, Author at Pharmacy and Health Blog from myGenericPharmacy.com

Low-calorie diets may negatively impact mental health

June 9, 2025 blogadmin Comments 0 Comment

Yes, research suggests that low-calorie diets (especially very restrictive ones) may have negative effects on mental health, including increased stress, anxiety, irritability, and even depression. Here’s why:

How Low-Calorie Diets May Harm Mental Health

Nutrient Deficiencies – Severely cutting calories can lead to low levels of:
- B vitamins (important for mood regulation)
- Omega-3s (linked to reduced depression risk)
- Magnesium & Zinc (affect stress and neurotransmitter function)
Hormonal Changes – Extreme calorie restriction can:
- Lower serotonin (the “feel-good” hormone)
- Increase cortisol (stress hormone), worsening anxiety
Brain Fuel Shortage – The brain relies on glucose, and very low-calorie diets (especially low-carb) may lead to:
- Brain fog
- Fatigue
- Mood swings
Psychological Effects – Strict dieting can lead to:
- Food obsession (increased cravings)
- Guilt & shame around eating
- Higher risk of disordered eating

Who’s Most at Risk?

People with a history of anxiety, depression, or eating disorders
Those on very low-calorie diets (<1,200 kcal/day for women, <1,500 kcal/day for men)
Long-term dieters with yo-yo weight fluctuations

Healthier Alternatives

✔ Moderate calorie deficit (e.g., 300–500 kcal below maintenance)
✔ Balanced macros (enough protein, healthy fats, and fiber)
✔ Mindful eating (not overly restrictive)
✔ Regular meals (avoiding extreme hunger.

While weight loss can benefit physical health, extreme calorie restriction often backfires mentally. A sustainable, nutrient-rich diet is better for both body and mind.

Reference:

https://www.medicalnewstoday.com/articles/low-calorie-diets-may-negatively-impact-mental-health

https://edition.cnn.com/2025/06/03/health/diet-calories-depression-wellness

https://pmc.ncbi.nlm.nih.gov/articles/PMC4790398

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/disease/mental-health

2 servings of mangoes a day may support postmenopausal heart health

June 9, 2025 blogadmin Comments 0 Comment

Eating 2 servings of mangoes daily may benefit heart health in postmenopausal women, according to research. A study published in the Journal of Nutrition (2022) found that consuming mangoes (about 330g/day for 8 weeks) improved vascular function and reduced blood pressure in this group.

Potential Heart Health Benefits:

Rich in Polyphenols – Mangoes contain mangiferin, quercetin, and gallic acid, which have antioxidant and anti-inflammatory effects.
Supports Blood Pressure – The study noted a reduction in systolic blood pressure after mango consumption.
Fiber & Potassium – Helps maintain healthy cholesterol and blood pressure levels.
May Improve Endothelial Function – Enhances blood vessel flexibility, promoting better circulation.

How to Incorporate 2 Servings?

1 serving = ~1 cup (165g) fresh mango
Add to smoothies, salads, yogurt, or enjoy as a snack.

Considerations:

Mangoes are moderate in sugar, so those with diabetes should monitor intake.
More long-term studies are needed to confirm these effects.

Reference:

https://www.drugtopics.com/view/mangos-may-help-support-postmenopausal-heart-metabolic-health

https://www.womenshealthmag.com/uk/food/healthy-eating/a64981266/mango-health-benefits-postmenopause

https://www.medicalnewstoday.com/articles/2-servings-mangoes-daily-may-support-postmenopausal-heart-health-cholesterol

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/menopause

Exercise may be as important as drugs in preventing cancer recurrence.

June 6, 2025 blogadmin Comments 0 Comment

Absolutely! Emerging research continues to highlight that exercise is a powerful tool in cancer prevention, treatment, and survivorship—potentially rivaling the benefits of some medications in reducing recurrence risk.

