, Author at Pharmacy and Health Blog from myGenericPharmacy.com

Can prediabetes be reversed with diet and exercise

November 25, 2023 blogadmin Comments 0 Comment

Diabetes, more especially type 2 diabetes, is emerging as one of the 21st century’s most difficult medical issues. It is also anticipated that 380 million individuals globally will receive a diabetes diagnosis by 2025. Diabetes management and treatment are increasingly important because it is a risk factor for many other diseases and chronic health conditions, including stroke, kidney disease, cardiovascular disease, and blindness, to name a few. However, many people are thought to be in a precursor stage known as prediabetes before they go on to develop type 2 diabetes. People with this illness have blood sugar levels that are higher than normal but not high enough to be classified as type 2 diabetes. However, a significant risk factor for type 2 diabetes is prediabetes. The statistics of those who have prediabetes provide a clear picture when it comes to scaling this issue: more than one in three persons in the U.S. S. along with the U. K. have been identified as prediabetic. Therefore, if prediabetes is considered an early warning sign of type 2 diabetes, people can take steps to reverse the course of this condition and it is possible to reverse this condition with significant lifestyle changes.

On our May podcast, “In Conversation: Can diet and exercise help reverse prediabetes?” Dr. Thomas Barber, an associate clinical professor at Warwick Medical School and consultant endocrinologist at University Hospitals Coventry and Warwickshire, joined Dr. Hilary Guite and me. Additionally, Healthline Media and Medical News Today Managing Editor Angela Chao shared her personal story of reversing her diagnosis of prediabetes and the lifestyle changes she made to maintain it. In Angela’s instance, few medical professionals would have thought that her blood sugar levels were concerning. She is not thin, young, and energetic like most people with prediabetes or those at risk of getting diabetes. She did, however, admit that at the time she led a fairly sedentary lifestyle. She said that because my readings were so low on the spectrum, I don’t even think my primary care physician at the time talked to me about it beyond providing the range and the diagnosis. She did, however, add that some doctors and her medical friends seemed concerned about the changes to the cutoff point for readings that qualified as prediabetes.

According to Dr. Barber, the diagnosis of diabetes and prediabetes was previously made using fasting glucose readings or a conventional glucose tolerance test. In this test, participants were given 75 grams of a sugar-filled beverage, and their blood sugar levels were monitored for the following two hours. Additionally, the definition of prediabetes is constantly changing and may vary from nation to nation. Definitions vary amongst societies and prestigious organizations. According to Dr. Barber, the first thing to really keep in mind is that there is a continuum involved when discussing diabetes or prediabetes. Should we choose the U. S. along with the U. K. For instance, there are variations in the thresholds and units of measurement applied when diagnosing prediabetes. As you point out, there are various units, which makes it a little confusing. However, in essence, in the U. K. for glucose, we use millimoles per liter, and in the U.S. S. milligrams per deciliter, to be exact. We typically use millimoles per mole in clinical settings now, and we have for a while, according to Dr. Barber. He went on, “I think that further complicating matters is the hemoglobin A1C, which has two different percentage units, one that we have historically used and the other that is now replaced by millimoles per mole.

According to Dr. Barber, glucose is a continuous variable rather than a discrete measure. He clarified that while everyone can agree on what is elevated and what is normal, there are kind of disagreements about everything in between. The World Health Organization approved hemoglobin A1C as a test for diabetes a few years ago. While additional glucose readings can be useful, Dr. Barber stated that medical professionals do primarily rely on A1C in current clinical practice. With regard to prediabetes in the U.S. K. this is predicated on an A1C of 39 to 47 mmol per mol; according to him, 39 is equal to an A1C of 5 points 7 percent. Anything that raises the hemoglobin A1C level above 48 millimoles per mole, or 6.5% of the baseline, is considered diabetes by definition. According to him, in order to diagnose type 2 diabetes, we should ideally have at least two of those readings that are elevated. When Angela was diagnosed, her A1C was 5 points8 percent, and anything above 5 points7 was considered prediabetes. Dr. Barber reminded us that, in the United States, Angela’s readings would not have been regarded as prediabetes and that, in recent years, the diagnostic criteria for diabetes have gradually decreased. K. at the time, since the values were extremely near to normal and not quite below the cut-off.

Usually, prediabetes shows no symptoms at all. On the other hand, some people may occasionally have frequent thirst, wake up in the middle of the night to urinate, experience blood sugar spikes, or have energy crashes. Prediabetes is frequently asymptomatic, so many people who are diagnosed with it may have had it for months or even years. Furthermore, it can easily go unreported unless people are tested for it, according to Dr. Barber. In describing her personal experience, Angela said, “I definitely didn’t have a wide range of symptoms.”. On the other hand, I was definitely already drinking water on a regular basis. I therefore found it difficult to determine whether anything was changing. Low blood sugar, particularly if she went for prolonged periods without eating, was something she did notice prior to the diagnosis. Over the years, she said, there has been a consistent pattern of significant fluctuations in her blood sugar levels, which she could feel physically. She can, however, fast trouble-free for more than 16 hours now because of certain lifestyle adjustments. Sugar surges and falls may be considered preemptive indicators of diabetes.

According to Dr. Dot Barber, prediabetes is a general term that can refer to either elevated fasting glucose or elevated postprandial glucose. Dr. Dot Barber stated that fluctuations in blood sugar levels, or glycemia, were often observed in the context of insulin resistance. Glucose levels tend to rise a little higher than they should, he explained, because the beta cells can’t produce enough insulin, for example, or the insulin isn’t as effective after a meal. He explained that without careful monitoring of blood sugar levels throughout the day, people might not physically notice these changes. “I guess the difference really is that most of the time, in the context of prediabetes, we’re not aware of this,” he said. It makes perfect sense that as you lead a healthier lifestyle, lose weight, and reverse prediabetes, your blood sugar levels will stabilize. He mentioned Angela’s description of the changes she saw and said that the insulin becomes more effective and can handle the fluctuations in glycemia better.

Obesity, having a high body mass index, and being overweight are some of the most well-known risk factors for type 2 diabetes. Additionally, as we age, our vulnerability increases. And the reason for that is that as we age, the beta cells and insulin’s receptors can no longer function as well, and insulin itself becomes slightly less effective. Accordingly, as we age, our chance of having prediabetes and diabetes rises, according to Dr. Barber. Dr. Barber added that eating a diet heavy in high-glycemic foods and sugary drinks, as well as stress, can all raise risk. Conversely, he asserted that a diet low in simple carbohydrates and high in fiber can delay the onset of dysglycemia. Genetics and ethnic origin are other factors to consider. Dr. Dot Barber presented the results of a recent study she and her colleagues carried out in the U. K. which revealed that, at a BMI of 23.9%, individuals of South Asian ethnicity had the same risk of developing diabetes as did white people at 30.

In contrast, Angela’s risk was increased by her family history. My mother, a retired medical doctor, had warned me since I was a teenager about the slight family history of type 2 diabetes on my father’s side. She also mentioned that everyone on that side of the family was thin and had no weight problems. Dr. According to Barber, diabetes is frequently attributed to lifestyle decisions, but many people are unaware that it is a hereditary disorder. According to him, patients with a strong family history may not always exhibit the characteristics of type 2 diabetes, such as being middle-aged, male, obese, and having a large abdomen. That’s the idea that most people with type 2 diabetes have of the typical person. And, he added, as you say, Angela doesn’t conform to any of those stereotypes of what that entails. Dr. Barber also emphasized that having a genetic predisposition to diabetes at birth can result in dysglycemia even in the absence of those other factors. More than 40 genes and gene mutations have been found to increase your risk of developing type 2 diabetes. Additionally, he stated that even though each effect is relatively weak on its own, adding them all together can have a cumulative effect. Through a combination of intermittent fasting, a balanced diet with an increased amount of lower-glycemic index foods and complex carbohydrates, and a sig, Angela was able to reverse her diabetes.

