Browsed by
Category: Heart disease

Heart health may be impacted by the bacteria in your gut.

Heart health may be impacted by the bacteria in your gut.

Comments 0 Comment

Heart health may be impacted by some gut bacteria, particularly certain strep species that are typically found in the mouth and digestive tract.

Gut bacteria in particular, according to researchers, may be connected to the development of plaque, which can result in clogged arteries.

According to experts, the new research expands on other studies that suggest a connection between gut flora and cardiovascular health. A new study reveals that the mouth and gut may be the origin of several cardiac issues.

A key contributor to heart attacks are deposits of fat, cholesterol, and other chemicals called atherosclerotic plaques, also referred to as clogged arteries.

According to Swedish researchers, a higher prevalence of these plaques is linked to the presence of specific oral bacteria, mainly Streptococcus, in the gut.

The research, conducted by scientists at Uppsala and Lund University and reported in the journal Circulation, was based on an examination of the gut flora and cardiac imaging of 8,973 persons between the ages of 50 and 65 who had no history of heart disease.

“We found that oral bacteria, especially species from the Streptococcus genus, are associated with increased occurrence of atherosclerotic plaques in the small arteries of the heart when present in the gut flora,” said Dr Tove Fall, a study author and professor of molecular epidemiology at the department of medical sciences and the SciLifeLab at Uppsala University.

Information from the gut bacteria and heart health study

The development of plaque in the blood arteries of the heart was detected early by researchers using cutting-edge imaging technologies.

They coupled the details with genetic sequencing information on a variety of bacteria that live in the stomach (as well as the mouth and throat).

In addition to the link between Streptococcus anginosus and atherosclerotic plaque, researchers also noted that Streptococcus oralis appeared to be connected to plaque accumulation.

According to the study’s findings, levels of some Streptococcus species in the mouth and the gut were associated with fatty deposits in the arteries.

Dr. Marju Orho-Melander, a senior author of the study and a professor of genetic epidemiology at Lund University, said, “We have just begun to grasp how the human host and the bacterial community in the various compartments of the body affect one other.”

According to our study, people who carry streptococci in their stomach have changed cardiovascular health. We must now look into whether these bacteria have a significant role in the emergence of atherosclerosis, she added in a press release.

Plaque buildup is facilitated by two different bacteria species.

One of the most important links the researchers discovered after looking at cardiac imaging and gut flora was with two particular bacteria.

Streptococcus species and indicators of systemic inflammation in the blood have a close relationship. Researchers connected the bacteria with diseases of the oral cavity because they were the same species that were discovered in the mouth.

According to Mesilhy, “Streptococcus anginosus and Streptococcus oralis subsp. Oralis were the most prevalent in [this study group] patients with coronary atherosclerosis.”

Mesilhy continued, “Previous research in mice suggest that oral exposure to Streptococcus species induces plaque formation.

How do gut microbes affect heart health?

Dr. Kezia Joy, an advisor for the UK-based online healthcare company Welzo who was not involved in the study, said that “emerging evidence suggests that alterations in the composition and function of the gut microbiota, commonly referred to as dysbiosis, may contribute to various health conditions, including cardiovascular diseases.”

According to studies, specific gut bacteria can create metabolites such as trimethylamine N-oxide (TMAO), which has been linked to the onset and development of atherosclerosis. “TMAO has been linked to increased oxidative stress, atherosclerotic plaque development, and inflammation. Furthermore, the development of physiological systems including lipid metabolism, inflammation, and immunological responses all of which are important contributors to the development of cardiovascular diseases can be influenced by the gut microbiota.”

Dr. Bina Joe, chair of the physiology and pharmacology department at the University of Toledo in Ohio and founding director of the school’s Centre for Hypertension and Precision Medicine, stated that “the strength of this study is that it’s a large cohort [of participants], the researchers have done a very careful analysis of them at an early stage of cardiovascular disease, and the use of biomarkers” to identify particular gut bacteria that may contribute to plaque formation.

The significance of studying gut microbes

The Swedish study, according to Joe, who has previously led research into the connections between gut bacteria and high blood pressure, is a significant advancement in a field of study where the link between bacteria and cardiovascular illness is more hypothesized than established.

For instance, flossing is now recommended by dentists as a technique to reduce the buildup of mouth germs that may increase the risk of heart disease.

“We don’t know why, but it works,” said Joe.

Further investigation into the exact bacteria that affect cardiovascular disease and the execution of longitudinal studies that could demonstrate a causation rather than an association between gut flora and heart health are questions for future study, according to Joe.

Streptococcus bacteria, for instance, present in both the mouth and the gut, but it’s doubtful that just one strain is to blame for plaque formation because bacteria cannot thrive in both an anaerobic environment like the gut and an oxygen-rich one like the mouth.

Joe remarked, “It’s unclear whatever species of Streptococcus [the researchers] are referring to. In the end, a large community of bacteria may be at play rather than a specific strain.

Summary

A link between gut flora and coronary atherosclerotic plaques has been demonstrated by a recent study.

Researchers studied gut flora and cardiac imaging, and the results showed a strong connection between two different kinds of bacteria.

The study also demonstrated a connection between certain of the species linked to levels of the same species in the mouth and the accumulation of fatty deposits in heart arteries. These findings imply that microorganisms affect several biological systems.

REFERENCES:

For Heart disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_99

Food categories that could reduce cardiovascular risk.

Food categories that could reduce cardiovascular risk.

Comments 0 Comment

Researchers looked into how various meal groups affected cardiovascular health. They discovered a relationship between lower cardiovascular risk and diets high in fruits, vegetables, legumes, nuts, whole-fat dairy, and fish.

To determine how much each element contributes to risk reduction overall, more research is required. A significant risk factor for cardiovascular disease (CVD) is an unhealthy diet.

Higher intakes of processed meats, refined cereals, and sugar-sweetened beverages. These in particular, are known to raise the risk of cardiovascular disease.

Likewise, there is a correlation between lower CVD risk with diets like the Mediterranean, Healthy Eating Index (HEI), and the Dietary Approaches to Stop Hypertension (DASH) diet. All of these diets call for consuming more of:

  • Fruit
  • Vegetables
  • Legumes
  • Nuts
  • Fish

Recent research has revealed that several foods, such as whole-fat dairy. They were previously believed to raise the risk of CVD and may instead have beneficial or neutral benefits. Many of these fresh discoveries have not yet, however, been included in dietary recommendations.

Furthermore, it is unknown whether earlier findings hold true for other regions of the world because the majority of dietary studies have been carried out in North America, Europe, and East Asia.

Researchers have looked at nutrition and health data from 80 nations on five continents.

In all geographic areas, they discovered a relationship between diets high in fruit, vegetables, nuts, legumes, seafood, and whole-fat dairy with a reduced risk of CVD and mortality. The results were more compelling for lower-income nations.

‘PURE’ diet versus Mediterranean and DASH diets

First, the researchers looked at information from 166,762 people between the ages of 35 and 70 who lived in 21 low-, middle-, and high-income nations on five continents. The individuals were monitored for an average of 9.3 years.

Six food categories associated with decreased death rates were used by the researchers to establish a score for a healthy diet:

  • fruit
  • vegetables
  • legumes
  • nuts
  • fish
  • dairy

The diet score was given the name “PURE” diet score in honour of the research it was based on.

Overall, the researchers found that the average diet score was 2.95. Also, the nations with a higher per-capita gross national income had a higher prevalence of healthier diet ratings.

During the follow-up period, they also tallied a total of 8,201 significant CVD events and 10,076 fatalities.