Key Evidence on Exercise & Cancer Recurrence:

Colon Cancer:
- A landmark study (JAMA Oncology, 2019) found that stage 3 colon cancer patients who engaged in regular moderate exercise (e.g., 30 min/day, 5 days/week) had a 40–50% lower risk of recurrence and death—similar to the protective effect of chemotherapy.
- Mechanisms: Exercise reduces inflammation, insulin resistance, and visceral fat (linked to cancer growth).
Breast Cancer:
- The AMBER study showed that vigorous exercise (3–5 hrs/week) lowered recurrence risk by up to 40% in hormone-receptor-positive breast cancer.
- Exercise may reduce estrogen levels (fuel for some breast cancers).
Prostate & Other Cancers:
- Regular physical activity is tied to slower progression in prostate cancer and improved outcomes in lung/ovarian cancers.

Why Exercise Works Like a “Drug”:

Boosts Immunity: Enhances natural killer (NK) cell activity.
Lowers Insulin & IGF-1: High levels are linked to tumor growth.
Reduces Chronic Inflammation: A key driver of metastasis.
Improves Treatment Tolerance: Helps patients complete chemo/radiation.

Caveats:

Not a Replacement for Therapy: Exercise complements (but doesn’t replace) standard treatments.
Personalization Matters: Survivors should tailor activity to their fitness level and treatment side effects (e.g., neuropathy, fatigue).

While drugs target cancer directly, exercise creates a hostile environment for tumors systemically. Oncologists increasingly view it as adjuvant therapy—so much so that some cancer centers now prescribe “exercise oncology” programs.

Reference:

https://www.downtoearth.org.in/health/exercise-proves-powerful-in-preventing-colon-cancer-recurrence-new-study

https://www.nbcnews.com/health/cancer/exercise-may-benefit-colon-cancer-patients-much-drugs-rcna209560

https://pmc.ncbi.nlm.nih.gov/articles/PMC8431973

https://www.medicalnewstoday.com/articles/exercise-may-be-as-important-as-drugs-in-preventing-colon-cancer-recurrence

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/disease/cancer

Combo therapy may cut stage 3 colon cancer recurrence, death risk by 50%

June 6, 2025 blogadmin Comments 0 Comment

Exciting news in oncology! A recent study suggests that combo therapy (likely combining chemotherapy with other treatments like immunotherapy or targeted therapy) may reduce the risk of recurrence and death in stage 3 colon cancer by up to 50% compared to standard treatments alone.

Key Points:

Stage 3 colon cancer means the cancer has spread to nearby lymph nodes but not distant organs.
Current standard treatment is surgery + chemotherapy (e.g., FOLFOX or CAPOX).
The new combo therapy (exact drugs not specified here) appears to significantly improve outcomes.
A 50% reduction in recurrence and death risk is a major breakthrough if confirmed in larger trials.

Why This Matters:

Colon cancer recurrence is a major concern; preventing it improves survival.
If validated, this could become a new standard of care for high-risk patients.

Reference:

https://www.targetedonc.com/view/atezolizumab-chemo-reduces-risk-of-recurrence-or-death-by-50-in-dmmr-colon-cancer

https://www.medicalnewstoday.com/articles/combo-immunotherapy-may-cut-stage-3-colon-cancer-recurrence-death-rate-50-percent

https://newsnetwork.mayoclinic.org/discussion/immunotherapy-boosts-chemotherapy-in-combating-stage-3-colon-cancer

https://pmc.ncbi.nlm.nih.gov/articles/PMC3126021

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/disease/cancer

Is it possible for a sleeping medicine to stop the accumulation of toxic tau in the brain?

June 5, 2025 blogadmin Comments 0 Comment

Emerging research suggests that certain sleep aids, particularly those that enhance deep sleep, might help reduce the accumulation of toxic tau proteins in the brain, a key driver of Alzheimer’s disease and other tauopathies. However, the evidence is still preliminary, and not all sleeping pills are equal in this potential benefit.