She advised against strict dieting, keto, and quick, drastic changes that aren’t long-term. Dr. Barber acknowledged that while this approach obviously worked for Angela, not many people would be able to make such drastic life changes and may find it challenging. According to Dr. Barber, there is evidence to suggest that intensive lifestyle treatments that prioritize diet, physical activity, weight loss, and other related factors can effectively prevent or postpone the onset of type 2 diabetes. In my opinion, it serves as a kind of early warning system that indicates when a person needs to make a lifestyle change. He added that it must be beneficial if it inspires or motivates people to alter their way of life.

REFERENCES:

https://www.medicalnewstoday.com/articles/in-conversation-can-diet-and-exercise-reverse-prediabetes?utm_source=ReadNext
https://www.hopkinsmedicine.org/health/wellness-and-prevention/prediabetes-diet
https://www.healthline.com/health/diabetes/how-to-reverse-prediabetes-naturally
https://www.healthcentral.com/condition/type-2-diabetes/how-can-you-reverse-prediabetes
https://www.breathewellbeing.in/blog/reverse-your-prediabetes-with-the-best-diet-and-exercise/

For diabetes disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_95

Plant-based diets can reduce the risk of diabetes and heart disease in place of meat.

November 25, 2023 blogadmin Comments 0 Comment

German researchers discovered that replacing meat with plant-based alternatives may significantly lower the risks of cardiovascular disease, type 2 diabetes, and all-cause mortality after analyzing more than 30 studies. Research indicates that substituting 50 grams (1.88 ounces) of processed meat with plant-based foods on a daily basis reduces the risk of cardiovascular disease by 25%. Processed meat substitution was linked to a 21% decreased risk of death from all causes. Red and processed meats, as well as other animal products, are staples of the Western diet. Scientists are concerned that this eating pattern depletes natural resources, causes adverse climate change, and fuels a host of noncommunicable illnesses. The argument for promoting plant-based dietary alternatives is becoming stronger in light of the negative effects the Western diet has on the environment and human health. Plant-based diets may help reduce the risk of coronary heart disease, type 2 diabetes, cardiovascular disease, and overall mortality, according to some studies. However, a systematic review and meta-analysis of the full cardiometabolic implications of replacing meat with plants have not yet been examined in research. Researchers from German institutions worked together to address this shortfall in a paper that examined the subject. The article containing their meta-analysis and systematic review was released in BMC Medicine.

Our results suggest that a move away from animal-based eg dairy, eggs, butter, poultry, and red and processed meat) to plant-based eg foods high in fruits, vegetables, whole grains, nuts, and olive oil) are positively correlated with both all-cause mortality and cardiometabolic health, according to the authors. The research team used Web of Science, Embase, and MEDLINE to conduct a thorough literature search. Studies that employed substitution analyses to replace animal-based food with plant-based food were among them. Health outcomes like cardiovascular disease, coronary heart disease, type 2 diabetes, and all-cause mortality were also covered in the studies that were consulted. Additionally, the studies were prospective observational studies carried out among a general population of healthy individuals. Using the Risk of Bias in Non-Randomized Studies of Interventions tool, each study was subjected to an evaluation of potential bias. With the use of the Grading of Recommendation, Assessment, Development, and Evaluations protocol, the team assessed the degree of evidence for each association. For the purpose of their final analyses, the research team reduced the number of studies they found from 1,216 to 32. A manual search produced five more studies, bringing the total number of meta-analyses to 37.

“It is the first systematic review and meta-analysis that summarized the associations between the substitution of plant-based foods with animal-based foods with a wide range of cardiometabolic outcomes, such as mortality from cardiovascular disease; incidence of cardiovascular disease, coronary heart disease, and type 2 diabetes; mortality from diabetes; and mortality from all causes,” state the authors of this work. The researchers found a “moderate certainty of evidence” linking a daily replacement of one egg with nuts to a decreased mortality rate from cardiovascular disease. Similar outcomes were obtained when olive oil was substituted for butter. Every day, replacing 50 grams (g) of processed meat with 28 grams of nuts was linked to a decreased incidence of coronary heart disease. Nuts or legumes were not a suitable substitute for chicken or seafood. The evidence supporting the hypothesis that substituting nuts or legumes for red meat lowers the risk of coronary heart disease was only weakly conclusive. The researchers also discovered an inverse relationship between the frequency of type 2 diabetes and replacing butter with olive oil, red meat with nuts, or one egg a day with nuts. Lastly, the researchers observed a moderate certainty of evidence for a decreased risk of death from all causes when substituting whole grains or nuts for red meat. This risk was also decreased by substituting nuts or legumes for processed meat or nuts for unprocessed red meat.

Each day, replacing dairy or one egg with nuts, legumes, butter, or olive oil was linked to a decreased risk of death from all causes. These results are consistent with a previous review that found consuming more plant-based foods instead of red meat reduced the risk of coronary heart disease and all-cause mortality. This study backs up other research linking increased meat intake to all-cause mortality, type 2 diabetes, coronary heart disease, and stroke. This study represents the first of its kind meta-analysis. To gather dietary data, validated food frequency questionnaires were employed. Among the cohorts, the average follow-up period was 19 years. With a few exceptions based on gender, both males and females were included in the majority of the studies. Registered dietitian and nutritionist Eva De Angelis spoke with Medical News Today about this study. She did not participate in the study. “Quite a fascinating systematic review that further highlights the vital role that plant foods can have on our overall health, and how too many animal foods can have the opposite effect,” was how De Angelis described the investigation. The study’s use of numerous, varied prospective studies, which “provide a higher quality of evidence,” impressed her. The research team did, however, note a number of limitations with their investigation and emphasized that their “findings should be interpreted with caution.”.

Several of the examined studies made use of hypothetical food substitutions. Additionally, studies’ portion sizes varied, leading to unfair comparisons of dietary alternatives. Relative confounding and measurement errors were possible when using only prospective observational studies. Furthermore, subgroup analyses were not possible due to the small number of studies included in the final analysis. Dairy products, for example, were evaluated as a single group. The writers pointed out that a vast variety of distinct products (e.g. g. cheese, yogurt, and milk) that have varying correlations with cardiometabolic outcomes. De Angelis remarked, “Among the weaknesses, I would mention that many of the analyzed studies were observational, so the information only allows us to make associations, not causality. This implies that we cannot be certain what other factors may have contributed to the results. The review’s authors believed that additional studies were necessary to bolster the available data. They expressed hope that future research would highlight plant-based alternatives to meat and dairy while also examining new connections. Sara Chatfield, a registered dietitian and nutritionist, and also spoke about this study. She did not participate in the study. Chatfield noted that because animal production uses so many resources and occupies so much land, switching to a more plant-based diet can have a positive impact on the environment.

