer medicines for this difficult-to-treat disease. Dr. Eichner is upbeat, but more study is required to validate the results.

According to “our findings,” treating patients concurrently with both of these already-approved medications “may significantly limit the growth of lung tumours for this set of patients.”

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Dementia due to brain damage by high blood pressure?

April 1, 2023 blogadmin Comments 0 Comment

According to research, some aggressive blood pressure medicines can benefit brain health. As per them, the therapies function by opening up neural pathways in the perivascular regions of the brain.

According to experts, a balanced diet, regular exercise, enough sleep, and avoiding overstimulation are all important components of maintaining excellent brain health. Researchers may be able to detect people with severe cognitive impairment with the aid of additional research.

Dementia, a general term for a multitude of illnesses affecting memory loss and cognitive deterioration, affects more than 55 million individuals worldwide. Scientists are unsure of the exact aetiology of dementia, but they do know that certain factors can affect whether or not someone gets dementia. High blood pressure is one of these.

According to earlier studies, those who have high blood pressure are more likely to experience dementia, including Alzheimer’s disease.

Researchers from the University of Edinburgh in the United Kingdom and Jagiellonian University Medical College in Krakow, Poland, have now identified the precise regions of the brain that may be harmed by high blood pressure and are connected to the onset of dementia.

What is blood pressure?

The amount of power the heart exerts to pump blood through the arteries is measured as a person’s blood pressure.

The doctor gets two distinct readings while taking your blood pressure. The highest figure reflects the systolic pressure experienced as the heart pumps blood into the arteries. The diastolic pressure, which the heart experiences between heartbeats, is represented by the bottom number. They are both expressed in millimetres of mercury (mmHg).

For instance, the systolic and diastolic pressures of normal blood pressure are both less than 120 and 80 mmHg, respectively (but more than 90mmHg systolic and 60mmHg diastolic).

High blood pressure is seen as beginning when the systolic and diastolic pressures both rise to 130 and 80, respectively. Stage 2 high blood pressure is defined as systolic and diastolic pressures of at least 90mmHg and 140mmHg, respectively.

High blood pressure

Hypertension, also referred to as high blood pressure, develops when the amount of effort required for blood to flow through the arteries is too great.

This may occur if plaque inside the artery walls, which contains cholesterol, causes the arteries to become damaged or narrower.

A person’s chance of acquiring high blood pressure may be increased by a number of variables, such as:

unsound diet
obesity
inactivity
Using tobacco or alcohol
genetics
certain illnesses, like diabetes

How does high blood pressure affect the brain?

The lead author of this study and professor of cardiovascular medicine at Jagiellonian University Medical College in Krakow, Poland, and the University of Edinburgh in the United Kingdom, Prof. Tomasz Guzik, believes that having high blood pressure can negatively impact the structure and operation of the brain in a variety of ways.

“For example, hypertension can have a serious influence on your brain’s blood vessels, causing them to change in shape, stiffen, and form clogged arteries. “Small vessel disease” is a condition that results from the malfunction of smaller blood vessels in the brain caused by high blood pressure, which is passed from bigger to smaller blood vessels.

“High blood pressure not only impacts the flow of blood to the brain, but it also speeds up pathological processes including neurodegeneration and inflammatory activationTrusted Source. Dementia, memory loss, and other cognitive impairments are all caused by these conditions, said Tomasz Guzik, Ph.D.

Furthermore, according to Prof. Guzik, excessive blood pressure might harm the brain’s white matter.

He said that damage to this area can result in poor cognitive performance and raise the risk of stroke. “The white matter is formed of nerve fibres that transfer information across different brain regions,” he said.

According to him, this emphasises how crucial it is to keep blood pressure under control in order to avoid white matter damage and the accompanying cognitive problems.

Blood pressure study

The individuals were split into two groups by the scientists for their analysis. With a goal of 120 mm Hg systolic pressure, 243 patients in one group had highly intense treatment for high blood pressure.

The second group, consisting of 199 individuals, received routine care with a 140 mm Hg goal. Pre- and post-study MRIs were used to compare the number of perivascular spaces in each participant’s brain.

The innermost layer of the brain contains spaces filled with cerebrospinal fluid known as Virchow-Robin spaces, or perivascular spaces (PVS), according to Dr. Sandra Narayanan, a vascular neurologist and neuro-interventional surgeon at the Pacific Stroke & Neurovascular Center at Pacific Neuroscience Institute in California.

They may get bigger as a result of neurodegenerative processes, demyelinating diseases, inflammation, or ageing. They aid in clearing the brain of metabolic waste and water, she said.

The American Heart Association states that a normal blood pressure reading is less than 120/80 mm Hg. Elevated blood pressure is defined for adults as 120 to 129 mm Hg for the systolic pressure (the top number) and less than 80 mm Hg for the diastolic pressure.

High blood pressure is defined as a persistently high systolic pressure of 130 mm Hg or higher, or a diastolic pressure of 80 mm Hg or higher.

Hypertension-dementia link

Thousands of participants from the UK Biobank, COGENT, and the International Collaboration for Blood Pressure provided observational data for this study, which Prof. Guzik and his team conducted using a combination of brain magnetic resonance imaging (MRI), genetic analysis, and observational data.

After examination, scientists discovered alterations in nine regions of the brain connected to both deteriorating cognitive function and elevated blood pressure.

The putamen, which is in charge of learning and motor control, is one of these regions. Alzheimer’s disease and putamen dysfunction are related, according to earlier study.

White matter regions, the anterior thalamic radiation, the anterior corona radiata, and the anterior limb of the internal capsule were also affected by high blood pressure.

Both basic and complicated behaviours are planned and carried out by the anterior thalamic radiation, whereas the anterior corona radiata supports decision-making and emotion regulation. Moreover, the internal capsule’s anterior limb supports motivation, decision-making, and cognitive processing.

What you can do to improve brain health?

According to Narayanan Sajd, “many risk factors for neurodegenerative illnesses, such senior age, tend to be progressive.” There are significant potential clinical consequences on quality and quantity of life for these debilitating and pervasive illnesses if some of the associated clinical aspects are changeable.

According to the study’s findings, maintaining a healthy blood pressure level is crucial for maintaining a healthy brain.

The Mediterranean diet, which is low in fat and abundant in fruits and vegetables, is one example of a nourishing diet that the Alzheimer’s Association recommends. It’s also crucial to challenge your intellect by learning something new.

Behavioral scientist, relationship expert, and developer of the Happiness Hypothesis Method Clarissa Silva advises incorporating the following into your life:

Exercise. Daily aerobic activity for at least 30 minutes encourages the growth of new neurons in the brain.
Sleep. Regular sleeping patterns prevent the onset of brain fog and can make it worse throughout the day.
Overstimulation. Work productivity may be hampered by multitasking, which also adds to our brain’s ongoing overstimulation. Neuroplasticity in the brain is enhanced by concentrating on one task at a time and taking a break before moving on to the next one.
Unattended trauma. Trauma affects cognitive performance, self-esteem, and decision-making. Working with a qualified specialist to address trauma can start the process of reversing current cognitive impairment and preventing further degenerative disorders.

According to Silva, limiting screen time can aid in neuron regeneration. “Setting up a routine. At first thing in the morning and an hour before going to bed, try to cut back on checking your gadget. The constant overstimulation that we experience throughout the day needs to be repaired in our brains.

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