In the end, people with diet scores of 5 or 6 had a considerably lower risk of developing cardiovascular problems than participants with diet scores of 0 or 1.

They had a total of:

  • a 30% decrease in the mortality rate
  • Reduced risk of stroke by 19%
  • 18% decreased CVD risk
  • Heart attack risk is reduced by 14%.

The PURE diet score was applied to data from five more studies, encompassing 96,955 participants in 70 different countries, and the researchers discovered comparable outcomes.

They also noted that compared to other popular diet scores, such as the HEI, Mediterranean, and DASH diet scores, the PURE diet score exhibited a marginally greater correlation with CVD or death.

However, compared to the Planetary diet score, the PURE diet score was noticeably more predictive of death and major CVD events.

In order to strike a balance between a nutritious diet and a sustainable food system, the Planetary diet was created. The emphasis on plant-based foods and weekly limits of 98 grammes of red meat, 203 grammes of chicken, and 196 grammes of fish make it the most restricted diet of those under study.

How to eat for a healthy heart?

The study’s authors suggest eating every day as follows based on the PURE diet score:

  • 5 portions of fruit and vegetables each day
  • 1/2 cup of legumes
  • an amount of nuts
  • 0.3 fish servings
  • 2 dairy servings
  • one-half dish of red meat
  • 0.3 portions of chicken

Additionally, they advised 2-3 weekly servings of fish and 3-4 weekly servings of beans.

How diet is good for your heart?

Dr. Debbie Fetter, an assistant professor at the University of California, Davis who teaches nutrition but was not involved in the study, discussed the potential cardiovascular health benefits of diets high in fruits, vegetables, nuts, legumes, seafood, and whole grains with us.

Foods derived from plants, such as fruits, vegetables, and whole grains, are nutrient-dense and contain phytochemicals, which are protective agents. According to Dr. Fetter, phytochemicals can minimize inflammation and oxidation, which helps protect against chronic diseases like CVD.

Dr. Mary Greene, a board-certified cardiologist at Manhattan Cardiology in New York City, who was also not engaged in the study, was another person we spoke with. She pointed out that reducing processed foods may also contribute to some of the diet’s advantages.

We are aware that consuming fewer processed foods foods tainted by human manufacturing, foods containing additives, chemicals, and preservatives to keep them shelf-stable can reduce inflammation in the body, which has a negative impact on the cardiovascular system in particular. Avoiding these foods will help to maintain cardiovascular health, according to Dr. Greene.

“The food groups identified by this study, when consumed in their most natural state, can help to preserve cardiovascular health,” she continued.

Separating apart whole foods from processed foods

We enquired about the study’s limitations from senior clinical dietitian Dana Hunnes, Ph.D., of the UCLA Medical Centre in Los Angeles who was not engaged in it. She pointed out that the study did not identify causal relationships; it just documented connections.

“The best we can do with this type of study is to say that these six foods are associated with lower risk for cardiovascular disease, but it doesn’t really look at how powerful each of those six foods is in potentially ‘causing’ cardiovascular disease,” Dr. Hunnes said.

This, she said, is crucial because it’s possible that the majority of health advantages came from eating more fruits, veggies, nuts, and legumes, and that those who ate these items also ate fish and dairy, which may have minor benefits.

The results, Dr. Greene continued, are open to interpretation. Although a pint of rich ice cream is technically a full-fat dairy product, she pointed out that it is also a highly processed and fattening item, so it is best to stay away from it.

The low-fat, sugar-free flavoured creamer, which is a highly processed item that contains chemicals linked to diabetes, obesity, and heart disease, would be a better substitute for a splash of heavy cream in your daily coffee. Making the distinction when discussing these various dietary groups is crucial, she continued.

No need to switch to a vegan diet

The study, according to Dr. Fetter, supports the idea that choosing nutrient-rich foods including fruits, vegetables, legumes, nuts, seafood, and dairy can lower CVD risk.

She continued, observing that the relatively restrictive Planetary Diet Score was less predictive of cardiovascular health and mortality than the PURE diet score.

“This finding supports varying your dietary pattern and suggests that if you do consume animal-source foods, you can do so in moderation rather than completely restrict or avoid them,” she said.

“You don’t necessarily need to go completely plant-based to lower your risk of heart disease, but rather moderate amounts of fish and dairy were found to be linked to a reduced risk of CVD in this analysis,” she said in her analysis.

REFERENCES:

For Heart disease treatments that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?therapy=11

Can you prevent heart attack with monthly Vitamin D dose?

Can you prevent heart attack with monthly Vitamin D dose?

Comments 0 Comment

A crucial fat-soluble vitamin for supporting the immune system and bone health is vitamin D. Australian researchers monitored a group of elderly individuals. This is to determine whether vitamin D supplements could lower the incidence of serious heart disease events.

For five years, the test group received a monthly vitamin D supplement from the researchers.

The participants who took vitamin D supplements did have a slight risk decrease for several major cardiovascular events, even though it was not as significant as the researchers had hoped.

According to a study that was recently published in the BMJ, an Australian research team conducted a clinical trial. This was to see if vitamin D may help prevent major heart disease events like heart attacks and strokes.

The older persons were tracked by the researchers between the ages of 60 and 84. Heart disease is thought to be more likely to strike people in this age bracket.

When comparing the control and test groups, the researchers found that vitamin D had no effect on strokes. However, they did discover that the rate of major cardiovascular events was 9% lower in the vitamin D supplement group.

What is Vitamin D?

In addition to supporting the immune system and other processes, vitamin D is crucial for strong bones. The human body responds to sun exposure by producing vitamin D. A person can increase their vitamin D intake by eating particular foods or taking supplements.

For strong bones and teeth, vitamin D is necessary. In addition, it performs a variety of other crucial functions in the body, including controlling immunological response and inflammation.

Despite its name, vitamin D is actually a hormone or prohormone rather than a vitamin.

Detailed research on vitamin D

The leading cause of death in the United States is cardiovascular disease (CVD). Although CVD can affect adults of any age, those 65 and beyond have the highest illness rates.

CVD can be dangerous and may be and the potential strain it may have on the healthcare system. Researchers have been exploring strategies to both treat and prevent the illness.

The authors of the study noted that earlier studies had limitations and did not demonstrate a link between vitamin D and lowering the risk of CVD. Because of the author’s observation, vitamin D has biological effects which suggest it could influence cardiovascular disease. Therefore, they conducted a more thorough investigation.

21,315 participants in the study ranged in age from 60 to 84. Participants who were already taking vitamin D supplements or had a history of diseases like sarcoidosis and hypercalcemia were excluded from the study.

A 60,000 IU vitamin D-3 pill was given to the test group once a month for five years. The control group consumed a sugar pill.

In order to understand the individuals’ socioeconomic level, way of life, and eating habits, the researchers gathered baseline data. They collected surveys, tested blood samples, and kept an eye out for adverse events throughout the trial. This is to ensure sure the participants were taking their supplements as prescribed.

The individuals also allowed researchers access to their medical records. So that they could gather data on mortality, prescribed drugs, and cardiovascular events.

Does vitamin D aid the heart?

A few previous observational studies have hinted at a potential link between reduced incidence of CVD and higher blood levels of vitamin D.

This new study suggests that vitamin D supplementation may have some advantages, even if clinical studies have not yet conclusively shown that it improves heart health.

When compared to the placebo group, the number of heart attack events among people taking vitamin D was 19% lower. Additionally, the vitamin D group had decreased rates of coronary revascularization, which might involve treatments like a heart bypass or a coronary artery bypass graft.