Actually, the two nutritionists that spoke with concurred that increasing the amount of whole plant foods consumed can only benefit the planet and all of its inhabitants. According to studies cited by Chatfield, adopting a plant-based diet could cut land use related to diet by 76% and greenhouse gas emissions by 49%. The nutritionists issued a warning, though, saying that depending on a person’s health, preferences, and food accessibility, a completely plant-based diet might not be the best choice for them. However, De Angelis stressed that trying to increase the amount of plant-based foods in your diet can be a quick and easy step toward better health.

REFERENCES:

https://www.medicalnewstoday.com/articles/swapping-meat-for-plant-based-foods-may-lower-diabetes-and-heart-disease-risk
https://dentistry.co.uk/2023/11/24/plant-based-diets-may-cut-diabetes-and-heart-disease-risk-study-shows/
https://www.news-medical.net/news/20231120/Switching-from-animal-based-to-plant-based-foods-reduces-risk-of-heart-disease-diabetes-and-mortality.aspx
https://www.hsph.harvard.edu/news/hsph-in-the-news/swapping-red-meat-for-healthy-proteins-may-help-your-heart/

For heart disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_99

Why does drinking red wine give me headaches?

November 24, 2023 blogadmin Comments 0 Comment

A recent study found that a red wine compound influences the way the body metabolizes alcohol, which may contribute to headaches. Because red wine contains more histamine, tannins, and quercetin than white wine, red wine is more likely to give headaches. Experts advise consuming white wine, drinking plenty of water, and avoiding drinking right before bed to reduce headaches. Wine is usually the preferred alcoholic beverage during the holidays. Unfortunately, some people can get a headache from even a small amount of wine—red wine in particular. A recent investigation into the causes of headaches associated with red wine as opposed to other alcoholic beverages that don’t have the same effect was published in the journal Scientific Reports. It has been found by researchers that the high flavonoid content of red wine, specifically quercetin, affects the way the body metabolizes alcohol, which can cause headaches. It’s interesting to note that fruits and vegetables alike contain the antioxidant quercetin. However, it may have unfavorable side effects if combined with alcohol.

Wine chemist and corresponding author Dr. Andrew Waterhouse, professor emeritus in the UC Davis Department of Viticulture and Enology, told Medical News Today, “The most interesting aspect of this project is that the effect is not direct.”. To put it another way, we discovered that quercetin glucuronide was the “culprit,” but if you ate it in another meal, you wouldn’t experience a headache. Our hypothesis states that a headache can only happen if alcohol and quercetin are consumed at the same time. That, in my opinion, explains why things have taken so long to resolve, stated Dr. Waterhouse. According to Cleveland Clinic neurologist Dr. MaryAnn Mays, “red wine contains more tannins and histamines compared to white wine, which are contributing factors of headaches.”. Another possible factor, quercetin, may be the cause of red wine headaches in humans. In particular, when quercetin is metabolized with alcohol, its form changes. According to Carolyn Stolte, a certified nurse practitioner with Mercy Personal Physicians in Baltimore, Maryland, “questercetin converts to a different form—quercetin glucuronide—when it interacts with alcohol during metabolism.”. Researchers discovered that acetaldehyde, a known toxin, accumulates as a result of this metabolism. She clarified, “This results in the traditional red wine side effects of flushing, headaches, and nausea.

According to Stolte, red wine has historically been thought to have higher levels of tannins and histamines than white wine, which can cause sensitivity in certain individuals. Because quercetin in wine can trigger headaches in certain people, even small amounts of wine can cause headaches. Furthermore, grape cultivation affects quercetin levels; exposure to sunlight during growth may result in a higher content of quercetin. “When we drink alcohol, our bodies start working quickly to break it down into other compounds that are easier to get rid of,” said Dr. Nate Wood, a medical education fellow and instructor at the Yale School of Medicine’s department of general internal medicine. Acetaldehyde is one of these substances. Many of the unpleasant hangover symptoms that we are all familiar with, such as headaches, have been linked to acetaldehyde use. Luckily, acetaldehyde is also broken down by an enzyme that is produced by our bodies. “It’s known as aldehyde dehydrogenase,” he said. Quercetin-3-glucuronide, a derivative of quercetin found in red wine, might function similarly. Dr. Wood continued, “New research demonstrates that it is effective in blocking aldehyde dehydrogenase.”

Similar to individuals with the genetic variation, acetaldehyde accumulates, aldehyde dehydrogenase becomes less effective, and headaches result. This quercetin derivative has been found to be present in higher concentrations in red wine than in white wine, which may help to explain why red wine appears to give people headaches more often than white wine. The first thing to realize is that, according to Mays, “there are two parts of alcohol metabolism: alcohol dehydrogenase and acetaldehyde dehydrogenase.”. “Quercetin may be obstructing that metabolism, leading to an accumulation of acetaldehyde.”. It might also be necessary to account for a genetic component. According to Mays, “some people may not have the enzyme that breaks down histamines in wine to metabolize alcohol.”. “Those people are more vulnerable. For instance, about 40% of people from Eastern Asia report having negative alcohol-related side effects, such as headaches and facial flushing. In particular, their aldehyde dehydrogenase is dysfunctional. “Some Eastern Asians have higher blood levels of acetaldehyde when they drink, which can lead to more negative side effects from alcohol, such as headaches, fast heart rate, nausea, and facial flushing,” Dr. Wood said.

“Red wine will probably have the same physiological effects on them as other forms of alcohol. Since the enzyme already fails to function, the quercetin derivative cannot impede its ability to inhibit the aldehyde dehydrogenase enzyme, he said. But when it comes to red wine, those with functional aldehyde dehydrogenase in their bodies might experience more severe headaches than with other forms of alcohol. According to Dr. Wood, this is because the quercetin derivative is preventing their body’s aldehyde dehydrogenase from functioning properly. According to Stolte, our understanding of why some people are more susceptible to wine-induced headaches is still evolving.”. According to recent research, wine sensitivity may be influenced by genetics. There may be a genetic component to how different people metabolize substances like quercetin, tannins, and histamines,” he continued. According to Stolte, it’s also critical to consider the person’s overall health and any underlying medical conditions. For instance, compared to the general population, people with underlying migraines are more likely to suffer wine-induced headaches. The University of California scientists hope to investigate this further in the future, she said. Women are also more prone to wine-related headaches. According to Dolores Woods, a registered dietitian at the UTHealth Houston School of Public Health, “women have more body fat than men, which stores alcohol. Women metabolize alcohol more slowly than men do because they have less alcohol dehydrogenase (the enzyme responsible for alcohol metabolism) in their blood.

REFERENCES:

https://www.medicalnewstoday.com/articles/headaches-after-drinking-red-wine-flavanols-quercetin#Why-some-people-are-more-susceptible-to-wine-headaches-than-others
https://www.health.harvard.edu/diseases-and-conditions/ask-the-doctor-what-causes-red-wine-headaches
https://www.healthline.com/health/wine-headache
https://www.everydayhealth.com/headache/does-drinking-red-wine-give-you-a-headache-a-new-study-may-explain-why/

For medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com

Is it possible to detect Parkinson’s or Alzheimer’s early with a portable device?

