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Hearing aids may almost 50% lower the risk of dementia.

Hearing aids may almost 50% lower the risk of dementia.

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The effect of hearing aids on slowing cognitive decline was studied in the largest clinical research to date.

Researchers discovered a 48% decrease in risk among those who were at an increased risk of dementia. The findings contribute to the body of knowledge on the relationship between hearing loss and cognitive decline.

According to the National Institute on Ageing, someone worldwide gets dementia, a group of illnesses that damage the brain. Also, result in cognitive decline and memory loss, every three seconds.

Alzheimer’s disease (AD) is the most prevalent form of dementia.

Dementia can occur for a variety of reasons, and there are a number of risk factors for dementia as well. Hearing loss is one of them. Hearing loss and a higher risk of dementia have been linked in previous studies.

The largest clinical experiment to look into whether a hearing loss therapy intervention can lessen a person’s risk for cognitive decline has now been completed. The results have been published by researchers from the Ageing and Cognitive Health Evaluation in Elders (ACHIEVE) study.

Researchers showed that using a hearing aid and getting support and counselling from an audiologist significantly reduced cognitive deterioration in individuals in a higher-risk subgroup by 48%.

Recognising those who use hearing aids

The study discovered differences in hearing aid usage based on geography, gender, and ethnicity.

Nearly 115,000 adults over the age of 66 who had hearing loss and insurance coverage from a significant. Also, private insurance firm between 2008 and 2016 were studied using data from these individuals.

Participants were followed up on by the team 3 years after their diagnosis and one year prior.

Men were more likely to use hearing aids if they had hearing loss. In actuality, 13.3 percent of men and 11.3 percent of women purchased hearing aids.

Additionally, 13.6% of white persons, 9.8% of African Americans, and 6.5 % of those of Latino descent received a hearing aid.

Nearly 37% of hearing-impaired Americans who wore hearing aids resided in the north-central region of the nation, compared to 5.9% of persons in the mountain states.

Those who wore hearing aids had an 18% decreased chance of receiving a dementia diagnosis within three years of a hearing loss diagnosis (including Alzheimer’s disease).

Hearing aid users had a 13 percent lower likelihood of receiving treatment for injuries sustained from falls and an 11 percent lower risk of receiving a diagnosis of depression or anxiety by the end of the three-year period.

The study’s findings, ACHIEVE

Participants in the ACHIEVE study range in age from 70 to 84, have mild to moderate hearing loss that is untreated, and do not have significant cognitive impairment. Four American locations were used to carry out the study.

977 individuals in all were recruited for the study. About 740 of them were recently recruited healthy community participants. The Atherosclerosis Risk in Communities (ARIC) study has about 240 participants.

Researchers found that participants in the ARIC group had more cognitive risk factors, poorer baseline cognitive scores, and a faster rate of cognitive deterioration over the course of the study’s three years than the other participants.

One group of participants underwent a three-year intervention that included receiving hearing aids, a self-management “toolkit” for hearing loss, and regular training and counselling with an audiologist.

Only speaking sessions with a health educator to address the prevention of chronic diseases were provided to the control group.

After three years, researchers discovered that ARIC study participants who received hearing aids and intervention had decreased the rate of their cognitive loss by 48%.

The ACHIEVE study’s co-principal investigator, Dr. Frank Lin, a professor at the Bloomberg School of Public Health and the Johns Hopkins University School of Medicine, said, “A 48% reduction in cognitive deterioration is significant, and we were happy to learn that the benefit was so big.”

How are hearing loss and cognitive deterioration related?

Dr. Lin claims that it has been well established for more than ten years by researchers that hearing loss significantly increases the risk of dementia and cognitive decline.

But he continued, “We didn’t know if treating hearing loss may actually slow cognitive deterioration and perhaps even cut the likelihood of dementia.”

Dr. Lin outlined three key factors that shed light on why dementia and hearing loss may be linked:

“First, hearing loss causes speech and sound to be muddled before they reach the brain, which makes it harder for the brain to understand the signals coming from the ear. The brain’s capacity to sustain thinking and memory is therefore reduced.”

Second, hearing loss depletes the areas of the brain that are normally activated by speech and sound, which can result in atrophy and modifications to the brain’s structure and function.

Thirdly, communication difficulties brought on by hearing loss might result in social isolation, another dementia risk factor, according to Dr. Frank Lin, co-principal investigator of the ACHIEVE project.

This is not the first study to look into the relationship between dementia, hearing loss, and hearing aids.

According to a 2022 study, wearing hearing aids may slow the cognitive impairment brought on by hearing loss.

Additionally, an observational study released in April 2023 discovered hearing loss was linked to a higher risk of dementia, and that utilising hearing aids may potentially help reduce that risk.

Additional proof that treating hearing loss enhances cognitive

Dr. Courtney Voelker, a board-certified neurotologist and the director of the Adult & Paediatric Cochlear Implant Programme at the Pacific Neuroscience Institute at Providence Saint John’s Health Centre in Santa Monica, California, commented on the study after reading it and said that it is an exciting study that provides additional proof that not only is hearing loss connected to cognitive decline as we age, but that we can also take action to prevent it.

According to her, there is growing evidence, which includes this study, that treating hearing loss aggressively can enhance cognition. This treatment may include cochlear implants or hearing aids, depending on the severity of the hearing loss. And it’s really exciting.

Dr. Voelker claimed that when discussing cognitive decline with her patients, she emphasises the significance of maintaining brain neuron activation and stimulation.

“And it’s very interesting patients really respond to this,” she added. “People who may have initially been reluctant to adopt hearing aids take the possibility of developing cognitive dementia very seriously when making their choice.” He also explains to patients why we allow people to go without hearing aids even though we would never allow someone to go without glasses if they had vision problems. Additionally, patients appear to connect with that parallel. According to neurotologist Dr. Courtney Voelker, “We want our hearing to be as crisp and clear as our vision is with glasses.”

Understanding hearing loss

The World Health Organisation (WHO) estimates that 20% of people worldwide have some form of hearing loss.

There are several reasons why someone could lose their hearing, including:

  • exposure over time to loud noises
  • hearing loss
  • destruction of the inner ear
  • a torn eardrum
  • a history of hearing loss in the family
  • some diseases, such meningitis, that raise the body’s temperature
  • a few medicines

Furthermore, hearing loss becomes more prevalent as we age, with the majority of cases typically happening beyond the age of 60.

Hearing loss can be either temporary or permanent, depending on the circumstances. There is currently no solution for age-related hearing loss, and it may get worse with time.

REFERENCES:

For Alzheimer’s disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_478

Do reading and puzzle-solving fade away dementia?

Do reading and puzzle-solving fade away dementia?

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Dementia is a chronic neurological disease that affects memory and thought processes and affects millions of individuals worldwide. The most prevalent type of dementia is Alzheimer’s.

There are various medications available to help manage dementia symptoms, but there is no known treatment for the illness.

Significant research is being done to find out more about the pathophysiology of dementia and to create therapies, but it is also being done to find out how lifestyle changes may affect dementia risk and cognition.

This study looks at the effects of reading and crossword puzzles and other cognitively stimulating activities on dementia risk and cognition.

High levels of cognitive activity, such as reading, playing games like checkers and puzzles, and writing letters, can delay the start of Alzheimer’s disease by five years in those 80 years and older, according to a study published in Neurology in 2021.

Another study indicated that more time spent engaging in cognitively passive activities, like watching TV, is associated with an increased risk of dementia, whereas more time engaged in cognitively active activities, like using a computer, is associated with a decreased risk of dementia.

