This is a significant finding that adds to our understanding of Alzheimer’s disease and its potential differences between men and women.

Here is a detailed breakdown of the study and its implications:

The Headline: Women with Alzheimer’s Have Lower Levels of Healthy Fats

This finding points to a specific biological difference that could help explain why women are disproportionately affected by Alzheimer’s disease.

Key Details of the Study

This research, led by the University of South Australia and published in the journal EBioMedicine, provides a crucial clue in the puzzle of Alzheimer’s.

What they did:

1. Participants: The study analyzed blood plasma samples from hundreds of participants in the Australian Imaging, Biomarker and Lifestyle (AIBL) study.
2. Comparison: They compared the levels of various lipids (fats) in:
   • People with Alzheimer’s disease vs. healthy cognitively normal individuals.
   • Men vs. Women within these groups.
3. Key Finding: Researchers discovered that women with Alzheimer’s disease had significantly lower levels of a specific type of healthy fat called plasmalogens compared to:
   • Healthy women.
   • Men with Alzheimer’s.

What are Plasmalogens?
Plasmalogens are a special class of phospholipids (a core component of cell membranes). They are particularly abundant in the brain, heart, and immune cell membranes. Their crucial roles include:

• Structural Integrity: Helping to form and protect nerve cell membranes (neurons).
• Synaptic Function: Playing a key role in communication between brain cells.
• Antioxidants: Protecting brain cells from oxidative stress and damage, which is a major contributor to Alzheimer’s.

Why This Finding is So Important

1. Addresses a Major Disparity: Approximately two-thirds of people living with Alzheimer’s disease are women. While women living longer has been a historical explanation, this study suggests there may be a specific biological mechanism at play that makes the female brain more vulnerable.
2. Suggests a “Two-Hit” Model: The researchers propose that the hormonal changes of menopause (particularly the drop in estrogen, which usually helps protect the brain) might be the first “hit” that makes the brain vulnerable. The subsequent significant loss of plasmalogens could be the second “hit” that accelerates the path toward Alzheimer’s.
3. Potential for New Tools: This discovery could lead to:
   • Early Diagnostic Blood Tests: Measuring plasmalogen levels could become a biomarker to identify women at higher risk long before symptoms appear.
   • Novel Treatment Strategies: Therapies aimed at boosting or preserving plasmalogen levels could be developed as a preventative measure or to slow disease progression.

How to Support Plasmalogen Levels (Based on Current Knowledge)

It’s important to note that this research is still emerging, and no specific treatments exist yet. However, plasmalogens are synthesized in the body from precursors found in food.

Dietary sources of precursors include:

• Shellfish: Shrimp, scallops, mussels
• Cold-Water Fatty Fish: Salmon, mackerel, herring, sardines (also excellent sources of brain-healthy omega-3s DHA and EPA).
• Organ Meats: Such as liver (in moderation).
• Certain Leafy Greens and Soy Products: Contain compounds that may support synthesis.

General Dietary Patterns Linked to Brain Health:

• Mediterranean Diet: Rich in fish, healthy fats (olive oil, nuts), and antioxidants, which is consistently associated with a lower risk of cognitive decline.
• DASH and MIND Diets: Specifically designed to support brain health.

Important Caveats and Considerations

• Correlation vs. Causation: This study shows a strong association, but it does not yet prove that low plasmalogens cause Alzheimer’s. It might be a consequence of the disease. Further research is needed.
• Not a Solo Cause: Alzheimer’s is a complex disease with many contributing factors, including genetics (like the APOE-e4 gene, which has a stronger effect in women), vascular health, and overall lifestyle.
• Do Not Self-Supplement: Plasmalogen supplements are available but are not rigorously tested or regulated for preventing or treating Alzheimer’s. It is essential to consult a doctor before considering any supplement.

Conclusion

This study is a vital step toward understanding the biological reasons why women are at greater risk for Alzheimer’s. By identifying the specific depletion of protective plasmalogens in women with the disease, it opens up new avenues for gender-specific research, diagnostics, and future treatments.

For now, the best advice remains: Maintain a heart-healthy and brain-healthy lifestyle—a balanced diet rich in omega-3s, regular physical activity, mental stimulation, and strong social connections—as these are proven to support overall cognitive health.

Reference:

https://www.news-medical.net/news/20250820/Women-with-Alzheimers-show-reduced-levels-of-healthy-unsaturated-fats.aspx

https://www.medicalnewstoday.com/articles/women-with-alzheimers-have-lower-levels-of-healthy-fats-study-finds

https://www.hindustantimes.com/lifestyle/health/research-reveals-women-with-alzheimer-s-show-20-drop-in-omega-fatty-acids-same-pattern-not-found-in-men-101755847516259.html

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/disease/alzheimer-disease