November 24, 2023 blogadmin Comments 0 Comment

The identification of biomarkers for Alzheimer’s or Parkinson’s disease that can be found in bodily fluids like blood, urine, and saliva could aid in the discovery and development of new medications and therapies. Last year, a team of scientists created a wireless gadget that can identify SARS-CoV-2 strains in particular by detecting a very small number of molecules. They have now demonstrated that their gadget can be modified to identify chemicals connected to Parkinson’s and Alzheimer’s diseases. Researchers from the University of California, San Diego have demonstrated that their wireless, handheld device, which they developed to identify particular biomolecules, can also identify molecules linked to Parkinson’s and Alzheimer’s diseases. Initially, the instrument was designed to identify SARS-CoV-2, the virus responsible for COVID-19. Aptamers, which are brief strands of DNA or RNA that bind exclusively to particular molecules, are how it functions. Electrical energy can flow when binding occurs on the machine’s single-atom-thick graphene layer, producing a positive reading that verifies the presence of the molecule. In a previous study, it was demonstrated that their device could identify particular strains of the SARS-CoV-2 virus when very few viruses were present.

In their most recent study, this group of researchers demonstrated that their apparatus can identify various forms of tau and beta-amyloid, peptides that are characteristic of Alzheimer’s disease, as well as α-synuclein, a peptide that is present in higher concentrations in the brains of patients with Parkinson’s disease. To test the device’s capacity to identify these molecules, samples extracted from the autopsied brains of departed patients were used. The quantity of Americans who suffer from Alzheimer’s disease. S. may increase from 6.77 million to 13.78 million by 2060 if no major advancements are made in the field. While it has proven difficult to design clinical trials demonstrating the efficacy of drugs with cohorts of patients already exhibiting symptoms of the disease, breakthroughs are required not only in the diagnosis but also in the development of treatments. Currently, MRI, PET scanning, and neurocognitive testing are used in combination to detect Alzheimer’s disease, often after cognitive decline and other symptoms have started. The way that PET scans function is by looking for amyloid plaques, which are created when a peptide called beta-amyloid tangles with tau to form plaques. The cognitive decline that is observed in patients with Alzheimer’s disease is believed to be caused by these tangles interfering with nerve cell signaling in the brain.

The majority of studies concentrate on the existence, functions, and potential mechanisms of these peptides because Alzheimer’s disease patients’ brains have these plaques. Because these peptides are found in the brain, isolating them is still difficult and may require surgery. The findings of the study demonstrated that the apparatus the researchers had created could accurately and precisely identify several forms of these beta-amyloid peptides at low concentrations. Lead author Dr. Ratnesh Lal told Medical News Today in an interview, “What we saw in this paper is that the amount of beta-amyloid that goes into the brain in the saliva is almost 1,000 times more than what is the sensitivity of our system.”. He claimed that because there was no cross-reactivity to skew results, the device’s strength came from the electrical system’s sensitivity.

According to the paper’s authors, they plan to test the device’s ability to identify these molecules in blood plasma and cerebrospinal fluid before moving on to saliva and urine. Dr. Thomas K. Karikari, an assistant professor of psychiatry at the University of Pittsburgh who studies biomarkers for Alzheimer’s disease and was not involved in the research, stated that more research needs to be done to determine the best kind of biomarkers to detect Alzheimer’s disease in various types of body fluid. Standardized pathology tests on tau and amyloid present additional difficulties in obtaining consistent enough results to prevent false positives and negatives. Because amyloid is naturally very sticky, it can be challenging to separate and manipulate. Because of the blood-brain barrier, blood concentrations and concentrations in other tissues outside of the brain may not always reflect most changes observed in the brain. Dr. Karikari told that his own research had looked at the phosphorylation patterns on Alzheimer’s specific tau-peptides to determine which specific molecules could be determined to have come from the brain and present in different concentrations in Alzheimer’s patients compared to a non-disease population. Put another way, you cannot tell if these biomarkers have come from the brain and not somewhere else in the body.

His earlier studies have demonstrated that tau binding is especially strong in the vicinity of the salivary gland. At the time, we demonstrated that there was no difference in saliva quality between the diagnostic group. Because tau in saliva would not always come from the brain, it was determined that tau in saliva was not a reliable biomarker for Alzheimer’s disease. “So we actually ended that at that point,” Dr. Karikari said. But now, he stated, “perhaps we can go back and be able to characterize the tau from the saliva much better,” since research has been done to identify the phosphorylation patterns on tau that define Alzheimer’s disease. “Dr. Less research has been done on urine, according to Karikari, and gathering urine from elderly patients who are incontinent presents unique difficulties. The device should be on the market in a year, according to the paper’s authors, who say they intend to apply for FDA approval in the next five to six months.

REFERENCES:

https://www.medicalnewstoday.com/articles/wireless-handheld-device-may-detect-alzheimers-parkinsons-biomarkers-early
https://newatlas.com/medical/portable-device-alzheimers-parkinsons-biomarkers/
https://www.altonmemorialhospital.org/Health-Library/View-Content?contentTypeId=6&contentId=2118881603
https://challenge.carleton.ca/parkinsons-alzheimers-early-detection/

For alzheimers disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_239

An improved blood test could aid in the early stage detection of lung cancer.

November 23, 2023 blogadmin Comments 0 Comment

Worldwide, lung cancer is the primary cause of cancer-related deaths. The majority of lung cancer cases are diagnosed at an advanced stage, which reduces the 5-year survival rate. At the moment, low-dose CT is the only screening option available for lung cancer, and it has certain drawbacks. According to a cancer genomics company, a blood test for early-stage lung cancer detection has been developed. Globally, lung cancer is the primary cause of cancer-related mortality. Lung cancer was the cause of approximately 2 million diagnoses and 1 in 8 deaths in 2020. The type of cancer, the time of diagnosis, and whether the cancer has spread to other parts of the body all affect a person’s 5-year survival rate for lung cancer. Early-stage lung cancer is more curable. Previous studies have demonstrated that because many people do not exhibit clear symptoms at an early stage, the majority of lung cancer cases are diagnosed at an advanced stage. Currently, low-dose computed tomography (CT) scanning is the only method of screening for lung cancer. CT scans, however, occasionally result in false positives or negatives.

Currently, research is being done on a novel method of early lung cancer detection. The first results of a novel blood test for the identification of early-stage lung cancer were presented at the annual congress of the European Society for Medical Oncology this year. created by Personalis Inc., a cancer genomics company. The new test, known as the NeXT Personal ctDNA assay, can identify minute amounts of circulating tumor DNA (ctDNA) in blood, indicating the presence of residual or recurrent cancer, according to Dr. Richard Chen, executive vice president of research and development at Personalis Inc. and chief medical officer. According to Chen, who spoke with Medical News Today, “the NeXT Personal technology leverages whole genome sequencing and advanced noise suppression with NeXT SENSE technology to identify an ultra-sensitive, unique genetic signature derived from a patient’s tumor.”. “This distinct signature is monitored in the patient’s bloodstream over an extended period to detect any lingering or recurrent cancer, attaining an industry-best sensitivity of approximately 1 part per million of ctDNA. He continued, “This increased sensitivity offers the potential for earlier detection, more accurate monitoring, earlier recurrence risk assessment and intervention, and significant advancement in lung cancer care.

The primary finding from the work with the NeXT Personal assay in TRACERx, according to Dr. Charles Swanton, principal investigator for the study and deputy clinical director of the Francis Crick Institute in London, concerns disease stratification in early-stage lung cancer. “At the moment, we don’t always have the ability to direct additional supplemental therapy, called adjuvant therapy, to those who would benefit it most because we have an imperfect system to understand which patients will typically have a poor clinical outcome following surgical resection of their primary tumor with curative intent,” Swanton told Medical News Today. This results in some patients receiving insufficient care while others receive excessive care. Better methods of classifying patients into those who will and won’t recover well from surgery are therefore desperately needed. Our investigation was set against this realization. According to Swanton, it’s critical to accurately categorize patients as high- or low-risk because this allows for “individualized” adjuvant therapy trials.