Although the rate of major cardiovascular events was 9% lower overall in the groups receiving vitamin D, the study’s results did not indicate a lower rate among minor cardiovascular events.

The scientists cautioned about the 9% decline, saying it’s likely that users of statins or other cardiovascular medications may have contributed to it.

“For total major cardiovascular events, there was some indication of a stronger effect in those who were using statins or other cardiovascular drugs at baseline,” the authors wrote.

Because of this, the authors state that additional research is necessary before they can state with certainty that vitamin D alone prevents CVD.

The authors conclude that their research “indicates that supplementation with vitamin D may reduce the incidence of major cardiovascular events, particularly myocardial infarction, and coronary revascularization.”

“Those who were taking statins or other cardiovascular medications at the outset may have noticed this beneficial impact more clearly. The authors write, “Subgroup studies in other major trials might assist to explain this issue.

Does vitamin D suffice to lower the risk of CVD?

We had a discussion about the study with Dr. Yu-Ming Ni, a cardiologist from MemorialCare Heart and Vascular Institute at Orange Coast Medical Centre in Fountain Valley, California. Dr. Ni did not believe that the study’s findings were yet significant enough to demonstrate that vitamin D supplementation can lower rates of CVD.

“After reading this study, it is tempting to draw the conclusion that there may be a trend towards a benefit for vitamin D supplementation for the prevention of cardiovascular disease, especially as it relates to the prevention of heart attacks myocardial infarction,” he stated.

According to Dr. Ni, the new study “did not demonstrate a significant benefit of Vitamin D supplementation, even if there was a small benefit” when compared to previous studies on vitamin D and CVD.

Dr. Ni stated that vitamin D is still an essential supplement for bone health even though she did not believe the study offered hope for using it to lower the incidence of CVD.

When we discussed the report with Dr. Dmitriy Nevelev, associate director of cardiology at Staten Island University Hospital in New York, he had a somewhat different perspective on it.

Dr. Nevelev added that although earlier sizable studies on vitamin D and CVD had not revealed a “significant effect,” “many of these studies had limitations such as suboptimal adherence with daily therapy, an insufficient dose of vitamin D, or an overall lower risk population.”

REFERENCES:

For Heart disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_99

People with blocked arteries may get stroke during exercise

People with blocked arteries may get stroke during exercise

Comments 0 Comment

Exercise may cause a stroke in patients with severely blocked arteries, according to research. The study, according to experts, is intriguing but they point out that it is based on a computer model.

They also point out that the majority of people who don’t have clogged arteries still benefit from exercise.

It turns out there is a purpose for the recommendations to visit a doctor before beginning new workout programs that are typically included with them.

In people with blocked or restricted carotid arteries, exercise may increase the risk of stroke. This is according to a recent study published in Physics of Fluids.

Even so, carotid stenosis, which is another name for this ailment, only affects about 3% of the general population.

According to the study, those who have moderate to severe artery blockage should exercise with caution. But the majority of people gain from regular exercise, which is advised for heart health.

The researchers also concluded that exercise is still helpful for preserving healthy blood flow in those who are in good health. Also, in those whose arteries are only mildly clogged.

Exercise increases heart rate and can increase stroke risk.

Researchers examined the relationship between exercise-induced heart rates and resting heart rates for the study.

They stimulated blood flow in carotid arteries in the following stages of stenosis using a computational model:

  • without obstruction
  • a little 30% obstruction
  • having a medium 50% obstruction

According to the research, exercise increased stress in the arteries’ obstructed region in persons with mild blockages. This increased the risk of stenosis rupture.

A stroke that is ischemic could result from this blockage once it enters the brain. But exercise helped the stimulated carotid in people with no stenosis or modest blockage.

Dr. Somnath Roy, Ph.D., an associate professor of mechanical engineering at the Indian Institute of Technology Kharagpur, India, is the study’s lead author. “Intense exercise shows adverse effects on patients with moderate or higher stenosis levels,” he stated in a statement.

It significantly raises the shear stress at the stenosis zone, raising the risk of the stenosis rupturing. The blood from the ruptured plaque may then reach the brain’s blood supply and result in an ischemic stroke.

The study team also suggested that a high heart rate would make it more likely for another stenosis to emerge.

How dangerous are blocked carotid arteries?

The brain and the tissues of the face are nourished by carotid arteries that are situated on either side of the neck.

A plaque that forms inside the inner carotid walls as a result of the accumulation of fat, cholesterol, and other particles can constrict the artery.

This narrowing, known as stenosis, is risky because it restricts blood flow and oxygen to the brain and may result in a stroke. Detecting it at an early stage of development might also be challenging.

In a healthy individual, the increased heart rate that comes with exercise stabilizes the drag force acting on the artery wall. This lowers the likelihood of stenosis.

The authors of the study noted that for those already dealing with stenosis, the outcome might be different.

Exercise truly increases the risk of stroke?

According to Dr. Adi Iyer, a neurosurgeon and interventional neuroradiologist at Providence Saint John’s Health Centre in California, medical professionals have long recognized that having a greater resting heart rate increases a person’s chance of having a stroke.

Iyer argued that the study’s suggested link between exercise-induced elevated heart rate and stroke in individuals with moderate or severe carotid stenosis is novel “and still remains unclear.”

This study used computer modeling, which is not a perfect representation of actual human physiology. For instance, the circle of Willis, a system of collateral circulation in the human brain, joins the arteries that run from the left to right and front to back of the brain.

The stroke risk for actual patients will eventually be determined by the patency of these collaterals and a host of other variables, according to neurosurgeon Dr. Adi Iyer.

Iyer stated that “temporary weakness or numbness on one side of the face or body, or even temporary vision loss from one eye. This can be the most common signs of a narrowed carotid artery.”

“Patients should seek physicians’ recommendations on lifestyle modifications, including exercise regimens when there is a moderate or severe blockage in the carotid artery,” Iyer advised.

Patients should seek surgical consultations because there are now several extremely effective. Minimally invasive procedures are available to them for unblocking their obstructed carotid arteries.

Exercise with clogged arteries should be avoided.

Exercise is frequently advised to avoid cardiovascular disease, according to study author Dr. Somnath Roy, PhD, associate professor in the Department of Mechanical Engineering at the Indian Institute of Technology Kharagpur in India.

According to existing research, exercise-induced faster pulse rate reduces pressure on the arterial wall and delays the development of stenotic occlusion. Through our numerical projections, “we have seen similar characteristics for healthy arteries.”

The oscillatory shear index (WSS) showed increased oscillation levels for artery models with advanced stenosis or constriction, according to Roy.

The likelihood of additional stenosis advancement and extremely high shear stress may increase with higher levels of these oscillations.

If levels are very high, stenotic plaque may begin to fracture and form blood clots or emboli (a foreign body blocking an artery). This may travel to the brain, obstruct weaker blood arteries, and trigger a stroke.

“By using computer simulations based on physiologically relevant data, the authors have described the impact of higher heart rates on hemodynamics in healthy and stenosed carotid arteries. According to Dr. Joseph C. Maroon, clinical professor, vice chairman, and Heindl scholar in neuroscience at the University of Pittsburgh’s Department of Neurosurgery, “It is not clinical research.

“I find the observations interesting. They are arguing that stenotic lesions that are 50% or more likely to be obstructive of blood flow may be more likely to cause a heart attack or stroke.

According to Roy, the research team intends to examine the consequences of high heart rates at additional arterial models. This includes coronary artery, aorta, and others, in subsequent studies.

How stenosis is impacted by exercise?

As seen in the study, patients with moderate or more severe stenosis may experience negative effects from vigorous activity.

