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Important benefits between heart and regular exercises.

Important benefits between heart and regular exercises.

Although getting regular physical activity throughout the week may be challenging, it is good for cardiovascular health.

Regular moderate to vigorous physical activity during the week had similar effects on cardiovascular health as moderate to vigorous physical activity concentrated over one to two days, generally the weekend, according to a recent study.

The results demonstrated that the risk of heart attacks, atrial fibrillation (AFib), heart failure, and stroke was reduced in both “weekend warriors” and regular exercisers.`

Exercise has important health benefits, such as lowering the risk of cardiovascular disease, type 2 diabetes, and metabolic syndrome. Some people may find it challenging to engage in regular physical activity during the week, which may cause them to engage in more intense physical activity on the weekends.

A recent study compared patterns of physical activity behaviour between individuals who spread their physical activity out over the course of the week with those who concentrated their moderate to strenuous physical activity over one or two days.

According to research, both forms of exercise were linked to a similar reduction in the risk of heart attack, atrial fibrillation, heart failure, and stroke.

Weekend workouts versus weekday workouts

The present study’s researchers emphasized that the recommended amount of exercise is 150 minutes per week of moderate to intense activity.

They sought to determine whether the linked health advantages changed between two important groups:

Weekend warriors are those who engage in a sustained period of moderate to vigorous physical activity over one to two days. Individuals who evenly distribute their moderate to vigorous physical activity throughout the week

A group with activity levels of fewer than 150 minutes per week was also included by the researchers in order to establish an exact comparison. This group was deemed inactive because they fell short of the required amount of activity per week.

The UK Biobank cohort study’s nearly 90,000 participants were included in the study. Participants tracked their physical activity levels by wearing accelerometers on their wrists for a week. Based on their degree of activity, researchers categorised participants as weekend warriors, frequently active, or inactive.

A little over 42% of participants were weekend warriors. 34.7% were classified as inactive, compared to 24.4% who reported exercising frequently. In their data analysis, researchers took into account variables like age, educational attainment, and tobacco usage.

Regular exercise and weekend warrior activity both reduced the risk of AFib (an irregular heart rhythm), heart attacks, heart failure, and stroke. Similar hazards were reduced in both groups.

According to Dr. Shaan Khurshid, author of the study and director of the Demoulas Centre for Cardiac Arrhythmias at Massachusetts General Hospital, “both a weekend warrior type activity pattern and a more even activity pattern were each associated with similar reductions in risk of heart attack, heart failure, atrial fibrillation, and stroke as compared to inactive individuals.”

Limitations of the research and future directions

This study did have certain shortcomings in particular.

First, the study’s ability to generalize is constrained by the fact that it largely consisted of white, British subjects. Second, because the data only covered one week of activity, it’s likely that participants behaved differently than usual or altered their usual behavior as a result of being observed.

Researchers also point out that depending on the kind of exercise a person engages in, the accuracy of identifying moderate to strenuous physical activity can change. They employed a classification scheme that took into account a variety of activities, which might have affected the outcomes.

Finally, because this data collection occurred several years before the collection of accelerometry data, data on variables may have been incorrectly categorized.

The following study limitations were highlighted by Dr. Gregory Katz, an outside observer and assistant professor in the Department of Medicine at NYU Grossman School of Medicine’s Leon H. Charney Division of Cardiology as well as a cardiologist.

The major issue is that the study’s conclusions are somewhat constrained because participants weren’t monitored for long stretches of time in terms of tracking their exercise. They just used an accelerometer to evaluate them for seven days. This involves observing tens of thousands of people for a week of exercise and then keeping track of their health consequences for much longer than that. Thus, there is a limit to how broadly applicable this is.

Drs. Ellinor and Khurshid also identified the following areas as needing more study:

“We intend to examine if weekend warrior-style activities have comparable advantages over other human illnesses and diseases. Our findings might inspire more research on concentrated physical activity programs, which might be more useful and effective.