“It could have a significant impact to be able to withhold treatment from patients who are unlikely to benefit while providing it to a population of patients who would.” he said. In terms of recurrence detection, we are aware that recurrence can be identified nearly a year ahead of routine clinical surveillance in patients who have evidence of ctDNA in the blood after surgery. Similar to the pre-operative data, this allows for the implementation of aggressive treatment in the early-metastatic setting, thereby providing a more individualized approach to treatment. According to Chen, Personalis is now offering the NeXT Personal test for clinical testing as a part of an early access program. According to him, between 20 and 40 percent of patients with early-stage lung cancer eventually experience a recurrence, depending on the stage. The sensitivity of some recurrence detection techniques, such as imaging or other blood tests, may be restricted. It may be possible to treat or advance treatment for lung cancer patients sooner if more sensitive methods for identifying cancer that remains after treatment or recurs. “.

According to Swanton, the new blood test’s next research steps would involve validating the results in prospective cohorts. He stated, “This will pave the way for routine clinical use and the identification of particular cohorts where an ultra-sensitive assay can be applied.”. Dr. John Roberts, a thoracic surgeon with Lynn Cancer Institute, a division of Baptist Health South Florida, at Boca Raton Regional Hospital, told Medical News Today after reviewing details about the new NeXT Personal ctDNA assay that since CT scanning has been shown to reduce lung cancer mortality more than any medical intervention, an accurate blood test should have a similar effect. He clarified, “All of our blood testing for lung cancer only detects advanced cancer.”. Since a CT scan is currently the only method available for screening for lung cancer, any test that could be used as an early cancer screening would represent a significant advancement. According to Roberts, the majority of lung cancer patients who experience recurrence following treatment are already incurable when the disease is detected. It would be beneficial for any test to identify recurrences early on. “.

Sara Belton, PhD, a nurse navigator for the Lung Screening Program at the Cardiothoracic Outpatient Clinic in California at Providence Saint John’s Health Center, was also interviewed by Medical News Today regarding this study. She stated that any tools that can assist clinicians in the diagnosis and long-term management of lung cancer are most welcome. She works as a nurse navigator and focuses on lung cancer screening. According to Belton, “a blood test for lung cancer genome detection is being developed by several research consortia and is considered by many in the field as the ‘Holy Grail’ for lung cancer diagnosis.”. “If this research is successful, physicians will benefit from having a more accessible and potentially more accurate modality for screening for lung cancer than the current gold standard, CT imaging scans, which are best used in conjunction with clinical interpretation and excellent imaging visualization. I’m glad to hear this and am interested in learning more about their outcomes in the future. She went on to say that having an inexpensive, readily available blood test that can be used to screen for lung cancer will enable medical professionals to increase screening efforts, which are currently low in the US.

According to Belton, “current clinical guidelines for lung cancer screening recommend that only current or former smokers who are over 50 and have a smoking history of at least 20 pack years be screened for lung cancer every year.”. Nonetheless, these recommendations do not apply to the up to 10% of lung cancer patients who have never smoked. These are frequently the ones whose lung cancer is discovered too late to receive the best care and results. “A more widely available blood test would enable us as clinicians to identify these non-smokers who are at risk, and would enable us to intervene and treat them at an early enough stage to ensure favorable health outcomes, and potentially prevent them from passing away from lung cancer,” the speaker continued. “This would be a huge advancement in lung cancer care and screening, and I am optimistic that a blood test of this kind will be made commercially available in the coming years”.

REFERENCES:

https://www.medicalnewstoday.com/articles/new-blood-test-may-help-better-detect-early-stage-lung-cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196057/
https://www.dundee.ac.uk/stories/blood-test-aid-better-detection-lung-cancer
https://ecancer.org/en/news/15412-new-research-suggests-a-simple-blood-test-could-improve-the-early-detection-of-lung-cancer

For lung cancer disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_115

Why physical activity is essential for a long and healthy life.

November 23, 2023 blogadmin Comments 0 Comment

It appears that humanity has been searching for the “Fountain of Youth”—that is, means to guarantee a longer, healthier life—since the beginning of time. And while there may not yet be any “wonder” treatments or medical advancements that will allow us to live much past the age of 100, numerous recent studies have offered compelling proof that small, doable lifestyle adjustments can help us live longer and be healthier while lowering our chance of passing away too soon. For instance, research presented at the Scientific Sessions of the American Heart Association in 2023 revealed that eight healthy habits could potentially halt the progression of biological aging by up to six years. These behaviors have to do with eating right, keeping a healthy weight, abstaining from tobacco, taking care of one’s sleep hygiene, controlling blood pressure, cholesterol, and blood sugar, and—above all—remaining physically active. In the most recent episode of our podcast, “In Conversation,” Medical News Today speaks with Drs. Edwina (Eddie) Brocklesby and Borja del Pozo Cruz about the connection between exercise and a long and healthy life. Dr. Del Pozo Cruz is an adjunct associate professor in the University of Southern Denmark’s Department of Sports Science and Clinical Biomechanics and principal researcher in the Applied Health Sciences at the University of Cadiz in Spain.

Dr. del Pozo Cruz has worked with other researchers to carry out a number of studies examining the relationship between the risk of dying from various causes and the type of exercise. Dr. Being the oldest British woman to finish an Ironman Triathlon at the age of 72, Brocklesby earned the moniker “Iron Gran,” which has helped her become well-known. In addition, she founded and serves as CEO of Silverfit, a nonprofit that encourages lifetime fitness. Dr. del Pozo Cruz and colleagues examined data from 500,705 participants followed up for a median of 10 years in a study published in JAMA Internal Medicine in August 2023 to determine the relationship between various forms of exercise and an individual’s mortality risk. The effects of three types of physical activity were examined in the study: muscle-strengthening exercises like weightlifting, vigorous aerobic exercises like running, and moderate aerobic exercises like walking or light cycling. Its conclusions showed that the most effective way to lower the risk of death was to combine all of these types of exercise in a balanced way. More precisely, a reduced risk of all-cause mortality was linked to at least two strength training sessions per week, over 150 minutes of intense exercise, and approximately 75 minutes of moderate aerobic exercise.

Dr. del Pozo Cruz and his associates recommended combining at least 150–225 minutes of moderate physical activity with approximately 75 minutes of vigorous exercise, as well as two or more strength training sessions per week, to lower the risk of death specifically associated with cardiovascular disease. Dr. Brocklesby, also known as “Eddie,” is a prime example of the value of mixing up your workout routines. In fact, preparing for and competing in a triathlon entails strength training in addition to a balanced “diet” of moderate to intense exercise. Triathlons are endurance multisport races in which competitors swim, cycle, and run. What is the minimal “amount” of exercise that could help prevent some of the conditions that pose the greatest threat to health, though, for those who are not nearly as athletic? Dr. Del Pozo Cruz and associates might have also discovered a response to this query. The results of a prior study were released in the European Heart Journal in December 2022. According to this study, even two minutes a day of intense exercise could significantly reduce the risk of dying from cancer or cardiovascular events.

