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Resist age-related cognitive decline with daily probiotics.

Resist age-related cognitive decline with daily probiotics.

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According to the outcomes of a scientific experiment, those with mild cognitive impairment who took a probiotic for 30 days performed better on cognitive tests.

After the trial, those who took probiotics had lower levels of a type of bacteria linked to cognitive impairment in their gut microbiomes.

According to the research, altering gut flora may be a promising strategy for treating chronic illnesses like cognitive impairment.

Probiotic therapy may help persons with moderate cognitive impairment (MCI) regain cognitive function, according to a clinical investigation.

There is an urgent need for more research,” declared Mashael R. Aljumaah, the primary study author and a doctorate candidate in microbiology at the University of North Carolina at Chapel Hill, in light of the global rise in dementia and Alzheimer’s disease (AD).

People with cognitive impairment were given daily probiotics of Lactobacillus rhamnosus GG during the double-blind randomised study. Also, after three months, their cognitive test results improved.

The researchers examined the participants’ stool samples and discovered significant quantities of Lactobacillus rhamnosus GG, or LGG, as well as a decrease in the quantity of Prevotella, a different family of bacteria frequently detected in individuals with cognitive deterioration.

These alterations imply a favourable change in the microbiota makeup of the subjects.

“Numerous earlier animal investigations, which showed LGG’s beneficial effects on several physiological situations, led to its development as a possible therapeutic probiotic. As a probiotic, LGG is also well-known for its capacity to withstand acidity and stick to intestinal walls,” according to lead researcher Michael R. Aljumaah.

Probiotic’s effects on mild cognitive impairment

To conduct the study, researchers contrasted those who had minor cognitive impairment with those who did not.

They aimed to spot, comprehend, and try to sway the early phases of cognitive deterioration. Finding biomarkers that could indicate the onset of cognitive decline was a part of that endeavor.

The age range of the 169 participants in the clinical trial ranged from 52 to 75 years old. As a control group, those without cognitive disorders were assigned to one group. People with cognitive problems were assigned to another group.

For three months, either LGG or a placebo was given to both groups. There were no negative effects in either group.

Prevotella, one such biomarker, was discovered in adults with cognitive impairment by Aljumaah and her coworkers. The fact that receiving LGG seemed to lessen its presence points to a potential future for microbiome re-balancing.

Aljumaah added, “By developing microbiome-targeted therapies, we may be able to delay the onset of cognitive impairment.”

Prevotella bacteria and long-term illnesses

Aljumaah clarified that while the Prevotella family of bacteria is present in persons with cognitive loss, it is not totally evident that their effect is solely detrimental.

For instance, the bacteria Prevotella has been linked to autoimmune, inflammatory, and cognitive disorders. According to Aljumaah, it is frequently discovered in persons who have Crohn’s disease or inflammatory bowel disorders such rheumatoid arthritis (RA).

Additionally, because it originates from plant-based diets, Prevotella bacteria may aid in the processing of fiber and is linked to metabolites that are crucial for maintaining gut health.

This raises the question of whether specific Prevotella species or strains may contribute to these illnesses, or whether a particular genetic characteristic or mechanism may be to blame, Aljumaah observed.

Greater research with LGG bacteria is required.

Board-certified neurologist Dr. Santosh Kesari, director of neuro-oncology at the Pacific Neuroscience Institute in Santa Monica, California, who was not involved in the study, told MNT that he considered the participants’ receiving cognitive advantages “intriguing.”

However, Dr. Kesari urged further investigations to confirm their findings and make sure that adding LGG bacteria doesn’t have any negative side effects.

He also raised concern that an attempt to treat a condition by adding a probiotic to the gut microbiome would upset the bacterial equilibrium, leading to negative effects.

“Focusing on a positive effect on brain health could have a counterproductive effect in another organ system,” Dr. Kesari warned.

Health effects of the gut-brain relationship

It’s crucial to keep in mind that our knowledge of the precise pathways tying the gut microbiome to cognitive function is still in its infancy, according to Aljumaah.

According to Aljumaah, “more specifically, our understanding about which members of the gut [microbiome] are involved remains limited.”

Aljumaah also suggested a number of potential routes for communication between the two dispersed bodily regions, including the vagus nerve and the immune system.

Additionally, metabolites like short-chain fatty acids and even neurotransmitters made by the gut flora may be implicated.

Dr. Kesari proposed that the microbiome’s influence on brain function might be more indirect.