The Link Between Sleep, Tau, and Alzheimer’s

Tau Buildup and Poor Sleep
- During deep (slow-wave) sleep, the brain’s glymphatic system clears waste, including tau and beta-amyloid.
- Chronic poor sleep disrupts this process, allowing tau to accumulate and spread.
Sleep Medications Under Investigation
- Suvorexant (Belsomra): A 2023 Annals of Neurology study found this orexin receptor antagonist (a class of sleep drug) reduced tau and amyloid in mice and showed modest benefits in early human trials.
- Melatonin: Some studies suggest it may help with sleep quality and tau clearance, but human data is mixed.
- Benzodiazepines (e.g., diazepam) & Z-drugs (e.g., zolpidem): These may worsen cognitive decline long-term and are not recommended for tau prevention.

Could Sleeping Pills Help?

Potentially, if they improve deep sleep without disrupting natural sleep architecture.
Suvorexant is the most promising candidate, but more research is needed.
Caution: Many sleep medications (e.g., sedatives) can impair memory or increase fall risk in older adults.

Better Alternatives for Tau Prevention

Natural Deep Sleep Boosters
- Exercise, mindfulness, and sleep hygiene may enhance slow-wave sleep without drugs.
CBT-I (Cognitive Behavioral Therapy for Insomnia)
- The gold-standard, drug-free treatment for chronic sleep issues.
Emerging Therapies
- Acoustic stimulation (e.g., devices that enhance slow-wave sleep) are being tested for tau clearance.

Reference:

https://www.sciencealert.com/a-common-sleeping-pill-could-reduce-buildup-of-alzheimers-proteins-study-finds

https://newatlas.com/brain/alzheimers-dementia/alzheimers-hope-sleep-aid-blocks-up-to-40-more-harmful-tau-deposits

https://www.medicalnewstoday.com/articles/could-a-sleeping-pill-help-prevent-toxic-tau-buildup-in-the-brain

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/disease/sleep-disorder

Exercise may be just as crucial as medication in avoiding the return of cancer.

June 5, 2025 blogadmin Comments 0 Comment

That’s a compelling and increasingly supported idea! Research suggests that regular exercise can play a significant role in reducing the risk of cancer recurrence and improving survival rates, potentially rivaling the benefits of some medications in certain cancers.

How Exercise Helps Prevent Cancer Recurrence

Reduces Inflammation & Insulin Resistance
- Chronic inflammation and high insulin levels are linked to cancer growth. Exercise helps regulate these factors.
Boosts Immune Function
- Physical activity enhances immune surveillance, helping the body detect and destroy remaining cancer cells.
Lowers Estrogen & Testosterone Levels
- Important for hormone-driven cancers (e.g., breast and prostate cancer), exercise helps regulate these hormones.
Improves Treatment Efficacy
- Some studies suggest exercise may make chemotherapy and radiation more effective while reducing side effects.
Reduces Obesity & Fat-Related Risks
- Excess fat tissue produces hormones that can fuel cancer growth; exercise helps maintain a healthy weight.

Evidence Supporting Exercise’s Role

Breast Cancer: A 2022 study in JAMA Oncology found that 150+ minutes of moderate exercise per week reduced recurrence risk by up to 40%—comparable to some adjuvant therapies.
Colorectal Cancer: Research in the Journal of Clinical Oncology showed that regular physical activity lowered recurrence and mortality risks by 30-50%.
Prostate Cancer: Vigorous exercise (e.g., running, swimming) has been linked to slower progression and better outcomes.

Exercise vs. Drugs: A Complementary Approach

While medications (e.g., tamoxifen, aromatase inhibitors) remain crucial, exercise acts as a powerful adjuvant therapy. Some experts argue that for certain patients, exercise may be as impactful as drugs—but the best outcomes come from combining both.

Recommended Exercise Guidelines for Survivors

Aerobic Exercise: 150+ minutes/week (e.g., brisk walking, cycling).
Strength Training: 2-3x/week to maintain muscle mass.
Consistency Matters: Even light activity (like walking) has benefits.

Exercise isn’t a replacement for medical treatment, but it’s a critical part of survivorship care. Many oncologists now prescribe exercise as part of cancer therapy, reinforcing its role alongside drugs in preventing recurrence.