The study participants who never participated in intense exercise had a 4 percent chance of passing away within 5 years, but this risk was halved when they started participating in less than 10 minutes of intense activity each week, according to the researchers. Furthermore, the risk of death was further reduced by half for those who exercised for at least 60 minutes a week. Dr. del Pozo Cruz stressed in our podcast that practically any amount of exercise, no matter how small, is better than none at all. A recent study supports this assertion, saying that any activity, no matter how small, is better for heart health than leading a sedentary lifestyle. He did, however, issue a warning that, in contrast to exercise done for enjoyment, physical activity connected to household tasks or employment may occasionally cause more harm than good. Once more, new research indicating a connection between physically demanding jobs and an increased risk of cognitive impairment lends credence to his theory.

The study found that jobs involving a lot of standing and handling stressful situations, like nursing and caregiving, retail, and farming, were among the most frequently linked to intense physical activity. Therefore, even though physical activity of any kind is beneficial to health, engaging in intense or strenuous physical activity while working may increase the risk of developing certain illnesses. Furthermore, recreational exercise has been shown to have an impact on joint integrity and other aspects of physical health, especially as one ages. Dr. del Pozo Cruz and Eddie both stressed in our podcast how important it is to speak with a reliable healthcare professional who can offer personalized advice on the best types of exercise to undertake. Listen to our podcast episode in full below or on your preferred streaming platform to learn more about how and why various forms of exercise can support longevity, as well as to hear Edwina’s story of becoming “Iron Gran.”.

REFERENCES:

https://www.medicalnewstoday.com/articles/in-conversation-why-exercise-is-key-to-living-a-long-and-healthy-life
https://www.who.int/news-room/fact-sheets/detail/physical-activity
https://www.cdc.gov/physicalactivity/basics/pa-health/index.htm
https://www.heart.org/en/healthy-living/fitness/fitness-basics/why-is-physical-activity-so-important-for-health-and-wellbeing

For medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com

Parkinson’s disease and dementia may have an impact on the brain due to nanoplastics.

November 22, 2023 blogadmin Comments 0 Comment

Scientists at Duke University School of Medicine have discovered that nanoplastics alter a particular protein in the brain, which results in alterations connected to dementias other than Parkinson’s. Worldwide, Parkinson’s disease affects more than 10 million individuals. Scientists are aware that a person’s lifestyle, genetics, and environment all contribute to the development of disease. Researchers at Duke University School of Medicine discovered that a particular protein in the brain is impacted by nanoplastics, which are minuscule plastic particles that break down in the environment and can seep into soil and water. These changes have been connected to Parkinson’s disease and other forms of dementia. Science Advances, a journal, published the study recently. Parkinson’s disease is thought to be the neurological ailment with the fastest global growth rate. According to research, the condition affects over 10 million people worldwide. For now, there is no treatment for Parkinson’s disease. Although the exact cause of the illness is still unknown, scientists do know that genetics, lifestyle choices, and environmental factors all have an impact.

Parkinson’s disease is not usually heritable or transmissible, according to Dr. Andrew West, professor in the Department of Pharmacology and Cancer Biology at Duke University School of Medicine and the study’s principal investigator. Environmental exposure to toxins and pesticides is thought to be a contributing factor in the disease’s risk. Dr. West told Medical News Today, However, the known environmental risks account for a very small percentage of what may be lurking out there, increasing our risk of getting sick. Once we have determined that there is a real risk of disease or that the disease will progress due to environmental factors, we can take precautions to reduce that risk. Mr. According to West, he and his colleagues first used various kinds of nanoparticles to help with biomarker assays for dementia and Parkinson’s disease diagnosis. By coincidence, they discovered that a protein called alpha-synuclein, which has been connected to brain disorders, could be greatly inhibited by some forms of nanoparticles.

In this study, three test tube models, cultured neurons, and a Parkinson’s disease-modeling mouse were utilized by the researchers. Dr. West and his colleagues discovered that the alpha-synuclein protein is drawn to and accumulates in response to nanoparticles of the plastic polystyrene used to make foam packing peanuts, egg cartons, and disposable drinking cups. Dr. West said, We discovered through various assays that nanoplastics may sever portions of the alpha-synuclein protein, which typically binds to lipids in the brain, and twist the protein into a form that may encourage aggregation associated with disease.. But the issues don’t end there; the plastics may also damage the machinery that is meant to break down aggregates, which are part of the lysosome, a component of the cell. Dr. West continued, We believe the interactions we observed in the model are driven by this ‘two-hit’ mechanism.

Microplastics are the first tiny particles formed when plastic degrades in the environment. After that, the microplastics keep breaking down to create new ones. According to a March 2022 study, people’s gastrointestinal tracts absorb roughly 5 grams of microplastic and nanoplastic per week on average. The general health of an individual may be harmed by both microplastics and nanoplastics, according to earlier research. For instance, studies have shown that nanoplastics may be connected to specific cancer types and can also interfere with the normal functions of lung and liver cells. Furthermore, there has previously been research on the connection between brain health and nanoplastics. According to studies that were released in June 2020, the brain can be adversely affected by micro- and nanoplastic exposure, which increases the risk of neuronal disorders. According to a study that was released in April 2023, mice that consumed nanoplastics had lower short-term memory and cognitive function.

According to Dr. West, these findings strongly suggest that technology should be developed to track the build-up of plastic pollution in the human brain and to track the susceptibility of various individuals to Parkinson’s disease and other neurological disorders based on their individual exposures. We could create laws and technological solutions to ensure that harmful nanoplastic actors stay out of our food and water if we understood the precise molecular makeup of these individuals. As for the research’s next steps, Dr. West stated that they hope to conduct longer-term studies using chronic dosing to find out how various nanoplastic kinds impact various molecular processes that are thought to be responsible for disease risk and progression. In order to make our lab models more informative, he continued, we also need to have a better idea of what lifetime exposures to different types of nanoplastics look like.. MNT also discussed this study with Dr. Rocco DiPaola, a neurologist who oversees the Movement Disorder Program at Jersey Shore University Medical Center’s Hackensack Meridian Neuroscience Institute.

According to Dr. DiPaola, this study could add to our understanding of the mechanisms underlying Parkinson’s disease and other disorders linked to alpha-synuclein. It has long been believed that a major contributing factor to the development of these disorders is a combination of genetic factors and an environmental trigger. It is an additional possible cause of these illnesses. When asked how readers can protect themselves from environmental factors that may increase their risk for Parkinson’s disease and other types of dementia, Dr. DiPaola said that while there is no way to mitigate all risks, limiting exposure to toxins, such as pesticides, would be one way to limit risk. Environmental factors are likely one of many factors that play a major role in the development of Parkinson’s disease. He continued, Previous environmental studies have found increased risk with exposure to well water, growing up in a rural area, and pesticide exposure.

REFERENCES:

https://www.medicalnewstoday.com/articles/parkinsons-dementia-how-nanoplatics-affect-protein-in-brain#More-insights-into-what-may-cause-neurodegenerative-diseases
https://www.news-medical.net/news/20231117/Study-links-nanoplastics-to-Parkinsons-disease-and-dementia.aspx
https://www.sciencedaily.com/releases/2023/11/231117181023.htm
https://www.science.org/doi/10.1126/sciadv.adi8716

For parkinsons disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_293

Alzheimer’s disease is associated with hidden belly fat in middle age.