Five experts were interviewed to learn more about themes such as how cognitively stimulating activities lower the risk of dementia, what else lowers the risk of dementia, and what action should be taken in light of the research.

Engaging pursuits increase mental capacity

Dr. Joyce Gomes-Osman, vice president of interventional therapy at Linus Health and a volunteer assistant professor of neurology at the University of Miami Miller School of Medicine, was the first person the experts spoke with.

She claimed that engaging in intellectually demanding activities, like reading and crossword puzzles, increases one’s cognitive reserve, which she compared to the amount of one’s mental library and lowers the chance of developing dementia, and improves cognition.

Every knowledge we acquire is like a book on a shelf. The library keeps expanding as more books are added. You might wonder why this matters, though. Building a library of knowledge in your brain, then, acts as a buffer against memory loss, she explained.

She said, “When your library is large, even if many volumes are checked out, there will still be plenty of other books on the shelves, serving as alternatives and maintaining the library in good condition.”

She outlined how education and experiences in life, particularly those that are difficult and require thought, help people grow their cognitive reserves over the course of their lives.

Research

Researchers looked into the effects of early cognitive development, educational attainment, and leisure activities on cognitive reserve in a recent study that was published in 2022 in Neurology.

From their early years up until the age of 69, they monitored 1,184 persons from the United Kingdom. At that age, the participants underwent a cognitive test with a possible score of 100.

Ultimately, the researchers discovered that those with a bachelor’s degree or more typically scored 1.22 points higher than those with no formal schooling. In comparison to individuals who participated in only four of these activities, those who participated in six or more leisure activities such as educational classes, volunteer work, and social activities scored an average of 1.53 points more.

Meanwhile, those with professional or intermediate-level jobs outperformed those with partially skilled or unskilled jobs by 1.5 points or more on average. Additionally, they discovered that those with better reading skills exhibited a slower rate of cognitive deterioration than those with worse reading skills.

The brain is exercised in several ways during mental exercises.

Dr. David Hunter, an assistant professor of neurology at McGovern Medical School at UTHealth Houston, was also interviewed by experts. Research, he said, has shown that even people with advanced dementia can benefit from what he refers to as “mental exercise”—anything that simultaneously stimulates various sections of the brain.

Just a few examples are reading, crosswords, painting, conversation, gaming, and work. The sole restriction, in reality, is that watching TV all day doesn’t count.

He noted that if patients are unable to engage in their previous interests, other options include colouring books, music, word searches, and simple chat.

Does the cognitive reserve have a limit?

Even if specialists concur that a person’s cognitive reserve is crucial in assisting them in maintaining their thinking abilities, they also point out that there are limits to how much we can improve this reserve through “mental exercises.”

Raphael Wald, a board-certified neuropsychologist with a doctorate in psychology from Baptist Health Marcus Neuroscience Institute, stated to experts:

“Because they have more cognitive reserve, people with high IQs typically fare better with dementia”. However, once dementia has developed, cognitive activities like crossword puzzles cannot stop the degenerative process. But it might make things go more slowly.

We also had a conversation with Dr. Karen D. Lincoln, a professor at the University of California, Irvine’s Department of Environmental and Occupational Health.

While some research indicates that mental workouts like crossword puzzles or word games reduce cognitive deterioration in those with mild cognitive impairment, the research is still ambiguous, she observed.

Puzzles alone may not always enhance cognitive ability or reduce the incidence of dementia, but these kinds of mental tasks are crucial for brain stimulation. Instead of breaking our circulatory system down into discrete sections, we must take it all into account.

Dr. Gomes-Osman concurred that focusing just on mentally stimulating activities is insufficient for lowering the risk of dementia. She pointed out that the “cutting-edge” research in the subject demonstrates that various healthy behaviours are most effective at reducing dementia risk and improving thinking abilities.

What are the 12 modifiable dementia risk factors?

Dr. Gomes-Osman used the Lancet Commission’s 2020 report on dementia prevention, intervention, and care when discussing which behaviours to focus on.

The study identified 12 risk factors for dementia, which together account for 40% of dementia cases.

  • The education level of a person
  • their degree of interpersonal ties
  • unsound hearing
  • workout regimen
  • depression indications
  • using alcohol
  • adult obesity
  • pollution from the air exposure
  • smoking customs
  • head trauma
  • High blood pressure, or hypertension
  • diabetes

According to the report’s authors, addressing these factors can lower the risk of dementia by lowering neuropathological damage. This includes accumulation of tau protein and inflammation, and by either boosting or maintaining cognitive reserve.

Dr. Gomes-Osman stated, “Just to give you an idea, if we all took these steps today, we would reduce dementia cases by over a third next year.”

How to lower the risk of dementia?

It’s crucial to stress that learning something new can strengthen your brain even if you’re already suffering from memory loss. Learning something new will sharpen your memory, focus, and thinking processes while also enhancing your quality of life, according to Dr. Gomes-Osman.

She continued by saying that having fresh, joyful experiences and taking in new sights could both benefit brain function.

Picking something that is neither too easy nor too difficult is crucial in this situation since our brains respond positively to novelty, she explained.

“Change the place where you perform your favorite activities. Going to new areas can boost your outlook on life and strengthen your brain“, according to Dr. Gomes-Osman.

Try walking somewhere new if you typically go for a walk, for instance. Additionally, you might choose a different route to get to work or a different grocery store. Even locating the milk aisle in several stores will need you to use creative problem-solving techniques. Don’t let a day pass without getting out and seeing something new, advised Dr. Joyce Gomes-Osman.

“A special note for African Americans,” Dr. Lincoln said, “who have the highest risk of dementia and Alzheimer’s disease in the United States.”

If you enjoy playing bid whist, dominoes, or spades, you are truly exercising your brain, he claimed. “The games are played with others, not necessarily because they are difficult or need good recall. Social interaction benefits the brain.

REFERENCES:

For Mental disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_478

Can slowing and weakening grip be signs of dementia?

Can slowing and weakening grip be signs of dementia?

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We lose muscle mass as we age. Humans lose roughly 10% of their body’s muscular mass by the age of 50. The beginning stages of dementia in elderly individuals may be signaled by a decline in physical strength, according to Edith Cowan University researchers.

We all know that as we age, our muscular mass declines. Grip strength and how quickly and steadily people stand up from a chair are two methods to gauge this.

According to research, people start losing muscle mass in their 30s or 40s, and by the time they are 50, they have lost 10% of their total muscle mass. Then, between 50 and 70, we lose an additional 30% of our muscular mass.

Dementia is a broad term for illnesses that affect a person’s cognitive function. Now, researchers from Edith Cowan University in Australia have discovered evidence suggesting a loss of muscle strength may be a signal for older people getting dementia.

Timed Up and Go (TUG) and grip strength were utilized by the researchers as indicators of muscle strength.

Why measure grip strength?

A grip strength test may be used by medical professionals to assess a patient’s hand and forearm muscle health.

The tool used for this straightforward test is a dynamometer. Simply by squeezing the dynamometer with all of their might while holding it in their palm, the user may measure the amount of force applied.

A person’s grip strength has long been regarded as a diagnostic of their general health. Previous studies have linked diminished grip strength to a higher risk of cardiovascular and all-cause mortality.

Additionally, previous research discovered that grip strength is a good predictor of an ageing person’s health-related quality of life.

What exactly is a TUG test?

Doctors can assess a patient’s mobility and balance using the Timed Up and Go (TUG) exam.

A person is instructed to sit on a typical chair while taking the TUG test. The individual is instructed to stand up, move to a queue approximately 10 feet from the chair, turn around, move back to the chair and then sit back down in it while a medical practitioner measures them with a stopwatch.

The doctor can observe the patient’s gait and examine their mobility to look for postural or balance problems.