The importance of physical activity

As this study has shown, different people will engage in different amounts of physical exercise each week. The true problem is figuring out how to make time for physical activity in our daily life. For suitable physical activity suggestions, people should speak with their doctor. This is especially true if they are unaware of what levels and types of physical exercise are satisfactory.

Finding things you enjoy, working out with a friend, and designating certain times for exercise, according to the Centres for Disease Control and Prevention, could all help you become more active.

The important advantages of exercise were further emphasized by Dr. John Bhadorani, a board-certified interventional cardiologist at MemorialCare Heart & Vascular Institute at Saddleback Medical Centre in Laguna Hills, California, who was also not involved in the study:

Because it has a favourable effect on the heart and blood vessels, exercise is essential for cardiovascular health. Regular exercise improves cardiovascular health by strengthening heart muscle, reducing blood pressure, lowering bad cholesterol (LDL), and raising good cholesterol (HDL). Additionally, it helps people stay at a healthy weight, increases blood flow, and makes it easier for the body to use oxygen.

According to Dr. John Bhadorani, “This study suggests that this activity may not need to occur every day throughout the week but rather concentrated over 1-2 days as long as you are reaching the target of >150 minutes per week.”


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Cardiovascular benefits in elderly from antidiabetic drugs.

Cardiovascular benefits in elderly from antidiabetic drugs.

Researchers found that some types of diabetes medications can lower the risk of heart illnesses when coupled with other diabetic medications in a trial including older military veterans.

According to experts, heart health problems are widespread in diabetics, thus a larger segment of the population may benefit from the research. Drugs for GLP1, DPP4, and SGLT2 were used in the trial.

According to a study published today in the Annals of Internal Medicine, some diabetic drugs may reduce the risk of cardiovascular events when combined with other diabetes treatments.

Researchers compared conventional diabetes treatment plans to three key classes of diabetes medications: GLP1, DPP4, and SGLT2.

Recent clinical trials for novel diabetes medicines, the researchers noted:

  • tested the medications only against a placebo, not in competition with one another
  • only tested on individuals with heart disease when examining the cardiovascular benefits

The best pharmaceutical class for lowering the risk of cardiovascular disease, even in those without a history of the condition, was something the researchers sought to determine.

They claimed that when compared to DPP4 treatments, GLP1 therapies lowered the risk of adverse cardiovascular events and hospitalisations for heart failure.

Compared to DPP4 medications, SGLT2 therapies did not lower the number of hospitalisations for heart failure or cardiovascular events.

Information about the diabetic drug study

Between 2001 and 2016, the researchers examined the medical records of approximately 100,000 veterans who had been prescribed diabetes drugs including metformin, insulin, or sulfonylurea.

Then, one of the three more recent drugs—GLP1, DPP4, or SGLT2—was introduced. Following up was done until 2019.

Agonists of the GLP1 receptor included:

  • Exenatide
  • Liraglutide
  • Semaglutide

Inhibitors of SGLT2 included:

  • Empagliflozin
  • Dapagliflozin
  • Canagliflozin

Among the DPP4 inhibitors were:

  • Alogliptin
  • Linagliptin
  • Saxagliptin
  • Sitagliptin

Participants’ median ages ranged from 67 to 8.5 years, and their median time with diabetes was 8.5 years.

The results revealed:

When compared to DPP4 inhibitors, GLP1 reception agonists have a 20% lower incidence of significant adverse cardiovascular events and heart failure hospitalisations in persons with type 2 diabetes who have never had a heart condition. The risk reduction amounts to around three fewer heart failure episodes, strokes, or fatalities per 1,000 patients using the drug for a year.

When compared to DPP4 inhibitors, SGLT2 inhibitors did not lower hospitalisations for heart failure and cardiovascular events.

Dr. Kathleen Dungan, an endocrinologist at The Ohio State University Wexner Medical Centre, said that therapy should focus on effectiveness in reaching and maintaining treatment objectives for glucose and weight management.

As a result, she said, “some GLP1-based therapies have greater potential to help patients achieve these goals than SGLT2i or DPP-4 inhibitors.” The complexity and method of administration, patient desire, other co-occurring illnesses, side effects, and cost are all person-centered aspects that may be more significant.