November 22, 2023 blogadmin Comments 0 Comment

It has been discovered that higher concentrations of proteins that impair brain function are linked to visceral fat in the abdomen. According to researchers, creating metrics for visceral fat may help identify Alzheimer’s disease early on. According to experts, losing belly fat may help reduce the chance of getting Alzheimer’s. Adults in their middle years who have visceral fat around their internal organs in their abdomen may be more susceptible to Alzheimer’s. Based on research presented at the annual meeting of the Radiological Society of North America, having such fat deposits could cause changes in the brain related to Alzheimer’s up to 15 years before symptoms of the neurological disease appear — and as early as age 50. In this study, middle-aged people without any indications of cognitive problems were asked to participate in order to find correlations between high body mass index (BMI) scores, obesity, insulin resistance, and fatty abdominal tissue and amyloid and tau proteins, which are known to disrupt cellular communication in the brain.

Researchers at Washington University School of Medicine in St. Louis were led by Dr. Mahsa Dolatshahi, a post-doctoral research fellow at the Mallinckrodt Institute of Radiology (MIR). Louis, the brain region known to be affected early by amyloid pathology in Alzheimer’s disease, previously reported that a higher visceral to subcutaneous fat ratio in the belly was associated with a higher presence of amyloids in the precuneus cortex. According to those researchers, there was a correlation between elevated brain inflammation and higher levels of visceral fat. According to the new study, men are more likely than women to have belly fat and Alzheimer’s diseaseNo previous study has linked a specific type of fat to the actual Alzheimer’s disease protein in cognitively normal people, despite other studies linking BMI with brain atrophy or even a higher dementia risk, Dolatshahi stated in a press release. Comparable research has not looked into the distinct roles of visceral and subcutaneous fat, particularly in relation to the amyloid pathology of Alzheimer’s disease, as early as midlife. Dr. Mary Ellen Koran, an assistant professor of radiology and radiological sciences at Vanderbilt University Medical Center, said, It makes sense that visceral fat is linked to poorer brain health since we already know it’s linked to so many bad health outcomes, including heart health. But it’s important that we do the studies like these to define that link with evidence..

Visceral fat’s inflammatory secretions may lead to inflammation in the brain, one of the main mechanisms contributing to Alzheimer’s disease, according to DolatshahiWe don’t know whether this is a cause or effect—possibly an unhealthy lifestyle is linked to worse brain health in addition to more visceral fat, said Koran, a radiology expert who has identified Alzheimer’s disease. Before we can advance this clinically, more research in this area is necessary. For instance, she stated, It needs to be investigated because I don’t think we know what a ‘normal’ amount of visceral fat is. The results, according to researchers, may make it possible to identify Alzheimer’s disease early in an at-risk groupWe now have a uniquely better understanding of why this factor may increase risk for Alzheimer’s disease by moving beyond body mass index (BMI) in better characterizing the anatomical distribution of body fat on MRI, stated Dr. Cyrus Raji, senior study author, associate professor of radiology and neurology, and director of neuromagnetic resonance imaging at MIR.

According to Koran, the issue with utilizing BMI to evaluate health risks is that it ignores people who have a lot of muscle mass. Similarly, visceral and subcutaneous fat cannot be distinguished using waist circumference as a benchmark. Since visceral fat is known to be associated with a number of negative health outcomes, the expert suggested that alternative methods of assessing visceral fat be explored. Non-invasive imaging is a good fit for this purpose. Maybe in the future, we’ll be able to measure this using an inexpensive, radiation-free technique like ultrasound. According to the study, reducing belly fat may lower the risk of Alzheimer’s. According to Taylor Wilson, founder of Active Recovery Companions and an expert in nutrition and exercise, one strategy that has been proven effective in reducing belly fat is engaging in regular aerobic exercise, which includes activities like running, swimming, cycling, and dancing. These activities raise your heart rate and increase oxygen flow throughout your body. He told Medical News Today, Your body burns calories when you engage in aerobic exercise, including those stored in the belly area.Over time, a decrease in belly fat and overall weight loss may result from this calorie burn. Furthermore, studies have demonstrated that aerobic exercise significantly reduces belly fat in comparison to resistance training alone.

We know we can target fat with exercise and a healthy diet, but there are also new, effective drugs like Ozempic coming to market, Koran continued. However, more research is needed to determine how these medications affect visceral fat and brain function over the long run. Although the Food and Drug Administration has approved Ozempic and other comparable drugs for the treatment of type 2 diabetes, most of them still lack the necessary approval to be used for weight loss. Currently, some doctors are prescribing some of those medications off-label to help patients lose weight.

REFERENCES:

https://www.medicalnewstoday.com/articles/hidden-belly-fat-in-midlife-linked-to-alzheimers-disease
https://www.insideprecisionmedicine.com/topics/patient-care/hidden-belly-fat-linked-to-higher-alzheimers-risk/
https://neurosciencenews.com/midlife-visceral-fat-alzheimers-25235/
https://www.healthline.com/health-news/this-type-of-hidden-belly-fat-linked-to-higher-alzheimers-disease-risk

For alzheimer medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_239

All highly processed foods associated with diabetes and cancer

November 21, 2023 blogadmin Comments 0 Comment

A recent study found that the emergence of several chronic conditions is linked to a diet high in ultra-processed foods. Extremely processed foods derived from animals and drinks with added sugar and artificial sweeteners are especially prone to cause diabetes, heart disease, and cancer at the same time. Experts advise against overindulging in ultra-processed foods like breads, cereals, and plant-based substitutes, even though this study did not find any such connection. Ultra-processed foods can be difficult to identify because they are usually grouped based more on processing level than nutritional value. Ultraprocessed food consumption has been connected to a number of distinct chronic illnesses, including diabetes, cardiovascular disease, and cancer. They are also connected to comorbidities, or combinations of these diseases, a large study now confirms. The study indicates that individuals with a diet high in ultra-processed foods have a 9 percent higher chance of developing cardiovascular and cardiometabolic comorbidities. The study found that beverages sweetened with artificial sweeteners and animal products had the highest increase in risk. The researchers did not discover any correlation between comorbidities, plant-based substitutes, and ultra-processed breads and cereals.

Data from the European Prospective Investigation into Cancer and Nutrition (EPIC) are analyzed in this study. A prospective cohort study is being conducted to investigate the relationships between environmental, genetic, dietary, and lifestyle risk factors and cancer as well as other diseases. The researchers examined data from 266,666 participants for the new study. The NOVA index was used to rank the foods they consumed in relation to their processing level. A median of 11.2 years of follow-up was conducted to monitor the emergence of chronic illnesses. The precise characteristics that characterize a problematically processed food are a matter of debate. This is mostly due to the fact that most modern foods require some processing, unless they are purchased straight from the farm. Healthy foods like tofu, simple bread, canned tuna or beans, and cheese can all be considered processed foods. Ultra-processed foods, or UPFs, are the main cause for concern, though. Most researchers use the NOVA index, which was created by Carlos Monteiro and associates at Sao Paolo University in Brazil, as the standard. The World Health Organization’s scientist in nutrition and metabolism and lead investigator for the new study, Dr. Heinz Freisling, described how the index operates as follows: NOVA classifies foods into four categories: fresh or minimally processed, culinary ingredients, processed, and ultra-processed, not according to their nutrient profile.