The TUG test can typically be completed in 10 seconds or less by most healthy older persons. A person may be at a higher risk of falling if the time is longer than 13.5 seconds.

According to earlier research, the TUG test assesses older persons’ risk of falling and predicts their level of frailty.

Dementia and muscle tone

Dr. Marc Sim, senior research fellow in the Nutrition & Health Innovation Research Institute at Edith Cowan University in Joondalup, Australia, and the study’s first author claims that they chose to look into a connection between muscle function and dementia because existing research indicates significant connections between physical capacity, including muscle mass (e.g. sarcopenia), and cognitive health.

He explained to us, “When considered in the context of dementia, at a community level, the utilisation of quick, affordable, and straightforward tests such as grip strength and TUG are quite appealing.”

This could be used as a screening tool to assist physicians in identifying patients who are most at risk and to facilitate the promotion of primary preventative interventions, like exercise and diet. At the community level, screening for dementia risk is infrequently done, he added.

According to Dr. Sim, the methods they used to assess the muscular function of research participants—grip strength and TUG tests—were chosen because they are both straightforward and simple to carry out and are currently advised as functional tests as part of sarcopenia criteria in Australia.

These tests, which take around 3 minutes to complete by doctors, have extremely strong evidence supporting their ability to predict a variety of unfavorable outcomes in older populations, including falls, fractures, CVD, and mortality.

Dementia risk factors that are significant

More than 1,000 women with an average age of 75 were examined for this study by Dr. Sim and his team using information from the Perth Longitudinal Study of Ageing in Women.

Each lady took the TUG test and had her grip strength evaluated by researchers. After five years, the tests were conducted once more.

The researchers discovered that over the following 15 years, 17% of study participants either experienced a dementia event, such as a dementia-related hospitalization or death.

A study participant developing dementia was shown to be much more likely to have reduced grip strength and slower TUG, according to the research team. In addition, women who performed poorly on the TUG tests and had the weakest grip strength had a twofold increased risk of developing dementia in later life.

Other risk variables like smoking, drinking, and levels of physical activity had no bearing on this.

“I would not say the results are shocking because these functional tests are probably going to give a snapshot of the current health state. Especially because exercise, a major risk factor for dementia, is less likely to be practiced by persons who struggle with everyday routines of life due to physical constraints,” Dr. Sim said.

“What caught my attention was the significant risk of dementia related with functional loss over a five-year period, where individuals who experienced the greatest deterioration were also at the highest risk. This is another crucial topic that clinicians should think about, he continued.

How the loss of grip strength affects cognitive function

After reading this study, Dr. Raphi Wald, a board-certified neuropsychologist at Baptist Health South Florida’s Boca Raton Regional Hospital who was not involved in it, told us that it is helpful in confirming what we already knew and strongly suspected about deteriorating physical and mental abilities.

Before substantial degeneration starts, a number of frequently subclinical signs and symptoms of dementia appear. This is just another indication to physicians that a process might be starting and has to be attended to, he said.

When asked what he would want to see as the next stages for this research, Dr. Wald responded, “I think it would be great to have additional information regarding those people that successfully address their muscle weakness and how much it lessens their risk for dementia once they do so.”

These results are consistent with earlier studies that have shown that grip strength and mobility are correlated with various aspects of cognitive decline in older adults, according to Ryan Glatt, senior brain health coach and director of the FitBrain Programme at Pacific Neuroscience Institute in Santa Monica, California, who was also not involved in this study.

“Collecting information on strength, gait, and mobility in clinical settings might assist create a comprehensive collection of information that may be useful in predicting the likelihood of dementia. The relationship between these mobility and strength measurements and other facets of brain health would be intriguing,” he continued.

Looking out for indications of cognitive deterioration

We also discussed this research with Dr. William Buxton, a board-certified neurologist who serves as the director of fall prevention and neuromuscular and neurodiagnostic medicine at the Pacific Neuroscience Institute at Providence Saint John’s Health Centre in Santa Monica.

Dr. William Buxton stated, “This study tells us that the extra few minutes to perform some really basic simple testing in the office, even just routine visits, like the Time Up and Go test and testing grip strength, can give us good, scientifically grounded reasons to encourage physical activity.”

Dr. Buxton, who was also not involved in the study, continued, “And for those individuals to pay a little bit closer attention to watching for cognitive decline that we may be able to slow down as a result of paying that extra attention.”

Dr. Buxton stated that he would like to see a comparable study conducted in men as well as research to see whether working out in a group had any further advantages.

“We are aware that persons who maintain their social connections are less likely to encounter cognitive impairments that are either developing or deteriorating. Therefore, I’d be interested to see if group exercise that is linked to social engagement will have additional benefits in addition to those that come from individual exercise,” he continued.

REFERENCES:

For Alzheimer’s disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_478

Adults with dementia might be helped with internet surfing.

Adults with dementia might be helped with internet surfing.

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A new study found a strong correlation between older adults’ regular internet use and a much lower incidence of dementia.

A “sweet spot” of up to two hours a day of internet use was also discovered by the study, beyond which the risk of dementia is expected to rise.

Experts advise providing assistance to elderly folks so they can use new web technology and remove access restrictions.

The impact of internet use among elderly people as a strategy for preventing dementia is the subject of a recent study.

According to the study, older adults who regularly use the internet have a roughly 50% lower risk of developing dementia than older adults who do not.

In this study, 18,154 persons without dementia were followed for an average of 7.9 years and up to 17.1 years to assess their cognitive health. The study’s participants ranged in age from 50 to 64.9 at the outset.

When compared to non-users, internet users who used it frequently had a 43% lower incidence of dementia. A dementia diagnosis had been made for 4.68% of the participants by the end of the trial.

With a U-shaped data curve, the study also hypothesized that the positive impacts of internet use varied with people’s levels of online activity.

The results indicate that the biggest reduction in dementia risk was seen in persons who used the internet between 0.1 and 2 hours per day.

Was that of any use?

A greater risk of dementia persisted for those who never used the internet or spent more than two hours online. The authors do warn that due to the small sample sizes, there were no discernible changes between user groups.

The study’s authors also investigated the effects of generational differences, educational level, race-ethnicity, sex, and gender on the relationship between internet use and dementia risk. They discovered that these factors had no effect on the risk of dementia.

Optimum level of internet usage

There was sort of a sweet spot where, if you used the internet for a half-hour to two hours a day, it was protective against dementia, according to Dr. Scott Kaiser, an expert in geriatric family medicine at the Pacific Neuroscience Institute who was not involved in this study.

He emphasized that “too much internet time was not protective, or potentially harmful.”

Dr. Kaiser is a co-founder of Determined Health, a group devoted to assisting seniors in fortifying their social ties.

Dr. Kaiser pointed out that older people who spend too much time online may be “highly exposed to negative images of aging, and feeling lower self-worth, and feeling bad about getting older that would be an example where too much time could potentially have a negative effect.” This is known as “doom-scrolling,” or compulsively scrolling through social media feeds laden with bad news.

A sedentary, unhealthy lifestyle may be encouraged by spending too much time online. The study’s conclusions could be impacted by the fact that it did not precisely record what its participants performed online.

Additionally not participating in the study, Dr. Snorri Bjorn Rafnsson of the University of West London in the United Kingdom told us that “these specific results merit further investigation.”

What could be the causes of some older individuals using the internet too much? Do they feel alone? isolated socially? What other dangers to their bodily or mental health could there be? What is happening among individuals who don’t use the internet at all, on the other hand? Dr. Snorri Bjorn Rafnsson stated, “I believe that these are questions that could be further investigated in studies in the future.”