“Although flow volume is not reduced until an artery has 90% or greater stenosis. The suggestion is that the shear and flow disturbances caused by a 50% narrowing of an artery can disrupt the lining of the artery (the intima). Also, precipitate clotting and obstruction despite a normal flow,” Maroon said.

This is a crucial finding that requires confirmation and more research. It’s crucial to take into account any potential variations between a computer model and a human heart rate while learning more about the connection between exercise and stenosis.

“Substantial variability in human heart rate (as compared to a computer model) can occur during different-impact workouts, sports, and isometric exercises,” said Dr. Sandra Narayanan, a board-certified vascular neurologist, and neuro-interventional surgeon at the Pacific Stroke & Neurovascular Centre at the Pacific Neuroscience Institute in Santa Monica, California.

The length of sustained heart rate elevation and its detrimental effects on cerebrovascular risk in individuals with moderate-to-severe carotid artery stenosis are related. Although further research is required to fully understand this relationship.

Additionally, Narayanan said it would be useful to determine whether a particular activity is more likely to increase lifestyle risk. Also, if the risk is more closely linked to tachycardia and is independent of cause.

Conclusion

In patients with severely clogged carotid arteries, an elevated heart rate can result in a stroke, claims a recent study.

However, carotid stenosis is not very common in the general populace. Exercise keeps the blood flowing normally in patients with no or little obstruction.

For the majority of people, regular exercise continues to provide some of the best protection against heart disease. The relationship between exercise-induced heart rate and stenosis has to be further studied.

For individuals with moderate or more severe stenosis levels, experts advise walking, yoga, and balance exercises.

REFERENCES:

For Stroke medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_99

Avoid hypertension and heart disease with Japanese plump.

Avoid hypertension and heart disease with Japanese plump.

Comments 0 Comment

Globally, almost 1.3 million people suffer from high blood pressure. Additionally, the top global risk factor for death is hypertension. One is greatly at risk for developing various forms of heart disease if they have high blood pressure.

Juice concentrate is made from the Japanese plum, according to Temple University researchers. It may aid persons with hypertension who are at risk for cardiovascular disease.

The juice concentrate was also discovered by scientists to help prevent the development of hypertension.

High blood pressure, sometimes referred to as hypertension medically, affects about 1.3 million people worldwide. This makes it the leading cause of mortality.

According to research, having high blood pressure increases the chance of other cardiovascular conditions such as atrial fibrillation, heart failure, stroke, and coronary heart disease.

Currently, Temple University researchers think that the Japanese plum juice concentrate can help lower cardiovascular disease risk in persons with hypertension and may even help prevent high blood pressure. A mouse model was used for the investigation.

Is it possible for Japanese plum to lower blood pressure?

It is customary in Japan to use the word “ume” to refer to the Japanese plum, or Prunus mume, also known as the Japanese apricot.

For use in wine or juice beverages, it is occasionally transformed into an infused juice concentrate. It is known as bainiku-ekisu.

This study’s senior author, Dr. Satoru Eguchi, is a professor in the Cardiovascular Research Centre at the Sol Sherry Thrombosis Research Centre and Centre for Metabolic Disease Research at the Lewis Katz School of Medicine at Temple University. He said the study was motivated by the need for treatments other than prescription medications for hypertension.

Even while they normalise blood pressure, he told us, “current treatments are insufficient to normalise the risk of cardiovascular disease death and incidences like myocardial infarction or stroke.” “Compared to subjects with normal blood pressure, hypertension patients have a higher risk for cardiovascular disease regardless of treatment or drug-induced blood pressure normalisation.”

Researchers claim that prior studies in blood vessel smooth muscle cells shown that bainiku-ekisu helped prevent angiotensin II-induced signals that promote proliferation. Circulatory hormone angiotensin II is recognised to contribute to the emergence of hypertension.

“Angiotensin II is a major hormone (regulating) blood pressure and contributes to the development of hypertension in humans,” stated Dr. Eguchi. In cultured vascular cells, our earlier study showed that it reduced angiotensin II signaling and function. All other fruit extracts failed to change the effects of angiogenic factors in these cells. Our in vitro results, however, were somewhat limited. Thus, we proposed the hypothesis that it might lower blood pressure. Also, the related vascular issues are caused by hypertension in vivo.

Preventing the development of cardiovascular disease

Dr. Eguchi and his team tested their hypotheses on the ume juice concentrate, bainiku-ekisu, using a mouse model for this study.

Angiotensin II was infused into mice to raise their blood pressure. The mice were then given water that either contained bainiku-ekisu or normal water.

Analysis revealed that mice who drank the water with bainiku-ekisu did not develop hypertension.

The Dainik-kiss additionally assisted in shielding their vasculature from the damaging effects of angiotensin II. For instance, mice given the juice concentrate only experienced slight aortic hypertrophy. Whereas mice given normal water experienced severe aortic hypertrophy.

The researchers also discovered that bainiku-ekisu assisted in reducing immune cell levels, which would typically lead to an inflammatory process connected to hypertension.

Additionally, scientists found that bainiku-ekisu prevented the cellular switch from aerobic metabolism to glycolysis which is typically seen in hypertension. This aids in preventing the body from suffering from oxidative stress, which can lead to inflammation, vascular stiffness, and even the emergence of more serious cardiovascular disease.

According to Dr. Eguchi, “Our animal studies indicate that bainiku-ekisu may lower blood pressure in patients with hypertension.” “It is okay to mix with standard treatment. Reducing the amount of medication required to maintain normal blood pressure may also be helpful.

Additionally, he continued, “Taking bainiku-ekisu may help you avoid complications related to hypertension, like heart attack and stroke.”

Previous studies on the health advantages of ume

The Japanese plum is grown on a tree that, like cherry trees, blooms with plum blossoms in the spring, ushering in festive occasions in Japan.

In warm to subtropical climates, Japanese plum trees thrive. The Japanese plum has been grown for thousands of years in China and Japan, but it has also spread to other regions of the world, including sections of the United States.

The Japanese plum has a taste that is more acidic and tart even though it resembles Western plums or apricots in appearance and scent.

The Japanese plum is frequently used to make umeboshi, which is a highly salted and pickled plum that is used as a condiment in conventional Japanese cuisine, in addition to being processed into the infused juice concentrate known as bainiku-ekisu.

Japanese plum has previously been investigated for its potential health advantages. According to earlier studies, ume may aid those who experience the symptoms of gastroesophageal reflux disease (GERD) with their digestive problems.

Other research have revealed that ume contains anti-inflammatory and antioxidant effects and may help prevent obesity and allergy disease.

Additionally, a 2017 study discovered that persons with grade I hypertension who consumed ume extract daily saw an improvement in their diastolic blood pressure.

Study restrictions and conclusions

In addition, we discussed the latest findings with Dr. Rigved Tadwalkar, a board-certified cardiologist at Providence Saint John’s Health Centre in Santa Monica, California.

Although it was conducted on mice, he said, “what’s interesting is that bainiku-ekisu was able to attenuate hypertension and protect against vascular remodelling, which is really quite positive.”

Dr. Tadwalkar did advise caution, however, because there is still much to learn about ume and bainiku-ekisu as potential remedies.

“This is somewhat novel, and mouse models don’t always reflect the complex pathophysiology of human cardiovascular disease,” he said. Therefore, it is evident that human testing would be necessary to establish the effectiveness, safety, and dosage for controlling this.

Dr. Tadwalkar continued, “It does give a potential avenue for these alternative medicines in the therapy of cardiovascular disease. So altogether, it’s encouraging, but obviously, I approach the subject with a little bit of scepticism.”