The final category, according to study observer Michelle Routhenstein, a preventive cardiology dietitian at EntirelyNourished . com, is foods that are made solely with a combination of industrial processes. There is still opportunity for individual opinions because ingredients play a significant role in the overall story and processing level alone does not tell it all. According to Dr. Dot Freisling, foods classified as [u]ltra-processed are those that are unfit for home preparation due to a shortage of ingredients and equipment. Colorants, artificial sweeteners, food preservatives, and other substances are a few examples of these ingredients. It is not yet clear why ultra-processed foods show this strong link with a wide range of conditions, which makes it a hot topic of research why consuming them might lead to comorbidities, according to Dr. Freisling. He surmised that it might be related to the easily accessible and reasonably priced nature of these foods for the end user. People often overindulge in these because they are meant to be flavorful and shelf-stable. For instance, according to Dr. Freisling, a bag of tortilla chips can easily defeat a simple boiled corn cob. He added that artificial sweeteners and other additives might be involved. He went on to say that the modified food matrix, which is a food’s natural structure or matrix at the microscopic level, and the complete absence of dietary fiber might both be significant factors. Routhenstein pointed out that the process. She also mentioned that ultra-processed foods like chips, crackers, and cookies have the highest AGE levels per gram.

REFERENCES:

https://www.medicalnewstoday.com/articles/ultra-processed-foods-linked-to-cancer-diabetes
https://www.wcrf.org/latest/news-and-updates/new-study-reveals-ultra-processed-foods-linked-to-increased-cancer-risk-diabetes-and-heart-disease/
https://www.healthline.com/health-news/ultraprocessed-foods-cause-heart-disease-cancer
https://www.imperial.ac.uk/news/242892/ultra-processed-foods-linked-increased-risk-cancer/

For cancer medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_115

Can heart attacks and strokes be prevented with semaglutide injections such as Ozempic

November 21, 2023 blogadmin Comments 0 Comment

In a large new randomized controlled trial, semaglutide—the active ingredient in weight-loss medications Ozempic and Wegovy—significantly decreased the number of cardiac events in individuals without diabetes. Every study participant had pre-existing cardiovascular disease, defined as a BMI over 27 and a history of a heart attack, stroke, or symptomatic peripheral arterial disease. Even though semaglutide-associated weight loss is probably a contributing factor to the decrease in cardiac events, the study’s authors observed a decrease in events even prior to reaching maximum weight loss. The chemical name for the blood-sugar-controlling medications Rybelsus, Wegovy, and Ozempic—which were created for diabetics—is semaglutide. Additionally approved as weight-loss drugs in the U.S. are Ozempic and Wegovy. S. According to earlier studies, semaglutide lowers the risk of cardiovascular disease in diabetics. According to a recent large-scale international trial, semaglutide may have positive cardiovascular effects even in those without diabetes. The new study found that taking semaglutide for three years reduced heart attacks, strokes, and deaths by 20% for individuals with pre-existing cardiovascular disease (CVD) who were overweight or obese and took a placebo.

More than 17,000 persons with preexisting cardiovascular disease who were overweight or obese were enrolled in the randomized, controlled study. Neither type 1 nor type 2 diabetes was present. 15,425 participants ultimately finished the trial. On semaglutide, study participants lost an average of 9.4% of their body weight. Semaglutide causes weight loss that lasts as long as the patient takes the drug. It is usually taken for the rest of one’s life. Even though a significant weight loss may lower cardiovascular disease risk factors, the trial indicates that more is happening. Dr. 1. Semaglutide is a GLP-1 agonist; according to Michael Lincoff, it’s a hormone that’s derived from the gut. GLP-1 agonists are released into the gastrointestinal tract and work by going to the brain’s hunger centers to suppress appetite and cravings, according to Dr. Jayne Morgan, a cardiologist and clinical director of the Piedmont Healthcare Corporation’s Covid Task Force in Atlanta, Georgia, who was not involved in the study.

Semaglutide can inhibit glucagon, enhance the production of insulin, and slow stomach emptying by activating receptors in the pancreas. The result of all these activities is a decrease in food intake and appetite. The study’s authors speculate that participants’ heart health was enhanced by more than just losing weight. Dr. Lincoff stated, We saw differences in the [number of cardiovascular] event rates very early on, within a few months of starting the drug, but the maximum weight loss didn’t occur until 65 weeks after starting the drug. Dr. GLP-1 agonists stimulate the same receptors which are present in a lot of different parts of the body, according to Lincoff. These can be found in the pancreas, heart, blood vessels, brain, gut, and other organs. Dr. Nicole Weinberg, a cardiologist who was not involved in the study, hypothesized that semaglutide’s benefits for CVD patients might be related to a decrease in blood sugar levels that cause inflammation all over the body. Dr. Weinberg stated, The more chronic inflammation you have in your body, the more at risk you are for a variety of different conditions.

In cardiology, inflammation or the depositing or plaquing of cholesterol within the body are two of our main concerns. And a lot of that can be caused by the inflammation that high blood sugar causes, Dr. Weinberg went on. Furthermore, blood sugar spikes might not only affect those who have diabetes. Dr. Dot Weinberg continued, We’re beginning to understand that people have blood sugar spikes, and even just spikes in blood sugar are dangerous to people’s cardiovascular health.. Dr. Perhaps their blood pressure and cholesterol are well-managed, but we’re still seeing that there are continued levels of atherosclerosis that are depositing despite what one would consider to be traditional medical therapy, stated Weinberg, indicating that she will support semaglutide for specific patients. High blood pressure, diabetes, and other factors are frequently linked to obesity’s negative health effects. Semaglutide is the first medication that can directly lower the risk of obesity, according to Dr. Lincoff, who also stated that obesity carries an excess risk of heart disease, and that risk is not completely explained by or controlled by risks associated with high body weight.. As modifiable risk factors, high blood pressure, diabetes, smoking, and cholesterol put us in the same place. Beside those, obesity is another modifiable risk factor that can be controlled in order to prevent heart disease.

The price and accessibility of semaglutide are two practical problems. Dr. The drug costs $1,300 a month, according to Morgan, which is problematic if the medication is meant to be a lifetime maintenance treatment for heart disease, diabetes, and obesity prevention and mitigation. The annual cost of this medication alone is close to $16,000. Weinberg brought up U’s limited character. S. coverage for semaglutide insurance. It remains inaccessible to certain individuals. I believe that as research and data increase, obtaining this medication will get easier and easier for people, the speaker stated. Dr. Morgan would have preferred that the trials included a more representative sample of participants. Despite making up more than 51% of the global population, women made up only 28% of trial participants. Moreover, this trial did not even identify menopausal women, who have the highest risk of heart disease, she said. According to her, Black [people] fared even worse, comprising just under 4 percent of trial participants, despite making up nearly 18 percent of the world’s population. 9 percent of the world’s population is white, yet 85 percent of the study participants were white. Dr. Morgan stated that the medication may be a potential game-changer for diabetes management, obesity management, and cardiovascular health, especially as we age, even though more research is needed and accessibility concerns need to be resolved. The leading cause of death in the United States is heart disease. S. Heart disease was not overthrown, she noted, even during the height of the COVID pandemic. She stated, The cardiac endpoints are crucial pieces of information that continue to boost these compounds into prime time and beyond, with our growing obesity and diabetes epidemics in younger and younger demographics.

REFERENCES:

https://abcnews.go.com/GMA/Wellness/semaglutide-helps-reduce-risk-heart-attack-stroke-people/story?id=104844299
https://www.uchealth.org/today/wegovy-study-finds-weight-loss-drug-semaglutide-cuts-heart-attacks-strokes-cardiac-deaths/
https://www.healthline.com/health-news/semaglutide-reduces-heart-attack-stroke-risk
https://www.medicalnewstoday.com/articles/semaglutide-injections-ozempic-wegovy-help-prevent-heart-attacks-stroke

For heart disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_99