How internet use may help ward against dementia?

“We know that learning new things and maintaining cognitive engagement is critical for protecting our brains and reducing our risk of developing dementia,” says Dr. Kaiser.

Because learning new information and using new technologies may excite the brain and improve people’s cognitive performance, we might say that using the internet in later life may have direct cognitive benefits.

Dr. Rafnsson pointed out that older persons could utilize the internet to look up general information or health-related information. Another factor encouraging elderly individuals to use the internet is the development of telemedicine.

Regular internet use may also result in positive interpersonal interactions. In a report titled “Our Epidemic of Loneliness and Isolation,” the U.S. Surgeon General discusses the significance of social connection.

How do seniors feel about getting older?

In general, engaging in online activities may encourage a positive outlook on aging, which can have favorable effects on one’s health. Dr. Becca Levy, the author of Breaking The Age Code, was mentioned by Dr. Kaiser.

It is “an amazing work of where we know that our perceptions of ageing actually impact how we age in terms of our longevity, our risk of dementia, just the very way that we think about ageing,” he said.

Dr. Kaiser proposed three mechanisms by which age stereotypes can influence the likelihood of dementia and ageing:

  • It is well known that having a pessimistic mindset can be unhealthy.
  • A recipe for poor health is to treat one’s body like an old vehicle that won’t be on the road for very long.
  • Stress-related elevated cortisol levels and systemic inflammation.

Increasing accessibility to the internet

The suggestion made by Dr. Rafnsson is that “older adults should be supported to learn and use new online technology for whatever purpose they wish.”

He said, “There are many elderly persons who still encounter numerous obstacles, such as a lack of technical skills, cost, social support, etc.

Dr. Rafnsson added, “These hurdles may make it difficult for many older persons to gain from the cognitive and social advantages of utilizing the internet.”

Dr. Kaiser opined that “we should be working towards a more connected society for all.”

Risk factors for dementia

Scientists are still researching dementia, but they have identified some risk factors that can increase your likelihood of getting the disease. The following are some examples, according the Centres for Disease Control and Prevention (CDC):

  • Advancing years. People 65 and older are most commonly affected by dementia.
  • Family background. The likelihood of someone having dementia increases if they have parents or siblings who have the disease.
  • Race/ethnicity. Dementia strikes older Black Americans twice as frequently as older White Americans. Dementia is 1.5 times more likely to affect Hispanic people than White people.
  • Poor heart health. If diseases like high blood pressure, high cholesterol, and smoking are not effectively managed, they raise the chance of dementia.
  • Brain damage caused by trauma. The risk increases with head injuries, particularly when they are serious or frequent.

REFERENCES:

For Alzheimer’s disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_478

Can Alzheimer’s be cured with a new genetic therapy?

Can Alzheimer’s be cured with a new genetic therapy?

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There is presently no cure for Alzheimer’s disease, which is thought to be the root cause of dementia in 32 million individuals worldwide.

The majority of experts think that aberrant amyloid and tau protein buildups in the brain trigger alterations that lead to Alzheimer’s disease.

An experiment using a brand-new gene silencing treatment for Alzheimer’s disease that aims to reduce the body’s level of tau protein was carried out by a multidisciplinary team of researchers.

The most widely accepted explanation regarding the origins of Alzheimer’s disease is that it results from aberrant accumulations of the proteins amyloid and tau, which alter the brain. However, scientists are still unsure of the exact mechanism by which this disease develops.

Alzheimer’s disease, which is believed to afflict 32 million people worldwide, has no known cure, although doctors can treat its symptoms to enhance a patient’s quality of life.

A new gene silencing therapy for Alzheimer’s disease has now being tested by an international team of experts. The treatment turns off the tau protein-coding gene, which reduces the body’s production of the protein.

What impact does tau protein have on Alzheimer’s?

The core cells of the neurological system, called neurons, are where tau is most frequently found. Tau aids in maintaining the tube-like interior shape of nerve cells in a healthy brain.

Microtubules are structures that resemble tubes that aid in maintaining cell shape and guarantee that other proteins and chemicals move around the entire neuron with ease.

The tau protein in an Alzheimer’s patient’s brain separates from the microtubules and instead binds to other tau proteins inside the brain cell. As a result, the microtubules break down and aberrant tau protein accumulations occur.

These tau protein accumulations come together to form “tangles” within the brain cells. As a result, the neurons are unable to communicate with one another.

We spoke with Dr. David Merrill, an adult, and geriatric psychiatrist and the director of the Pacific Brain Health Centre at Providence Saint John’s Health Centre in Santa Monica, California, who was not involved in this study. “We know that tau tangles track with the progression of Alzheimer’s, meaning the worse that Alzheimer’s gets, the more tau tangles there are throughout more and more of the brain,” he said.

And ultimately, he continued, “those lead to neuron dysfunction and death.”

Blocking the gene that codes for tau

In this investigation, scientists developed a medication intended to silence the tau protein-encoding gene. The microtubule-associated protein tau (MAPT) gene is the one in question.

Antisense oligonucleotide BIIB080 is the name of the investigational medication. Small bits of RNA or DNA are used in this type of therapy to prevent a particular RNA from carrying out its intended function. In this instance, those are to act as guidelines for the creation of the tau protein.

Researchers included 46 patients with mild Alzheimer’s disease, with an average age of 66 years, in this phase 1 clinical research. The experiment was held between 2017 and 2020.

Throughout a 13-week treatment period, the trial compared four doses of the experimental medication injected into the nervous system through the spinal canal to a placebo.

Researchers discovered that 24 weeks after therapy, levels of both total tau and phosphorylated tau had decreased by more than 50% in trial participants in the treatment groups that had received the highest dose of the medication.

Over 90% of participants finished the post-treatment period, and 94% of those who received the drug and 75% of those who received a placebo reported mild or moderate side effects. The most frequent side effect of the experimental medication was headaches upon injection.

A ‘plausible’ therapy strategy

Dr. Merrill described this study’s ability to mute the expression of the gene that causes tau tangles in the brains of Alzheimer’s patients as “amazing” when asked about it.

Dr. David Merrill stated that this study “is the first step in demonstrating that this is a safe approach with a plausible biologic mechanism that can then be tested to see if it indeed does what we would expect, which is slow down the progression of Alzheimer’s disease and be a disease-modifying therapy that results in people’s cognition being better for longer.”

Non-participant in this study, Dr. Raphi Wald is a board-certified neuropsychologist at the Marcus Neuroscience Institute, established at Baptist Health South Florida’s Boca Raton Regional Hospital.

According to him, “a great deal of research is currently being conducted on preventing or destroying the abnormal proteins that appear on the brains of people with Alzheimer’s disease.”

“Compared to those without the disease, people with Alzheimer’s tend to have higher levels of the two proteins tau and amyloid in their brains. The majority of Alzheimer’s research has been devoted to preventing these diseases from spreading throughout the brain. This research suggests what might be a useful strategy for doing that,” he said.

The Alzheimer’s Association’s senior director of scientific programs and outreach, Dr. Claire Sexton, commented on this study.

While Alzheimer’s disease anti-amyloid therapies have gotten a lot of attention, the drug development landscape is much bigger, with a variety of targets and approaches being researched, she said. This is a positive report on phase 1 research that targets tau, one of the main indicators of Alzheimer’s disease, using a gene silencing strategy.

What comes next?

Dr. Wald stated that when it comes to the next steps in this research, the most crucial factor with these treatments is how they impact the daily lives of those at risk for or dealing with Alzheimer’s disease.

“Reducing tau is not a guarantee that people will not go on to have worsening cognitive functioning,” he advised. According to Dr. Merrill, the next logical step would be a phase 2 experiment to assess side effect tolerance and safety.