Dr. Tadwalkar concurred, saying it’s critical to look into alternative treatments for cardiovascular illnesses.

“Today’s patient is looking for a range of options and they want to have a specific treatment plan that’s tailored to their needs and circumstances,” he added. “This offers a slightly more individualized approach. And it can include all of the popular holistic treatments, including dietary adjustments, lifestyle changes, and all-natural cures combined.

“I think it allows patients to feel more empowered because they can take a little bit more of an active role in their own care,” Dr. Tadwalkar continued. According to my observations, patients are frequently much more likely to be interested in conventional medication when they may adopt a complementary strategy that encourages the use of alternative medicines.

REFERENCES:

For Heart disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_99

Cardiovascular benefits in elderly from antidiabetic drugs.

Cardiovascular benefits in elderly from antidiabetic drugs.

Comments 0 Comment

Researchers found that some types of diabetes medications can lower the risk of heart illnesses when coupled with other diabetic medications in a trial including older military veterans.

According to experts, heart health problems are widespread in diabetics, thus a larger segment of the population may benefit from the research. Drugs for GLP1, DPP4, and SGLT2 were used in the trial.

According to a study published today in the Annals of Internal Medicine, some diabetic drugs may reduce the risk of cardiovascular events when combined with other diabetes treatments.

Researchers compared conventional diabetes treatment plans to three key classes of diabetes medications: GLP1, DPP4, and SGLT2.

Recent clinical trials for novel diabetes medicines, the researchers noted:

  • tested the medications only against a placebo, not in competition with one another
  • only tested on individuals with heart disease when examining the cardiovascular benefits

The best pharmaceutical class for lowering the risk of cardiovascular disease, even in those without a history of the condition, was something the researchers sought to determine.

They claimed that when compared to DPP4 treatments, GLP1 therapies lowered the risk of adverse cardiovascular events and hospitalisations for heart failure.

Compared to DPP4 medications, SGLT2 therapies did not lower the number of hospitalisations for heart failure or cardiovascular events.

Information about the diabetic drug study

Between 2001 and 2016, the researchers examined the medical records of approximately 100,000 veterans who had been prescribed diabetes drugs including metformin, insulin, or sulfonylurea.

Then, one of the three more recent drugs—GLP1, DPP4, or SGLT2—was introduced. Following up was done until 2019.

Agonists of the GLP1 receptor included:

  • Exenatide
  • Liraglutide
  • Semaglutide

Inhibitors of SGLT2 included:

  • Empagliflozin
  • Dapagliflozin
  • Canagliflozin

Among the DPP4 inhibitors were:

  • Alogliptin
  • Linagliptin
  • Saxagliptin
  • Sitagliptin

Participants’ median ages ranged from 67 to 8.5 years, and their median time with diabetes was 8.5 years.

The results revealed:

When compared to DPP4 inhibitors, GLP1 reception agonists have a 20% lower incidence of significant adverse cardiovascular events and heart failure hospitalisations in persons with type 2 diabetes who have never had a heart condition. The risk reduction amounts to around three fewer heart failure episodes, strokes, or fatalities per 1,000 patients using the drug for a year.

When compared to DPP4 inhibitors, SGLT2 inhibitors did not lower hospitalisations for heart failure and cardiovascular events.

Dr. Kathleen Dungan, an endocrinologist at The Ohio State University Wexner Medical Centre, said that therapy should focus on effectiveness in reaching and maintaining treatment objectives for glucose and weight management.

As a result, she said, “some GLP1-based therapies have greater potential to help patients achieve these goals than SGLT2i or DPP-4 inhibitors.” The complexity and method of administration, patient desire, other co-occurring illnesses, side effects, and cost are all person-centered aspects that may be more significant.

Dungan stated that “some limitations [of this study] prevent our ability to directly apply the findings to usual care.” These include a brief follow-up period, a lack of demographic diversity, missing or incomplete data, and nonrandom prescribing patterns, any of which could affect the study findings.

He told us, “This study provides important information on using two classes of diabetes medications, especially for people without known cardiovascular disease.”

The significance of the diabetic medication research

People with diabetes have a younger average age of onset and a twofold increased risk of heart disease. According to the Centres for Disease Control and Prevention, having diabetes increases your risk of developing heart disease.

Additionally, elevated blood pressure, “bad” cholesterol, and triglyceride levels are more prevalent among diabetics. These ailments can make you more likely to experience a cardiovascular incident.

Dr. Sanjay Bhojraj, an interventional cardiologist at Providence Mission Hospital in California, remarked, “This study is a superb example of the new convergence of therapeutics for diabetes and cardiovascular diseases.”

“In the past, the cardiology community has mainly refrained from optimizing diabetic drugs either out of worry over medication-related problems or out of fear of alienating other treating physicians. Primary prevention studies like this one are an appeal to cardiologists to finally enter the fray and treat diabetes like we treat cholesterol or deal with quitting smoking.”

According to Bhojraj, “Now we have real-world data, in a [veterans] population, suggesting a significant decrease in major adverse cardiovascular events using GLP-1 receptor antagonists in patients who have diabetes without prior [cardiovascular disease],” she said. This could help the doctor decide which class of diabetic medication to add to standard-of-care treatment regimens to reduce cardiovascular risk.

It’s interesting to note that both the GLP-1 and SGLT-2 medication classes had positive treatment outcomes in the whole group of individuals undergoing primary and secondary prevention.

The bottom line, the cardiology community needs to take action and incorporate glucose optimization into our treatment strategies, according to Bhojraj, “if we truly want to protect our patients from serious adverse cardiovascular events.”

Treating coexisting conditions common with diabetes

According to a 2019 study, nearly 75% of patients had at least one other chronic health condition when they received a type 2 diabetes diagnosis. 44% of people have two or more conditions.

Diabetes and a number of other common comorbid illnesses include:

  • obesity
  • dyslipidemia
  • blood pressure is high.
  • heart condition
  • renal illness
  • mental health conditions
  • sleep problems
  • cancer

According to Dr. Minisha Sood, an endocrinologist at Lenox Hill Hospital in New York, “Generally speaking, a GLP1 RA is preferred over an SGLT-2 for the weight benefit in patients with diabetes and obesity – two conditions which overlap more often than not.”

But she added, “This study also reveals another advantage of selecting a GLP1 over an SGLT-2 in patients without cardiovascular disease.”

These medications can help with other comorbid conditions as well, experts point out.

Dr. Rigved Tadwalkar, a cardiologist at Providence Saint John’s Health Centre in California, said, “This research is encouraging and supports a growing body of evidence that these medications have multiple beneficial effects.”

“GLP-1 receptor agonists are currently being used to treat obesity off-label, according to the literature. He informed us that SGLT2 inhibitors are also licensed to treat chronic renal disease and heart failure.”

REFERENCES:

For Alzheimer’s disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?therapy=11

long time beta-blockers use doesn’t enhance heart health.

long time beta-blockers use doesn’t enhance heart health.

Comments 0 Comment

Following a heart attack, beta-blockers are frequently prescribed to patients to treat high blood pressure and heart conditions.

According to a recent study, taking drugs over the long term after a heart attack doesn’t seem to benefit cardiovascular health.

The observational study, according to experts, offers useful data, but they also point out that beta-blockers continue to be helpful for a large number of people.

Research in the journal Heart found no evidence that long-term beta-blocker use improved cardiovascular health or decreased the risk of further heart attacks.

Researchers looked at the medical records of persons who had a heart attack between 2005 and 2016 and required hospital treatment using the Swedish national registry for coronary heart disease.