The microbiome is really the doorway for nutrition, nutrients, and how things are metabolized, according to Dr. Kesari, therefore it has a huge impact on overall body health, including brain function. “You are what you eat, as the saying goes, and this is really the scientific proof of that,” said Dr. Kesari.

Improving health outcomes by changing the microbiome

Undoubtedly, the microbiome is medicine’s most challenging and exciting frontier in terms of human health. Prevotella serves as an illustration of how the microbiome is likewise a challenging field of research.

Whether or not researchers can ever fully comprehend the microbiome to control or rebalance its residents, Dr. Kesari said, “I think it has to get there.”

We are aware that nutrition and obesity are the main causes of morbidities in the United States. Many of these conditions are preventable, and the microbiome plays a role in some of them. There is no chance that our eating patterns will change very soon. So, in my opinion, the only solution to lessen the cost pressures of healthcare is if we can obtain a probiotic that may help us stay healthier, said neurologist Dr. Santosh Kesari.

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Latest note on dry eye treatment with probiotics.

Latest note on dry eye treatment with probiotics.

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Dry eye, a disorder in which the eyes are unable to sufficiently lubricate themselves, affects about 12% of the world’s population. The dry eye condition is now incurable.

Researchers from Houston, Texas’ Baylor College of Medicine have discovered a probiotic bacterial strain that enhanced dry eye in a mouse model.

Dry eye is a disorder where the eyes do not produce enough tears to keep them adequately lubricated, resulting in pain, and affects about 12% of the world’s population.

The symptoms of dry eye disease can be managed with a variety of treatments even if there is currently no cure for the condition.

These remedies include over-the-counter eye drops, prescription drugs, and surgical procedures including inserting punctual plugs into the tear ducts of the eye.

Currently, scientists from Houston, Texas Baylor College of Medicine have discovered a probiotic bacterial strain that enhanced dry eye using a mouse model.

Dry eye: what is it?

Even though most people equate tears with sobbing, healthy eyes constantly generate tears. These tears, collectively referred to as the tear film, lubricate the eye, clear away any foreign objects, and shield the eyes from infection as a person blinks.

Dry eye illness can occasionally be brought on by an individual’s eyes not producing enough natural tears. There are several causes for this, including:

  • an issue with the tear film
  • tears that dry up too soon
  • age greater than 50
  • taking specific prescription drugs, like antihistamines
  • environmental problems such as wind, smoke, and arid weather
  • eyelid abnormality
  • prolonged use of contact lenses

having certain illnesses, such as thyroid problems, lupus, rheumatoid arthritis, diabetes, or Sjögren’s syndrome.

Dry eye disease symptoms include:

  • feeling of stinging, stinging, or scratchiness in your eyes
  • like there is something in your eye
  • mucous around or in the eyes
  • sensitivity to light
  • inflamed or red eyes
  • Using contact lenses is challenging
  • fuzzy vision
  • eyes that are very wet.

Dry eye can result in eye infections and even damage to the cornea if it is not properly recognized and treated. Severe corneal injury may possibly result in visual loss.

The tummy and dry eyes

Previous studies suggest that dietary modifications may help manage dry eye in addition to medication interventions.

Omega-3 supplements dramatically reduced the symptoms and indicators of dry eye disease in patients with the condition, according to a 2019 study.

In 2019, another study found that giving persons with dry eye conditions short-term vitamin A supplements helped to improve the quality of their tears.

Finding innovative treatments for dry eye is crucial, according to Dr. Laura Schaefer, assistant professor of molecular virology and microbiology at Baylor College of Medicine in Houston, Texas, and study’s lead author.

Only a few medications are now available to treat dry eye, and for some individuals, these medications do not perform very well to alleviate symptoms, she explained. In the U.S., dry eye affects about 1 in 20 people.

Since their prior research demonstrated a functional connection between gut bacteria and the symptoms of dry eye disease, Dr. Schaefer said she and her team chose to concentrate on studying a probiotic bacterial strain in the gut to treat dry eye.

She explained, “We conducted a number of trials utilising gut bacteria taken from Sjögren syndrome patients who have severe dry eye, from healthy patients with no eye disease. In dry settings, mice colonised with gut bacteria from Sjögren patients exhibit worse dry eye symptoms than mice colonised with gut bacteria from healthy patients.

“This suggests that the gut bacteria from healthy people protect the surface of the eye in dry conditions, and therefore one possible treatment avenue for dry eye would be probiotic bacteria that have similar protective effects,” Dr. Schaefer continued.