He continued, “And then the actual phase 3 trial would be to really look at treatment efficacy.” “Does memory get better? Does Alzheimer’s patients’ memory deterioration slow down over time? I’d want to see this medication investigated in later-stage clinical trials to determine whether it improves or maintains memory function in Alzheimer’s.

Dr. Sexton emphasized that more research with varied populations will be required to adequately assess the safety, target engagement, and clinical effect in all populations because the study’s subjects were all white.

“However, given the role of tau in not only Alzheimer’s but other dementias — known as tauopathies these results are a significant development and a further cause for optimism in the field,” she continued.

“The therapeutic study aimed against tau is funded by the Alzheimer’s Association Part the Cloud research grant programme, including a project by Dr. Ross Paterson at University College London. According to Dr. Sexton, the subject of his research is a unique substance that is intended to lessen tau formation in Alzheimer’s patients that is associated to dementia.

REFERENCES:

For Alzheimer’s disease medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?therapy=31

Important note on dementia affected by music.

Important note on dementia affected by music.

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There is growing evidence that listening to music helps reduce anxiety and improve happiness in those who are living with dementia. What is it about music, though, that has such a strong impact on our brains? Does this effect last a long time, too?

You may have seen a video of an elderly person with dementia who, while not remembering their family members, starts playing the notes to a tune they used to know on the piano or violin, or who sways to the music while bringing back a flood of memories.

Many people’s questions concerning dementia, a neurological illness, are confused by this phenomenon. How can someone forget their kids’ names but recall something as difficult as a piece of classical music?

Our April podcast “In Conversation: Investigating the Power of Music for Dementia” set out to respond to of questions, including this one. Dr. Kelly Jakubowski, an assistant professor of music psychology at Durham University, and Beatie Wolfe, a musician, and spokesperson for the non-profit organization Music for Dementia, joined the discussion this month.

Health benefits of music

Music is a creative fusion of rhythm, harmony, and emotion expression, whether instrumental or lyrical. Its many health advantages have also been supported by numerous studies.

For instance, a 2013 study discovered that listening to music before stressful situations can assist the nervous system unwind and recover more quickly. In the same year, another study discovered that children in hospitals who were listening to music experienced less pain and anxiety.

In addition to its physiological advantages, research has shown that music has a good effect on cognitive health.

According to a recent study, persons between the ages of 62 and 78 may see a slower deterioration in cognitive function if they actively practice and listen to music. The ability of the brain to rewire itself, which is essential for learning and memory formation, was found to increase with participation in musical activities in particular parts of the brain.

In terms of actively learning music, a study from 2023 revealed that regular music training might offer the brain considerable functional advantages and help keep it young.

These findings suggest that music therapy may be an effective method for treating dementia, a condition that is characterized by a variety of symptoms, including memory loss and issues with thinking, language, and problem-solving.

Being in complete silence

However, the absence of sound and music—silence—has an impact on our health that is at least as great as that of sound and music. Silence can be soothing and restorative, reducing brain wave frequency while also lowering blood pressure, according to a 2020 study.

In fact, studies have shown that excessive noise and loud sounds are harmful to cognitive health. According to a 2022 study, dementia may have a particular risk factor for people who are exposed to loud noises regularly, such as noisy traffic.

Beatie, one of our guests, talked about her experiences recording her “Raw Space” album in the Bell Labs anechoic chamber, which was the world’s quietest room, and how it affected her.

“It was one of the most life-changing events I believe I’ve ever had, and I keep going back to it. Even now, it seems to have almost gained relevance. We are being barraged from every direction with social media and notifications, and all of these things that are hitting us are kind of frazzling us, as the world has simply become noisier, both literally in terms of sound as well as information, she added.

The engineers usually had to take breaks because it was so intense, but I was assured that I’d be able to stay in there for about 15 minutes since you can hear your blood racing through your veins. I ended up working for at least 100 hours, she claimed.

Recognising songs over names

Dr. Guite brought up the issue of persons with dementia remembering song lyrics but not their own children’s names and emphasized repetition and how music can simultaneously activate several brain regions and networks.

We’ve spoken about how music affects the brain globally, but the repeating of a child’s name occurs throughout a lifetime, whereas a song may only be played once a month or once a year. She questioned, “How can we explain that?

According to Dr. Jakubowski, procedural memory is related to the capacity to fill in the words of songs.

The ability to remember motor sequences, such as how to ride a bike, is an example of procedural memory, correct? People still have this kind of memory for the motor sequence of singing along to lyrics even though they may not have this kind of semantic memory for names and locations, she explained. This is likely because they have sung along to that song many times before, or at least have done so in their minds many times.

She said that the brain might preserve some of this form of memory, which might help to explain why some people with dementia are still able to sing along or play an old song on an instrument.

If a person had previously played the piano, they frequently could still play those well-known compositions rather late in the condition, according to the expert.

Observing how music affects dementia

In 2014, Beatie started a study called “The Power of Music” in a chain of care facilities run by the Priory Group in the UK.

The video and photos from that encounter make it clear how the dementia patients in such care homes begin to tap their feet, clap their hands, and sing along—some with their eyes gleaming.

She explained to us how it all began after she performed original English songs in a Portuguese elderly home. “In the case of my father-in-law, I was going to play just for him, but I wound up playing to this whole ward of about 100 people with dementia and Alzheimer’s, who were all sitting around the table listening to me play,”

Except for this relative, none of them were fluent in English. And I was playing brand-new English tunes that they had no prior familiarity with. People were clapping, waking up, and singing along as much as they could, she continued.

Beatie was inspired by this to investigate the claim that music, whether you were familiar with it or not, had strong emotional effects. She was motivated by the neuroscientist Oliver Sacks, who wrote in his book Musicophilia that music appreciation was not necessary for its influence.

One particular song’s impact on the audience stood out when she performed original songs for residents of care homes in the U.K.

How long does music have an impact?

Dr. Jakubowski pointed out that while the acute health benefits of music are pretty clear, sustained exposure is required to discuss long-term benefits.

“You can’t anticipate that listening to music will always be beneficial years from now just because you listened to one song three years ago. It is more advantageous to engage with music more frequently than to hear it once and then never again”, according to her.

She also emphasized the different ways in which listeners might interact with music.

“Even listening to recorded music regularly offers long-term advantages for people with dementia—reducing agitation, decreasing apathy, boosting mood, occasionally enhancing [a] feeling of identity, etc. So, in my opinion, there are various ways to interact with music,” she said.

REFERENCES:

For Dimentia medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?therapy=31

Dementia risk may increase with frequent colds and flu.

Dementia risk may increase with frequent colds and flu.

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According to studies done on humans, a greater lifetime exposure to microbial illnesses is linked to a slower decline in cognitive function as people age.

By intermittently giving mice the inflammation-causing bacterial toxin lipopolysaccharide, a recent animal study examined the effect of inflammation brought on by recurrent microbial infections on cognitive function.

The study discovered that early middle-aged mice with mild-to-moderate inflammation brought on by repeated lipopolysaccharide treatment had deficiencies in memory and learning.

These results in ageing mice imply that mild-to-moderate illness brought on by microbial infections may require more vigorous therapy than the existing standard of care, particularly in populations susceptible to cognitive impairment, such as the elderly.

The standard medical advise for those with mild to moderate infections is to obtain enough rest and drink more fluids. It’s interesting to note that a recent study in the journal Brain, Behaviour, and Immunity claims that repeated inflammation brought on by giving a bacterial toxin to middle-aged rats led to cognitive deficiencies. Along with these cognitive deficiencies, the hippocampus, a part of the brain important for learning and memory, experienced changes in the plasticity of its neurons.