Records from 43,618 persons, with an average age of 64, were included in the study. There were about 1 in 4 women. None of them had left ventricular systolic dysfunction or cardiac failure.

One year after being hospitalized for a heart attack, of the participants, 34,253 (78%) were using beta-blockers, whereas 9,365 (22%) were not.

For an average of 4.5 years following their hospitalisation, the researchers followed up with the participants.

Researchers evaluated the two groups in terms of:

  • Death rates from all causes
  • Additional heart attacks
  • Getting re-vascularized, a procedure to bring back blood flow to certain areas of the heart
  • Heart attack

2,028 (22%) and 6,475 (19%) of the beta-blocker users had one of these occurrences during the observation period.

There was no noticeable difference in the rates between the two groups, according to the researchers, who took demographic factors and pertinent co-morbid disorders into account.

According to real-time data, the use of long-term beta-blockers after a heart attack in persons without heart failure or left ventricular systolic dysfunction was not linked to better cardiovascular outcomes.

Physician response to beta-blocker research

The interventional cardiologist at MemorialCare Heart & Vascular Institute at Orange Coast Medical Centre in California, Dr. Hoang Nguyen, recommended beta blockers for patients with left ventricular dysfunction since they had a demonstrable mortality benefit.

According to him, beta blockers are a lifetime in this patient population. “Beta blockers are necessary for patients with a history of coronary artery disease who are not candidates for bypass surgery or stents to lower angina symptoms and hospitalizations for this symptom. I might try to wean them off of beta blockers, especially if they have serious adverse effects if they have undergone revascularization (either with stents or bypass surgery) or have normally left ventricle function.“

This study has prompted some doctors to reconsider their methods, but not all of them are presently prepared to do so.

According to Dr. Devin Kehl, a non-invasive cardiologist at Providence Saint John’s Health Centre in California, “this study suggests that a long-term continuation of beta-blockers following myocardial infarction may not be of significant benefit in patients without any of those factors and with normal cardiac function.” However, because it was an observational study, the results might have been impacted by unrecognized confounders.

To be more clear about whether beta-blockers should be continued or stopped after one year following myocardial infarction, randomized trials are required, according to Kehl, who spoke to us. “Caution is needed in interpreting the results of this type of analysis and applying this clinical practice,” Kehl said.

In conclusion, it is still necessary for a patient’s cardiologist to exercise careful clinical judgement when deciding how long beta-blocker therapy should be administered after myocardial infarction.

Beta-blockers

Beta-blockers are used to treat high blood pressure and heart conditions.

They accomplish this by preventing the negative effects that stress hormones have on the heart and can lower heart rate. They are also beneficial for migraines.

Beta-blockers are typically regarded as secure and efficient. However, there are some adverse effects, such as:

  • Fatigue
  • easily running out of breath
  • Unsteadiness or faintness
  • Depression

Nguyen notes that side effects of the drugs include memory loss and impaired sexual function.

“Perhaps we should try to wean patients off beta blockers if a beta blocker is not needed after one year, especially if the patient’s heart function is normal,” Nguyen suggested.

Some people might not be able to take them or might quit taking them because of the negative effects.

The use of beta-blockers

After the first year of treatment, Miller typically stops prescribing beta-blockers to heart attack survivors with intact cardiac function.

They are only kept on the drug if there is another condition, like hypertension, that calls for it.

Those with heart failure, irregular cardiac rhythm, hypertension, and recurring palpitations that happen without a known trigger (like caffeine), are candidates who can benefit from beta-blockers.

“The patient should always discuss with their physician whether or not a beta-blocker is a suitable treatment and/or should be discontinued,” he said.

Reduce the dosage gradually rather than stopping the drug all at once if a patient decides to stop taking it.

Considering the future

Medication observation studies examine participants’ responses to a drug or treatment without changing their circumstances.

Observational studies are not regarded by medical practitioners as being as reliable as randomised, controlled trials. However, when prescribing medications, they provide important information for doctors and other medical professionals.

“Beta-blockers have long been and will continue to remain a cornerstone medical therapy following a myocardial infarction as they have been clearly demonstrated to reduce the risk of recurrent events and death,” said Kehl. However, clinical trials have not examined the benefit of beta-blockers in patients with normal cardiac function beyond three years after a myocardial infarction, and their benefit is strongest in the early period post-myocardial infarction, according to the study.

Additionally, patients with and without cardiac dysfunction were included in a mixed cohort in clinical trials looking at the benefits of beta-blockers, the author continued. “It is unclear if long-term use of beta-blockers after myocardial infarction benefits people with normal cardiac function. Due to a lack of data from clinical research, the American College of Cardiology guidelines do not directly address the issue. Currently, a long-term continuation of beta-blockers depends on carefully examining the patient’s cardiac history and determining whether there are any other distinct indications for using beta-blockers, such as arrhythmias, angina, cardiac dysfunction, heart failure, or hypertension.”

REFERENCES:

For Heart disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_99

Talk therapy for depression may lower heart disease risk.

Talk therapy for depression may lower heart disease risk.

Comments 0 Comment

The benefits of talk therapy may go beyond the treatment of mental disease, however, they are crucial in the management of depression. Researchers are still trying to figure out how depression and cardiovascular disease are related.

According to a study, those with depression who had relief from their symptoms following psychotherapy also had a lower risk of developing cardiovascular disease.

One of the most prevalent mental illnesses, depression can have negative effects on other aspects of health. Researchers are still trying to figure out how depression treatment affects the outcomes of cardiovascular disease and how the two are related to one another.

In a recent study, published in the European Heart Journal, it was investigated how the use of psychotherapies to treat depression affected the progression of cardiovascular disease.

The researchers discovered that people who experienced reduced depression following psychotherapy also experienced a decreased risk for developing new cardiovascular illnesses, coronary heart disease, stroke, and all-cause death.

Talk Therapy

Mental health experts interact with their patients through talk therapy, sometimes called psychotherapy. Talk therapy is meant to aid in the identification of problems that are generating emotional pain.

Everybody experiences emotional ups and downs. Some people’s issues are transient, therefore no therapy is required. However, for some people, attending talk therapy can significantly improve their mood and even alter their attitude on life.

It could be appropriate to think about talk therapy if you’re dealing with a medical condition, losing a loved one, or experiencing anxiety, stress, or depression.

For some people, talk therapy can provide a secure setting to talk about feelings and emotions brought on by everyday stressors, a medical condition, interpersonal conflict, bereavement, or the effects of a particular event.

Other people may experience the same problems in a complex way, leading to a diagnosis of a mental illness like depression or anxiety.

Once the problems are located, a therapist will work with you to comprehend how these pressures affect your life and will assist you come up with solutions and techniques to lessen the severity of the symptoms.

A talk therapy session typically lasts for 50 minutes to an hour. The frequency and duration of therapy sessions depend on the severity of your symptoms and your treatment plan.

You might anticipate going to counselling once a week at first. Attending weekly appointments provides you the chance to get to know your therapist and become accustomed to the process, even though it may feel like a big commitment.

As you learn coping mechanisms and start to exhibit signs of progress, the number of meetings may increase to twice a month.

Talk therapy is used to treat depression.

A frequent mental ailment that affects people all around the world is depression. It can be crippling and challenging to control. Depression and other health issues can have complicated relationships.

For instance, those who have certain chronic conditions may be more susceptible to depression. People with depression may also be more susceptible to other health issues like pain and type 2 diabetes.

Individuals’ mental and physical health depend on receiving prompt treatment for depression.

One often-used element of depression treatment is psychotherapy. Talk therapy is a frequent abbreviation for psychotherapy. There are various forms of psychotherapy, but they can all concentrate on addressing issues, spotting negative thought patterns, and controlling actions and emotions.