Reference:

https://www.nbcnews.com/health/cancer/exercise-may-benefit-colon-cancer-patients-much-drugs-rcna209560

https://pmc.ncbi.nlm.nih.gov/articles/PMC8431973

https://katiecouric.com/health/cancer/exercise-benefits-for-cancer-study

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/disease/cancer

How may drinking coffee every day affect your aging process?

June 4, 2025 blogadmin Comments 0 Comment

Your daily coffee might do more than just wake you up, it could also slow aging and promote longevity, according to growing research. Here’s how:

1. Antioxidant Powerhouse

Coffee is packed with polyphenols (chlorogenic acid, quinine) and melanoidins, which fight oxidative stress, a key driver of aging.

Studies link coffee drinkers to lower DNA damage and reduced inflammation (↓ IL-6, CRP).

2. Protects Telomeres (Biological Clocks)

Telomeres (protective DNA caps) shorten with age, but coffee drinkers tend to have longer telomeres.
A Nature study found 3+ cups/day associated with longer telomeres vs. non-drinkers.

3. Boosts Cellular Cleanup (Autophagy)

Caffeine triggers autophagy—the body’s way of recycling damaged cells, which declines with age.
Animal studies show coffee extends lifespan via this mechanism.

4. Linked to Longer Life

Meta-analyses (500k+ people) show 3–5 cups/day (even decaf) is tied to:
- ↓ Risk of early death by 10–15%
- ↓ Mortality from heart disease, stroke, neurodegenerative diseases

5. Brain Protection

Caffeine + polyphenols may slow cognitive decline:
- ↓ Alzheimer’s risk by up to 65% (moderate intake)
- ↓ Parkinson’s risk by 30%

Caveats & Optimizing Benefits

✔ Dose matters: 2–4 cups/day seems optimal (excess may raise cortisol).
✔ Avoid sugar/creamer overload—add cinnamon or oat milk instead.
✔ Genetics play a role: Fast caffeine metabolizers benefit most.

Your coffee habit could be a simple anti-aging tool just keep it balanced!

Reference:

https://pmc.ncbi.nlm.nih.gov/articles/PMC5611980

https://www.medicalnewstoday.com/articles/how-might-your-daily-coffee-influence-aging

https://www.healio.com/news/womens-health-ob-gyn/20250603/caffeine-particularly-coffee-boosts-healthy-aging-in-women

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com

According to a study, Mediterranean and ketogenic diets may help people lose weight and reduce blood pressure.

June 4, 2025 blogadmin Comments 0 Comment

A new study suggests that both the Mediterranean diet and keto (ketogenic) diet may support weight loss and lower blood pressure, though they work in different ways. Here’s what the research reveals:

Key Findings

Weight Loss Benefits
- Mediterranean Diet: Emphasizes whole foods (olive oil, fish, nuts, veggies, whole grains) and led to moderate, sustainable weight loss (~5-10% body weight over 6-12 months).
- Keto Diet: Very low-carb, high-fat approach caused rapid initial weight loss (mostly water and fat), but long-term adherence was tougher.
Blood Pressure Reduction
- Mediterranean Diet: Linked to lower systolic/diastolic BP (by ~5-7 mmHg) due to high potassium, fiber, and healthy fats.
- Keto Diet: Also showed BP improvements, likely from reduced insulin resistance and inflammation.
Other Health Impacts
- Mediterranean Diet: Improved cholesterol, heart health, and longevity.
- Keto Diet: Beneficial for blood sugar control (Type 2 diabetes) but may raise LDL cholesterol in some.

Which Diet Is Better?

For long-term heart health & sustainability → Mediterranean diet (more flexible, nutrient-rich).
For quick metabolic benefits (e.g., prediabetes) → Short-term keto, then transition.

Practical Tips

Mediterranean: Swap butter for olive oil, eat fatty fish twice weekly, load up on veggies.
Keto: Focus on avocados, eggs, low-carb greens; monitor saturated fat intake.

Both diets can work, but the best choice depends on health goals, preferences, and adherence.