Elderly people are more prone to microbial infections, which could exacerbate the decline in cognitive function in elderly people and result in dementia or moderate cognitive impairment.

The results of this study point to the possibility that older persons may require more intensive therapies in order to avoid these illnesses’ long-term consequences on cognitive function. It is crucial to remember that since this study used a mouse model, it is unknown whether the conclusions apply to people as well.

Brain aging contributed by inflammation

As a result of the biological changes brought on by brain ageing, a loss in several cognitive capacities is shown during the course of normal ageing. Similar to this, cognitive impairment seen in neurodegenerative diseases like Alzheimer’s disease is connected to pathological brain ageing.

According to studies, several variables, including inflammation brought on by microbial infections, may accelerate the aging of the brain. For instance, higher lifetime exposure to infectious agents is linked to worse cognitive function and a faster decline in cognitive function in older people.

Additionally, research using animal models has demonstrated that inflammation brought on by microbial exposure might affect cognitive function. Animals are injected with the toxin lipopolysaccharide (LPS), which is found in the outer membrane of gram-negative bacteria, to study the effects of inflammation brought on by microbial infections.

These investigations on animals have demonstrated that LPS injection can elevate cytokine levels in the brain, a family of inflammatory proteins, and result in abnormalities in cognitive function. Additionally, as people age, these negative effects of LPS become more obvious.

The majority of these studies have looked at how LPS affects brain and cognitive function when it is given continuously or in single doses. According to these research, even a single dose of LPS-induced inflammation can alter the brain permanently.

However, little study has been done on the effects of lifetime exposure to microbial illnesses on alterations in the brain and cognitive function. In genetically modified mouse models of Alzheimer’s disease, there is some indication that repeated injection of LPS can raise the risk of cognitive impairment.

EFfects of LPS-induced inflammation

In the current investigation, mice were given escalating dosages of LPS every 15 days for 2.5 months. Repeated injection of the same amount of LPS causes tolerance to develop, which includes the absence of an inflammatory reaction, according to prior studies.

The researchers worked around this problem by gradually increasing the LPS dose over the course of the five injections. The mice experienced mild illness after each LPS treatment, but they recovered within 15 days.

Two weeks after giving the last dosage of lipopolysaccharide, the researchers then tested the animals’ behaviour to see how well they could think. At 5–6 weeks after the last injection, the researchers also put the animals to death to look at how inflammation brought on by lipopolysaccharide affected the brain.

Saline-treated mice made comprised the control group. The mice were 10 months old when the study began, which corresponds to the transition from late adulthood to middle age.

The scientists discovered that mice given LPS injections displayed cognitive abnormalities in learning and memory retention of information acquired the day before.

Researchers observed alterations in the hippocampus in mice who received LPS injections on a sporadic basis. In Alzheimer’s disease, the hippocampus, which is important for memory and learning, exhibits the illness’s initial signs of degradation.

Interleukin-6 (IL-6) gene expression was upregulated in the hippocampus of LPS-treated mice as one of these modifications. This is in line with other research that found higher IL-6 levels following LPS treatment in cognition-related brain areas.

Additionally, the researchers discovered that giving LPS affected neuronal plasticity but not baseline signal transmission. Particularly, the LPS-treated animals displayed reduced long-term potentiation (LTP) between neurons in the hippocampus.

Linking flu frequency to dementia risk

Dr. Elizabeth Engler-Chiurazzi, a behavioral neuroscientist at Tulane University and co-author of the study, said the conclusions have significant ramifications for human brain health and disease.

“At the moment, staying in bed, getting lots of rest, drinking soup, and allowing your body to do its work of eradicating the infection is the standard of care for the common cold or the flu virus. According to my knowledge, this advice is offered to the entire population and is given regardless of the likelihood that dementia will develop in the future.

Dr. Elizabeth Engler-Chiurazzi stated, “Our results may be the first in a series of studies that could indicate that treatment for the common cold or other sources of intermittent infection among patients at high risk for cognitive decline/dementia may need to be more aggressive than the standard recommendations of rest and fluids.”

According to these findings, a history of more “flu-like” episodes may be a risk factor for cognitive problems in later life. According to Dr. Engler-Chiurazzi, some research conducted in people have started to investigate this connection. The results are consistent with our mouse observations.

It’s too soon to say for sure.

Dr. Engler-Chiurazzi issued a warning, noting that it’s possible that these findings won’t apply to people.

Although there are significant species differences in how these systems react, the immune system composition of mice and people is similar, according to the researcher. However, more research is required to determine how well these findings are replicated in human populations.

The mechanisms behind the cognitive losses following repeated LPS treatment will also be looked at by the authors.

Dr. Engler-Chiurazzi stated, “An immediate next step for our group is to repeat these studies and determine the extent to which common brain consequences seen in dementia, such as a leaky blood-brain barrier or activation of brain immune cells (microglia), are observed after repeated intermittent exposure to sickness-like inflammation in the body.”

Dr. Engler-Chiurazzi also mentioned that they have not looked at how viral infections affect cognitive function but are now doing so using an animal model.

REFERENES:

For Dementia medications that have been suggested by doctors worldwide are available here https://mygenericpharmacy.com/index.php?cPath=77_478

How Bone Density May Be Linked to Dementia Risk?

How Bone Density May Be Linked to Dementia Risk?

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According to researchers, a decline in bone density may be associated with a higher risk of dementia.

Low bone density and dementia tend to develop at later age, but the researchers caution that they are unsure of why there may be a connection.

A nutritious diet and regular exercise, according to experts, are two strategies to enhance overall bone health.

A study was published in Neurology, the official journal of the American Academy of Neurology. People with low bone density may be more likely to develop dementia. 3,651 individuals with an average age of 72 whose medical histories and X-rays were examined by Dutch researchers.

Everybody underwent physical exams, including X-rays and dementia screenings, as well as interviews every four to five years.

Prior to the trial, none of the subjects had dementia. Among the conclusions were:

  • Dementia affected 688 people (19%) over an average of 11 years.
  • 90 of the 1,211 individuals with the lowest bone density who lived the longest had dementia.
  • During a decade, 57 of the 1,211 individuals with the highest bone density had dementia.

The researchers found that those with lower bone density were 42% more likely to develop dementia than those with higher bone density. Even after controlling for age, sex, education, other illnesses, medicinal use, and family history of dementia.

The study only demonstrates a connection, not cause and effect, the researchers noted.

Bone density and dementia

According to the researchers, bone density loss may occur in the early stages of dementia and, if it does, may be a sign of risk.

With that information, healthcare providers may focus on providing earlier and more regular screenings. Also, a better care to those who have bone loss.

The researchers also stated that little was known about a potential connection in the years preceding dementia and that inactivity and poor nutrition. Both of which are present in dementia patients, both cause bone loss, which is accelerated by inactivity.

The majority of the individuals in the study were Europeans over the age of 70. They poses a drawback in that the findings may not be generalizable to other races, ethnicities, and age groups.

Dr. Joel Salinas, is a behavioural neurologist, researcher at NYU Langone Health and the chief medical officer at Isaac Health in New York. He stated that he always believes that additional research is necessary to determine why there may be a relationship.

According to Salinas, “In this scenario, there could be a few reasons why there is an association between dementia and bone loss.”

He listed a few potential explanations:

  • These two illnesses have a strong connection to ageing.
  • Both disorders may be influenced by inflammation in some way.
  • nutrition, diet, and way of life.

Salinas continued, “Improving lifestyle factors like nutrition and activity levels can never be too late. Even if there are already symptoms of cognitive deterioration, putting out a conscious effort in these areas can help prevent the progression of dementia.