Talk therapy is used to treat depression, according to Dr. Sarah-Nicole Bostan, a clinical health psychologist and director of behaviour change strategy at Signos who was not involved in the study.

Psychotherapy is frequently suggested as a first-line treatment for depression because of its well-known efficacy and minimal to no side effects, except for brief discomfort during therapy. One of the most successful evidence-based forms of treatment for depression is cognitive behavior therapy (CBT), which includes behavioral activation. In CBT, patients learn more constructive ways to view themselves as well as how to put new behaviors and routines into practice to help them feel better.

“Effectiveness of therapy can be measured throughout treatment through validated assessments, but at a bare minimum should be assessed at the beginning and end of a course of treatment,” she said. The indirect effects of psychotherapy on other aspects of health are still a subject of research.

Psychotherapy reduces the risk of CVD

Heart and blood vessel issues fall under the broad area of cardiovascular disease (CVD). Heart attack, stroke, and heart failure are a few examples of cardiovascular ailments.

This retrospective cohort study’s researchers sought to comprehend the connection between the risk for cardiovascular disease and the efficacy of treating depression.

In their investigation, researchers used 636,955 participants. Each participant had finished a term of treatment and met certain threshold requirements for depression. Additionally, none of the participants in the Improving Access to Psychological Therapy programme had cardiovascular illness prior to utilising it.

Researchers checked in on individuals on average three years later to see how often cardiovascular events and all-cause deaths occurred.

Researchers discovered that the greatest benefit was experienced by those whose depression improved after psychotherapy. According to what they discovered, “those whose depression symptoms improved after therapy were 12% less likely to experience a cardiovascular event than those who did not.”

They also discovered a link between reduced risk of coronary artery disease, stroke, and all-cause mortality and improved depression following medication. People under the age of 60 had a larger reduced risk of cardiovascular disease than people beyond the age of 60.

Study restrictions

This study contributes to our understanding of the effects of psychotherapy on other aspects of health. To have a deeper grasp in this area, more research is required.

There were some important restrictions on the study. First, participant self-reporting is used in the assessments of improved depression, which has several drawbacks. Examining every item that might have helped with the improvement of depressed symptoms is also difficult.

Additionally, the study is unable to demonstrate that treating depression lowers the chance of developing cardiovascular disease. It’s likely that individuals made further lifestyle adjustments that decreased risk.

Researchers are aware that reverse causality is a possibility, and the findings of the study cannot be applied to those who do not seek treatment for depression. The study had a short follow-up period as well, so future research may use longer time periods.

Finally, data on a number of possible confounders, such as participant social support, alcohol consumption, or tobacco use, were lacking. These unaccounted-for variables might have affected the effectiveness of depression treatment and cardiovascular risk.

Next steps in research

Overall, the research shows that psychotherapy has a big impact on other health outcomes.

Dr. Sarah-Nicole Bostan said, “This research confirms what we’ve known for quite some time, which is that even a small number of sessions lasting anywhere between 30 minutes and an hour over a few short months can not only significantly ameliorate depression symptoms, but can also set someone on a healthier trajectory for years to come by providing patients with the tools to address their future stressors.”

More investigation is required in this field, but the study shows the value of psychological therapy, according to Celine El Baou.

“This study is a preliminary step towards understanding this link. To establish causation or comprehend specific behavioral or biological factors, more study is required. It does, however, highlight how crucial it is to ensure that psychological therapies are widely available, she added.

REFERENCES:

For Heart disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_99

Higher risk of heart failure: Urban vs Rural area.

Higher risk of heart failure: Urban vs Rural area.

Comments 0 Comment

According to an observational study, American people who live in rural locations are 19% more likely overall to get heart failure than those who reside in metropolitan areas.

American black men who live in rural areas are 34% more likely than their urban counterparts to experience heart failure. Compared to Black women in rural regions, Black women in urban areas had an 18% higher risk.

Also, compared to white women living in urban settings, white women in rural regions had a 22% higher risk of heart failure.

According to the U.S. Department of Agriculture, approximately 46 million Americans, or 14% of the population, resided in rural regions in 2020.

In the 1980s, the number of deaths per 100,000 people in rural and urban areas was roughly similar, but by 2016, there were 135 more deaths per 100,000 people in rural areas than in urban ones, according to a 2019 study.

According to the US Centres for Disease Control and Prevention, people who live in rural areas have a higher risk of dying from heart disease, cancer, accidental injury, chronic lower respiratory disease, and stroke than people who live in urban areas.

As per a sizable observational study conducted by scientists at the National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health, and the Vanderbilt University Medical Centre in Tennessee, Americans who live in rural areas are 19% more likely overall to develop heart failure than those who live in urban areas.

Researchers acknowledged that this study is the first to examine the relationship between rural American life and heart failure cases that are newly diagnosed.

Study of heart failure in rural vs. urban areas

More than 2,700 persons in 12 states (Alabama, Arkansas, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, Tennessee, Virginia, and West Virginia) provided data that was collected over a 13-year period.

The information was obtained from The Southern Community Cohort Study, a National Cancer Institute-funded long-term health study of persons in the Southeast of the United States.

“At the end of the study period, the researchers found that living in rural America was associated with an increased risk of heart failure among both women and Black men, even after adjustment for other cardiovascular risk factors and socioeconomic status,” a news release for the study stated.

The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), provided the majority of the funding for the study. The research results, which were developed in association with Nashville, Tennessee’s Vanderbilt University Medical Centre, were released in JAMA Cardiology.

Conduction of Rural heart disease study

The Southern Community Cohort Study (SCCS) included 27,115 persons who were the subject of the study.

Participants from Alabama, Arkansas, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, Tennessee, Virginia, and West Virginia were among the first to be enrolled in the study by its researchers, which got underway in 2002.

Approximately 86% of those people were chosen from community health centers that offer medical care to underserved groups.

A little over 20% of the SCCS participants who were chosen for the study were residents of rural areas. This study only included participants who identified as Black or non-Hispanic White because, as the researchers explain in their publication, there were insufficient numbers of participants from other racial and ethnic groups.

Approximately 69% of the chosen individuals were Black. Participants’ ages ranged from 24 to 54. Only those participants were chosen for the trial who did not initially report having heart failure.

According to research, participants from rural areas had somewhat higher body mass indices and rates of hypertension, diabetes, cardiovascular disease, and hyperlipidemia than those from urban areas.

Both stroke and depression rates were lower among rural inhabitants than among their urban counterparts. Diet and exercise habits were comparable between the two populations. In addition to being more likely to be married and have less formal schooling, individuals from rural areas were also less likely to now smoke.

Greatest risk is for Rural Black men

Participants experienced 7,542 occurrences of heart failure between the study’s beginning and a median 13-year follow-up.

When the heart is unable to adequately pump blood throughout the body, heart failure results. Shortness of breath when performing daily tasks or difficulty breathing while lying down are symptoms.

1,865 of the heart failure incidents involved rural individuals, whereas 5,677 were city dwellers.

After accounting for variables like age, sex, and race as well as cardiovascular risk factors, health behaviors, and socioeconomic factors in their analysis, the researchers concluded that adults who live in rural areas have an overall higher risk of developing heart failure than their counterparts in urban areas of 19%.

Black men from rural areas had the highest risk of heart failure. Compared to their urban counterparts, this group had a 34% higher chance of developing heart failure.

Women were likewise more vulnerable. Rural Black and White women had an 18% and 22% higher risk of heart failure than women who lived in metropolitan areas.