Probiotic bacteria research for dry eye

Dr. Schaefer and her team used a mouse model of dry eye for this study. First, mice received an antibiotic to eradicate “good” bacteria from their digestive tracts. After that, they were given either the probiotic bacterial strain Limosilactobacillus reuteri DSM17938 or a saline solution as a control before being placed in extremely dry conditions.

After 5 days, researchers discovered that mice fed the probiotic bacterial strain had ocular surfaces that were healthier and more intact than mice given saline fluid.

The mice given the probiotic bacteria also had more goblet cells in the tissue of their eyes. The cells known as goblet cells are responsible for producing mucin, a crucial component of tears.

“Our hypothesis was that the probiotic would be protective of the eye, and it was exciting to prove that is true,” stated Dr. Schaefer. It has been demonstrated via extensive research that the probiotic strain DSM17938 reduces inflammation in other tissues, most notably the gut, and enhances intestinal barrier function. However, it hasn’t previously been assessed in relation to the eye.

Future therapeutic options

We also discussed this study, in which he was not engaged, with Dr. Benjamin Bert, an ophthalmologist at Memorial Care Orange Coast Medical Centre in Fountain Valley, California.

“It was actually a pretty fascinating study to see the multi-components that are involved with both our understanding of the dry eye and then also our future abilities to treat dry eye,” he said.

Taking supplements, such as omega-3 supplements, has previously been found to be helpful for treating people with particular forms of dry eye. So it’s exciting to consider the gut microbiome as a potential therapy target, Dr. Bert said.

He explained that since this study was conducted using a mouse model, a human study would be required as the next phase in the investigation.

“It would be really interesting to see this used as a supplement in a human trial to really prove what their hypothesis is, of this being a significant benefit or a possible treatment that could be used for patients with dry eye,” he continued.

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Know how antibiotics can affect your body weight.

Know how antibiotics can affect your body weight.

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It is frequently stated that there is no magic weight-loss medicine. However, a recent University of Chicago study that looked at how the immune system, gut flora, and food. They suggested that the same type of medication used to treat ear infections and strep throat may also be useful in helping us lose excess weight.

According to study researcher of the University of Chicago MD-PhD, the findings point to a potential link between weight gain. Also, the types of bacteria found in the gut, which suggests that in the future, antibiotics that kill bacteria may join diet and exercise in the fight against obesity.

What are Antibiotics?

Antibiotics are potent drugs that treat some diseases and can even save lives. They either kill germs or prevent them from multiplying.

The immune system can usually eliminate bacteria before they grow and produce symptoms. Even if symptoms appear, the immune system is typically able to handle and ward off the infection. This is because white blood cells (WBCs) destroy harmful germs.

However, occasionally there are too many dangerous germs for the immune system to completely eliminate. The usage of antibiotics is appropriate here.

Penicillin was the original antibiotic. Ampicillin, amoxicillin, and penicillin G are just a few examples of penicillin-based antibiotics that are still readily available and have been used for many years to treat a range of illnesses.

Modern antibiotics come in a variety of forms, but in the US, they are often only available with a prescription. Over-the-counter (OTC) creams and ointments contain topical antibiotics.

Antibiotics and weight loss

Our bodies naturally create lymphotoxin, which controls the immune system’s role in promoting the growth of some types of bacteria (specifically, the kind that encourages weight gain) in the stomach. And we consume some bacteria: Probiotics, often known as beneficial bacteria, are an increasingly well-liked addition to foods like probiotic yoghurt and pills.

Probiotics, often known as beneficial bacteria, are an increasingly well-liked addition to foods like probiotic yoghurt and pills.

According to certain professionals, antibiotics may be specifically formulated to encourage weight reduction. Since they can simultaneously boost the growth of some bacteria while inhibiting the growth of other bacteria. However, there are more than 500 different bacterial strains in the intestine, and it is yet unclear which specific strains prevent weight growth. Only then may these bacteria be used to combat fat.

Antibiotics and weight gain

Surprisingly, scientists have been aware that antibiotics contribute to weight growth for more than 70 years. According to a 1955 New York Times article, the pharmaceutical corporation Pfizer actually sponsored a contest among its animal feed salesmen to determine who could put on the most weight. These men got onto a scale in front of a crowd in a hotel ballroom after eating food spiked with antibiotics.

Antibiotics have been linked to weight gain, and this is supported by data as well as anecdotes. Numerous studies all support the same conclusion. For instance, a 2018 study that compiled more than 12 studies involving more than 500,000 kids found that infants who received antibiotics were more likely to be overweight. These weight gains persist into adulthood, according to a more recent study that was published in Nature Reviews Endocrinology.

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