Common Bed Partners

In the elderly population, Low bone mineral density (BMD) and dementia frequently co-occur, with bone loss accelerating in dementia patients as a result of inactivity and poor nutrition. It’s unknown, though, how much bone loss already exists before dementia manifests.

The new findings are based on 3651 seniors (mean age 72 years, 58% women). These were dementia-free between 2002 and 2005 and participated in the Rotterdam Study.

Dual-energy radiography absorptiometry (DXA) was used to measure BMD at the femoral neck, lumbar spine, and overall body at that time. The trabecular bone score, which provides additional information like bone microarchitecture, was also calculated. Up to January 1st, 2020, participants were monitored.

Age, sex, education, physical activity, smoking status, body mass index, blood pressure, cholesterol, history of comorbidities (stroke and diabetes), and apolipoprotein E genotype were all taken into account while doing the analyses.

In the 688 people who underwent follow-up who got dementia, the majority (77%), had Alzheimer’s disease.

Preventing bone loss

Dr. Nahid Rianon, a professor of general medicine at McGovern Medical School at UTHealth Houston who was not involved in the study, responded to Medical News Today when asked what would account for the connection between poor bone density and dementia risk:

Although this is a very useful study, it is impossible to determine if low bone density causes dementia, whether dementia causes low bone density, or whether low bone density and dementia share a risk factor.

The findings are significant because each of the three hypotheses has a critical role to play. To prevent both fatal diseases, it is imperative to find out if they share a common cause.

According to Rivadeneyra, “Dementia and bone health are two typical diseases we all struggle with to some extent as we age, so it’s no surprise there would be a correlation.” “We are aware that smoking increases the risk of dementia, low bone density, and cardiorespiratory problems. As we age, alcohol misuse is also linked to weak bones and dementia. Many of these ‘age-related’ diseases we frequently see are caused by heart disease, prolonged pharmaceutical usage (for some medications), injuries and trauma, metabolic issues like thyroid disease or diabetes, and a strong family history (genetics).

Consuming a diet high in calcium and vitamin D is also essential.

Osteoporosis and women

Osteoporosis is a prominent factor in broken bones in older men and postmenopausal women. Although each bone in the body has the potential to fracture, hip, vertebral, and wrist fractures are the most common in older people.

According to Dr. Gayatri Devi, a neurologist at Lenox Hill Hospital in New York, “women have a higher risk of osteoporosis and dementia, which could be related to decrease of oestrogen after menopause.”

According to Devi, those who engage in less physical activity—often older adults due to conditions like heart disease, diabetes, and stroke—have lower bone density and, thus, are at a greater risk for dementia.

The crucial conclusion, she continued, is that treating low bone density can lower the risk of dementia, fractures, and hospitalisation. “I think that everyone over the age of 50 should get a baseline bone density test because there is a good treatment, either through medication or exercise.”

Study limitations and implications

Dr. Wiggins noted that although other studies have described such relationships, since the majority of the patients in this study were in their 70s and of European heritage, they might not apply to other populations.

We must be careful not to conclude that lower bone density directly causes dementia, he cautioned, since this study merely found a link between bone and brain health.

Board-certified neuropsychologist Dr. Karen D. Sullivan, who runs the Pinehurst, North Carolina-based practise I CARE FOR YOUR BRAIN and was not engaged in the study, said:

The results of this study suggest that dementia may be more likely to strike those with inadequate bone density. According to Dr. Sullivan, this study “adds to the persuasive body of literature that demonstrates that maintaining bone health integrity is a crucial component of successful ageing.

“Evidence-based techniques for enhancing bone health after age 50 include putting a premium on high-quality animal/plant protein, polyunsaturated fatty acids, fruits and vegetables high in potassium, fibre, and foods high in calcium and vitamin D having the greatest study backing. In order to maintain strong, healthy bones as we age, frequent weight-loading and resistance exercises are also necessary, the expert concluded.

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Type 2 diabetes drug may help lower rose dementia risk.

Type 2 diabetes drug may help lower rose dementia risk.

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According to new research, older persons with newly diagnosed type 2 diabetes mellitus (T2DM) who have a history of stroke or ischemic heart disease may benefit most from treatment with the thiazolidinedione pioglitazone.

In general, over the course of an average of 10 years, patients who took pioglitazone had a 16% lower risk of dementia. This compares to the people who take medication, according to a large cohort study from Korea.

However, the risk of dementia was decreased by 54% and 43%, respectively, among people with ischemic heart disease and stroke histories.

Reports

There will be 139 million cases of dementia worldwide by 2050, with the number continuing to rise. Dementia is more likely to affect some people, particularly those with type 2 diabetes.

Researchers have shown that persons with type 2 diabetes who used the diabetic medication pioglitazone had a lower risk of dementia in old age.

Dementia affects an estimated 55 million individuals worldwide, and by 2050, that figure is anticipated to rise to 139 million.

Type 2 diabetes and dementia

Why would someone with type 2 diabetes have a higher chance of getting dementia?

At Pinehurst, North Carolina, Dr. Karen D. Sullivan, a board-certified neuropsychologist and proprietor of I CARE FOR YOUR BRAIN, claims that diabetes has a detrimental effect on nearly every system of the body, including the brain.

“Compared to people without diabetes, people with type 2 diabetes have a 50–60% increased risk of developing dementia. She stated in an interview with Medical News Today that this is one of the most potent modifiable risk factors for dementia.

She said: “The insulin resistance we detect in diabetes increases atherosclerosis and alters energy metabolism. This results in microvascular alterations in the brain and ultimately a decrease of blood supply to networks of neurons.”

16% lower risk with pioglitazone

Researchers used information on newly diagnosed type 2 diabetics without dementia from the National Korean Health Database for their investigation. The average follow-up period for the more than 91,000 participants was 10 years. 3,467 of the individuals received the medication pioglitazone.

Following examination, researchers discovered that 8.3% of those taking pioglitazone experienced dementia. This is opposed to 10% of those with type 2 diabetes who did not take the medication.

Scientists discovered that persons with type 2 diabetes who took pioglitazone were 16% less likely to acquire dementia later in life after controlling for a number of lifestyle factors. This study was limited by the fact that it was based on data from insurance claims. Therefore it is possible that some participants did not even take pioglitazone.

The study contains no data on the severity of the illness, the participants’ glycemic control, or their genetic susceptibility to dementia.

How blood vessels may play a role

Dr. Eosu Kim is a professor in the Department of Psychiatry in the College of Medicine at Yonsei University in Seoul, Republic of Korea, and the lead author of this study responded when asked how pioglitazone helps reduce the risk of a person with type 2 diabetes developing dementia by pointing out that this study was to investigate the association between pioglitazone use and incidence of dementia, not how — with what mechanisms — this drug can suppress dementia pathology.

Nonetheless, he told Medical News Today, “Several could be recommended based on [the] basic pharmacological activities of this medicine and findings from past studies.”

“First of all, maintaining healthy blood sugar levels is advantageous for brain activities. Also, this medication enhances cells’ capacity for metabolism and encourages them to use bioenergy more effectively. This helps the brain’s insulin resistance.

“Second, certain studies have demonstrated that pioglitazone removes harmful beta-amyloid proteins from the brain. One of the main causes of Alzheimer’s disease is the buildup of beta-amyloid in the brain, he continued.

“Lastly,” he continued, “we hypothesise that pioglitazone’s anti-dementia action may be related to increasing blood vessel health as we found that this medication is more beneficial in diabetic patients who have blood circulation difficulties in the heart or brain than in those without such problems.

