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What are the causes of Angiosarcoma disease?

What are the causes of Angiosarcoma disease?

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A uncommon kind of cancer called angiosarcoma develops in the lining of lymph and blood arteries. The immune system includes the lymphatic vessels. The lymph vessels remove waste materials, viruses, and germs from the body.

Anywhere in the body can develop cancer of this kind. But the skin of the head and neck is where it usually manifests itself. Rarely, it can develop in the skin of other bodily parts, such the breast. Alternately, it might develop in deeper tissues like the liver and heart. Angiosarcoma can develop in locations that have already received radiation therapy.

Symptoms of Angiosarcoma

A skin-related angiosarcoma

Angiosarcoma typically develops in the skin of the head and neck. On the scalp, it often occurs. The following are signs of this type of angiosarcoma:

  • a bump on the skin that resembles a bruise
  • a lesion that resembles a bruise and enlarges over time
  • a wound that could bleed if scratched or jarred
  • Skin around the lesion is swollen.

Organ-specific angiosarcoma

Angiosarcoma frequently results in pain when it affects organs like the liver or heart. The angiosarcoma’s location will affect any additional symptoms.

Causes of angiosarcoma

Most angiosarcomas have unknown origins. Researchers have found a number of variables that could raise the disease’s risk.

Angiosarcoma develops when the DNA of cells lining a blood artery or lymph channel changes. The instructions that inform a cell what to do are encoded in its DNA. The adjustments, which scientists refer to as mutations, instruct the cells to divide quickly. When healthy cells would perish, the alterations prevent the cells from dying.

As a result, cancer cells can accumulate and spread outside of the blood vessel or lymph channel. Cancerous cells are able to infiltrate and obliterate healthy body tissue. Cancer cells could eventually separate and travel to different parts of the body.

Risk elements

The following factors can raise your risk of developing angiosarcoma:

  • Radiation treatment. Angiosarcoma risk may rise after radiation therapy for cancer or other disorders. An uncommon side effect of radiation therapy is angiosarcoma.
  • Swelling brought on by damaged lymph vessels. Lymphedema is swelling brought on by a buildup of lymph fluid. When the lymphatic system becomes obstructed or injured, it occurs. When lymph nodes are removed during surgery, lymphedema can result. This is frequently carried during during cancer surgery. When there is an infection or other disorders, lymphedema can also occur.
  • Chemicals. Exposure to a number of substances has been related to liver angiosarcoma. These substances include arsenic and vinyl chloride, for instance.
  • Inherited syndromes. Angiosarcoma risk can increase in those who are born with specific gene mutations. Examples include the mutations in the BRCA1 and BRCA2 genes that lead to neurofibromatosis, Maffucci syndrome, or Klippel-Trenaunay syndrome.

Genetic disorders linked to Angiosarcoma

Genetic abnormalities that alter genes that are intended to guard you against malignancies have been linked, according to researchers. Conditions specifically include:

  • Two-sided retinoblastoma. The retina in the back of your eyes is where this rare cancer develops.
  • Ollier illness. This uncommon condition affects how your bones grow.
  • Syndrome Maffucci. Your bones’ cartilage is affected by this uncommon condition.

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How can prostate cancer affects Sexual health?

How can prostate cancer affects Sexual health?

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Prostate cancer patients who are undergoing or have had treatment can experience sex-related issues. These include troubles with fertility, losing interest in sex, and getting an erection.

A lump or tumour is created when cells in the prostate tissue develop uncontrolled, a condition known as prostate cancer or cancer of the prostate gland. The urethra, the tube that takes urine from the bladder to leave the body, can become blocked if the tumour becomes large enough.

Prostate cancer often has little effect on sexual function, although in rare instances, it may cause erection problems. On the other hand, the entire cancer experience, including its effects on the reproductive system and its treatments, which may involve radiation therapy, surgery, or hormone therapy, might lead to issues.

The most prevalent non-skin cancer in men in the US is prostate cancer. According to the Centers for Disease Control and Prevention, about 13 out of every 100 American men are affected (CDC).

Psychological factors

It is common to experience anxiety and depression after receiving a cancer diagnosis and while undergoing treatment. Relationship tension can also be caused by anxiety.

Multiple physical changes brought on by prostate cancer might have an impact on a person’s sexual confidence. These may consist of:

  • Constipation issues and urine leaking
  • having trouble getting an erection
  • decreased generation of sperm
  • lower fertility
  • These problems may have an impact on sexual performance and desire.

An active course of treatment may not be necessary if the cancer is in its early stages and slow-growing. This strategy is referred to as cautious waiting. Although worry may persist and the individual may still have less interest in sex as a result, monitoring does not have adverse effects that lead to sex issues. Counseling could assist them in overcoming this.