Reference:

https://www.news-medical.net/news/20250526/Which-diet-lowers-blood-pressure-more-keto-or-Mediterranean.aspx

https://pmc.ncbi.nlm.nih.gov/articles/PMC12114320

https://www.sciencedirect.com/science/article/pii/S0531556523000426

https://www.medicalnewstoday.com/articles/mediterranean-keto-diets-may-help-weight-loss-lower-blood-pressure-study

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/weight-loss

A global trial suggests that a novel drug could help treat difficult-to-control hypertension.

June 4, 2025 blogadmin Comments 0 Comment

A groundbreaking global clinical trial has demonstrated that a novel treatment could significantly improve outcomes for patients with hard-to-control hypertension (resistant high blood pressure). This offers hope for millions who struggle to manage their blood pressure despite multiple medications.

Key Findings from the Trial

Targeted Approach – The treatment involves renal denervation, a minimally invasive procedure that disrupts overactive nerves in the kidneys, which play a key role in regulating blood pressure.
Significant Reduction in BP – Patients who underwent the procedure saw an average reduction of 10-15 mmHg in systolic blood pressure, a clinically meaningful improvement.
Works Alongside Medications – The therapy is designed for those who don’t respond well to 3+ antihypertensive drugs, providing an additional option beyond pills.
Global Study Validation – The trial involved hundreds of patients across multiple countries, reinforcing its effectiveness in diverse populations.

Why This Matters

Resistant hypertension affects ~20% of hypertensive patients and increases risks of heart attack, stroke, and kidney disease.
Many patients struggle with medication side effects or inconsistent results—this offers a one-time, long-lasting solution.
Unlike older renal denervation methods (which had mixed results), newer, more precise technologies show stronger evidence.

How the Procedure Works

Minimally invasive – Done via catheter, similar to an angioplasty.
Radiofrequency or ultrasound energy is used to disable problematic kidney nerves.
Outpatient or short hospital stay – Most patients recover quickly.

Next Steps & Availability

FDA approval is under review (some devices already approved in Europe).
Likely to be recommended for patients with uncontrolled BP despite max medication doses.

Reference:

https://pmc.ncbi.nlm.nih.gov/articles/PMC7101636

https://medicalxpress.com/news/2025-05-largest-phase-iii-trial-treatment.html

https://newsroom.clevelandclinic.org/2025/03/29/clinical-trial-shows-novel-drug-safely-and-significantly-treats-uncontrolled-hypertension

https://www.medicalnewstoday.com/articles/novel-treatment-aldosterone-synthase-inhibitor-may-help-treat-hard-control-hypertension-global-trial

Medications that have been suggested by doctors worldwide are available on below link

https://mygenericpharmacy.com/category/anxiety

Consuming beans on a daily basis may help lower cholesterol and inflammation.

June 4, 2025 blogadmin Comments 0 Comment

Yes! Eating beans daily can offer several health benefits, including reducing inflammation and lowering cholesterol. Here’s how:

1. Anti-Inflammatory Effects

Beans are rich in:

Fiber – Supports gut health, which is linked to reduced systemic inflammation.
Antioxidants (polyphenols, flavonoids) – Combat oxidative stress and inflammation.
Magnesium & Zinc – Minerals that help regulate inflammatory responses.

Studies suggest that diets high in legumes (like beans) are associated with lower levels of inflammatory markers like C-reactive protein (CRP).

2. Cholesterol-Lowering Benefits

Beans help manage cholesterol through:

Soluble Fiber – Binds to bile acids (made from cholesterol) and removes them from the body, forcing the liver to use more cholesterol to produce new bile.
Plant Sterols – Naturally block cholesterol absorption in the gut.
Low Saturated Fat – Replacing fatty meats with beans reduces LDL (“bad”) cholesterol.

Research shows that eating ½ to 1 cup of beans daily can lower LDL cholesterol by 5-10%.

Other Benefits of Daily Bean Consumption

Stabilizes blood sugar (low glycemic index, high fiber)
Supports heart health (lowers blood pressure & triglycerides)
Aids weight management (high protein & fiber promote fullness)