Strongest defence in people with heart illness

Speaking about the heart, Dr. Kim and his team discovered that individuals with type 2 diabetes who had previously experienced an ischemic stroke or ischemic heart disease benefited from pioglitazone the most in terms of dementia protection.

Researchers discovered that dementia risk was lowered by 54% in people with ischemic heart disease. Also, by 43% in people with ischemic stroke. Dr. Kim claimed that these outcomes astounded him and his team. It was a surprising discovery, he added.

“Ischemic heart or brain disorders are key risk factors for dementia, thus it would have made sense if pioglitazone’s effects were found to be less effective in those with these conditions. The outcome, though, was the exact reverse of what was anticipated, he said.

Anti-diabetic drugs against dementia

Dr. Kim stated that the next stage of this research is looking at how current anti-diabetic medications or potential medications. These meds enhance cell energy metabolism can inhibit dementia pathogenesis in animal models.

To confirm this medication’s anti-dementia properties and the risk-benefit ratio of using it, prospective trials are required in clinical research. That is, [a] balance between adverse symptoms and advantageous long-term consequences of this medication in terms of dementia prevention,” he said.

Dr. Sullivan replied that the next stage for pioglitazone would be to evaluate long-term safety in people and determine the ideal dose that minimises side effects while maintaining the desired results.

Due to safety concerns, pioglitazone is presently only used as a second-line medication for type 2 diabetes. It is well recognised to raise the risk of fractures, weight gain, and heart failure hospitalisation.

Until then, Dr. Sullivan advised persons with type 2 diabetes to focus on stabilising their blood glucose levels because both high blood sugar (hyperglycemia) and low blood sugar (hypoglycemia) might harm brain blood vessels.

According to her, brain damage occurs when people experience extreme highs and lows.

REFERENCES:

  • https://www.medscape.com/viewarticle/988388
  • https://www.bmj.com/company/newsroom/older-class-of-type-2-diabetes-drugs-linked-to-22-reduced-dementia-risk/
  • https://www.medicalnewstoday.com/articles/type-2-diabetes-drug-may-help-lower-increased-dementia-risk

For more details, kindly visit below.

Undenieable causes and symptoms of Diabetes you must know.

Undenieable causes and symptoms of Diabetes you must know.

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What is diabetes?

Diabetes mellitus, also known as just diabetes, is a metabolic condition that raises blood sugar levels. Insulin is a hormone that transports sugar from the blood into your cells where it can be stored or utilised as fuel. When you have diabetes, your body can’t use the insulin it does make or doesn’t produce enough of it.

Diabetes-related high blood sugar left untreated can harm your kidneys, nerves, eyes, and other organs. However, you can safeguard your health by learning about diabetes and taking measures to prevent or control it.

Types of diabetes

There are several varieties of diabetes:

  • Type 1: Diabetes type 1 is an autoimmune condition. The immune system targets and kills insulin-producing cells in the pancreas. Uncertainty surrounds the attack’s origin.
  • Type 2: When your body gets resistant to insulin, type 2 diabetes develops and blood sugar levels rise. About 90% to 95%Trusted Source of people with diabetes have type 2, making it the most prevalent kind.
  • Type 1.5: Latent autoimmune diabetes in adulthood is another name for type 1.5 diabetes (LADA). Like type 2 diabetes, it develops gradually during maturity. LADA is an autoimmune condition that cannot be controlled by a healthy diet or way of living.
  • Diabetes gestational: Diabetes gestational is excessive blood sugar when pregnant. This form of diabetes is brought on by substances the placenta secretes that block insulin.

Despite having a similar name to diabetes mellitus, the uncommon illness known as diabetes insipidus is unrelated. Your kidneys are removed from your body too much fluid in a separate ailment. Each kind of diabetes has specific symptoms, underlying conditions, and therapies.

Prediabetes

When your blood sugar is higher than normal but not high enough to be diagnosed with type 2 diabetes, the condition is known as prediabetes. It happens when your body’s cells don’t react to insulin as it should. Later on, type 2 diabetes may result from this.

According to experts, more than one in three Americans have prediabetes, but more than 80% of those individuals are completely unaware of their condition.

Symptoms of diabetes

The onset of diabetes is accompanied by blood sugar increases.

General symptoms

The symptoms of kinds 1, 2, and 1.5 (LADA) are identical, however they manifest more quickly than those of types 2 and 1.5. Type 2 usually has a slower onset. This diabetes is more likely to cause tingling nerves and slow-healing wounds.

Type 1 in particular, if untreated, can result in diabetic ketoacidosis. At this point, the body’s level of ketones is harmful. Although less typical in other forms of diabetes, it is nevertheless conceivable.

Diabetes’s typical signs and symptoms include:

  • increased appetite
  • heightened thirst
  • slim down
  • excessive urination
  • hazy vision
  • extreme exhaustion
  • not-healing wounds

Men’s symptoms

Men with diabetes may have the following in addition to the typical symptoms:

Women’s symptoms

Diabetes symptoms in women might include:

Gestational diabetes

The majority of women who develop gestational diabetes show no symptoms. When doing a routine oral glucose tolerance test or blood sugar test, which is often done between the 24th and 28th week of pregnancy, medical professionals frequently find the issue.

A person with gestational diabetes may, in extremely rare circumstances, also feel increased thirst or urination.

Diabetes symptoms might be so subtle that they are first difficult to identify. Discover the symptoms that call for a visit to the doctor.

Causes of diabetes

Each form of diabetes has a unique set of reasons.

Diabetes type 1

Type 1 diabetes has an unknown specific cause, according to doctors. The immune system wrongly targets and kills insulin-producing beta cells in the pancreas for some unknown cause.

Some people may be affected by their genes. Additionally, a virus may trigger an immune system attack.

Diabetes type 2

The cause of type 2 diabetes is a result of both hereditary and environmental factors. Your risk is further increased if you are overweight or obese. The effects of insulin on your blood sugar are resisted by your cells more when you are overweight, especially in the abdomen.

Families are prone to this condition. Family members have genes that increase their risk of type 2 diabetes and obesity.

Diabetes of type 1.5

When your own antibodies attack your pancreas, you have type 1.5 autoimmunity. like kind 1. Although additional research is required, it might be inherited.

Gestational diabetes

Hormonal changes during pregnancy are the cause of gestational diabetes. The placenta secretes hormones that reduce the sensitivity of a pregnant person’s cells to the effects of insulin. Pregnancy-related elevated blood sugar can result from this.

Gestational diabetes is more likely to develop in people who are overweight before becoming pregnant or who put on too much weight while pregnant.

Diabetes complications

Your body’s organs and tissues are harmed by high blood sugar. Your risk of complications increases as your blood sugar level rises and as you live with it for a longer period of time.

Diabetes-related complications include:

  • stroke, heart attack, and heart disease
  • neuropathy
  • nephropathy
  • Retinopathy and reduced eyesight
  • loss of hearing
  • harm to the feet, such as infections and unhealed wounds
  • skin problems include fungal and bacterial infections
  • depression
  • dementia

Gestational diabetes

Gestational diabetes that is not treated might result in issues for both the mother and the unborn child. Baby-related complications can take the following forms:

  • preterm delivery
  • higher-than-average birth weight
  • a later-life increase in the risk of type 2 diabetes
  • low blood glucose
  • jaundice
  • stillbirth

A woman who has gestational diabetes during pregnancy runs the risk of getting type 2 diabetes or high blood pressure (preeclampsia). You can also need a C-section, often known as a caesarean delivery. Future pregnancies also have a higher risk of developing gestational diabetes.

Although diabetes can cause major medical issues, you can manage the disease with medication and a change in lifestyle.

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