Dungan stated that “some limitations [of this study] prevent our ability to directly apply the findings to usual care.” These include a brief follow-up period, a lack of demographic diversity, missing or incomplete data, and nonrandom prescribing patterns, any of which could affect the study findings.

He told us, “This study provides important information on using two classes of diabetes medications, especially for people without known cardiovascular disease.”

The significance of the diabetic medication research

People with diabetes have a younger average age of onset and a twofold increased risk of heart disease. According to the Centres for Disease Control and Prevention, having diabetes increases your risk of developing heart disease.

Additionally, elevated blood pressure, “bad” cholesterol, and triglyceride levels are more prevalent among diabetics. These ailments can make you more likely to experience a cardiovascular incident.

Dr. Sanjay Bhojraj, an interventional cardiologist at Providence Mission Hospital in California, remarked, “This study is a superb example of the new convergence of therapeutics for diabetes and cardiovascular diseases.”

In the past, the cardiology community has mainly refrained from optimizing diabetic drugs either out of worry over medication-related problems or out of fear of alienating other treating physicians. Primary prevention studies like this one are an appeal to cardiologists to finally enter the fray and treat diabetes like we treat cholesterol or deal with quitting smoking.”

According to Bhojraj, “Now we have real-world data, in a [veterans] population, suggesting a significant decrease in major adverse cardiovascular events using GLP-1 receptor antagonists in patients who have diabetes without prior [cardiovascular disease],” she said. This could help the doctor decide which class of diabetic medication to add to standard-of-care treatment regimens to reduce cardiovascular risk.

It’s interesting to note that both the GLP-1 and SGLT-2 medication classes had positive treatment outcomes in the whole group of individuals undergoing primary and secondary prevention.

The bottom line, the cardiology community needs to take action and incorporate glucose optimization into our treatment strategies, according to Bhojraj, “if we truly want to protect our patients from serious adverse cardiovascular events.”

Treating coexisting conditions common with diabetes

According to a 2019 study, nearly 75% of patients had at least one other chronic health condition when they received a type 2 diabetes diagnosis. 44% of people have two or more conditions.

Diabetes and a number of other common comorbid illnesses include:

  • obesity
  • dyslipidemia
  • blood pressure is high.
  • heart condition
  • renal illness
  • mental health conditions
  • sleep problems
  • cancer

According to Dr. Minisha Sood, an endocrinologist at Lenox Hill Hospital in New York, “Generally speaking, a GLP1 RA is preferred over an SGLT-2 for the weight benefit in patients with diabetes and obesity – two conditions which overlap more often than not.”

But she added, “This study also reveals another advantage of selecting a GLP1 over an SGLT-2 in patients without cardiovascular disease.”

These medications can help with other comorbid conditions as well, experts point out.

Dr. Rigved Tadwalkar, a cardiologist at Providence Saint John’s Health Centre in California, said, “This research is encouraging and supports a growing body of evidence that these medications have multiple beneficial effects.”

“GLP-1 receptor agonists are currently being used to treat obesity off-label, according to the literature. He informed us that SGLT2 inhibitors are also licensed to treat chronic renal disease and heart failure.”


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What is meant by erectile dysfunction nerve damage?

What is meant by erectile dysfunction nerve damage?

About 30 million men in the United States alone suffer from erectile dysfunction (ED), a frequent type of sexual dysfunction. If you struggle to get or keep an erection strong enough for sex, you may have erectile dysfunction.

Another possibility is that you can have an erection, but not frequently enough to engage in sexual activity when you want to. ED can be brought on by a number of things, including cardiovascular problems and psychological conditions including sexual performance anxiety.

Sometimes, issues with your neurological system can have an impact on how you behave sexually and either induce or exacerbate erectile dysfunction. The term “neurogenic” or “neurological ED” is used to describe this kind of erectile dysfunction.

Neurological ED

Any form of erectile dysfunction brought on by a neural system disorder is referred to as neurological erectile dysfunction, or neurological ED. The development and maintenance of an erection both before and during sex are significantly influenced by your neurological system.