Some people may be concerned that they have a sexually transmitted infection (STI), but prostate cancer is not a STI and cannot be transferred by sexual activity or any other method.

Prostate cancer affecting sex life

Even prior to starting treatment, having prostate cancer might have an impact on your sexual life. However, it could take some time for you to notice how it affects you.

Typically, prostate cancer doesn’t immediately affect how you sex (unless your prostate gets very large). However, receiving a cancer diagnosis, regardless of the type, can have psychological or emotional effects. And you’re less likely to be interested in having sex if your diagnosis makes you feel scared, apprehensive, or depressed. The term “poor libido” is sometimes used to describe this.

If you often engage in sexual activity with someone, they may experience stress or sadness as a result of your diagnosis, which could affect their libido as well.

And as you might expect, sex is less likely to occur frequently if neither you nor your spouse are particularly interested in having it. This suggests that those who receive a prostate cancer diagnosis may be less likely to engage in sexual activity. Additionally, initiating treatment for prostate cancer frequently results in new sexual difficulties.

Prostate cancer treatments affect your sex life?

Hormone therapy, surgery, and radiation therapy are the top prostate cancer treatments. Your sexual life may be impacted by any of these treatments. Because of this, it’s critical to comprehend the possibility of sexual side effects during prostate cancer therapy so that you and your healthcare team can make the best decisions possible.

Treatment for prostate cancer may have an impact on:

  • Libido (sex drive)
  • Erections
  • Ejaculation
  • sexual enjoyment
  • Testicle and penis size

Possible sexual side effects of prostate cancer and/or its treatment

Sexual adverse effects are conceivable with prostate cancer as well as the available therapies (surgery, radiation, and/or hormone therapy). The following list includes some of the most frequently mentioned side effects of prostate cancer on a person’s sexual function:

  • Erectile dysfunction: A man may occasionally struggle to achieve or sustain an erection following a prostatectomy (surgical to remove the prostate).
  • Loss of interest in sex: Managing a cancer diagnosis and receiving treatment can be stressful and draining, thus it is common for someone to momentarily lose interest in sex during this time. The desire for sexual activity can also be decreased by some medications, such as hormone therapy.
  • Ejaculatory issues: Men who have undergone therapy for prostate cancer may notice that their ejaculations are diminished or nonexistent. Compared to prior treatment, orgasm may also feel different.
  • Lack of self-assurance or low sexual self-esteem: Having trouble getting an erection, having urine leakage, and/or having less or no semen volume may all lead to feelings of sexual self-consciousness or performance anxiety.

Things a person can do for a healthy sex life after prostate cancer

One can overcome these challenges and regain a healthy sex life after cancer by being informed about the potential sexual health effects of prostate cancer and its treatment. Following prostate cancer therapy, a person can improve their sexual life in the following ways:

  • Penile rehabilitation: Improvements in erections within the first year following surgery may enhance general contentment and quality of life, while the effects of penile rehabilitation are still under question.
  • Erection aids: There are a number of erectile dysfunction treatments available, including prescription drugs, vacuum devices, and penile implants, which are mechanical devices inserted surgically into the penis to enable a man to get an erection whenever he wants.
  • Counseling or sex therapy: When it comes to sexual function, a person’s mental health is just as vital as their physical health. A person might think about consulting a psychologist or sex therapist for help through a significant life event, including receiving a cancer diagnosis and undergoing treatment.
  • Open communication: Honest, open communication with a sexual partner is essential for a patient who is in a relationship. This can reduce sexual performance anxiety for both partners, enable them to manage their expectations for their sexual connection, and build a foundation of trust for future intimacy.

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What’s the link between Cancer treatment and ED?

What’s the link between Cancer treatment and ED?

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Your sex life may change as a result of physical and psychological side effects of cancer treatment. These alterations are referred to as “sexual side effects” by doctors. They consist of modifications to your sex interest and your capacity for sexual action.

Physical, mental, or emotional adverse effects from sexual activity are possible. Your attitude, sense of wellbeing, energy level, and body image can all be impacted by cancer therapy. All of these factors can influence your sexual life.

Whether your cancer diagnosis and/or treatment may alter your sexual life is something you should discuss with your medical team. If at all possible, do this before beginning treatment. The optimal form of treatment for you can be impacted by it. Getting a second opinion might be wise if you are extremely concerned.

Sexual problem during cancer

Your sexual health may change as a result of having cancer or the therapy for it, either during or after treatment. These modifications could go or stay put. Everyone is unique.