“We addressed, as much as we could, things that we thought could be playing a role in our observation,” Roger stated. We anticipated that we would discover such a difference, but we did not anticipate the size of the difference we discovered.

Racial and gender biases play?

The fact that Black men and women had a higher chance of developing heart failure in rural locations wasn’t surprising to Keisha Ray, an assistant professor of bioethics and medical humanities at McGovern Medical School at UTHealth Houston in Texas.

“It is consistent with what health disparities scholars have consistently maintained—discrimination like racism and sexism touches all parts of Black people’s and women’s lives,” she said. “Racism also affects people’s access to the resources they need for good heart health, such as access to wholesome foods, leisure activities, adequate housing and income, and access to preventive healthcare.”

Because of chauvinism, health professionals frequently fail to take women seriously, Ray continued.

She stated that “women are frequently not believed when they complain of illness or their poor health is downplayed and dismissed.” This might delay the delivery of care that could save their lives.

REFERENCES:

For Heart failure medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_99

Can Obstructive sleep apnea cause cognitive decline?

Can Obstructive sleep apnea cause cognitive decline?

Comments 0 Comment

According to a study, people who have obstructive sleep apnea may experience cognitive decline.

The study is distinctive because all of its subjects were in good health and were free of the comorbid conditions that are frequently cited as the processes behind the association between sleep apnea and cognition.

According to the study, males as young as middle age can experience cognitive decline brought on by obstructive sleep apnea.

When a person has obstructive sleep apnea (OSA), their airway occasionally becomes obstructed for at least 10 seconds while they are asleep. It has been hypothesised that the cardiovascular or metabolic comorbidities that cause these breathing disruptions are the cause of the eventual decline in cognitive function.

According to a recent research of individuals without these comorbidities, sleep apnea itself can cause cognitive deterioration as early as age 40.

Men from a distinctive group took part in the study. People with systemic hypertension, hyperlipidemia, diabetes, cardiovascular disease, and other metabolic illnesses are more likely to be diagnosed with OSA.

This study is the first to examine the cognitive impact of OSA in otherwise healthy and non-obese persons because none of the study participants had any such comorbidities.

In their otherwise healthy subjects, the researchers discovered that OSA was associated with worsened executive function, visuospatial memory, vigilance (sustained attention), psychomotor function, and impulsive control.

Obstructive sleep apnea

According to a recent examination of data from 16 countries, 425 million adult men and women between the ages of 30 and 69 have moderate-to-severe OSA, and 936 million have mild-to-severe OSA. One estimate places the number of Americans with the illness at 25 million.

Sleep apnea might be one of two forms. The brain is unable to regularly signal the breathing muscles in people with less common central sleep apnea. OSA is more prevalent.

The dilator muscles that normally maintain the soft palate at the back of the throat open during breathing malfunction in people with obstructive sleep apnea or enable the tongue to impede the airway. Respiration is halted until the affected individual gasps or snorts to reopen the airway and restore breathing, which frequently happens before they completely awaken.

The link between obstructive sleep apnea and cognitive decline

According to the study’s findings, males who had severe obstructive sleep apnea had deficiencies in:

  • Vigilance
  • executive ability
  • Visual recognition memory in the short term
  • esteem on a social and emotional level

These issues were present in the males with mild obstructive sleep apnea as well, though not to the same extent as the individuals with severe versions of the illness. In reality, they hardly ever outperformed the control group in a meaningful way.

Even though the majority of men with sleep apnea had medical comorbidities, the study’s participants had none, including cardiovascular disease, diabetes, chronic inflammation, or depression. The authors pointed out that earlier studies blamed concomitant illnesses rather than sleep apnea for cognitive deficiencies.

Ivana Rosenzweig, MD, Ph.D., FRCPsych, a sleep specialist and consultant neuropsychiatrist, and the study’s lead author, said in an email to Healthline that “in our small proof-of-concept cross-sectional study, we demonstrated cognitive deficits in male patients with obstructive sleep apnea, even without any comorbidities.” This is extremely relevant because the current prevailing theory holds that cognitive deficiencies in this age range may be caused by comorbidities connected to obstructive sleep apnea.“

Rosenzweig stated, “Our research demonstrates that sleep apnea is sufficient to initiate cognitive alterations. Since the majority of these patients were (otherwise) healthy males with this condition, the vast majority of them were consciously ignorant that they already had cognitive abnormalities detected by the extremely sensitive testing battery.

The following are some potential causes of the cognitive issues, according to the researchers:

  • sporadic low oxygen
  • high blood carbon dioxide levels
  • changes in the brain’s blood flow
  • fragmented sleep
  • Neuroinflammation

They stated that sleep apnea is a disorder that could be harmful.

Sleep apnea and dementia

The chance of developing dementia, including Alzheimer’s disease, may be considerably raised by sleep apnea. An assessment of research from 2022 found that it does not appear to raise the likelihood of acquiring vascular dementia.

Unfortunately, dementia can also cause sleep disruptions, according to Merrill. “Sleep disturbances increase dementia risk,” she said. As a result, your memory may eventually deteriorate to the point of dementia, which will make it harder for you to sleep. In this way, disturbed sleep can contribute to a downward spiral, making it even more crucial to recognize and address sleep problems during early and midlife adult development. Dementia affects sleep in several different ways, Merrill continued. “Dementia is a neurodegenerative illness, which means that brain cells begin to malfunction and die as time passes.

The brain’s sleep centres begin to malfunction when a person loses brain cells, making it harder for us to communicate with our bodies to stay asleep. Sleep is frequently broken up or even inverted, keeping patients awake all night before they fall asleep for the most of the day.

Merrill stated, “Ideally, sleep will be optimised years before the potential onset of dementia.” “With better sleep, we may be able to postpone the age at which dementia first manifests itself. To increase a person’s healthy life span as much as feasible, sleep quality should be improved.

The CDC recommends that those aged 61 to 64 receive seven to nine hours of sleep per night, while those aged 65 and over should aim for seven to eight hours.

Causes of OSA and cognitive damage

“Craniofacial and physiological particularities can be a risk factor for OSA — having a short chin, large tonsils, a large tongue, etc.,” said neuroscientist Dr. Nadia Gosselin from the University of Montreal in Canada, who was not involved in the study.

According to her, “these peculiarities increase a person’s risk of upper-airway obstruction during sleep.”

Although it is unclear how OSA causes cognitive loss, several of its fundamental characteristics, such as sleep disruption, intermittent hypoxemia, neuroinflammation, and oxidative stress, may be to blame.

According to Dr. Gosselin, OSA stops sleep from playing its part in memory consolidation, brain plasticity, and the elimination of cerebral metabolic waste by continuously fragmenting sleep.

She stated that systemic inflammation and blood-brain barrier disruption resulting in neuronal death are two more potential causes.

According to one study, the hippocampus and the entorhinal cortex, two areas of the brain that degrade quickly in Alzheimer’s disease, have higher levels of oxidative stress and inflammation.

How to treat sleep apnea

The good news is that OSA can frequently be treated by making small lifestyle adjustments, such eating better, working out more, and decreasing weight, she continued.

Through a range of therapy techniques, doctors can also assist patients in controlling OSA.

The CPAP machine, which uses continuous positive airway pressure to keep the airway open while you sleep, is the OSA technology that is used the most frequently. People with central sleep apnea may also be given medication, CPAP machines, or other breathing aids.

Other OSA therapies include oral mandibular advancement devices or dental appliances that prevent the tongue from obstructing the throat. Additionally, there are neurostimulation implants for OSA, and surgery can occasionally be beneficial.

REFERENCES:

For Cognitive decline medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_478