Arousal and stimulation are the precursors to erections. The erectile tissue inside your penis receives impulses from neurons in your brain and pelvic region when you become aroused by physical contact or sexual imagery.

Due to the expansion of the blood vessels that supply your erectile tissue as a result of these impulses, more blood is pumped into your penis. The size and strength of an erection are a result of this blood.

The tunica albuginea, a fibrous membrane, contracts as blood continues to flow into your penis, trapping the blood inside the tissue and maintaining your erection, enabling you to engage in sex. Several factors influence this process such as:

This process may be disrupted when your nervous system is compromised, making it impossible for you to achieve and/or maintain an erection.

Causes of Neurological ED

There are a number of disorders that can lead to neurological erectile dysfunction, including neurological conditions that harm the nerves in specific areas of your body and injuries or surgeries that cause damage to your nervous system.

Typical neurological ED causes include:

Injuries to the neurological system

Sexual problems including erectile dysfunction and anejaculation are frequently brought on by injuries to the neurological system, such as spinal cord injuries (inability to ejaculate). These problems are frequently transient. For instance, after two years, the majority of men with spinal cord injuries resume some penile function, according to study.

Surgery on the bladder or prostate

The nerves and blood vessels surrounding the penis can be harmed during several surgical treatments for prostate or bladder cancer, which could result in erectile dysfunction. Many men discover that as they heal from this kind of surgery, their erection quality and sexual function gradually improve.

Diabetic nerve injury (nerve damage due to diabetes)

Diabetes, especially when it’s uncontrolled or inconsistently treated, can result in diabetic neuropathy, a type of nerve damage. Strong erectile dysfunction and poorly controlled diabetes have been linked in research. In fact, erectile dysfunction brought on by neuropathy affects 40 to 50 percent of men with diabetes.

A number of sclerosis

The central nervous system is harmed by multiple sclerosis (MS), which finally results in irreversible nerve loss. Erectile dysfunction may eventually result from this nerve injury. In some circumstances, drugs intended to treat MS symptoms may also cause ED.

Parkinson’s condition

Parkinson’s disease is an illness of the nervous system that worsens over time, and one of its symptoms is impotence. Other sexual difficulties, such as diminished sexual arousal and trouble initiating orgasm, are frequently experienced by men with Parkinson’s disease.


Some epileptic males experience erectile dysfunction. The levels of sex hormones like testosterone and prolactin, which are involved in sex drive and erections, may be affected by epileptic discharges as the source of this, according to experts.

Additional neurological reasons

Heavy metal toxicity and alcoholism are two more potential reasons of neurological ED, both of which can have an impact on the nerve tissue throughout your body. if you are afflicted, more than one component may be involved in the development of your neurological ED symptoms.

Symptoms of Neurological ED

Neurological erectile dysfunction, like ED brought on by poor cardiovascular health or psychological problems, can vary in severity. Those who experience neurological erectile dysfunction may:

  • having trouble getting an erection at any time or finding it impossible
  • being able to erect yet having trouble keeping it up long enough to engage in sex
  • possess the ability to erection but not frequently enough to engage in sex when you want to

Similar signs and symptoms to cardiovascular ED can be found in neurological ED.

Treatment for Neurological Erectile dysfunction

Damage to your neural system, whether through an accident, surgery, a disease that impairs nerve function, frequently results in ED. While certain neurological ED types go better with time, others need constant care and management.

Neurological ED can be treated with a variety of ED medications, gadgets, and surgical techniques. Many men discover that they can actually result in noticeable increases in their erections and sexual performance. Although they aren’t successful for everyone.

These medicines need to be discussed with a qualified healthcare provider online. They will decide whether or not a prescription is necessary.


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Is Obesity affecting the sexual health of Men?

Is Obesity affecting the sexual health of Men?


Overweight and obesity have become major public health problems worldwide, since they may reduce life expectancy by 7 years at the age of 40 years. Excess bodyweight is now the sixth biggest risk factor for the cause of global morbidity and mortality. Compared to normal weight subjects, overweight and obesity increase the risk of erectile dysfunction (ED) by 30–90%. Subjects with ED, however, tend to weigh more and have a greater waist circumference than those without, and are more likely to have hypertension and hypercholesterolemia.

