A global trial suggests that a novel drug could help treat difficult-to-control hypertension.
A groundbreaking global clinical trial has demonstrated that a novel treatment could significantly improve outcomes for patients with hard-to-control hypertension (resistant high blood pressure). This offers hope for millions who struggle to manage their blood pressure despite multiple medications.
Key Findings from the Trial
- Targeted Approach – The treatment involves renal denervation, a minimally invasive procedure that disrupts overactive nerves in the kidneys, which play a key role in regulating blood pressure.
- Significant Reduction in BP – Patients who underwent the procedure saw an average reduction of 10-15 mmHg in systolic blood pressure, a clinically meaningful improvement.
- Works Alongside Medications – The therapy is designed for those who don’t respond well to 3+ antihypertensive drugs, providing an additional option beyond pills.
- Global Study Validation – The trial involved hundreds of patients across multiple countries, reinforcing its effectiveness in diverse populations.
Why This Matters
- Resistant hypertension affects ~20% of hypertensive patients and increases risks of heart attack, stroke, and kidney disease.
- Many patients struggle with medication side effects or inconsistent results—this offers a one-time, long-lasting solution.
- Unlike older renal denervation methods (which had mixed results), newer, more precise technologies show stronger evidence.
How the Procedure Works
- Minimally invasive – Done via catheter, similar to an angioplasty.
- Radiofrequency or ultrasound energy is used to disable problematic kidney nerves.
- Outpatient or short hospital stay – Most patients recover quickly.
Next Steps & Availability
- FDA approval is under review (some devices already approved in Europe).
- Likely to be recommended for patients with uncontrolled BP despite max medication doses.
Reference:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7101636
https://medicalxpress.com/news/2025-05-largest-phase-iii-trial-treatment.html
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