A recent study indicates that while not everyone benefits greatly from avocados, some people may have much better blood sugar control. The study found a strong correlation between a lower incidence of type 2 diabetes and individuals with a newly discovered metabolic biomarker of avocado intake, including decreased fasting glucose and insulin. A new era of personalized nutrition may result from the study of one’s microbiome and body metabolites, or metabolomics. Only a weak correlation was found between avocado consumption and lower fasting insulin in a study looking into the relationship between avocado consumption and a lower risk of type 2 diabetes; this correlation vanished when body mass index (BMI) was taken into account. However, the study’s authors found that some individuals had a “avocado intake biomarker” that was strongly linked to lower fasting insulin and glucose levels as well as a lower risk of type 2 diabetes. The results of the study imply that customized metabolic profiling might be essential for determining which foods can consistently improve an individual’s health.
Small molecule byproducts of metabolic processes that take place in cells, tissues, or an organism are known as metabolites. The methodical study of the body’s metabolite-related chemical reactions is known as metabolomics. It enables scientists to recognize unique fingerprints connected to particular biological functions. According to the study, the metabolome and the well-known microbiome may be essential for creating individualized, focused health interventions. The Hass Avocado Board provided funding for the study, which was published in The Journal of Nutrition. Based on information from 6,220 adults, ages 45 to 84, who took part in the ongoing Multi-Ethnic Study of Atherosclerosis, the study was conducted (MESA). Between 2000 and 2002, participants were recruited at six locations across the United States, and until 2018, they were followed up with every 18 months. In addition to over 100 other foods from 47 food groups, people reported consuming avocados. Proton nuclear magnetic resonance analysis of fasting serum samples obtained during recruitment was used to derive metabolomic profiles for 3,438 of these individuals. “Metabolomics can provide us with an extra instrument to understand a person’s specific health problems and possible remedies in a more personalized manner,” said Dr. Jason Ng, a clinical associate professor of medicine at the University of Pittsburgh, Pennsylvania, who did not participate in this investigation, to Medical News Today.
Following a comparison between the Human Metabolome Database and the spectral features derived from the participant samples, three spectra were found to closely correspond with avocado intake. The study’s authors came to the conclusion that the three metabolic annotations—CH2-lysyl—represented the same metabolite since they were similar. They then computed a mean value for all three to determine their metabolic biomarker of avocado intake. The biomarker was found to be highly correlated with lower levels of insulin and fasting glucose, even after controlling for a number of potential confounding variables, such as adiposity, BMI, health behaviors, alcohol and smoke consumption, and sociodemographic characteristics. The authors discovered that this association was not as strong in those who had dysglycemia as they had predicted. They point out that alterations in a type 2 diabetic’s microbiome may have an impact on dysglycemia. Michelle Routhenstein, a cardiology dietitian and the proprietor of Entirely Nourished, stated, “The way we metabolize foods and the byproducts of food metabolism can help [shine] more light into how diets affect us and our cardiometabolic health.” She was not involved in this study. Additionally, it might shed light on the management of chronic diseases and aid in the control of cholesterol, triglycerides, and blood sugar levels. She continued.
According to Routhenstein, “vocados are rich in monounsaturated fatty acids and soluble and insoluble fiber, which can help control blood sugar levels.”. “We are aware that some foods are generally healthier than others,” Dr. Ng added. According to this study, avocados, for instance, may help the body’s metabolism of sugar. Since not all foods will benefit everyone equally, it would be beneficial to keep researching how these foods can affect specific individuals so that they can understand what could, in particular, benefit them the most, he continued. The World Health Organization (WHO) reports that the number of people with diabetes worldwide increased fourfold from 108 million in 1980 to 422 million in 2014. Over 95% of these individuals have type 2 diabetes. According to more recent data, there are currently over 500 million diabetics globally, and by 2050, there may be 13.3 billion diabetics worldwide. Diabetes is described as “a defining disease of the 21st century” in The Lancet. “Although diabetes is becoming more common worldwide, North Africa, the Middle East, Latin America, and the Caribbean are particularly affected.”. Even though diabetes is usually controllable, in the worst case it can lead to kidney failure, eyesight loss, a heart attack, or even the amputation of a lower limb. Avoiding smoking, maintaining a healthy diet, and getting regular exercise all lower the chance of developing diabetes. Drugs can help delay the onset and progression of illness.
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