Treatments that directly affect your genital organs are more likely to have physical side effects. Prostate, bladder, and testicular cancer treatments, for instance, are more likely than some other cancer treatments to have an impact on your capacity to physically engage in sexual activity. However, leukaemia treatment, for example, might also make you feel exhausted or ill, which can reduce your interest in sex. This is why discussing your unique diagnosis and what to expect with your medical team can be beneficial.

The following are examples of possible sexual side effects:

  • less sex-related interest
  • having trouble attaining or maintaining an erection long enough to engage in penetration. Other terms for this issue include “erectile dysfunction” and “ED.”
  • Orgasming before you’re ready is known as premature ejaculation.
  • urinating (peeing) while having an orgasm.
  • having a “dry” orgasm in which no sperm emerges. This can occur if semen exits the penis instead of flowing backward into the bladder.
  • suffering when having sex.

Inform your medical staff if you experience any of these issues before starting therapy. They might be able to assist or stop the difficulties from growing worse if they are aware of the issue. Additionally, during or after treatment, let your medical team know if you have any new issues or changes in your sexual health.

Treatments that can cause sexual problems

Surgery – The nerves that regulate erections can be harmed during procedures on the prostate, testicles, bladder, colon, and/or rectum. Consult your surgeon on “nerve-sparing” procedures. Additionally, surgery can result in “dry” ejaculation. You might find this upsetting or you might not.

Radiation treatment – ED may result after radiation therapy administered to the pelvis, which is the region around the hips. This may occur between six months and two years following the treatment. In two to three years, it might disappear or become better. What to do when you have ED should be discussed with your doctor.

Chemotherapy – Chemotherapy side effects can have an impact on your mood, sense of self, and sexual attraction. Weight gain or loss, nausea, vomiting, and diarrhoea are possible side effects. Additionally, you can stop having erections, but this normally returns with time. Any medication, including targeted therapy or immunotherapy, that is a part of your treatment plan should be discussed with your doctor for any potential sexual side effects.

Hormone treatment – Some prostate cancer treatments aim to reduce the amount of testosterone your body produces. Although it is done to treat the cancer, this may result in ED, reduced sex drive, and difficulties achieving an orgasm.

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How can Propecia result in Prostate cancer?

How can Propecia result in Prostate cancer?

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Propecia is a medical drug available to us under the generic name Finasteride which belongs to a class of medication called 5-alpha reductase inhibitors. This medicine is used alone or as a combination with to treat enlarged prostate in men by shrinking them. It is also used to treat hair loss or pattern baldness in men. 

Working mechanism

Propecia belongs to a class of medication called 5-alpha reductase inhibitors that generally works by blocking the action of 5-alpha reductase enzyme. When testosterone is converted into another hormone, it causes the prostate to grow or hair loss in males. The increase in testosterone in the body will decrease prostate size and increase hair growth in the scalp. Since less testosterone is being converted, serum levels of testosterone do increase in patients taking Propecia.

How to use Propecia?

Propceia is available to us in a form of pill that must be taken by mouth with or without food as per your doctor’s prescription. It is usually taken once a day daily. Swallow the tablet whole rather than chewing or crushing it in your mouth. The dosage and length of the treatment is based on your medical condition, response to the treatment and other medicine that you may be taking for the same or different reason. Your doctor may start you with a low dose which will increase gradually.

Take the medicine daily at the same time to get the most benefits from it. Do not increase your dose or take it more often than prescribed as this may also increase the risk of side effects without any improvement in your condition. Also in case of withdrawal from this medicine, it must be gradually decreased rather than immediate withdrawal. Discuss all the other medicines that you might be taking along with Propecia for the same or different reasons. Follow the medical prescription carefully and inform your doctor in case of any exception or confusion. 

How long does Propecia take to work? 

Propecia is a kind of medicine that does not work instinctively. You may feel a noticeable improvement in your symptoms or condition in the initial days of medication. However, Propecia may take around 6 months to deliver its maximum benefits. Also for hair loss problems, it may take 3-6 months to show improvement.

Side effects of Propecia

Common side effects observed while medicating with Finasteride are decreased sexual desire, decreased sexual ability, decrease in amount of semen release during sex or hair growth may occur. Inform your doctor if these conditions persist or get worse.

There are some serious side effects which must be informed to the doctor right away if observed such as a lump in the breast, nipple discharge, breast enlargement/pain, inability to urinate, pain in testicles, etc. There are also some severe allergic reactions involved with these medications which require immediate medical attention if observed such as rash, itching/swelling (especially of the face/tongue/throat), trouble breathing, severe dizziness, etc.

As per several studies, propecia is not expected to increase risk of high grade prostate cancer. It increases the testosterone level in the body which increases hair growth in the scalp and decreases the enlarged prostate size.

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