A link exists between ED and the metabolic syndrome, which is characterized by insulin resistance and abdominal obesity. A higher prevalence of sexual dysfunction exists among women with metabolic syndrome compared to matched control women. Physical activity and lifestyle changes aimed at reducing body weight are associated with improvements in both erectile and endothelial functions in obese men. In addition, preliminary research suggests that a Mediterranean-style diet could improve sexual function in women with metabolic syndrome. Changing your lifestyle, including regular physical activity and a healthy diet, is an effective and safe method for preventing cardiovascular disease and premature mortality in all population groups; it may also prevent and treat sexual dysfunction for both sexes.

Low testosterone role

Males with a large amount of belly fat often have lower than normal testosterone levels, which may require treatment. Low testosterone levels are associated with increased weight gain related to high estrogen and cortisol levels in men. There are several disorders having link with low testosterone level such as,

The connection between high BMI numbers and low testosterone levels has been found in many studies about low testosterone. It has been shown that losing weight helps increase testosterone production, which can resolve problems with erectile dysfunction or impotence.

Losing weight sometimes results in men gaining lean muscle and having normal testosterone levels once again, so they can experience normal sexual stamina and performance.

Effects of poor blood circulation on ED

Erections require an increased flow of blood to the penile region, as most men already know. Several health conditions, including inflammation, hypertension, and other conditions associated with obesity, can impair the heart’s ability to pump blood efficiently throughout the body.

There are many conditions that damage the inner lining of blood vessels. It is therefore much more difficult to achieve an erection when an increase in blood is not reaching the penis.

In addition to eating a diet high in unhealthy fats, sugars, and cholesterol, obese people also tend to suffer from poor nutrition. The arteries narrow and harden when you eat a low quality diet, which can be harmful to your heart and circulatory system. In addition to affecting blood flow, atherosclerosis also causes a thickening of the arteries.

Can weight loss really help Erectile dysfunction?

YES. Fortunately, weight loss can minimize, if not completely cure the erectile dysfunction. It has been scientifically shown that losing weight is one of the leading ways to restore healthy erectile function.

Researchers found promising results when they examined the connection between weight loss and erectile dysfunction. Among the men in the study who lost weight, more than 30% reported that they regained normal sexual function after losing weight. In addition, they displayed reduced inflammatory and oxidative markers, which are also related to erection maintenance and difficulty getting an erection.

Men do not need to take drastic measures in order to lose weight to cure ED, according to the study. A decrease in daily calories of 300 and increased exercise throughout the week was all participants needed to lose weight. A diet low in calories and an increase in physical activity is usually the most effective way to burn excess fat and pounds.

It is beneficial to lose weight in two ways. In addition to improving your physical health, losing weight also improves your mental health. By simply dropping a few pounds, you can cure any conditions that could cause ED, such as high blood pressure. A healthier diet will keep your arteries from narrowing and clogging, allowing blood to flow more efficiently.

Aside from feeling more confident and having higher self-esteem, losing weight also promotes a sense of self-esteem. Bedroom anxiety can be much easier to deal with when you feel and look your happiest. Positive self-images and feelings of self-worth can make a significant difference in sexual performance and stamina.

Tips for losing weight and belly fat to counter erectile dysfunction

In order to lose weight and regain control over your health, there is no shortcut. Maintaining your weight loss requires lifestyle changes that will serve you for years to come. Following are some of the most effective ways to loose weight.

  • Lean proteins, fruits, vegetables, and whole grains should be part of a balanced diet.
  • sugary drinks must be replaced with low calorie or low sugary drinks.
  • Drinking more water also helps in loosing fat.
  • Often a combination exercise with resistance training, stretching, and cardiovascular exercises must be the part of lifestyle.

An individual can feel huge difference in the overall health by loosing weight and getting rid of excess belly fat. More importantly, regaining sexual health and confidence boost in bedroom are result of following such discipline.


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